Jaime E C Hallak
Dados Biográficos
| ID | 141377 |
|---|---|
| NOME | Jaime E C Hallak |
| PRENOMES | Jaime E C |
| SOBRENOME | Hallak |
| ASSINATURA | HALLAK J E C |
| AFILIAÇÕES | Universidade de São Paulo |
| ORCID | 0000-0002-8784-0189 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 28 |
| TOTAL DE CITAÇÕES | 10 |
| TOTAL COMO AUTOR | 28 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 2010 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2026 |
| ÍNDICE H | 2 |
Trait mindfulness influences self-reported mental health in individuals with depression
Dispositional mindfulness, also known as trait mindfulness, refers to an individual dispositional tendency to attend the present moment experiences with openness, curiosity and awareness. It is often associated with well-being, particularly through its role with emotional regulation. Yet, it is not well understood how it may influence the expression of major depression symptoms. This cross-sectional study evaluated the influence of trait mindfuln…
Ayahuasca and Public Health III
Ayahuasca, a traditional Amazonian psychoactive brew, has gained increasing attention for its potential health benefits; however, no previous research has investigated its use in Portugal. This study aims to evaluate the health status, lifestyle behaviors, and psychosocial well-being of Portuguese ayahuasca users, comparing their self-reported health indicators with population norms. A cross-sectional online survey was conducted among 203 Portugu…
Comparative effects of ayahuasca and breathwork on self-reported cognitive flexibility, emotion regulation, positive affect, and sleep quality
Background and aimsResearch on classical psychedelics like ayahuasca is increasingly focused on treating mental disorders and enhancing well-being. Ayahuasca has shown promise in improving cognitive flexibility, emotion regulation, and sleep, though findings are mixed and further research is needed. This study tracked participants over three months, assessing cognitive flexibility, positive affect, emotion regulation, and sleep before and after a…
Why N,N-dimethyltryptamine matters
Iracema comes with the pot full of the green liquor. The shaman decrees the dreams to each warrior and distributes the wine of jurema, which carries the brave Tabajara to heaven." José de Alencar, in his poetic novel “Iracema” (1865)1. IntroductionThe "wine of jurema", used in ancient Brazilian shamanic rituals, is rich in N,N-dimethyltryptamine (DMT), a naturally occurring tryptamine like serotonin and melatonin. Widely found in plants and anima…
Neuroinflammation and schizophrenia – is there a link
Keywords: inflammation, schizophrenia, biomarkers, psychiatric genetics, neurobiology, neuroinflammation, psychotic disorders
Psychophysiological responses to group cognitive-behavioral therapy in depressive patients
Underground ibogaine use for the treatment of substance use disorders
Hallucinations and Hallucinogens
Mental health trajectories of Brazilian health workers during two waves of the Covid-19 pandemic (2020–2021)
This study aimed to: (a) monitor the progression of symptoms of mental health burden among frontline workers caring for COVID-19 patients in Brazil during the two waves of the pandemic, considering the number of new cases and deaths, and; (b) to verify the different mental health outcomes and potential associations with current burnout symptoms. A non-probabilistic sample of health professionals was assessed as the pandemic progressed in Brazil (…
Progression of the Covid-19 pandemic, Brazilian healthcare workers’ emotional burden and the effects on professional fulfillment at the end of the third wave
The lack of positive changes in mental health indicators coupled with decreased professional fulfillment over time highlights the pandemic's chronic effects and the need for organizations to monitor these workers' mental health, especially in developing countries like Brazil, where there is a high demand for health services and public policies are poorly structured and unstable
Monitoring the Mental Health and Professional Overload of Health Workers in Brazil
Few longitudinal studies assessed the less immediate consequences of the COVID-19 pandemic on health workers' mental health, especially in less developed countries. The objective was to assess the evolution of mental health indicators of Brazilian health workers providing care to COVID-19 patients, considering the beginning and first wave of the pandemic, identifying risk and protective factors. A non-probabilistic sample of health professionals …
Ayahuasca and Public Health II
Ayahuasca is a plant decoction in traditional Amazonian medicine. Its ritual use has been internationalized, leading to policy challenges that countries should address. This study evaluates the impact of regular ayahuasca ceremony participation on health by assessing the health status of 377 participants in ayahuasca ceremonies in the Netherlands using validated health indicators. A questionnaire was developed and administered to study participan…
Effects of Ayahuasca on Personality
Rationale: Previous studies with the serotonergic hallucinogens LSD and psilocybin showed that these drugs induced changes in personality traits, such as increases in Openness. However, results are inconsistent, and the effects of ayahuasca on personality were never investigated in a controlled trial. Objectives: To assess the effects of ayahuasca on personality in two randomized, placebo-controlled trials in healthy volunteers. Methods: Data fro…
Risk and Protective Factors for the Mental Health of Brazilian Healthcare Workers in the Frontline of Covid-19 Pandemic
The objective was to compare the mental health indicators of health workers providing care to individuals with COVID-19 in Brazil, considering sociodemographic and occupational variables and the risk perception of contamination by the Sars-CoV-2 of workers from different professions, identifying risk and protective factors. A sample of 916 health workers was assessed: physicians, nursing workers, and workers from other professions (psychologists,…
Cross-Sectional Associations Between Lifetime Use of Psychedelic Drugs and Psychometric Measures During the Covid-19 Confinement
Background: One of the main public health strategies adopted at the beginning of the COVID-19 pandemic consisted of implementing strict lockdowns to stop the transmission of the virus. Despite being an effective measure, the confinement and the associated social isolation create a stressful, potentially lengthy situations that has been proven to have several psychological consequences. Given the potential benefits that certain psychedelic drugs h…
Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression
Background Recent open-label trials show that psychedelics, such as ayahuasca, hold promise as fast-onset antidepressants in treatment-resistant depression. Methods To test the antidepressant effects of ayahuasca, we conducted a parallel-arm, double-blind randomized placebo-controlled trial in 29 patients with treatment-resistant depression. Patients received a single dose of either ayahuasca or placebo. We assessed changes in depression severity…
Ayahuasca and Public Health
Assessing the health status of ayahuasca users has been challenging due to the limitations involved in randomized clinical trials and psychometric approaches. The main objective of this study is the implementation of an approach based on public health indicators. We developed a self-administered questionnaire that was administered to long-term ayahuasca users around Spain. The questionnaire was administrated face-to-face to participants ( n = 380…
Internet method for the extraction of N,N-dimethyltryptamine from Mimosa hostilis roots
Background and aims: The psychoactive capacity of the alkaloid N,N-dimethyltryptamine (DMT) has been known for decades, and its presence in beverages used in religious contexts around the worldsuch as ayahuascahas attracted growing attention from the scientific community due to its possible anxiolytic and antidepressant effects. Mimosa hostilis, popularly known as jurema preta in Brazil, is a plant known to be utilized for extracting DMT, especia…
Ayahuasca turned on my mind's eye
Aphantasia (“blind imagination”) is a poorly described condition with an uncertain etiology, characterized by reduced or lack of voluntary visual imagery. Preliminary evidence in humans suggests that hallucinogenic or psychedelic drugs that act as agonists of cortical 5-HT2A receptors [lysergic acid diethylamide, psilocybin, and dimethyltryptamine (DMT)] enhance visual imagery. Interview and description of the case are presented in this study. A …
Effects of the Natural β -Carboline Alkaloid Harmine, a Main Constituent of Ayahuasca, in Memory and in the Hippocampus
The antiaddictive effects of ibogaine
Ibogaine is a naturally occurring hallucinogenic alkaloid with a therapeutic potential for reducing drug craving and withdrawal. To the best of our knowledge, no systematic review was previously performed assessing these effects. Thus, we conducted a systematic literature review of human studies assessing the antiaddictive effects of ibogaine. Papers published up to July 2, 2016 were included from PubMed, LILACS, and SciELO databases following a …
Detoxification from methadone using low, repeated, and increasing doses of ibogaine
Ibogaine is a natural alkaloid that has been used in the last decades as an adjuvant for the treatment of opiate withdrawal. Despite the beneficial results suggested by animal studies and case series, there is a lack of clinical trials to assess the safety and efficacy of ibogaine. Moreover, the majority of reports described cases of heroin-dependent individuals, with and without concomitant use of methadone, using high doses of ibogaine. Therefo…
Anxiety, panic, and hopelessness during and after ritual ayahuasca intake in a woman with generalized anxiety disorder
Background and aims: Ayahuasca is a dimethyltryptamine-and -carboline-rich hallucinogenic beverage traditionally used by indigenous groups of Northwest Amazonian for ritual and therapeutic purposes. Animal and human studies suggest that ayahuasca has antidepressant and anxiolytic potentials and has a good safety profile. However, anxiety-like reactions may also occur after ayahuasca intake, although they are rare. Methods: Case report
Antidepressant Effects of a Single Dose of Ayahuasca in Patients With Recurrent Depression
Ayahuasca is an Amazonian botanical hallucinogenic brew which contains dimethyltryptamine, a 5-HT2A receptor agonist, and harmine, a monoamine-oxidase A inhibitor. Our group recently reported that ayahuasca administration was associated with fast-acting antidepressive effects in 6 depressive patients. The objective of the present work was to assess the antidepressive potentials of ayahuasca in a bigger sample and to investigate its effects on reg…
Effects of Ayahuasca and its Alkaloids on Drug Dependence
Ayahuasca turned on my mind's eye
Aphantasia (“blind imagination”) is a poorly described condition with an uncertain etiology, characterized by reduced or lack of voluntary visual imagery. Preliminary evidence in humans suggests that hallucinogenic or psychedelic drugs that act as agonists of cortical 5-HT2A receptors [lysergic acid diethylamide, psilocybin, and dimethyltryptamine (DMT)] enhance visual imagery. Interview and description of the case are presented in this study. A …
The antiaddictive effects of ibogaine
Ibogaine is a naturally occurring hallucinogenic alkaloid with a therapeutic potential for reducing drug craving and withdrawal. To the best of our knowledge, no systematic review was previously performed assessing these effects. Thus, we conducted a systematic literature review of human studies assessing the antiaddictive effects of ibogaine. Papers published up to July 2, 2016 were included from PubMed, LILACS, and SciELO databases following a …
Internet method for the extraction of N,N-dimethyltryptamine from Mimosa hostilis roots
Background and aims: The psychoactive capacity of the alkaloid N,N-dimethyltryptamine (DMT) has been known for decades, and its presence in beverages used in religious contexts around the worldsuch as ayahuascahas attracted growing attention from the scientific community due to its possible anxiolytic and antidepressant effects. Mimosa hostilis, popularly known as jurema preta in Brazil, is a plant known to be utilized for extracting DMT, especia…
Detoxification from methadone using low, repeated, and increasing doses of ibogaine
Ibogaine is a natural alkaloid that has been used in the last decades as an adjuvant for the treatment of opiate withdrawal. Despite the beneficial results suggested by animal studies and case series, there is a lack of clinical trials to assess the safety and efficacy of ibogaine. Moreover, the majority of reports described cases of heroin-dependent individuals, with and without concomitant use of methadone, using high doses of ibogaine. Therefo…
Anxiety, panic, and hopelessness during and after ritual ayahuasca intake in a woman with generalized anxiety disorder
Background and aims: Ayahuasca is a dimethyltryptamine-and -carboline-rich hallucinogenic beverage traditionally used by indigenous groups of Northwest Amazonian for ritual and therapeutic purposes. Animal and human studies suggest that ayahuasca has antidepressant and anxiolytic potentials and has a good safety profile. However, anxiety-like reactions may also occur after ayahuasca intake, although they are rare. Methods: Case report
Comparação entre solicitações psiquiátricas de dois hospitais gerais universitários brasileiros
O objetivo do presente estudo foi comparar pedidos de interconsulta psiquiátrica realizados para dois hospitais gerais universitários brasileiros e avaliar a aplicabilidade de um protocolo de registro de interconsulta psiquiátrica (PRISMe). Foi realizada análise dos pedidos de interconsulta, do PRISMe anexado a eles e o número total de pedidos de interconsulta incluídos na amostra foi 541 (438 pedidos de interconsulta do HCFMRP-USP e 103 pedidos …
Marijuana, feijoada and the debate on drug legalization
OPINION article Front. Psychiatry, 05 March 2013 | https://doi.org/10.3389/fpsyt.2013.00007
Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression
OBJECTIVES: Ayahuasca (AYA), a natural psychedelic brew prepared from Amazonian plants and rich in dimethyltryptamine (DMT) and harmine, causes effects of subjective well-being and may therefore have antidepressant actions. This study sought to evaluate the effects of a single dose of AYA in six volunteers with a current depressive episode. METHODS: Open-label trial conducted in an inpatient psychiatric unit. RESULTS: Statistically significant re…
Antidepressant Effects of a Single Dose of Ayahuasca in Patients With Recurrent Depression
Ayahuasca is an Amazonian botanical hallucinogenic brew which contains dimethyltryptamine, a 5-HT2A receptor agonist, and harmine, a monoamine-oxidase A inhibitor. Our group recently reported that ayahuasca administration was associated with fast-acting antidepressive effects in 6 depressive patients. The objective of the present work was to assess the antidepressive potentials of ayahuasca in a bigger sample and to investigate its effects on reg…
Effects of Ayahuasca and its Alkaloids on Drug Dependence
Effects of the Natural β -Carboline Alkaloid Harmine, a Main Constituent of Ayahuasca, in Memory and in the Hippocampus
The antiaddictive effects of ibogaine
Ibogaine is a naturally occurring hallucinogenic alkaloid with a therapeutic potential for reducing drug craving and withdrawal. To the best of our knowledge, no systematic review was previously performed assessing these effects. Thus, we conducted a systematic literature review of human studies assessing the antiaddictive effects of ibogaine. Papers published up to July 2, 2016 were included from PubMed, LILACS, and SciELO databases following a …
Detoxification from methadone using low, repeated, and increasing doses of ibogaine
Ibogaine is a natural alkaloid that has been used in the last decades as an adjuvant for the treatment of opiate withdrawal. Despite the beneficial results suggested by animal studies and case series, there is a lack of clinical trials to assess the safety and efficacy of ibogaine. Moreover, the majority of reports described cases of heroin-dependent individuals, with and without concomitant use of methadone, using high doses of ibogaine. Therefo…
Anxiety, panic, and hopelessness during and after ritual ayahuasca intake in a woman with generalized anxiety disorder
Background and aims: Ayahuasca is a dimethyltryptamine-and -carboline-rich hallucinogenic beverage traditionally used by indigenous groups of Northwest Amazonian for ritual and therapeutic purposes. Animal and human studies suggest that ayahuasca has antidepressant and anxiolytic potentials and has a good safety profile. However, anxiety-like reactions may also occur after ayahuasca intake, although they are rare. Methods: Case report
Ayahuasca turned on my mind's eye
Aphantasia (“blind imagination”) is a poorly described condition with an uncertain etiology, characterized by reduced or lack of voluntary visual imagery. Preliminary evidence in humans suggests that hallucinogenic or psychedelic drugs that act as agonists of cortical 5-HT2A receptors [lysergic acid diethylamide, psilocybin, and dimethyltryptamine (DMT)] enhance visual imagery. Interview and description of the case are presented in this study. A …
Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression
Background Recent open-label trials show that psychedelics, such as ayahuasca, hold promise as fast-onset antidepressants in treatment-resistant depression. Methods To test the antidepressant effects of ayahuasca, we conducted a parallel-arm, double-blind randomized placebo-controlled trial in 29 patients with treatment-resistant depression. Patients received a single dose of either ayahuasca or placebo. We assessed changes in depression severity…
Ayahuasca and Public Health
Assessing the health status of ayahuasca users has been challenging due to the limitations involved in randomized clinical trials and psychometric approaches. The main objective of this study is the implementation of an approach based on public health indicators. We developed a self-administered questionnaire that was administered to long-term ayahuasca users around Spain. The questionnaire was administrated face-to-face to participants ( n = 380…
Internet method for the extraction of N,N-dimethyltryptamine from Mimosa hostilis roots
Background and aims: The psychoactive capacity of the alkaloid N,N-dimethyltryptamine (DMT) has been known for decades, and its presence in beverages used in religious contexts around the worldsuch as ayahuascahas attracted growing attention from the scientific community due to its possible anxiolytic and antidepressant effects. Mimosa hostilis, popularly known as jurema preta in Brazil, is a plant known to be utilized for extracting DMT, especia…
Effects of Ayahuasca on Personality
Rationale: Previous studies with the serotonergic hallucinogens LSD and psilocybin showed that these drugs induced changes in personality traits, such as increases in Openness. However, results are inconsistent, and the effects of ayahuasca on personality were never investigated in a controlled trial. Objectives: To assess the effects of ayahuasca on personality in two randomized, placebo-controlled trials in healthy volunteers. Methods: Data fro…
Risk and Protective Factors for the Mental Health of Brazilian Healthcare Workers in the Frontline of Covid-19 Pandemic
The objective was to compare the mental health indicators of health workers providing care to individuals with COVID-19 in Brazil, considering sociodemographic and occupational variables and the risk perception of contamination by the Sars-CoV-2 of workers from different professions, identifying risk and protective factors. A sample of 916 health workers was assessed: physicians, nursing workers, and workers from other professions (psychologists,…
Cross-Sectional Associations Between Lifetime Use of Psychedelic Drugs and Psychometric Measures During the Covid-19 Confinement
Background: One of the main public health strategies adopted at the beginning of the COVID-19 pandemic consisted of implementing strict lockdowns to stop the transmission of the virus. Despite being an effective measure, the confinement and the associated social isolation create a stressful, potentially lengthy situations that has been proven to have several psychological consequences. Given the potential benefits that certain psychedelic drugs h…
Monitoring the Mental Health and Professional Overload of Health Workers in Brazil
Few longitudinal studies assessed the less immediate consequences of the COVID-19 pandemic on health workers' mental health, especially in less developed countries. The objective was to assess the evolution of mental health indicators of Brazilian health workers providing care to COVID-19 patients, considering the beginning and first wave of the pandemic, identifying risk and protective factors. A non-probabilistic sample of health professionals …
Ayahuasca and Public Health II
Ayahuasca is a plant decoction in traditional Amazonian medicine. Its ritual use has been internationalized, leading to policy challenges that countries should address. This study evaluates the impact of regular ayahuasca ceremony participation on health by assessing the health status of 377 participants in ayahuasca ceremonies in the Netherlands using validated health indicators. A questionnaire was developed and administered to study participan…
Psychophysiological responses to group cognitive-behavioral therapy in depressive patients
Underground ibogaine use for the treatment of substance use disorders
Hallucinations and Hallucinogens
Mental health trajectories of Brazilian health workers during two waves of the Covid-19 pandemic (2020–2021)
This study aimed to: (a) monitor the progression of symptoms of mental health burden among frontline workers caring for COVID-19 patients in Brazil during the two waves of the pandemic, considering the number of new cases and deaths, and; (b) to verify the different mental health outcomes and potential associations with current burnout symptoms. A non-probabilistic sample of health professionals was assessed as the pandemic progressed in Brazil (…
Progression of the Covid-19 pandemic, Brazilian healthcare workers’ emotional burden and the effects on professional fulfillment at the end of the third wave
The lack of positive changes in mental health indicators coupled with decreased professional fulfillment over time highlights the pandemic's chronic effects and the need for organizations to monitor these workers' mental health, especially in developing countries like Brazil, where there is a high demand for health services and public policies are poorly structured and unstable
Why N,N-dimethyltryptamine matters
Iracema comes with the pot full of the green liquor. The shaman decrees the dreams to each warrior and distributes the wine of jurema, which carries the brave Tabajara to heaven." José de Alencar, in his poetic novel “Iracema” (1865)1. IntroductionThe "wine of jurema", used in ancient Brazilian shamanic rituals, is rich in N,N-dimethyltryptamine (DMT), a naturally occurring tryptamine like serotonin and melatonin. Widely found in plants and anima…
Neuroinflammation and schizophrenia – is there a link
Keywords: inflammation, schizophrenia, biomarkers, psychiatric genetics, neurobiology, neuroinflammation, psychotic disorders
Medicine (21 obras) · Psychiatry (20 obras) · Psychology (20 obras) · Psychedelics and Drug Studies (17 obras) · Ayahuasca (11 obras) · Clinical Psychology (11 obras) · Hallucinogen (10 obras) · Anxiety (8 obras) · Biochemical Analysis and Sensing Techniques (8 obras) · Internal Medicine (8 obras)