Brenda W J H Penninx
Biographic Data
| ID | 1727676 |
|---|---|
| NAME | Brenda W J H Penninx |
| GIVEN NAMES | Brenda W J H |
| FAMILY NAME | Penninx |
| SIGNATURE | PENNINX B W J H |
| AFFILIATIONS | Vrije Universiteit Amsterdam |
| ORCID | 0000-0001-7779-9672 |
| VERIFIED | Yes |
| TOTAL WORKS | 68 |
| TOTAL CITATIONS | 203 |
| AUTHOR COUNT | 68 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1996 |
| LATEST PUBLICATION YEAR | 2025 |
| H-INDEX | 9 |
Footprints from childhood
In clinical practice, it is important to explore the link between relational problems/adult attachment and past traumatic experiences, as they may fundamentally impact feelings of trust and safety. The impact is largest when childhood neglect and abuse occurred within families and when both parents are involved
Suicidal attempts and ideations in Kenyan adults with psychotic disorders
Suicidal ideation and SB are common in persons with psychotic disorders in this African setting and are associated with sociodemographic factors, such as young age and unemployment, and clinical factors, such as family history of suicidality. Interventions targeted at the community (e.g., economic empowerment) or at increasing access to care and treatment for persons with psychotic disorders may reduce the risk of suicide in this vulnerable popul…
The Impact of Covid-19 Lockdown on Adults with Major Depressive Disorder from Catalonia
The present study analyzes the effects of each containment phase of the first COVID-19 wave on depression levels in a cohort of 121 adults with a history of major depressive disorder (MDD) from Catalonia recruited from 1 November 2019, to 16 October 2020. This analysis is part of the Remote Assessment of Disease and Relapse-MDD (RADAR-MDD) study. Depression was evaluated with the Patient Health Questionnaire-8 (PHQ-8), and anxiety was evaluated w…
Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the Fads locus
Social and physical neighbourhood characteristics and 10-year incidence of depression and anxiety in older adults
Time for united action on depression
How Covid-19 shaped mental health
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12–16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half th…
The 5-year outcome of subjective quality of life in older schizophrenia patients
The mental health impact of the Covid-19 pandemic on people with and without depressive, anxiety, or obsessive-compulsive disorders
Potential Genetic Overlap Between Insomnia and Sleep Symptoms in Major Depressive Disorder
Background: The prevalence of insomnia and hypersomnia in depressed individuals is substantially higher than that found in the general population. Unfortunately, these concurrent sleep problems can have profound effects on the disease course. Although the full biology of sleep remains to be elucidated, a recent genome-wide association (GWAS) of insomnia, and other sleep traits in over 1 million individuals was recently published and provides many…
Longitudinal associations between negative life events and depressive symptoms—A 9-year longitudinal study on between-person and within-person effects and the role of family history
Research has shown that negative life events contribute to the development of depression. Moreover, it has been suggested that individuals with a family history of depression experience more negative life events and are more susceptible to the effect of negative life events. However, previous studies did not differentiate stable between-person effects (interindividual differences) and temporal within-person effects (intraindividual differences). …
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour
Sleep characteristics across the lifespan in 1.1 million people from the Netherlands, United Kingdom and United States
Does food intake mediate the association between mindful eating and change in depressive symptoms
Objective: To examine mediation by (i) diet quality and (ii) diet quantity in the associations of mindful eating domains with 3-year change in depressive symptoms. Design: Depressive symptoms were measured with the Center for Epidemiologic Studies Depression scale at baseline and 3-year follow-up. Four mindful eating domains (Focused Eating; Eating in response to Hunger and Satiety Cues; Eating with Awareness; Eating without Distraction) were mea…
Genome-wide association study identifies 48 common genetic variants associated with handedness
Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10−8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichmen…
Depression and obesity
Depressive Symptom Clusters in Relation to Body Weight Status
Background: There is strong evidence for a bidirectional association between depression and obesity. Several biological, psychological, and behavior-related factors may influence this complex association. Clinical impression and preliminary evidence suggest that patients with a diagnosis of major depressive disorder may endorse very different depressive symptom patterns depending on their body weight status. Until now, little is known about poten…
Associations of neighbourhood sociodemographic characteristics with depressive and anxiety symptoms in older age
We examined the long-term association between objective neighbourhood sociodemographic characteristics (index of socioeconomic position (SEP), average income, percent low-income earners, average house price, percent immigrants and urban density) with depressive and anxiety symptoms, covering five 3-year waves of the Longitudinal Aging Study Amsterdam (n = 3,772). Multi-level regression models assessed each neighbourhood-level characteristic separ…
Mindful eating and change in depressive symptoms
Depression and eating styles are independently associated with dietary intake
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders
Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. We conducted a meta-analysis of genome-wide association studies (GWAS) of gram/day (g/d) alcohol consumption in UK-Biobank, AlcGen and CHARGE+ consortia accumulating 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 novel, common loci, and investigate…
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
Bidirectional Prospective Associations Between Cardiac Autonomic Activity and Inflammatory Markers
Autonomic imbalance is associated with higher levels of inflammation. Independent data from two studies converge in evidence that higher HR predicts subsequent higher levels of CRP and IL-6. Inflammatory markers may also predict future ANS activity, but evidence for this was less consistent
The impact of conscientiousness, mastery, and work circumstances on subsequent absenteeism in employees with and without affective disorders
Affective disorders may particularly severely affect work functioning of employees who are highly conscientious or face high psychological job demands. Adjusting working conditions to their individual needs may prevent excessive work absence
Sex differences in the prevalence of mobility disability in old age
Disability incidence, recovery from disability, and mortality dynamically influence the sex differences in the prevalence of mobility disability. However, incidence has the greatest impact overall on the higher prevalence of disability in women compared with men
Exploring the effect of depression on physical disability
OBJECTIVES: This study examined the effect of depression on the incidence of physical disability and the role of confounding and explanatory variables in this relationship. METHODS: A cohort of 6247 subjects 65 years and older who were initially free of disability was followed up for 6 years. Baseline depression was assessed by the Center for Epidemiological Studies Depression Scale. Disability in mobility and disability in activities of daily li…
Longitudinal associations between depressive problems, academic performance, and social functioning in adolescent boys and girls
Depressive problems and academic performance, social well-being, and social problems in adolescents are strongly associated. However, longitudinal and bidirectional relations between the two remain unclear, as well as the role of gender. Consequently, this study focuses on the relation between depressive problems and three types of functioning in adolescents while testing gender differences. Depressive problems and functioning of 2,230 children w…
Direct and buffer effects of social support and personal coping resources in individuals with arthritis
The contribution of working conditions and social support to the onset of depressive and anxiety disorders among male and female employees
Social Network, Social Support, and Loneliness in Older Persons with Different Chronic Diseases
Objectives:This study examines whether patterns of social network size, functional social support, and loneliness are different for older persons with different types of chronic diseases. Methods:In a community-based sample of 2,788 men and women age 55 to 85 years participating in the Longitudinal Aging Study Amsterdam, chronic diseases status, social network size, support exchanges, and loneliness were assessed. Results:Social network size and …
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour
Associations of financial strain and income with depressive and anxiety disorders
BACKGROUND: Previous research has shown socioeconomic inequality in prevalence and onset of depressive disorders. It is not yet clear whether perceived financial strain is associated with depressive and/or anxiety disorders in addition to an objective indicator, such as income. This study examines whether financial strain is associated with the prevalence and onset/recurrence of depressive and/or anxiety disorders, above income. METHODS: Data are…
Accumulated and Differential Effects of Life Events on Cognitive Decline in Older Persons
Highly stressful events seem to be associated with a higher rate of cognitive decline, whereas mild chronic stressors may have an arousing function that stimulates cognitive performance
Exercise and Depressive Symptoms
This study examines and compares the effect of aerobic and resistance exercise on emotional and physical function among older persons with initially high or low depressive symptomatology. Data are from the Fitness, Arthritis and Seniors Trial, a trial among 439 persons 60 years or older with knee osteoarthritis randomized to health education (control), resistance exercise, or aerobic exercise groups. Depressive symptoms (assessed by the Center fo…
Psychological Distress in Victims of Elder Mistreatment
The objective of the study was to examine psychological distress in victims of elder mistreatment and to determine whether social support, coping style, mastery, and perceived self-efficacy favorably influence the psychological health of these victims. The study sample consisted of 77 subjects who reported recent chronic verbal aggression, physical aggression, or financial mistreatment, and a control group of 147 subjects who had not been mistrea…
Impact of depression on disablement in late middle aged and older persons
Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the Fads locus
Social and physical neighbourhood characteristics and 10-year incidence of depression and anxiety in older adults
Associations of neighbourhood sociodemographic characteristics with depressive and anxiety symptoms in older age
We examined the long-term association between objective neighbourhood sociodemographic characteristics (index of socioeconomic position (SEP), average income, percent low-income earners, average house price, percent immigrants and urban density) with depressive and anxiety symptoms, covering five 3-year waves of the Longitudinal Aging Study Amsterdam (n = 3,772). Multi-level regression models assessed each neighbourhood-level characteristic separ…
A blunted diurnal cortisol response in the lower educated does not explain educational differences in coronary heart disease
Do disease specific characteristics add to the explanation of mobility limitations in patients with different chronic diseases? A study in The Netherlands
STUDY OBJECTIVES: To determine whether disease specific characteristics, reflecting clinical disease severity, add to the explanation of mobility limitations in patients with specific chronic diseases. DESIGN AND SETTING: Cross sectional study of survey data from community dwelling elderly people, aged 55-85 years, in the Netherlands. PARTICIPANTS AND METHODS: The additional explanation of mobility limitations by disease specific characteristics …
Genome-wide association study identifies 48 common genetic variants associated with handedness
Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10−8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichmen…
Depression and eating styles are independently associated with dietary intake
Chronic Disease and Lifestyle Transitions
Health promotion may benefit from these findings in a way that patient groups at risk for not initiating healthy lifestyles might be identified sooner
Mindful eating and change in depressive symptoms
Lower body osteoarticular pain and dose of analgesic medications in older disabled women
OBJECTIVES: This study assessed use and dosage of analgesic medications in relation to severity of osteoarticular pain. METHODS: The type and dose of analgesic medication and the severity of pain in the lower back, hips, knees, or feet of 1002 older disabled women were assessed. RESULTS: Severe pain and the use of analgesic medications were reported by 48.5% and 78.8% of women, respectively. Among those who had severe pain, 41.2% were using less …
Self-reports and general practitioner information on the presence of chronic diseases in community dwelling elderly
Effects of Social Support and Personal Coping Resources on Mortality in Older Age
This study focuses on the role of social support and personal coping resources in relation to mortality among older persons in the Netherlands. Data are from a sample of 2,829 noninstitutionalized people aged between 55 and 85 years who took part in the Longitudinal Aging Study Amsterdam in 1992-1995. Social support was operationally defined by structural, functional, and perceived aspects, and personal coping resources included measures of maste…
Do disease specific characteristics add to the explanation of mobility limitations in patients with different chronic diseases? A study in The Netherlands
STUDY OBJECTIVES: To determine whether disease specific characteristics, reflecting clinical disease severity, add to the explanation of mobility limitations in patients with specific chronic diseases. DESIGN AND SETTING: Cross sectional study of survey data from community dwelling elderly people, aged 55-85 years, in the Netherlands. PARTICIPANTS AND METHODS: The additional explanation of mobility limitations by disease specific characteristics …
Direct and buffer effects of social support and personal coping resources in individuals with arthritis
Depressive Symptoms and Physical Decline in Community-Dwelling Older Persons
CONTEXT: Significant symptoms of depression are common in the older community-dwelling population. Although depressive symptoms and disability may commonly occur in the same person, whether depressive symptoms contribute to subsequent functional decline has not been elucidated. OBJECTIVE: To determine whether depressive symptoms in older persons increase the risk of subsequent decline in physical function as measured by objective performance-base…
Social Network, Social Support, and Loneliness in Older Persons with Different Chronic Diseases
Objectives:This study examines whether patterns of social network size, functional social support, and loneliness are different for older persons with different types of chronic diseases. Methods:In a community-based sample of 2,788 men and women age 55 to 85 years participating in the Longitudinal Aging Study Amsterdam, chronic diseases status, social network size, support exchanges, and loneliness were assessed. Results:Social network size and …
Psychological Distress in Victims of Elder Mistreatment
The objective of the study was to examine psychological distress in victims of elder mistreatment and to determine whether social support, coping style, mastery, and perceived self-efficacy favorably influence the psychological health of these victims. The study sample consisted of 77 subjects who reported recent chronic verbal aggression, physical aggression, or financial mistreatment, and a control group of 147 subjects who had not been mistrea…
Exploring the effect of depression on physical disability
OBJECTIVES: This study examined the effect of depression on the incidence of physical disability and the role of confounding and explanatory variables in this relationship. METHODS: A cohort of 6247 subjects 65 years and older who were initially free of disability was followed up for 6 years. Baseline depression was assessed by the Center for Epidemiological Studies Depression Scale. Disability in mobility and disability in activities of daily li…
Lower body osteoarticular pain and dose of analgesic medications in older disabled women
OBJECTIVES: This study assessed use and dosage of analgesic medications in relation to severity of osteoarticular pain. METHODS: The type and dose of analgesic medication and the severity of pain in the lower back, hips, knees, or feet of 1002 older disabled women were assessed. RESULTS: Severe pain and the use of analgesic medications were reported by 48.5% and 78.8% of women, respectively. Among those who had severe pain, 41.2% were using less …
Sex differences in the prevalence of mobility disability in old age
Disability incidence, recovery from disability, and mortality dynamically influence the sex differences in the prevalence of mobility disability. However, incidence has the greatest impact overall on the higher prevalence of disability in women compared with men
Exercise and Depressive Symptoms
This study examines and compares the effect of aerobic and resistance exercise on emotional and physical function among older persons with initially high or low depressive symptomatology. Data are from the Fitness, Arthritis and Seniors Trial, a trial among 439 persons 60 years or older with knee osteoarthritis randomized to health education (control), resistance exercise, or aerobic exercise groups. Depressive symptoms (assessed by the Center fo…
The role of coping resources and coping style in quality of life of patients with asthma or COPD
Impact of depression on disablement in late middle aged and older persons
Explanations of socioeconomic differences in changes in physical function in older adults
The findings indicate age-specificity of both the pattern of socioeconomic status differences in function in older persons and the mechanisms underlying these associations
Chronic Disease and Lifestyle Transitions
Health promotion may benefit from these findings in a way that patient groups at risk for not initiating healthy lifestyles might be identified sooner
The contribution of working conditions and social support to the onset of depressive and anxiety disorders among male and female employees
Association between Anxiety Disorders and Heart Rate Variability in The Netherlands Study of Depression and Anxiety (Nesda)
Objective: To determine whether patients with different types of anxiety disorder (panic disorder, social phobia, generalized anxiety disorder) have higher heart rate and lower heart rate variability compared with healthy controls in a sample that was sufficiently powered to examine the confounding effects of lifestyle and antidepressants. Methods: The standard deviation of the normal-to-normal intervals (SDNN), heart rate (HR), and respiratory s…
Depression and body mass index, a u-shaped association
The results of this study give evidence for a significant U-shaped trend in the association between BMI and depression
Overweight, Obesity, and Depression
CONTEXT: Association between obesity and depression has repeatedly been established. For treatment and prevention purposes, it is important to acquire more insight into their longitudinal interaction. OBJECTIVE: To conduct a systematic review and meta-analysis on the longitudinal relationship between depression, overweight, and obesity and to identify possible influencing factors. DATA SOURCES: Studies were found using PubMed, PsycINFO, and EMBAS…
Salivary Cortisol Levels in Persons With and Without Different Anxiety Disorders
OBJECTIVE: To examine the association between several subtypes of anxiety disorders and various cortisol indicators in a large cohort study. Anxiety disorders have been suggested to be linked to hypothalamic-pituitary-adrenal (HPA) axis activity, although results are scarce and inconsistent. No earlier studies have examined consistency of HPA axis findings across several anxiety subtypes and whether associations are state or trait dependent. METH…
Which Physician and Practice Characteristics are Associated With Adherence to Evidence-Based Guidelines for Depressive and Anxiety Disorders
BACKGROUND: Research on quality of care for depressive and anxiety disorders has reported low rates of adherence to evidence-based depression and anxiety guidelines. To improve this care, we need a better understanding of the factors determining guideline adherence. OBJECTIVE: To investigate how practice- and professional-related factors are associated with adherence to these guidelines. DESIGN: Cross-sectional cohort study. PARTICIPANTS: A total…
Comorbidity Patterns of Anxiety and Depressive Disorders in a Large Cohort Study
BACKGROUND: Comorbidity of depressive and anxiety disorders is common and has been shown to be a consistent predictor of chronicity. Comorbidity patterns among specific depressive and anxiety disorders have not been extensively reported. This study examines comorbidity patterns and temporal sequencing of separate depressive and anxiety disorders using data from a large psychiatric cohort. METHOD: Baseline data (N = 1,783) of the Netherlands Study…
Symptom Dimensions of Depression and Anxiety and the Metabolic Syndrome
OBJECTIVE: To investigate the association between depression and anxiety symptoms and the metabolic syndrome (MetSyn), using a dimensional approach. The association between depression and anxiety, on the one hand, and the MetSyn as a cluster or its individual components, on the other hand, is equivocal. The categorical nature of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition might partly explain the inconsistent finding…
Accumulated and Differential Effects of Life Events on Cognitive Decline in Older Persons
Highly stressful events seem to be associated with a higher rate of cognitive decline, whereas mild chronic stressors may have an arousing function that stimulates cognitive performance
O2-3.4 Heterogeneity in disability associated with major depressive disorder
Introduction Major depressive disorder (MDD) is the leading cause of disability worldwide and its impact on patients' functioning exceeds that of chronic medical conditions. Previous studies reported that severity of depression and disability show synchrony of change. However, there are patients with severe depressive symptoms who function rather well, suggesting that certain characteristics influence the association between depression severity a…
Medicine (52 works) · Psychiatry (47 works) · Psychology (42 works) · Clinical Psychology (28 works) · Anxiety (27 works) · Internal Medicine (24 works) · Depression (economics) (20 works) · Internal Medicine (17 works) · Clinical Psychology (16 works) · Longitudinal study (14 works)