G Lucotte
Biographic Data
| ID | 214428 |
|---|---|
| NAME | G Lucotte |
| GIVEN NAMES | G |
| FAMILY NAME | Lucotte |
| SIGNATURE | LUCOTTE G |
| AFFILIATIONS | Laboratoire de Génétique Cellulaire |
| VERIFIED | No |
| TOTAL WORKS | 10 |
| TOTAL CITATIONS | 5 |
| AUTHOR COUNT | 10 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1983 |
| LATEST PUBLICATION YEAR | 2012 |
| H-INDEX | 1 |
New contribution on the LRRK2 G2019S mutation associated to Parkinson's disease
Background: The LRRK2 G2019S mutation is an important genetic determinant of Parkinson’s disease (PD) across the world that occurs at an elevated frequency in North Africa. Aim: To estimate the date of the G2019S mutation in Berbers. Material and Methods: We determined the LRRK2 haplotypes in twenty-two G2019S carriers, mostly North Africans, and in one hundred twenty-four Arab, Moroccan Berber and Sephardi Jew controls, using seven microsatellit…
Original Synthetic Report
Background: The G2019S mutation in the LRRK2 gene is associated with 1-2% of sporadic Parkinson’s disease (PD) cases. In Europe, the prevalence of G2019S in sporadic PD patients depends on the population, being relatively high in Spain and Portugal but low in northern Europe. Aim: To drawn up a European frequency map of the G2019S mutation. Material and Methods: A map of G2019S mutation isofrequences in Europe has been drawn up using the Spatial …
Original Synthetic Report
Mutation 35delG in the connexin-26 gene is the main cause of recessive deafness in Europe. The aim of this study is to determine the percentage of carriers of this mutation in seven regions of the Greek-Turkish area; previous studies indicated that the prevalence of the mutation was relatively elevated in Greece. This study has been carried out on the genomic DNAs of a total of 1038 healthy subjects originating from Albania, Bulgaria, Athens (Gre…
Y-Chromosome Haplotypes in the Greek–Turkish Area
Various populations have contributed to the present-day gene pool in oriental Mediterranean (Aegean Sea) and are well documented for ancient history. The primary objective of the study is to report on the analysis of the paternal component of the variation (Y chromosome haplotypes) in contemporary populations in Greece, Crete, Turkey and Cyprus. A total of 245 males who hailed from five different locations in Turkey, Greece, and the islands of Cr…
Y-Haplotype X in the Balkans
A total of 2110 unrelated European male subjects were examined for the p49a,f TaqI Y-haplotype X. The results showed a remarkable mean peak of haplotype X frequencies (46.9%) among subjects from Croatia, and similar elevated frequency values were also found in their counterparts from Slovenia (41.5%), Bosnia (40.3%) and ex-Yugoslavia (36.7%). Frequencies of haplotype X decrease towards west (from 41.5% in Slovenia to less than 1% in northern Ital…
Characterization of the Y-Chromosome Sardinian–Corsican Haplotype
The Y chromosome of 523 Italian male subjects was examined for the 49a,f TaqI haplotype XII and for two microsatellites, YCAIIa and YCAIIb. Results were then compared to other populations living in the western Mediterranean basin whom we had previously studied: 419 French (including 328 Corsicans), 46 Italians from Milan, and 73 Tunisians. Haplotype XII is present in 127 out of the 1061 examined samples (11.9%), and most of the haplotype XII subj…
Brief communication
We analyzed Y‐chromosome haplotypes in the Nile River Valley in Egypt in 274 unrelated males, using the p49a,f Taq I polymorphism. These individuals were born in three regions along the river: in Alexandria (the Delta and Lower Egypt), in Upper Egypt, and in Lower Nubia. Fifteen different p49a,f Taq I haplotypes are present in Egypt, the three most common being haplotype V (39.4%), haplotype XI (18.9%), and haplotype IV (13.9%). Haplotype V is a …
Haplotypes of the Y chromosome in some populations of west Africa
One Y-specific DNA polymorphism (p49/Taql) was studied in a sample of 469 African males coming from twelve populations of sub-Saharan Africa. An high frequency (62.5%) of the Y-haplotype IV was observed in these populations, the most elevated percentage of this haplotype being observed in Mossis (from Burkina-Fasso). The “Arabic” haplotype V is present in these populations at a mean frequency of 8.7%. The “oriental” haplotype XI is present at a m…
Linkage disequilibrium between haplotypes and allelic incompatibilities detected with p49f, a probe located on the Y chromosome
We have analyzed linkage disequilibrium between haplotypes and allelic incompatibilities betweenTaqI RELPs concerning the probe 49f, located on the Y chromosome. For most (but one) observed haplotypes, discrepancies between observed and expected frequencies can be easily explained allowing a small number of incompatibilities beetween alleles
Chimpanzees show less variation than man
Brief communication
We analyzed Y‐chromosome haplotypes in the Nile River Valley in Egypt in 274 unrelated males, using the p49a,f Taq I polymorphism. These individuals were born in three regions along the river: in Alexandria (the Delta and Lower Egypt), in Upper Egypt, and in Lower Nubia. Fifteen different p49a,f Taq I haplotypes are present in Egypt, the three most common being haplotype V (39.4%), haplotype XI (18.9%), and haplotype IV (13.9%). Haplotype V is a …
Chimpanzees show less variation than man
Chimpanzees show less variation than man
Linkage disequilibrium between haplotypes and allelic incompatibilities detected with p49f, a probe located on the Y chromosome
We have analyzed linkage disequilibrium between haplotypes and allelic incompatibilities betweenTaqI RELPs concerning the probe 49f, located on the Y chromosome. For most (but one) observed haplotypes, discrepancies between observed and expected frequencies can be easily explained allowing a small number of incompatibilities beetween alleles
Haplotypes of the Y chromosome in some populations of west Africa
One Y-specific DNA polymorphism (p49/Taql) was studied in a sample of 469 African males coming from twelve populations of sub-Saharan Africa. An high frequency (62.5%) of the Y-haplotype IV was observed in these populations, the most elevated percentage of this haplotype being observed in Mossis (from Burkina-Fasso). The “Arabic” haplotype V is present in these populations at a mean frequency of 8.7%. The “oriental” haplotype XI is present at a m…
Brief communication
We analyzed Y‐chromosome haplotypes in the Nile River Valley in Egypt in 274 unrelated males, using the p49a,f Taq I polymorphism. These individuals were born in three regions along the river: in Alexandria (the Delta and Lower Egypt), in Upper Egypt, and in Lower Nubia. Fifteen different p49a,f Taq I haplotypes are present in Egypt, the three most common being haplotype V (39.4%), haplotype XI (18.9%), and haplotype IV (13.9%). Haplotype V is a …
Y-Chromosome Haplotypes in the Greek–Turkish Area
Various populations have contributed to the present-day gene pool in oriental Mediterranean (Aegean Sea) and are well documented for ancient history. The primary objective of the study is to report on the analysis of the paternal component of the variation (Y chromosome haplotypes) in contemporary populations in Greece, Crete, Turkey and Cyprus. A total of 245 males who hailed from five different locations in Turkey, Greece, and the islands of Cr…
Y-Haplotype X in the Balkans
A total of 2110 unrelated European male subjects were examined for the p49a,f TaqI Y-haplotype X. The results showed a remarkable mean peak of haplotype X frequencies (46.9%) among subjects from Croatia, and similar elevated frequency values were also found in their counterparts from Slovenia (41.5%), Bosnia (40.3%) and ex-Yugoslavia (36.7%). Frequencies of haplotype X decrease towards west (from 41.5% in Slovenia to less than 1% in northern Ital…
Characterization of the Y-Chromosome Sardinian–Corsican Haplotype
The Y chromosome of 523 Italian male subjects was examined for the 49a,f TaqI haplotype XII and for two microsatellites, YCAIIa and YCAIIb. Results were then compared to other populations living in the western Mediterranean basin whom we had previously studied: 419 French (including 328 Corsicans), 46 Italians from Milan, and 73 Tunisians. Haplotype XII is present in 127 out of the 1061 examined samples (11.9%), and most of the haplotype XII subj…
Original Synthetic Report
Background: The G2019S mutation in the LRRK2 gene is associated with 1-2% of sporadic Parkinson’s disease (PD) cases. In Europe, the prevalence of G2019S in sporadic PD patients depends on the population, being relatively high in Spain and Portugal but low in northern Europe. Aim: To drawn up a European frequency map of the G2019S mutation. Material and Methods: A map of G2019S mutation isofrequences in Europe has been drawn up using the Spatial …
Original Synthetic Report
Mutation 35delG in the connexin-26 gene is the main cause of recessive deafness in Europe. The aim of this study is to determine the percentage of carriers of this mutation in seven regions of the Greek-Turkish area; previous studies indicated that the prevalence of the mutation was relatively elevated in Greece. This study has been carried out on the genomic DNAs of a total of 1038 healthy subjects originating from Albania, Bulgaria, Athens (Gre…
New contribution on the LRRK2 G2019S mutation associated to Parkinson's disease
Background: The LRRK2 G2019S mutation is an important genetic determinant of Parkinson’s disease (PD) across the world that occurs at an elevated frequency in North Africa. Aim: To estimate the date of the G2019S mutation in Berbers. Material and Methods: We determined the LRRK2 haplotypes in twenty-two G2019S carriers, mostly North Africans, and in one hundred twenty-four Arab, Moroccan Berber and Sephardi Jew controls, using seven microsatellit…
Biology (10 works) · Genetics (10 works) · Gene (9 works) · Haplotype (8 works) · Genotype (7 works) · Geography (6 works) · Allele (5 works) · Forensic and Genetic Research (5 works) · Genetics (5 works) · Demography (4 works)