Alexander C Tsai
Biographic Data
| ID | 341857 |
|---|---|
| NAME | Alexander C Tsai |
| GIVEN NAMES | Alexander C |
| FAMILY NAME | Tsai |
| SIGNATURE | TSAI A C |
| AFFILIATIONS | Harvard University |
| ORCID | 0000-0001-6397-7917 |
| VERIFIED | Yes |
| TOTAL WORKS | 161 |
| TOTAL CITATIONS | 232 |
| AUTHOR COUNT | 152 |
| EDITOR COUNT | 9 |
| FIRST PUBLICATION YEAR | 2005 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 8 |
Inside the meat locker
The U.S. federal grant terminations of 2025 have had a chilling effect on American science. Grantees whose awards have been renegotiated under threat of termination must now determine how the revised terms constrain the language they use when reporting their findings in peer-reviewed publications. Standing in the meat locker of anticipatory compliance, scientists face strong incentives to adopt conservative interpretations of what the revised ter…
Perspectives of Traditional Healers, Religious Leaders, and Biomedical Providers on Depression and HIV Care in Rural Uganda
Psychosocial Mechanisms Linking Intersecting Stigmas and Condomless Anal Sex Among Transgender Women in India
Pathways to suicide attempts in rural Uganda
Parenting under the triple burden of violence, depression, and poor diet quality
Parenting while experiencing intimate partner violence (IPV), depression, and poor diet quality can contribute to child health inequities. Syndemic theory offers a framework to understand how maternal conditions can lead to inequitable child health outcomes, such as diarrheal disease: a risk factor for childhood mortality and stunting. This study uses the 2022 Nepal Demographic and Health Survey to test an intergenerational syndemic model address…
Defining a shift estimand on forgivingness without domesticating forgiveness
This commentary responds to Cowden et al.'s (2026) careful epidemiologic study of the population-wide changes in well-being that might follow from two explicitly defined "shift" scenarios applied to a three-item forgivingness measure. I value the paper's candor about its counterfactual aim: it is not asking whether forgiveness is good in the abstract, but what could plausibly happen if the distribution of measured forgivingness were moved in spec…
Design of a mobile mental health stigma reduction application for depression and anxiety
What breaks when federal commitments break
In this commentary on Beccia et al.'s mapping of the 2025 first-wave mental health and substance use-related federal grant terminations, I interpret what happened as a stress test of the U.S. postwar research funding compact. The damage was amplified because the U.S. scientific research enterprise is structurally fragile, characterized by debt-financed institutional growth premised on ever-rising federal budgets; heavy reliance on "soft money" sa…
Experienced stigma related to common mental illness and alcohol use disorder in rural Uganda
Background: Stigma remains a major barrier to mental health care in low- and middle-income countries (LMICs), yet little is known about how stigma operates for common mental illnesses (CMIs) and alcohol use disorder (AUD) in rural Uganda. Methods: We conducted 80 in-depth interviews (IDIs) with individuals and family members affected by CMIs (n=34) or AUD (n=46) in Buyende District, Uganda. Interviews were analyzed inductively using the framework…
Psychosocial problems, sexual violence victimization, and substance use among sexual and gender minorities in India
Social influence on women's contraceptive use
Myriad barriers impede women's access to contraception in Uganda and affect their reproductive autonomy. Almost half of married women of reproductive age in Uganda want to avoid pregnancy and one-third are undecided, yet only 38% use modern contraception. Interventions harnessing the influence of women's social networks may help to overcome these barriers and support desired contraceptive use. Using population-based longitudinal, socio-centric ne…
Experiences of adults who survived suicide attempts in rural Uganda
Suicide disproportionately burdens low- and middle-income countries. In Uganda, attempt survivors encounter intense stigma, minimal mental-health services and social exclusion, elevating their risk of future attempts. Rural African data on post-attempt experiences are scarce. From June to August 2023, we conducted semi-structured, in-depth interviews in Buyende District with 18 attempt survivors, 17 relatives, 10 healthcare workers and 9 communit…
Mixed Methods to Advance Global Health Research on Gender-Based Violence Syndemics
Emerging studies from low-and-middle-income countries (LMIC) have applied mixed methods to investigate gender-based violence (GBV) syndemics. There is currently no guidance on how to appropriately combine qualitative and quantitative methods when testing syndemic theory. This research introduces a mixed methods framework for testing GBV syndemics in LMIC. A multi-step approach was used for framework development. The framework centers on the disti…
Clarification of policy on retractions
‘We would look at the chickens as a source of security’
Background: Development interventions may promote sustainable livelihoods among participants via improved income generation, health, education, and quality of life. Within the development literature, microfinance institutions (MFIs) provide individuals with funds and/or start-up capital to develop small businesses. However, the evidence on whether MFIs are successful in ensuring sustainable livelihoods is mixed. In this study, we assessed partici…
A qualitative study of abortion decision-making trajectories among pregnant women at their first antenatal care visit in Kampala, Uganda
Background: In Uganda, only about half of women who want to avoid pregnancy are using modern contraceptives, leading to high numbers of unintended pregnancies and elevated maternal and neonatal morbidity and mortality. In this study, we aimed to learn more about women's abortion decision-making before continuing to carry a pregnancy. Methods: We utilised a qualitative study design and interviewed 31 purposively selected single and partnered pregn…
The Role of Health Networks in Disseminating Knowledge about Infant HIV Testing in Rural Uganda
Early testing of infants exposed to HIV can significantly decrease mortality for those linked to HIV treatment. Infants exposed to HIV should first be tested at 6 weeks of age, but only 60% are tested as recommended. Little research has focused on the role of social networks in disseminating information about infant HIV testing. We conducted a cross-sectional, sociocentric network study of all adults living in a rural parish in Uganda (N=1,383) a…
Factor Structure, Reliability, and Validity of the 10-Item HIV Stigma Scale for Adolescents and Youth Living with HIV in Rural, Southwestern Uganda
Gender-based violence syndemics in global health
The Place Where Danger Waits”
Perspectives of traditional healers, faith healers, and biomedical providers about mental illness treatment
Most people with mental illness in low and middle-income countries (LMICs) do not receive biomedical treatment, though many seek care from traditional healers and faith healers. We conducted a qualitative study in Buyende District, Uganda, using framework analysis. Data collection included interviews with 24 traditional healers, 20 faith healers, and 23 biomedical providers, plus 4 focus group discussions. Interviews explored treatment approaches…
Longitudinal Trends in Physical Activity Among Older Adults With and Without HIV in Uganda
Introduction Physical Activity (PA) and its links to frailty, quality of life (QoL), and other comorbidities in older Ugandans living with HIV remain under-explored. Methods We analyzed data from three annual assessments of older people living with HIV (PLWH) and age- and sex-similar people not living with HIV (PnLWH). We fitted linear generalized estimating equations (GEE) regression models to estimate the correlates of PA, including demographic…
Correlates of HIV treatment adherence self-efficacy among adolescents and young adults living with HIV in southwestern Uganda
Adherence to antiretroviral therapy (ART) among adolescents and young adults living with HIV (AYLHIV) in sub-Saharan Africa is sub-optimal compared to younger children and older adults. Adherence self-efficacy is one of the intrapersonal factors most strongly correlated with ART adherence. The role of adherence self-efficacy in ART adherence among AYLHIV is not well studied in Uganda. We enrolled 300 AYLHIV between October and December 2021 from …
A qualitative analysis of self-management needs of adolescents and young adults living with perinatally acquired HIV in rural, southwestern Uganda
The number of adolescents living with HIV remains high in sub-Saharan Africa with poorer HIV treatment outcomes among adolescents and young adults compared to individuals in other age groups. For adolescents and young adults living with perinatally acquired HIV (AYLPHIV), the transition from pediatric to adult HIV care is a particularly high-risk period. We conducted a qualitative study to understand self-management needs of AYLPHIV in rural, sou…
Setting research priorities for global pandemic preparedness
Background: In this priority-setting exercise, we sought to identify leading research priorities needed for strengthening future pandemic preparedness and response across countries. Methods: The International Society of Global Health (ISoGH) used the Child Health and Nutrition Research Initiative (CHNRI) method to identify research priorities for future pandemic preparedness. Eighty experts in global health, translational and clinical research id…
Syndemics
Promises and pitfalls of data sharing in qualitative research
Food insecurity, depression and the modifying role of social support among people living with HIV/Aids in rural Uganda
The social context of food insecurity among persons living with HIV/Aids in rural Uganda
From social networks to health
When you have no water, it means you have no peace
Food insufficiency, depression, and the modifying role of social support
Syndemic theory, methods, and data
Economic Opportunity, Health Behaviors, and Mortality in the United States
Objectives. We assessed whether economic opportunity was independently associated with health behaviors and outcomes in the United States. Methods. Using newly available, cross-sectional, county-level data from the Equality of Opportunity Project Database and vital statistics, we estimated associations between all-cause mortality rates (averaged over 2000-2012) and economic opportunity, adjusting for socioeconomic, demographic, and health system …
Rural–urban comparison of contextual associations with self-reported mental health status
The causal effect of education on HIV stigma in Uganda
The impact of a syndemic theory-based intervention on HIV transmission risk behaviour among men who have sex with men in India
The social network context of HIV stigma
Communal bereavement and resilience in the aftermath of a terrorist event
Prevalence and Correlates of Forced Sex Perpetration and Victimization in Botswana and Swaziland
Objectives. We sought to identify correlates of forced sex perpetration among men and victimization among women in Botswana and Swaziland. Methods. We surveyed a 2-stage probability sample of 2074 adults from the 5 districts of Botswana with the highest HIV prevalence rates and all 4 regions of Swaziland. We used multivariable logistic regression to identify correlates of forced sex victimization and perpetration. Results. Lifetime prevalence rat…
Methods in HIV-Related Intersectional Stigma Research
Researchers are increasingly recognizing the importance of studying and addressing intersectional stigma within the field of HIV. Yet, researchers have, arguably, struggled to operationalize intersectional stigma. To ensure that future research and methodological innovation is guided by frameworks from which this area of inquiry has arisen, we propose a series of core elements for future HIV-related intersectional stigma research. These core elem…
HIV Treatment Scale-Up and HIV-Related Stigma in Sub-Saharan Africa
Objectives. We estimated the association between antiretroviral therapy (ART) uptake and HIV-related stigma at the population level in sub-Saharan Africa. Methods. We examined trends in HIV-related stigma and ART coverage in sub-Saharan Africa during 2003 to 2013 using longitudinal, population-based data on ART coverage from the Joint United Nations Program on HIV/AIDS and on HIV-related stigma from the Demographic and Health Surveys and AIDS Ind…
Caregiver preferences for physically harsh discipline of children in rural Uganda
The high prevalence of physically harsh discipline preferences warrant interventions aimed at reframing caregivers' approaches to discipline
Integrating Intersectional and Syndemic Frameworks for Ending the US HIV Epidemic
Intersectional Stigma and HIV Continuum Outcomes Among Sexual Minority Men in Sub-Saharan Africa
Understanding the Association Between Mental Health Knowledge and Mental Health Service Utilization Among Black Adults
A mixed-methods, population-based study of a syndemic in Soweto, South Africa
Development and validation of the Soweto Stress Scale
Directly Observed Antidepressant Medication Treatment and HIV Outcomes Among Homeless and Marginally Housed HIV-Positive Adults
Objectives. We assessed whether directly observed fluoxetine treatment reduced depression symptom severity and improved HIV outcomes among homeless and marginally housed HIV-positive adults in San Francisco, California, from 2002 to 2008. Methods. We conducted a nonblinded, randomized controlled trial of once-weekly fluoxetine, directly observed for 24 weeks, then self-administered for 12 weeks (n = 137 persons with major or minor depressive diso…
Racial/Ethnic Disparities in Opioid-Related Mortality in the USA, 1999–2019
Physician Decisions to Discontinue Long-Term Medications Using a Two-Stage Framework
BACKGROUND: Physician decisions to discontinue prescription medications for chronic conditions are fundamental determinants of drug use but have been inadequately studied. The decision to stop growth hormone (GH) therapy is an important example because of high cost (approximately $26,000/y for a 48-kg child), complexity of treatment options, and expansion of patient populations. AIM: The aim of this study was to identify the factors that influenc…
Setting Priorities in Global Child Health Research Investments
This article provides detailed guidelines for the implementation of systematic method for setting priorities in health research investments that was recently developed by Child Health and Nutrition Research Initiative (CHNRI). The target audience for the proposed method are international agencies, large research funding donors, and national governments and policy-makers. The process has the following steps: (i) selecting the managers of the proce…
Rural–urban comparison of contextual associations with self-reported mental health status
Socioeconomic disparities in access to HIV/Aids treatment programs in resource-limited settings
This study employs data from rural South Africa to determine whether there were socioeconomic differences in the profile of HIV-infected persons living in the community and HIV-infected patients presenting for hospital-based outpatient HIV/AIDS care and related services. There were 776 HIV-infected persons aged 18-35 years in Limpopo Province, South Africa who were included in the study, including 534 consecutive patients who presented for care a…
Conceptual framework for understanding the bidirectional links between food insecurity and HIV/Aids
Prevalence and Correlates of Forced Sex Perpetration and Victimization in Botswana and Swaziland
Objectives. We sought to identify correlates of forced sex perpetration among men and victimization among women in Botswana and Swaziland. Methods. We surveyed a 2-stage probability sample of 2074 adults from the 5 districts of Botswana with the highest HIV prevalence rates and all 4 regions of Swaziland. We used multivariable logistic regression to identify correlates of forced sex victimization and perpetration. Results. Lifetime prevalence rat…
The social context of food insecurity among persons living with HIV/Aids in rural Uganda
Food insecurity is associated with morbidity and patterns of healthcare utilization among HIV-infected individuals in a resource-poor setting
OBJECTIVE: We undertook a longitudinal study in rural Uganda to understand the association of food insecurity with morbidity and patterns of healthcare utilization among HIV-infected individuals enrolled in an antiretroviral therapy program. DESIGN: Longitudinal cohort study. METHODS: Participants were enrolled from the Uganda AIDS Rural Treatment Outcomes cohort, and underwent quarterly structured interviews and blood draws. The primary predicto…
Mental health spillovers and the Millennium Development Goals
Based on
Setting priorities for development of emerging interventions against childhood pneumonia, meningitis and influenza
A cute lower respiratory infections, which broadly include pneumonia and bronchiolitis, are still the leading cause of childhood mortality. ALRI contributed to 18% of all deaths in children younger than five years of age in 2008 [1], and the main pathogens responsible for high mortality were Streptococcus pneumoniae, Haemophilus influenzae and respiratory syncytial virus [2-4]. In addition, meningitis was estimated to contribute up to 200 000 dea…
No Association Found Between Traditional Healer Use and Delayed Antiretroviral Initiation in Rural Uganda
Sexual Relationship Power and Malnutrition Among HIV-Positive Women in Rural Uganda
Evidence for the Reliability and Validity of the Internalized Aids-Related Stigma Scale in Rural Uganda
A typology of structural approaches to HIV prevention
Food insecurity, depression and the modifying role of social support among people living with HIV/Aids in rural Uganda
Internalized Stigma, Social Distance, and Disclosure of HIV Seropositivity in Rural Uganda
BACKGROUND: HIV is highly stigmatized, compromising both treatment and prevention in resource-limited settings. PURPOSE: We sought to study the relationship between internalized HIV-related stigma and serostatus disclosure and to determine the extent to which this association varies with the degree of social distance. METHODS: We fit multivariable Poisson regression models, with cluster-correlated robust estimates of variance, to data from 259 pe…
Domestic Violence and Perinatal Mental Disorders
Scaling Up mHealth
CITATION: Tomlinson, M., et al. 2013. Scaling up mHealth : where is the evidence?. PLoS Medicine, 10(2): e1001382, doi: 10.1371/journal.pmed.1001382.
Intimate Partner Violence and Incident Depressive Symptoms and Suicide Attempts
Impact of HIV‐related stigma on treatment adherence
US medical specialty global health training and the global burden of disease
BACKGROUND: Rapid growth in global health activity among US medical specialty education programs has lead to heterogeneity in types of activities and global health training models. The breadth and scope of this activity is not well chronicled. METHODS: Using a standardized search protocol, we examined the characteristics of US medical residency global health programs by number of programs, clinical specialty, nature of activity (elective, researc…
Does Effective Depression Treatment Alone Reduce Secondary HIV Transmission Risk? Equivocal Findings from a Randomized Controlled Trial
How Does Antiretroviral Treatment Attenuate the Stigma of HIV? Evidence from a Cohort Study in Rural Uganda
Directly Observed Antidepressant Medication Treatment and HIV Outcomes Among Homeless and Marginally Housed HIV-Positive Adults
Objectives. We assessed whether directly observed fluoxetine treatment reduced depression symptom severity and improved HIV outcomes among homeless and marginally housed HIV-positive adults in San Francisco, California, from 2002 to 2008. Methods. We conducted a nonblinded, randomized controlled trial of once-weekly fluoxetine, directly observed for 24 weeks, then self-administered for 12 weeks (n = 137 persons with major or minor depressive diso…
Achieving Consensus on Terminology Describing Multivariable Analyses
human; note; regression analysis, Humans; Regression Analysis
Medicine (128 works) · Environmental health (83 works) · Psychology (83 works) · Psychiatry (79 works) · HIV/AIDS Research and Interventions (65 works) · Demography (61 works) · Population (61 works) · Public health (54 works) · Adolescent Sexual and Reproductive Health (49 works) · Sociology (45 works)