Terence A Brown
Biographic Data
| ID | 3608219 |
|---|---|
| NAME | Terence A Brown |
| GIVEN NAMES | Terence A |
| FAMILY NAME | Brown |
| SIGNATURE | BROWN T A |
| AFFILIATIONS | University of Manchester |
| VERIFIED | No |
| TOTAL WORKS | 35 |
| TOTAL CITATIONS | 219 |
| AUTHOR COUNT | 35 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1992 |
| LATEST PUBLICATION YEAR | 2025 |
| H-INDEX | 9 |
New scientific evidence for the history and occupants of Tomb I (“Tomb of Persephone”) in the Great Tumulus at Vergina
The Great Tumulus of Vergina (Aegae) is considered to be the royal burial complex of the Macedonian kings. Beneath it four tombs were discovered, labeled Tomb I, II, III and IV. Several hypotheses have been proposed for the identities of the occupants of the “royal tombs”, but without scientific backing. We present new data from Tomb I (“The Tomb of Persephone”), which contained inhumed (unburnt), in situ and commingled adult skeletal remains, as…
Ancient DNA typing indicates that the “new” glume wheat of early Eurasian agriculture is a cultivated member of the Triticum timopheevii group
Ancient Mycobacterium leprae genomes from the mediaeval sites of Chichester and Raunds in England
A Case Study
The Franklin expedition set sail in 1845 in search of the Northwest Passage through the Canadian Arctic. During the first winter in the Arctic, three crewmen died of unknown causes. In the 1980s, Dr. Owen Beattie and his colleagues conducted autopsies, which indicated that all three may have suffered from tuberculosis at the time of death. In the present study, a bone sample from one of these individuals, Private William Braine, was analyzed for …
Ritual complexity in a past community revealed by ancient DNA analysis of pre-colonial terracotta items from Northern Ghana
Complications in the study of ancient tuberculosis
There are many reports of ancient DNA from bacteria of the Mycobacterium tuberculosis complex (MTBC) being present in skeletons with and without osteological indications of tuberculosis. A possible complication in these studies is that extracts might also contain DNA from the microbiome of the individual whose remains are being analysed and/or from environmental bacteria that have colonised the skeleton after death. These contaminants might inclu…
Complications in the study of ancient tuberculosis
The insertion sequence IS6110 is frequently used as a marker for the presence of ancient DNA (aDNA) derived from bacteria of the Mycobacterium tuberculosis complex (MTBC) in human archaeological remains. The specificity of polymerase chain reactions (PCRs) directed at IS6110 has, however, been questioned, because identical or similar elements have been identified in ‘mycobacteria other than tuberculosis (MOTT)’. These are Mycobacterium species, c…
Recent advances in ancient DNA research and their implications for archaeobotany
Ancient DNA study of the remains of putative infanticide victims from the Yewden Roman villa site at Hambleden, England
Biomolecular identification of ancient Mycobacterium tuberculosis complex DNA in human remains from Britain and continental Europe
Tuberculosis is known to have afflicted humans throughout history and re‐emerged towards the end of the 20th century, to an extent that it was declared a global emergency in 1993. The aim of this study was to apply a rigorous analytical regime to the detection of Mycobacterium tuberculosis complex (MTBC) DNA in 77 bone and tooth samples from 70 individuals from Britain and continental Europe, spanning the 1st–19th centuries AD. We performed the w…
Biomolecular Archaeology
Ancient biomolecules including DNA, proteins, and lipids are often preserved in archaeological skeletons or artifacts such as potsherds from cooking vessels. Techniques for analyzing these molecules have improved dramatically in recent years, though challenges remain in ensuring that results are authentic and not confused by the presence of contaminating modern biomolecules. Ancient DNA (aDNA) can be used to identify the sex, kinship relationship…
Sex identification of ancient DNA samples using a microfluidic device
Ancient DNA typing shows that a Bronze Age mummy is a composite of different skeletons
Next generation sequencing of DNA in 3300-year-old charred cereal grains
Mitochondrial DNA haplotypes of Devensian hyaenas from Creswell Crags, England
Spotted hyaena (Crocuta crocuta) remains have been recovered from British Middle and Upper Pleistocene sites at intervals within the period 700-730 ka BP. Morphological studies have suggested that hyaenas of the Last Interglacial sensu stricto (Ipswichian: Marine Isotope Stage [MIS] 5e, 130-115 ka BP) and Last Glacial (Devensian: MIS 3, 61-24 ka BP) were two distinct populations, the Ipswichian hyaenas becoming extinct in Britain during MIS 5 and…
A simulation of the effect of inbreeding on crop domestication genetics with comments on the integration of archaeobotany and genetics
Genetic analysis of wheat landraces enables the location of the first agricultural sites in Italy to be identified
Deficiencies and challenges in the study of ancient tuberculosis DNA
Kinship in Aegean Prehistory? Ancient DNA in Human Bones from Mainland Greece and Crete
Attempts were made to detect ancient DNA (aDNA) in samples of 89 human skeletons from Neolithic and Bronze Age sites in Greece and Crete. Ancient DNA was absent in specimens from Nea Nicomedia, Lerna, Kato Zakro: Karaviádena, and Mycenae Grave Circle A. For each of three skeletons sampled from Antron Grave Circle B, polymerase chain reactions (PCRs) gave products for nuclear but not mitochondrial DNA, but the yield of DNA was low and inconsistent…
Improved methodology for extraction and amplification of DNA from single grains of charred wheat
Latitudinal variation in a photoperiod response gene in European barley
Ancient DNA in human bones from Neolithic and Bronze Age sites in Greece and Crete
Kinship between burials from Grave Circle B at Mycenae revealed by ancient DNA typing
Brief communication
We present a method to distinguish authentic ancient DNA from contaminating DNA in a human bone. This is achieved by taking account of the spatial distribution of the various sequence families within the bone and the extent of degradation of the template DNAs, as revealed by the error content of the sequences. To demonstrate the veracity of the method, we handled two ancient human tibiae in order to contaminate them with modern DNA, and then subj…
The limits of biomolecular palaeopathology
Kinship between burials from Grave Circle B at Mycenae revealed by ancient DNA typing
The limits of biomolecular palaeopathology
Deficiencies and challenges in the study of ancient tuberculosis DNA
Latitudinal variation in a photoperiod response gene in European barley
Recent advances in ancient DNA research and their implications for archaeobotany
Ancient DNA typing indicates that the “new” glume wheat of early Eurasian agriculture is a cultivated member of the Triticum timopheevii group
Ancient DNA and the archaeologist
Out of molecular biology - the revolution of past decades in biological science - there now begins to come molecular archaeology, the study of DNA in ancient plants, animals and people to address questions of history as well as biology. Here is set out what molecular archaeology is about, how it works and what it has begun to do
Degradation of DNA in artificially charred wheat seeds
DNA from primitive maize landraces and archaeological remains
Biomolecular Archaeology
Ancient biomolecules including DNA, proteins, and lipids are often preserved in archaeological skeletons or artifacts such as potsherds from cooking vessels. Techniques for analyzing these molecules have improved dramatically in recent years, though challenges remain in ensuring that results are authentic and not confused by the presence of contaminating modern biomolecules. Ancient DNA (aDNA) can be used to identify the sex, kinship relationship…
Next generation sequencing of DNA in 3300-year-old charred cereal grains
Biomolecular archaeology of wheat
The study of ancient biomolecules in preserved wheat remains could provide information on both the initial development of agriculture and its subsequent trajectories and spread in relation to changing human society. We have detected ancient DNA in extracts prepared from charred, waterlogged and mineralized wheat seeds, and have used the polymerase chain reaction to study specific genetic regions of the ancient DNA preserved in Triticum spelta fro…
A simulation of the effect of inbreeding on crop domestication genetics with comments on the integration of archaeobotany and genetics
Ancient DNA study of the remains of putative infanticide victims from the Yewden Roman villa site at Hambleden, England
Ancient DNA in human bones from Neolithic and Bronze Age sites in Greece and Crete
Brief communication
We present a method to distinguish authentic ancient DNA from contaminating DNA in a human bone. This is achieved by taking account of the spatial distribution of the various sequence families within the bone and the extent of degradation of the template DNAs, as revealed by the error content of the sequences. To demonstrate the veracity of the method, we handled two ancient human tibiae in order to contaminate them with modern DNA, and then subj…
Ancient DNA typing shows that a Bronze Age mummy is a composite of different skeletons
Biomolecular identification of ancient Mycobacterium tuberculosis complex DNA in human remains from Britain and continental Europe
Tuberculosis is known to have afflicted humans throughout history and re‐emerged towards the end of the 20th century, to an extent that it was declared a global emergency in 1993. The aim of this study was to apply a rigorous analytical regime to the detection of Mycobacterium tuberculosis complex (MTBC) DNA in 77 bone and tooth samples from 70 individuals from Britain and continental Europe, spanning the 1st–19th centuries AD. We performed the w…
Genetic analysis of wheat landraces enables the location of the first agricultural sites in Italy to be identified
Complications in the study of ancient tuberculosis
There are many reports of ancient DNA from bacteria of the Mycobacterium tuberculosis complex (MTBC) being present in skeletons with and without osteological indications of tuberculosis. A possible complication in these studies is that extracts might also contain DNA from the microbiome of the individual whose remains are being analysed and/or from environmental bacteria that have colonised the skeleton after death. These contaminants might inclu…
Sex identification of ancient DNA samples using a microfluidic device
Non-random DNA damage resulting from heat treatment
Ritual complexity in a past community revealed by ancient DNA analysis of pre-colonial terracotta items from Northern Ghana
Mitochondrial DNA haplotypes of Devensian hyaenas from Creswell Crags, England
Spotted hyaena (Crocuta crocuta) remains have been recovered from British Middle and Upper Pleistocene sites at intervals within the period 700-730 ka BP. Morphological studies have suggested that hyaenas of the Last Interglacial sensu stricto (Ipswichian: Marine Isotope Stage [MIS] 5e, 130-115 ka BP) and Last Glacial (Devensian: MIS 3, 61-24 ka BP) were two distinct populations, the Ipswichian hyaenas becoming extinct in Britain during MIS 5 and…
DNA in charred wheat grains from the Iron Age hillfort at Danebury, England
The genetic history of wheat is the story of the world's temperate staple food. Arcahaeologically, charred grains are the common way wheat is preserved. Study of burnt spelt wheat from the British Iron Age shows DNA is present, and begins to shows the wheat's character
Ancient DNA and the archaeologist
Out of molecular biology - the revolution of past decades in biological science - there now begins to come molecular archaeology, the study of DNA in ancient plants, animals and people to address questions of history as well as biology. Here is set out what molecular archaeology is about, how it works and what it has begun to do
Biomolecular archaeology of wheat
The study of ancient biomolecules in preserved wheat remains could provide information on both the initial development of agriculture and its subsequent trajectories and spread in relation to changing human society. We have detected ancient DNA in extracts prepared from charred, waterlogged and mineralized wheat seeds, and have used the polymerase chain reaction to study specific genetic regions of the ancient DNA preserved in Triticum spelta fro…
DNA in charred wheat grains from the Iron Age hillfort at Danebury, England
The genetic history of wheat is the story of the world's temperate staple food. Arcahaeologically, charred grains are the common way wheat is preserved. Study of burnt spelt wheat from the British Iron Age shows DNA is present, and begins to shows the wheat's character
DNA in cremated bones from an early bronze age cemetery cairn
The discovery of polymeric DNA in charred wheat grains and other burnt plant remains prompted us to examine a set of cremated bones for the presence of ancient DNA. Extracts of cremated bones from an early Bronze Age cemetery cairn were analysed by hybridization probing and the polymerase chain reaction. Hybridization with two probes targeting human DNA resulted in strong positive signals. Polymerase chain reactions directed at a multicopy sequen…
DNA analysis of bones from Grave Circle B at Mycenae
Following the successful identification of at least two different family groups in Grave Circle B using facial reconstruction ( BSA 90 [1995], 107–36), a pilot project was carried out at Manchester to identify, analyse and match 22 DNA samples from burials in the Grave Circle. The first step was to determine whether ancient DNA has survived, as proved to be the case; the next was to use this information to sex the individual by polymerase chain r…
Digging for pathogens. Ancient emerging diseases
Edited by Charles L. Greenblatt. Rehovot, Israel: Balaban Publishers. 1998. 400 pp. ISBN 0-86689-053-X. $49.00 (paper)
DNA from primitive maize landraces and archaeological remains
Degradation of DNA in artificially charred wheat seeds
Non-random DNA damage resulting from heat treatment
Archaeogenetics
The limits of biomolecular palaeopathology
Brief communication
We present a method to distinguish authentic ancient DNA from contaminating DNA in a human bone. This is achieved by taking account of the spatial distribution of the various sequence families within the bone and the extent of degradation of the template DNAs, as revealed by the error content of the sequences. To demonstrate the veracity of the method, we handled two ancient human tibiae in order to contaminate them with modern DNA, and then subj…
Improved methodology for extraction and amplification of DNA from single grains of charred wheat
Latitudinal variation in a photoperiod response gene in European barley
Ancient DNA in human bones from Neolithic and Bronze Age sites in Greece and Crete
Kinship between burials from Grave Circle B at Mycenae revealed by ancient DNA typing
A simulation of the effect of inbreeding on crop domestication genetics with comments on the integration of archaeobotany and genetics
Genetic analysis of wheat landraces enables the location of the first agricultural sites in Italy to be identified
Deficiencies and challenges in the study of ancient tuberculosis DNA
Kinship in Aegean Prehistory? Ancient DNA in Human Bones from Mainland Greece and Crete
Attempts were made to detect ancient DNA (aDNA) in samples of 89 human skeletons from Neolithic and Bronze Age sites in Greece and Crete. Ancient DNA was absent in specimens from Nea Nicomedia, Lerna, Kato Zakro: Karaviádena, and Mycenae Grave Circle A. For each of three skeletons sampled from Antron Grave Circle B, polymerase chain reactions (PCRs) gave products for nuclear but not mitochondrial DNA, but the yield of DNA was low and inconsistent…
Sex identification of ancient DNA samples using a microfluidic device
Ancient DNA typing shows that a Bronze Age mummy is a composite of different skeletons
Next generation sequencing of DNA in 3300-year-old charred cereal grains
Mitochondrial DNA haplotypes of Devensian hyaenas from Creswell Crags, England
Spotted hyaena (Crocuta crocuta) remains have been recovered from British Middle and Upper Pleistocene sites at intervals within the period 700-730 ka BP. Morphological studies have suggested that hyaenas of the Last Interglacial sensu stricto (Ipswichian: Marine Isotope Stage [MIS] 5e, 130-115 ka BP) and Last Glacial (Devensian: MIS 3, 61-24 ka BP) were two distinct populations, the Ipswichian hyaenas becoming extinct in Britain during MIS 5 and…
Biomolecular Archaeology
Ancient biomolecules including DNA, proteins, and lipids are often preserved in archaeological skeletons or artifacts such as potsherds from cooking vessels. Techniques for analyzing these molecules have improved dramatically in recent years, though challenges remain in ensuring that results are authentic and not confused by the presence of contaminating modern biomolecules. Ancient DNA (aDNA) can be used to identify the sex, kinship relationship…
Biology (29 works) · Ancient DNA (24 works) · Archaeology (24 works) · Geography (20 works) · Genetics (19 works) · Forensic and Genetic Research (17 works) · Population (16 works) · Evolutionary biology (14 works) · Gene (14 works) · History (13 works)