William J Doyle
Biographic Data
| ID | 3997368 |
|---|---|
| NAME | William J Doyle |
| GIVEN NAMES | William J |
| FAMILY NAME | Doyle |
| SIGNATURE | DOYLE W J |
| AFFILIATIONS | Children's Hospital of Pittsburgh |
| VERIFIED | No |
| TOTAL WORKS | 20 |
| TOTAL CITATIONS | 69 |
| AUTHOR COUNT | 20 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1976 |
| LATEST PUBLICATION YEAR | 2017 |
| H-INDEX | 4 |
Dispositional Affect Moderates the Stress‐Buffering Effect of Social Support on Risk for Developing the Common Cold
OBJECTIVE: The aim was to examine whether trait positive and negative affect (PA, NA) moderate the stress-buffering effect of perceived social support on risk for developing a cold subsequent to being exposed to a virus that causes mild upper respiratory illness. METHOD: = 31.0 years, SD = 10.7 years; 49.0% female; 64.6% Caucasian). Perceived social support and perceived stress were assessed by self-report questionnaire and trait affect by aggreg…
Self-Rated Health in Healthy Adults and Susceptibility to the Common Cold
OBJECTIVES: To explore the association of self-rated health (SRH) with host resistance to illness after exposure to a common cold virus and identify mechanisms linking SRH to future health status. METHODS: We analyzed archival data from 360 healthy adults (mean [standard deviation] age = 33.07 [10.69] years, 45.6% women). Each person completed validated questionnaires that assessed SRH (excellent, very good, good, fair, poor), socioemotional fact…
Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk
We propose a model wherein chronic stress results in glucocorticoid receptor resistance (GCR) that, in turn, results in failure to down-regulate inflammatory response. Here we test the model in two viral-challenge studies. In study 1, we assessed stressful life events, GCR, and control variables including baseline antibody to the challenge virus, age, body mass index (BMI), season, race, sex, education, and virus type in 276 healthy adult volunte…
Parenthood and Host Resistance to the Common Cold
OBJECTIVE: To determine whether parenthood predicts host resistance to the common cold among healthy volunteers experimentally exposed to a common cold virus. METHODS: Participants were 795 healthy volunteers (age range = 18-55 years) enrolled in one of three viral-challenge studies conducted from 1993 to 2004. After reporting parenthood status, participants were quarantined, administered nasal drops containing one of four common cold viruses, an…
Objective and subjective socioeconomic status and susceptibility to the common cold.
OBJECTIVE: We ask whether subjective socioeconomic status (SES) predicts who develops a common cold when exposed to a cold virus. DESIGN: 193 healthy men and women ages 21-55 years were assessed for subjective (perceived rank) and objective SES, cognitive, affective and social dispositions, and health practices. Subsequently, they were exposed by nasal drops to a rhinovirus or influenza virus and monitored in quarantine for objective signs of ill…
Socioeconomic Status Is Associated With Stress Hormones
Objective: We assess whether socioeconomic status (SES) is associated with basal levels of cortisol and catecholamines and determine if any association between SES and these hormones can be explained (is mediated) by behavioral, social, and emotional differences across the SES gradient. Methods: One hundred ninety-three adult subjects, including men and women and whites and African-Americans, provided 24-hour urine catecholamine samples on each o…
Positive Emotional Style Predicts Resistance to Illness After Experimental Exposure to Rhinovirus or Influenza A Virus
OBJECTIVE: In an earlier study, positive emotional style (PES) was associated with resistance to the common cold and a bias to underreport (relative to objective disease markers) symptom severity. This work did not control for social and cognitive factors closely associated with PES. We replicate the original study using a different virus and controls for these alternative explanations. METHODS: One hundred ninety-three healthy volunteers ages 21…
Childhood Socioeconomic Status and Host Resistance to Infectious Illness in Adulthood
OBJECTIVE: Low childhood socioeconomic status (SES) is a risk factor for adult morbidity and mortality primarily attributable to cardiovascular disease. Here, we examine whether childhood SES is associated with adult host resistance to infectious illness, and whether the effect is limited to a critical period of low SES exposure, can be undone by changes in childhood SES, and is explained by adult SES. METHODS: Three hundred thirty-four healthy v…
Emotional Style and Susceptibility to the Common Cold
OBJECTIVE: It has been hypothesized that people who typically report experiencing negative emotions are at greater risk for disease and those who typically report positive emotions are at less risk. We tested these hypotheses for host resistance to the common cold. METHODS: Three hundred thirty-four healthy volunteers aged 18 to 54 years were assessed for their tendency to experience positive emotions such as happy, pleased, and relaxed; and for …
The Culture of Power and the Power of Culture
Journal Article The Culture of Power and the Power of Culture: Old Regime Europe, 1660–1789 Get access William Doyle William Doyle Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume 117, Issue 474, November 2002, Pages 1269–1270, https://doi.org/10.1093/ehr/117.474.1269 Published: 01 November 2002
Edmund Burke
1University of Bristol Edmund Burke: Reflections on the Revolution in France: A Critical Edition J. C. D.Clark (Stanford, CA/CambridgeCambridge U.P. 2001446£35 Paperback£12.95
Liberty, Equality, Fraternity
Journal Article Liberty, Equality, Fraternity: Exploring the French Revolution Get access William Doyle William Doyle Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume 117, Issue 471, April 2002, Page 482, https://doi.org/10.1093/ehr/117.471.482 Published: 01 April 2002
Psychological Stress, Cytokine Production, and Severity of Upper Respiratory Illness
OBJECTIVE: The purpose of this study is to assess the role of psychological stress in the expression of illness among infected subjects and to test the plausibility of local proinflammatory cytokine production as a pathway linking stress to illness. METHODS: After completing a measure of psychological stress, 55 subjects were experimentally infected with an influenza A virus. Subjects were monitored in quarantine daily for upper respiratory sympt…
The impact of personality on the reporting of unfounded symptoms and illness
This study examined the role of personality in the reporting of symptoms and illness not supported by underlying pathology. After assessment of the Big Five personality factors, 276 healthy volunteers were inoculated with a common cold virus. On each of the following 5 days, objective indicators of pathology, self-reported symptoms, and self-reported illness onset were assessed. Neuroticism was directly associated with reports of unfounded (witho…
Types of stressors that increase susceptibility to the common cold in healthy adults.
Two-hundred seventy-six volunteers completed a life stressor interview and psychological questionnaires and provided blood and urine samples. They were then inoculated with common cold viruses and monitored for the onset of disease. Although severe acute stressful life events (less than 1 month long) were not associated with developing colds, severe chronic stressors (1 month or longer) were associated with a substantial increase in risk of disea…
State and trait negative affect as predictors of objective and subjective symptoms of respiratory viral infections
State and trait negative affect (NA) were measured in healthy people immediately before an illness was induced through exposure to a respiratory virus. State NA, disease-specific health complaints (e.g., runny nose, congestion, and sneezing), and an associated objective marker of disease severity (mucus secretion weights) were assessed daily during the illness. Baseline trait and state NA were both associated with increased numbers of subsequent …
The interaction of stressors in the induction of increased levels of fluctuating asymmetry in the laboratory rat
Recent studies on fluctuating dental asymmetry have isolated single stressors as causative agents. Since most stressors are composite in nature, the present study was designed to determine the effects of the interaction of stressors in the induction of fluctuating dental asymmetry. Pregnant rats were assigned to one of six treatment groups and stressed with various combinations of heat, cold, noise and protein deprivation. The levels of fluctuati…
The differential contribution of premaxillary, maxillary, and palatine dimensions to sexual dimorphism in the adult olive baboon (Papio cynocephalus anubis)
Heat stress, fluctuating asymmetry and prenatal selection in the laboratory rat
Recent studies have demonstrated that stress may increase the fluctuating asymmetry of teeth and limbs in laboratory animals. The present study investigates the effects of heat on such parameters. Pregnant laboratory rats are exposed to temperatures of 33°C during gestation. Increases in fluctuating asymmetry of dental dimensions as well as bone density are found for the pups of such females when compared to unstressed controls. A general increas…
Infant babbling and speech
Previous scholars have claimed that the child's babbling (meaningless speech-like vocalizations) includes a random assortment of the speech sounds found in the languages of the world. Babbled sounds have been claimed to bear no relationship to the sounds of the child's later meaningful speech. The present research disputes the traditional position on babbling by showing that the phonetic content of babbled utterances exhibits many of the same pre…
Heat stress, fluctuating asymmetry and prenatal selection in the laboratory rat
Recent studies have demonstrated that stress may increase the fluctuating asymmetry of teeth and limbs in laboratory animals. The present study investigates the effects of heat on such parameters. Pregnant laboratory rats are exposed to temperatures of 33°C during gestation. Increases in fluctuating asymmetry of dental dimensions as well as bone density are found for the pups of such females when compared to unstressed controls. A general increas…
The interaction of stressors in the induction of increased levels of fluctuating asymmetry in the laboratory rat
Recent studies on fluctuating dental asymmetry have isolated single stressors as causative agents. Since most stressors are composite in nature, the present study was designed to determine the effects of the interaction of stressors in the induction of fluctuating dental asymmetry. Pregnant rats were assigned to one of six treatment groups and stressed with various combinations of heat, cold, noise and protein deprivation. The levels of fluctuati…
State and trait negative affect as predictors of objective and subjective symptoms of respiratory viral infections
State and trait negative affect (NA) were measured in healthy people immediately before an illness was induced through exposure to a respiratory virus. State NA, disease-specific health complaints (e.g., runny nose, congestion, and sneezing), and an associated objective marker of disease severity (mucus secretion weights) were assessed daily during the illness. Baseline trait and state NA were both associated with increased numbers of subsequent …
The impact of personality on the reporting of unfounded symptoms and illness
This study examined the role of personality in the reporting of symptoms and illness not supported by underlying pathology. After assessment of the Big Five personality factors, 276 healthy volunteers were inoculated with a common cold virus. On each of the following 5 days, objective indicators of pathology, self-reported symptoms, and self-reported illness onset were assessed. Neuroticism was directly associated with reports of unfounded (witho…
Liberty, Equality, Fraternity
Journal Article Liberty, Equality, Fraternity: Exploring the French Revolution Get access William Doyle William Doyle Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume 117, Issue 471, April 2002, Page 482, https://doi.org/10.1093/ehr/117.471.482 Published: 01 April 2002
The Culture of Power and the Power of Culture
Journal Article The Culture of Power and the Power of Culture: Old Regime Europe, 1660–1789 Get access William Doyle William Doyle Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume 117, Issue 474, November 2002, Pages 1269–1270, https://doi.org/10.1093/ehr/117.474.1269 Published: 01 November 2002
Edmund Burke
1University of Bristol Edmund Burke: Reflections on the Revolution in France: A Critical Edition J. C. D.Clark (Stanford, CA/CambridgeCambridge U.P. 2001446£35 Paperback£12.95
Infant babbling and speech
Previous scholars have claimed that the child's babbling (meaningless speech-like vocalizations) includes a random assortment of the speech sounds found in the languages of the world. Babbled sounds have been claimed to bear no relationship to the sounds of the child's later meaningful speech. The present research disputes the traditional position on babbling by showing that the phonetic content of babbled utterances exhibits many of the same pre…
The differential contribution of premaxillary, maxillary, and palatine dimensions to sexual dimorphism in the adult olive baboon (Papio cynocephalus anubis)
Heat stress, fluctuating asymmetry and prenatal selection in the laboratory rat
Recent studies have demonstrated that stress may increase the fluctuating asymmetry of teeth and limbs in laboratory animals. The present study investigates the effects of heat on such parameters. Pregnant laboratory rats are exposed to temperatures of 33°C during gestation. Increases in fluctuating asymmetry of dental dimensions as well as bone density are found for the pups of such females when compared to unstressed controls. A general increas…
The interaction of stressors in the induction of increased levels of fluctuating asymmetry in the laboratory rat
Recent studies on fluctuating dental asymmetry have isolated single stressors as causative agents. Since most stressors are composite in nature, the present study was designed to determine the effects of the interaction of stressors in the induction of fluctuating dental asymmetry. Pregnant rats were assigned to one of six treatment groups and stressed with various combinations of heat, cold, noise and protein deprivation. The levels of fluctuati…
State and trait negative affect as predictors of objective and subjective symptoms of respiratory viral infections
State and trait negative affect (NA) were measured in healthy people immediately before an illness was induced through exposure to a respiratory virus. State NA, disease-specific health complaints (e.g., runny nose, congestion, and sneezing), and an associated objective marker of disease severity (mucus secretion weights) were assessed daily during the illness. Baseline trait and state NA were both associated with increased numbers of subsequent …
Types of stressors that increase susceptibility to the common cold in healthy adults.
Two-hundred seventy-six volunteers completed a life stressor interview and psychological questionnaires and provided blood and urine samples. They were then inoculated with common cold viruses and monitored for the onset of disease. Although severe acute stressful life events (less than 1 month long) were not associated with developing colds, severe chronic stressors (1 month or longer) were associated with a substantial increase in risk of disea…
Psychological Stress, Cytokine Production, and Severity of Upper Respiratory Illness
OBJECTIVE: The purpose of this study is to assess the role of psychological stress in the expression of illness among infected subjects and to test the plausibility of local proinflammatory cytokine production as a pathway linking stress to illness. METHODS: After completing a measure of psychological stress, 55 subjects were experimentally infected with an influenza A virus. Subjects were monitored in quarantine daily for upper respiratory sympt…
The impact of personality on the reporting of unfounded symptoms and illness
This study examined the role of personality in the reporting of symptoms and illness not supported by underlying pathology. After assessment of the Big Five personality factors, 276 healthy volunteers were inoculated with a common cold virus. On each of the following 5 days, objective indicators of pathology, self-reported symptoms, and self-reported illness onset were assessed. Neuroticism was directly associated with reports of unfounded (witho…
The Culture of Power and the Power of Culture
Journal Article The Culture of Power and the Power of Culture: Old Regime Europe, 1660–1789 Get access William Doyle William Doyle Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume 117, Issue 474, November 2002, Pages 1269–1270, https://doi.org/10.1093/ehr/117.474.1269 Published: 01 November 2002
Edmund Burke
1University of Bristol Edmund Burke: Reflections on the Revolution in France: A Critical Edition J. C. D.Clark (Stanford, CA/CambridgeCambridge U.P. 2001446£35 Paperback£12.95
Liberty, Equality, Fraternity
Journal Article Liberty, Equality, Fraternity: Exploring the French Revolution Get access William Doyle William Doyle Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume 117, Issue 471, April 2002, Page 482, https://doi.org/10.1093/ehr/117.471.482 Published: 01 April 2002
Emotional Style and Susceptibility to the Common Cold
OBJECTIVE: It has been hypothesized that people who typically report experiencing negative emotions are at greater risk for disease and those who typically report positive emotions are at less risk. We tested these hypotheses for host resistance to the common cold. METHODS: Three hundred thirty-four healthy volunteers aged 18 to 54 years were assessed for their tendency to experience positive emotions such as happy, pleased, and relaxed; and for …
Childhood Socioeconomic Status and Host Resistance to Infectious Illness in Adulthood
OBJECTIVE: Low childhood socioeconomic status (SES) is a risk factor for adult morbidity and mortality primarily attributable to cardiovascular disease. Here, we examine whether childhood SES is associated with adult host resistance to infectious illness, and whether the effect is limited to a critical period of low SES exposure, can be undone by changes in childhood SES, and is explained by adult SES. METHODS: Three hundred thirty-four healthy v…
Socioeconomic Status Is Associated With Stress Hormones
Objective: We assess whether socioeconomic status (SES) is associated with basal levels of cortisol and catecholamines and determine if any association between SES and these hormones can be explained (is mediated) by behavioral, social, and emotional differences across the SES gradient. Methods: One hundred ninety-three adult subjects, including men and women and whites and African-Americans, provided 24-hour urine catecholamine samples on each o…
Positive Emotional Style Predicts Resistance to Illness After Experimental Exposure to Rhinovirus or Influenza A Virus
OBJECTIVE: In an earlier study, positive emotional style (PES) was associated with resistance to the common cold and a bias to underreport (relative to objective disease markers) symptom severity. This work did not control for social and cognitive factors closely associated with PES. We replicate the original study using a different virus and controls for these alternative explanations. METHODS: One hundred ninety-three healthy volunteers ages 21…
Objective and subjective socioeconomic status and susceptibility to the common cold.
OBJECTIVE: We ask whether subjective socioeconomic status (SES) predicts who develops a common cold when exposed to a cold virus. DESIGN: 193 healthy men and women ages 21-55 years were assessed for subjective (perceived rank) and objective SES, cognitive, affective and social dispositions, and health practices. Subsequently, they were exposed by nasal drops to a rhinovirus or influenza virus and monitored in quarantine for objective signs of ill…
Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk
We propose a model wherein chronic stress results in glucocorticoid receptor resistance (GCR) that, in turn, results in failure to down-regulate inflammatory response. Here we test the model in two viral-challenge studies. In study 1, we assessed stressful life events, GCR, and control variables including baseline antibody to the challenge virus, age, body mass index (BMI), season, race, sex, education, and virus type in 276 healthy adult volunte…
Parenthood and Host Resistance to the Common Cold
OBJECTIVE: To determine whether parenthood predicts host resistance to the common cold among healthy volunteers experimentally exposed to a common cold virus. METHODS: Participants were 795 healthy volunteers (age range = 18-55 years) enrolled in one of three viral-challenge studies conducted from 1993 to 2004. After reporting parenthood status, participants were quarantined, administered nasal drops containing one of four common cold viruses, an…
Self-Rated Health in Healthy Adults and Susceptibility to the Common Cold
OBJECTIVES: To explore the association of self-rated health (SRH) with host resistance to illness after exposure to a common cold virus and identify mechanisms linking SRH to future health status. METHODS: We analyzed archival data from 360 healthy adults (mean [standard deviation] age = 33.07 [10.69] years, 45.6% women). Each person completed validated questionnaires that assessed SRH (excellent, very good, good, fair, poor), socioemotional fact…
Dispositional Affect Moderates the Stress‐Buffering Effect of Social Support on Risk for Developing the Common Cold
OBJECTIVE: The aim was to examine whether trait positive and negative affect (PA, NA) moderate the stress-buffering effect of perceived social support on risk for developing a cold subsequent to being exposed to a virus that causes mild upper respiratory illness. METHOD: = 31.0 years, SD = 10.7 years; 49.0% female; 64.6% Caucasian). Perceived social support and perceived stress were assessed by self-report questionnaire and trait affect by aggreg…
Medicine (13 works) · Internal Medicine (10 works) · Psychology (10 works) · Internal Medicine (9 works) · Stress Responses and Cortisol (9 works) · Immunology (8 works) · Immunology (7 works) · Clinical Psychology (6 works) · Demography (6 works) · Psychiatry (5 works)