Jared M Baeten

• Cofactors of earlier uptake of modern postpartum family planning methods in Kenya

  Open Access•Nancy Ngumbau, Damaris Kimonge et al.•ARTICLE•PLOS Global Public Health•2025

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  There are limited data on uptake of postpartum family planning (FP), particularly in high HIV prevalence settings. We assessed the timing of modern postpartum FP initiation and the cofactors of earlier uptake using longitudinal data from a clinical trial conducted in Kenya to assess two models of PrEP delivery among pregnant and postpartum women (NCT#03070600). Time to uptake of modern postpartum FP was estimated using survival analysis methods, …

• Efficacy of the Dapivirine Vaginal Ring Accounting for Imperfect Adherence

  Open Access•Marla Husnik, Renee Heffron et al.•ARTICLE•AIDS and Behavior•2024

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• Population health impact, cost-effectiveness, and affordability of community-based HIV treatment and monitoring in South Africa

  Open Access•Maitreyi Sahu, Cara J Bayer et al.•ARTICLE•PLOS Global Public Health•2023

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  Community-based delivery and monitoring of antiretroviral therapy (ART) for HIV has the potential to increase viral suppression for individual- and population-level health benefits. However, the cost-effectiveness and budget impact are needed for public health policy. We used a mathematical model of HIV transmission in KwaZulu-Natal, South Africa, to estimate population prevalence, incidence, mortality, and disability-adjusted life-years (DALYs) …

• Post-trial access to and use of pre-exposure prophylaxis in Durban, South Africa

  Open Access•Ivana Beesham, Cecilia Milford et al.•ARTICLE•BMC Public Health•2023

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  We identified several barriers to post-trial PrEP access. Strategies to enhance PrEP access such as a reduction in waiting queues, convenient facility operating hours, and making PrEP more widely available and accessible are needed. It is also worth noting that oral PrEP access has expanded in South Africa from 2018 till now and this could improve access to PrEP for participants exiting trials who desire to continue PrEP

• Performance of Multiple Adherence Measures for pre-exposure Prophylaxis (PrEP) Among Young Women in Kenya

  Open Access•Nicholas Musinguzi, Kenneth Ngure et al.•ARTICLE•AIDS and Behavior•2023

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• Health Care Worker Perspectives of HIV Pre-exposure Prophylaxis Service Delivery in Central Uganda

  Open Access•Timothy R Muwonge, Rogers Nsubuga et al.•ARTICLE•Frontiers in Public Health•2022

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  Background: Scale-up of HIV pre-exposure prophylaxis (PrEP) services in Uganda is ongoing. However, health care workers (HCWs) may not be aware of PrEP nor what offering this service entails. We explored the impact of standardized HCW training on the knowledge and perspectives of PrEP service delivery in Uganda. Methods: We recruited HCWs from facilities that offered HIV-related services in Central Uganda. Using the Uganda Ministry of Health curr…

• Using an on-site modular training approach to amplify prep service delivery in public health facilities in Kenya

  Open Access•Elizabeth Irungu, Moses Musau et al.•ARTICLE•PLOS Global Public Health•2022

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  Delivery of oral PrEP, a potent HIV prevention intervention, has begun within public health systems in many countries in Africa. Training as many health providers as possible expeditiously is necessary to efficiently and rapidly scale up PrEP delivery among at risk populations and thereby realize the greatest impact of PrEP. We designed and implemented an innovative on-site modular training approach delivered in five two-hour modules. The modules…

• Examining Associations Between Mental Health, IPV Exposure, HIV Risk Behaviors, and PrEP Use in South African Women

  Open Access•Noah S Triplett, Sarah T Roberts et al.•ARTICLE•AIDS and Behavior•2022

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• Trajectories of Oral PrEP Adherence Among Young Kenyan Women

  Open Access•Nicholas Musinguzi, Maria Pyra et al.•ARTICLE•AIDS and Behavior•2022

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• A novel “HIV salience and Perception” scale is associated with PrEP dispensing and adherence among adolescent girls and young women in Kampala, Uganda

  Open Access•Jennifer Velloza, Andrew Mujugira et al.•ARTICLE•AIDS and Behavior•2022

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• Yes, I’m reminded, but it doesn’t mean I’m taking them”

  Open Access•Vallery Ogello, Kenneth Ngure et al.•ARTICLE•AIDS and Behavior•2022

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• Correlates of Dapivirine Vaginal Ring Acceptance among Women Participating in an Open Label Extension Trial

  Open Access•Brenda Gati Mirembe, Maria Valdez Cabrera et al.•ARTICLE•AIDS and Behavior•2022

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• Women’s experience receiving drug feedback and adherence counseling in MTN-025/Hope - an HIV Prevention open-label trial of the Dapivirine Vaginal Ring

  Open Access•Ariana Katz, Iván C Balán et al.•ARTICLE•AIDS and Behavior•2022

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• Multi-level Factors Driving Pre-exposure Prophylaxis Non-initiation Among Young Women at High Risk for HIV in Kenya

  Open Access•Ingrid T Katz, Kenneth Ngure et al.•ARTICLE•AIDS and Behavior•2022

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• Effects of the Waya Intervention on Marital Satisfaction and HIV Risk Behaviors in Western Kenya

  Open Access•Zachary Kwena, Elizabeth A Bukusi et al.•ARTICLE•Archives of Sexual Behavior•2022•Referencias: 49

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• “Now that PrEP is reducing the risk of transmission of HIV, why then do you still insist that we use condoms?” the condom quandary among PrEP users and health care providers in Kenya

  Elizabeth Irungu, Kenneth Ngure et al.•ARTICLE•AIDS Care•2021

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  Communication around condom use in the context of PrEP services presents a potential conundrum for patients and providers. Within the Partners Scale-Up Project, which supports integration of PrEP delivery in HIV care clinics, we interviewed 41 providers and 61 PrEP users and identified themes relating to condom messaging and use. Most providers counselled PrEP initiators to always use both PrEP and condoms, except when trying to conceive. However…

• Impact and experience of participant engagement activities in supporting dapivirine ring use among participants enrolled in the phase III MTN-020/Aspire study

  Open Access•Morgan Garcia, Ellen Luecke et al.•ARTICLE•BMC Public Health•2021

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  Our analysis supports the growing body of work illustrating the importance of meaningfully engaging research participants to achieve study success and aligns with other analyses of adherence support efforts during ASPIRE. While causation between PEA attendance and product use cannot be established, residual drug levels in returned rings strongly correlated with participant attendance at PEAs, and the benefits of incorporating PEAs should be consi…

• Correlates of Adherence to the Dapivirine Vaginal Ring for HIV-1 Prevention

  Open Access•Marla Husnik, Elizabeth R Brown et al.•ARTICLE•AIDS and Behavior•2021

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• Acceptability of the Dapivirine Vaginal Ring for HIV-1 Prevention and Association with Adherence in a Phase III Trial

  Open Access•Ashley Mayo, Erica N Browne et al.•ARTICLE•AIDS and Behavior•2021

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  We evaluated the acceptability of the 25 mg dapivirine vaginal ring (DVR) as an HIV prevention intervention and its influence on DVR adherence in the MTN-020/ASPIRE phase III trial. Acceptability measures were captured using ACASI at month 3 and end of product use (median 24 months, IQR 15-30). Monthly returned rings were classified as nonadherent if dapivirine release rate was ≤ 0.9 mg/month. Associations between acceptability measures and nonad…

• Integration of a Relationship-focused Counseling Intervention with Delivery of the Dapivirine Ring for HIV Prevention to Women in Johannesburg

  Open Access•Elizabeth Montgomery, Sarah T Roberts et al.•ARTICLE•AIDS and Behavior•2021

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• Acceptability and Feasibility of Pharmacy-Based Delivery of Pre-Exposure Prophylaxis in Kenya

  Open Access•Stephanie Roche, Njeri Wairimu et al.•ARTICLE•AIDS and Behavior•2021

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  As countries scale up pre-exposure prophylaxis (PrEP) for HIV prevention, diverse PrEP delivery models are needed to expand access to populations at HIV risk that are unwilling or unable to access clinic-based PrEP care. To identify factors that may influence implementation of retail pharmacy-based PrEP delivery in Kenya, we conducted in-depth interviews with 40 pharmacy clients, 16 pharmacy providers, 16 PrEP clients, and 10 PrEP providers from …

• The Influence of Perceived Dapivirine Vaginal Ring Effectiveness on Social Disclosure and Ring Adherence

  Open Access•Marie C D Stoner, Elizabeth R Brown et al.•ARTICLE•AIDS and Behavior•2021

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• Perceived Social Influences on Women's Decisions to use Medications not Studied in Pregnancy. A Qualitative Ethical Analysis of Preexposure Prophylaxis Implementation Research in Kenya

  Open Access•Kenneth Ngure, Susan Brown Trinidad et al.•ARTICLE•Journal of Empirical Research on…•2021•Referencias: 3

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  Implementation research ethics can be particularly challenging when pregnant women have been excluded from earlier clinical stages of research given greater uncertainty about safety and efficacy in pregnancy. The evaluation of human immunodeficiency virus (HIV) preexposure prophylaxis (PrEP) during pregnancy offered an opportunity to understand important ethical considerations and social influences shaping women's decisions to participate in the …

• Implementation of a fidelity monitoring process to assess delivery of an evidence-based adherence counseling intervention in a multi-site biomedical HIV prevention study

  Iván C Balán, Cody Lentz et al.•ARTICLE•AIDS Care•2020

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  Pre-Exposure Prophylaxis (PrEP) trials often implement counseling to support product adherence. Counseling fidelity can vary significantly across providers and time. Fidelity monitoring can ensure that counseling is delivered as designed. We describe the process, feasibility, and outcomes of monitoring Options counseling fidelity in an open-label study of the dapivirine vaginal ring MTN-025/HOPE. After initial training, 63 counselors from 14 site…

• Adherence to recommendations for ART and targeted PrEP use among HIV serodiscordant couples in East Africa

  Open Access•on behalf of the Partners Demonstration Project Team, Nicholas Musinguzi et al.•ARTICLE•BMC Public Health•2020

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  Half of participants completed the PrEP as a bridge to ART strategy and the majority stopped PrEP as recommended. These findings suggest that targeting PrEP to periods of risk is a promising approach; however, tailoring counseling around aligning PrEP use and HIV risk will be important for optimal strategy implementation

• Heterosexual HIV-1 transmission after initiation of antiretroviral therapy

  Open Access•Deborah Donnell, Jared M Baeten et al.•ARTICLE•The Lancet•2010

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• Knowledge and Attitudes About Male Circumcision for HIV-1 Prevention among Heterosexual HIV-1 Serodiscordant Partnerships in Kampala, Uganda

  Open Access•Kenneth K Mugwanya, Jared M Baeten et al.•ARTICLE•AIDS and Behavior•2010

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• A Post-Trial Assessment of Factors Influencing Study Drug Adherence in a Randomized Biomedical HIV-1 Prevention Trial

  Open Access•Shevin T Jacob, Jared M Baeten et al.•ARTICLE•AIDS and Behavior•2010

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• Combination HIV Prevention

  Open Access•Ann Kurth, Ann E Kurth et al.•ARTICLE•Current HIV/AIDS Reports•2011

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• What's Love Got to Do With It? Explaining Adherence to Oral Antiretroviral Pre-Exposure Prophylaxis for HIV-Serodiscordant Couples

  N C Ware, Monique A Wyatt et al.•ARTICLE•JAIDS Journal of Acquired Immune…•2012

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  OBJECTIVE: Adherence may be the "Achilles heel" of pre-exposure prophylaxis (PrEP), a promising biomedical approach to HIV prevention. This article presents an explanation of PrEP adherence for African serodiscordant couples derived from qualitative data. DESIGN: Explaining quantitative findings is one way qualitative investigation contributes to research in medicine and public health. This qualitative interview study was nested in the Partners P…

• Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women

  Jared M Baeten, Deborah Donnell et al.•ARTICLE•New England Journal of Medicine•2012

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  BACKGROUND: Antiretroviral preexposure prophylaxis is a promising approach for preventing human immunodeficiency virus type 1 (HIV-1) infection in heterosexual populations. METHODS: We conducted a randomized trial of oral antiretroviral therapy for use as preexposure prophylaxis among HIV-1-serodiscordant heterosexual couples from Kenya and Uganda. The HIV-1-seronegative partner in each couple was randomly assigned to one of three study regimens-…

• A qualitative study of barriers to consistent condom use among HIV-1 serodiscordant couples in Kenya

  Kenneth Ngure, Nelly Mugo et al.•ARTICLE•AIDS Care•2012

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  This study explored barriers to consistent condom use among heterosexual HIV-1 serodiscordant couples who were aware of the HIV-1 serodiscordant status and had been informed about condom use as a risk reduction strategy. We conducted 28 in-depth interviews and 9 focus group discussions among purposively selected heterosexual HIV-1 serodiscordant couples from Thika and Nairobi districts in Kenya. We analyzed the transcribed data with a grounded th…

• Correlation Between Pill Counts and Biologic Effects in an HIV-1 Prevention Clinical Trial

  Open Access•Deborah Donnell, Jared M Baeten et al.•ARTICLE•AIDS and Behavior•2012

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• Daily Short Message Service Surveys to Measure Sexual Behavior and Pre-exposure Prophylaxis Use Among Kenyan Men and Women

  Open Access•Kathryn Curran, Nelly Mugo et al.•ARTICLE•AIDS and Behavior•2013

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• Summary Measures of Adherence Using Pill Counts in Two HIV Prevention Trials

  Open Access•Kathy Baisley, Jared M Baeten et al.•ARTICLE•AIDS and Behavior•2013

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  For trials of user-dependent HIV prevention products, accurate adherence measurements are essential to interpret and compare results across trials. We used pill count data from two recent HIV prevention trials of herpes simplex virus type 2 (HSV-2) suppression, to show that estimates of adherence vary substantially depending on assumptions that are made in analysing pill count data. We associate calculated adherence with biological markers of ant…

• HIV Protective Efficacy and Correlates of Tenofovir Blood Concentrations in a Clinical Trial of PrEP for HIV Prevention

  Open Access•Deborah Donnell, Jared M Baeten et al.•ARTICLE•JAIDS Journal of Acquired Immune…•2014

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  BACKGROUND: Antiretroviral pre-exposure prophylaxis (PrEP) is a novel HIV prevention strategy for which adherence is a known determinant of efficacy. Blood concentrations of PrEP medications are one objective marker of adherence. METHODS: In a placebo-controlled PrEP efficacy trial of tenofovir disoproxil fumarate (TDF) and TDF with emtricitabine (FTC/TDF) among 4747 African women and men with an HIV-infected partner, we measured plasma tenofovir…

• My intention was a child but I was very afraid

  Kenneth Ngure, Jared M Baeten et al.•ARTICLE•AIDS Care•2014

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  We sought to understand fertility intentions and HIV risk considerations among Kenyan HIV-serodiscordant couples who became pregnant during a prospective study. We conducted individual in-depth interviews (n = 36) and focus group discussions (n = 4) and performed qualitative data analysis and interpretation using an inductive approach. Although most of the couples were aware of the risk of horizontal and vertical HIV transmission, almost all coup…

• Lay Social Resources for Support of Adherence to Antiretroviral Prophylaxis for HIV Prevention Among Serodiscordant Couples in sub-Saharan Africa

  Open Access•N C Ware, Emily E Pisarski et al.•ARTICLE•AIDS and Behavior•2014

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  Effectiveness of antiretroviral pre-exposure prophylaxis (PrEP) for HIV prevention will require high adherence. Using qualitative data, this paper identifies potential lay social resources for support of PrEP adherence by HIV serodiscordant couples in Uganda, laying the groundwork for incorporation of these resources into adherence support initiatives as part of implementation. The qualitative analysis characterizes support for PrEP adherence pro…

• Preferences for Daily or Intermittent Pre-exposure Prophylaxis Regimens and Ability to Anticipate Sex Among HIV Uninfected Members of Kenyan HIV Serodiscordant Couples

  Open Access•Sarah T Roberts, Renee Heffron et al.•ARTICLE•AIDS and Behavior•2014

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• Defining success with HIV pre-exposure prophylaxis

  Jessica E Haberer, David R Bangsberg et al.•ARTICLE•AIDS•2015

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  Introduction To date, six clinical trials have explored the efficacy of pre-exposure prophylaxis (PrEP) against HIV infection using oral tenofovir and/or emtricitabine/tenofovir [1–6]. Efficacy ranged from 0 to 75% [7], the variation of which can largely be explained by differences in PrEP adherence [8]. Efficacy data directly correlate with the objective adherence measures in those studies, and efficacy estimates were between 90 and 100% when ad…

• Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women

  Jared M Baeten, Thesla Palanee‐phillip et al.•ARTICLE•New England Journal of Medicine•2016

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  BACKGROUND: Antiretroviral medications that are used as prophylaxis can prevent acquisition of human immunodeficiency virus type 1 (HIV-1) infection. However, in clinical trials among African women, the incidence of HIV-1 infection was not reduced, probably because of low adherence. Longer-acting methods of drug delivery, such as vaginal rings, may simplify use of antiretroviral medications and provide HIV-1 protection. METHODS: We conducted a ph…

• Gendered differences in the perceived risks and benefits of oral PrEP among HIV-serodiscordant couples in Kenya

  Jennifer J Carroll, Kenneth Ngure et al.•ARTICLE•AIDS Care•2016

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  Pre-exposure prophylaxis (PrEP) is effective for preventing HIV among HIV-serodiscordant heterosexual couples. Gender roles may influence perceived personal and social risks related to HIV-prevention behaviors and may affect use of PrEP. In this study, interviews and focus groups were conducted with 68 individuals from 34 mutually disclosed serodiscordant heterosexual partnerships in Thika, Kenya. Sociocultural factors that affect adherence to Pr…

• “I never thought that it would happen … ” Experiences of HIV seroconverters among HIV-discordant partnerships in a prospective HIV prevention study in Kenya

  Kenneth Ngure, Sophie Vusha et al.•ARTICLE•AIDS Care•2016

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  In spite of access to behavioral and biomedical HIV prevention strategies, HIV transmission occurs. For HIV-serodiscordant couples, prevention programs can be tailored to address individual and couples' needs to preserve their relationship while minimizing HIV risk. Programs for serodiscordant couples may benefit from learning from experiences of couples who transmit HIV. We conducted 20 individual in-depth interviews with 10 initially HIV-serodi…

• Does Adherence Change When No One is Looking? Comparing Announced and Unannounced Tenofovir Levels in a PrEP Trial

  Open Access•Nicholas Musinguzi, Timothy R Muwonge et al.•ARTICLE•AIDS and Behavior•2016

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• Objective Measurement of Inaccurate Condom Use Reporting Among Women Using Depot Medroxyprogesterone Acetate for Contraception

  Open Access•Partners PrEP Study Team, Renee Heffron et al.•ARTICLE•AIDS and Behavior•2016

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• Depression and ART Initiation Among HIV Serodiscordant Couples in Kenya and Uganda

  Open Access•Partners Demonstration Project Team, Jennifer Velloza et al.•ARTICLE•AIDS and Behavior•2017

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• Fertility Intentions, Pregnancy, and Use of PrEP and ART for Safer Conception Among East African HIV Serodiscordant Couples

  Open Access•Partners Demonstration Project Team, Renee Heffron et al.•ARTICLE•AIDS and Behavior•2017

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• Impact of the Dapivirine Vaginal Ring on Sexual Experiences and Intimate Partnerships of Women in an HIV Prevention Clinical Trial

  Open Access•On behalf of the MTN-020/ASPIRE Study Team, Nicole Laborde et al.•ARTICLE•AIDS and Behavior•2017

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• Safer conception among HIV-1 serodiscordant couples in East Africa

  Kerry Hancuch, Jared M Baeten et al.•ARTICLE•AIDS Care•2018

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  For HIV-1 serodiscordant couples, HIV-1 exposure and risk of transmission is heightened during pregnancy attempts, but safer conception strategies can reduce risk. As safer conception programs are scaled up, understanding couples' preferences and experiences can be useful for programmatic recommendations. We followed 1013 high-risk, heterosexual HIV-1 serodiscordant couples from Kenya and Uganda for two years in an open-label delivery study of in…

• Lessons from PrEP

  Open Access•Kristin Beima‐Sofie, Susan Brown Trinidad et al.•ARTICLE•AIDS and Behavior•2018

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  This study explored how multinational HIV experts weigh clinical, evidential, and ethical considerations regarding pre-exposure prophylaxis in pregnant/breastfeeding women. Semi-structured interviews were conducted with experts in HIV policy, research, treatment, and implementation from three global regions. A constant comparative approach identified major themes. Experts noted that exclusion of pregnant women from research limits evidence regard…

Medicine (61 obras) · HIV/AIDS Research and Interventions (59 obras) · Family medicine (44 obras) · Adolescent Sexual and Reproductive Health (36 obras) · Public health (32 obras) · Human immunodeficiency virus (HIV (31 obras) · Nursing (31 obras) · HIV, Drug Use, Sexual Risk (29 obras) · Men who have sex with men (28 obras) · Pre-exposure prophylaxis (28 obras)