André Briend
Biographic Data
| ID | 5457518 |
|---|---|
| NAME | André Briend |
| GIVEN NAMES | André |
| FAMILY NAME | Briend |
| SIGNATURE | BRIEND A |
| AFFILIATIONS | University of Copenhagen |
| ORCID | 0000-0001-9390-8541 |
| VERIFIED | Yes |
| TOTAL WORKS | 48 |
| TOTAL CITATIONS | 70 |
| AUTHOR COUNT | 48 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1989 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 2 |
Reducing relapses after acute malnutrition treatment
Background Acute malnutrition remains a critical public health issue, particularly in emergency settings. While simplified treatment protocols show promise in improving access and cost-effectiveness, evidence on their impact on relapse rates remains limited. This study aimed to compare relapse incidence among children treated for severe acute malnutrition (SAM) using a simplified protocol versus the standard Community Management of Acute Malnutri…
Re-thinking “non-response” to wasting treatment
Children who receive therapeutic feeding for wasting treatment but do not reach the anthropometric definitions of recovery (usually within 12–16 weeks) are categorised as ‘non-responders’ and considered as treatment failures. We conducted a pooled analysis to explore the growth trajectories of non-responders and the appropriateness of the definition of ‘non-response’. We pooled 14 studies of children aged 6–59 months receiving treatment for wasti…
Distance From Treatment Is Associated With Poorer Admission Status and Worse Outcomes Among Acutely Malnourished Children
Distance from health facilities is an important predictor of treatment seeking and health outcomes. We aimed to describe the relationship between distance from care with admission characteristics and treatment outcomes among children admitted to malnutrition treatment. Data was collected as part of an observational study on the effectiveness of a simplified malnutrition treatment program in the Nara district of Mali. Treatment was provided at 37 …
Applying WHO Prioritization Criteria for Moderate Wasting
The World Health Organization's 2023 recommendations for managing moderate wasting provide criteria for prioritizing children to receive specially formulated foods (SFF) rather than counseling alone. However, the practical programmatic impact of such prioritization is unclear. This secondary analysis aimed to describe the caseload and treatment outcomes among moderately wasted 6- to 59-month-old Malian children, categorized into higher-priority (…
Predictors of change in early child development among children with stunting
Millions of children under 5 years in low- and middle-income countries fail to attain their development potential with accruing short- and long-term consequences. Low length/height for age (stunting) is known to be a key factor, but there is little data on how child characteristics are linked with developmental changes among children with stunting. We assessed the socioeconomic, household, anthropometric, and clinical predictors of change in earl…
Three‐arm clinical trial of improved flour targeting intestinal microbiota (Malinea)
The main objective of this project was to compare in the field conditions two strategies of re-nutrition of children with moderate acute malnutrition (MAM) aged from 6 to 24 months, targeting the microbiota in comparison with a standard regimen. A three-arm, open-label, pragmatic randomised trial was conducted in four countries (Niger, CAR, Senegal and Madagascar). Children received for 12 weeks either fortified blended flour (FBF control) = arm …
Correlates of early child development among children with stunting
Many children in low- and middle-income countries are not attaining their developmental potential. Stunting is associated with poor child development, but it is not known which correlates of stunting are impairing child development. We explored potential socioeconomic, nutritional, clinical, and household correlates of early child development among 12-59-month-old children with stunting in a cross-sectional study in Uganda. Development was assess…
The relationship between energy provided and growth during severe wasting treatment
Treatment of severe acute malnutrition aims at producing quick catch-up growth in children to decrease their short-term mortality risk. The extent to which catch-up growth is influenced by the amount of energy provided is unclear. This study assessed whether energy provided at admission is associated with catch-up ponderal growth among children with mid-upper arm circumference (MUAC) < 115 mm at admission. We conducted a secondary data analysis a…
Linear Growth During Treatment With a Simplified, Combined Protocol
A simplified, combined protocol treats children with moderate acute malnutrition (MAM), defined by mid-upper arm circumference (MUAC) of < 125 and ≥ 115 mm and no oedema, with 1 daily sachet of ready-to-use therapeutic food (RUTF) and those with severe acute malnutrition (SAM), defined by MUAC < 115 mm and/or oedema, with two daily sachets of RUTF. This protocol was previously shown to result in non-inferior recovery compared to standard treatmen…
How age and sex affect treatment outcomes for children with severe malnutrition
Age and sex influence the risk of childhood wasting. We aimed to determine if wasting treatment outcomes differ by age and sex in children under 5 years, enroled in therapeutic and supplementary feeding programmes. Utilising data from stage 1 of the ComPAS trial, we used logistic regression to assess the association between age, sex and wasting treatment outcomes (recovery, death, default, non-response, and transfer), modelling the likelihood of …
Prognostic value of different anthropometric indices over different measurement intervals to predict mortality in 6–59-month-old children
Objective: To compare the prognostic value of mid-upper arm circumference (MUAC), weight-for-height Z -score (WHZ) and weight-for-age Z -score (WAZ) for predicting death over periods of 1, 3 and 6 months follow-up in children. Design: Pooled analysis of twelve prospective studies examining survival after anthropometric assessment. Sensitivity and false-positive ratios to predict death within 1, 3 and 6 months were compared for three individual an…
Anthropometric criteria for best-identifying children at high risk of mortality
Objective: To understand which anthropometric diagnostic criteria best discriminate higher from lower risk of death in children and explore programme implications. Design: A multiple cohort individual data meta-analysis of mortality risk (within 6 months of measurement) by anthropometric case definitions. Sensitivity, specificity, informedness and inclusivity in predicting mortality, face validity and compatibility with current standards and prac…
Changing sex differences in undernutrition of African children
The study investigates sex differences in the prevalence of undernutrition in sub-Saharan Africa. Undernutrition was defined by Z -scores using the CDC-2000 growth charts. Some 128 Demographic and Health Surveys (DHS) were analysed, totalling 700,114 children under-five. The results revealed a higher susceptibility of boys to undernutrition. Male-to-female ratios of prevalence averaged 1.18 for stunting (height-for-age Z -score Z -score Z -score …
How do children with severe underweight and wasting respond to treatment? A pooled secondary data analysis to inform future intervention studies
Children with weight-for-age z-score (WAZ) <-3 have a high risk of death, yet this indicator is not widely used in nutrition treatment programming. This pooled secondary data analysis of children aged 6-59 months aimed to examine the prevalence, treatment outcomes, and growth trajectories of children with WAZ <-3 versus children with WAZ ≥-3 receiving outpatient treatment for wasting and/or nutritional oedema, to inform future protocols. Binary t…
Improving estimates of the burden of severe wasting
INTRODUCTION: Estimates of incident cases of severe wasting among young children are not available for most settings but are needed for optimal planning of treatment programmes and burden estimation. To improve programme planning, global guidance recommends a single 'incidence correction factor' of 1.6 be applied to available prevalence estimates to account for incident cases. This study aimed to update estimates of the incidence correction facto…
Effectiveness and Coverage of Treatment for Severe Acute Malnutrition Delivered by Community Health Workers in the Guidimakha Region, Mauritania
Geographical and economic access barriers to health facilities (HF) have been identified as some of the most important causes of the low coverage of severe acute malnutrition (SAM) treatment. The objective of this study is to assess the effectiveness and coverage of SAM treatment delivered by community health workers (CHWs) in the Guidimakha region in Mauritania, compared to the HF based approach. This study was a nonrandomized controlled trial, …
‘Severe malnutrition’
box Malnutrition affects millions worldwide and underlies almost half of deaths in children aged <5 years.1 Progress towards Sustainable Development Goal 2 (End hunger) was already slow but coronavirus-related secondary impacts now threaten nutritional crises described as: Biblical, on steroids, across generations .2 Towards effective actions, effective communication matters. Malnutrition involves a plethora of complex technical terminology. Some…
Boys are more likely to be undernourished than girls
Energy needs in the treatment of uncomplicated severe acute malnutrition
Outpatient therapeutic feeding protocols for the treatment of uncomplicated severe acute malnutrition in children were initially based on weight gain data from inpatient settings and expert knowledge of the physiological requirements during recovery. However, weight gain and energy requirements from historic inpatient settings may differ from modern outpatient settings and therefore may not be appropriate to guide current therapeutic feeding prot…
Relapse and regression to severe wasting in children under 5 years
Systematic reviews have highlighted that repeated severe wasting after receiving treatment is likely to be common, but standardised measurement is needed urgently. The Council of Research & Technical Advice for Acute Malnutrition (CORTASAM) released recommendations on standard measurement of relapse (wasting within 6 months after exiting treatment as per recommended discharge criteria), regression (wasting within 6 months after exiting treatment …
Concurrently wasted and stunted children 6‐59 months in Karamoja, Uganda
We assessed prevalence of concurrently wasted and stunted (WaSt) and explored the overlaps between wasted, stunted, underweight and low mid-upper arm circumference (MUAC) among children aged 6-59 months in Karamoja, Uganda. We also determined optimal weight-for-age (WAZ) and MUAC thresholds for detecting WaSt. We conducted secondary data analysis with 2015-2018 Food Security and Nutrition Assessment (FSNA) cross-sectional survey datasets from Kar…
Factors associated with concurrent wasting and stunting among children 6–59 months in Karamoja, Uganda
Children with concurrent wasting and stunting (WaSt) and children with severe wasting have a similar risk of death. Existing evidence shows that wasting and stunting share similar causal pathways, but evidence on correlates of WaSt remains limited. Research on correlates of WaSt is needed to inform prevention strategies. We investigated the factors associated with WaSt in children 6-59 months in Karamoja Region, Uganda. We examined data for 33,05…
Linear growth faltering and the role of weight attainment
Efforts to reduce the impact of stunting have been largely independent of interventions to reduce the impact of wasting, despite the observation that the conditions can coexist in the same child and increase risk of death. To optimize the management of malnourished children-who can be wasted, stunted, or both-the relationship between stunting and wasting should be elaborated. We aimed to describe the relationship between concurrent weight and hei…
Early development in children with moderate acute malnutrition
Malnutrition impairs cognitive, communication, and motor development, but it is not known how nutrition and health are associated with development in children with moderate acute malnutrition (MAM). We aimed to describe motor and language development of children with MAM and explore its nutrition and health-related correlates. This cross-sectional study used baseline data from a nutritional trial in children with MAM aged 6-23 months in Burkina F…
Improving screening for malnourished children at high risk of death
Objective To investigate whether children with concurrent wasting and stunting require therapeutic feeding and to better understand whether multiple diagnostic criteria are needed to identify children with a high risk of death and in need of treatment. Design Community-based cohort study, following 5751 children through time. Each child was visited up to four times at 6-month intervals. Anthropometric measurements were taken at each visit. Surviv…
Replacing Fats and Sweets With Vegetables and Fruits—A Question of Cost
Objectives. We examined the association between diet quality and estimated diet costs. Methods. Freely chosen diets of 837 French adults were assessed by a dietary history method. Mean national food prices for 57 foods were used to estimate diet costs. Results. Diets high in fat, sugar, and grains were associated with lower diet costs after adjustment for energy intakes, gender, and age. For most levels of energy intake, each additional 100 g of …
Do economic constraints encourage the selection of energy dense diets
Targeting nutritional interventions
To test whether regular monitoring of weight is an efficient way to detect the development of malnutrition, two cohorts of children in Bangladesh and the Caribbean were followed prospectively for 18 months. Results showed that, after 1 year of age, body weight was more closely correlated with weight at 6 months of age than with weight changes in the previous three months. Moreover, weight at 6 months was significantly more closely correlated with…
Targeting nutritional interventions
To test whether regular monitoring of weight is an efficient way to detect the development of malnutrition, two cohorts of children in Bangladesh and the Caribbean were followed prospectively for 18 months. Results showed that, after 1 year of age, body weight was more closely correlated with weight at 6 months of age than with weight changes in the previous three months. Moreover, weight at 6 months was significantly more closely correlated with…
Post‐flood nutritional anthropometry of children in Matlab, Bangladesh
The Matlab area was severely affected by the floods of 1988 in Bangladesh. To assess the impact of flooding in Matlab the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B) performed post‐flood surveys. Six‐hundred households were surveyed. In addition, length, weight, and mid‐upper arm circumference were measured in children aged 6–35 months. Baseline economic status appeared to be higher inside the Matlab embankment, whe…
Child survival
This paper examines recent studies which focus on the effectiveness of primary health care activities and concludes that in Bangladesh the potential for substantially improving child survival and growth is severely curtailed by unbalanced strategies. More specifically the paper argues: (1) that focusing interventions on at-risk children at about 6 months of age is more efficient and less costly in preventing malnutrition than monthly monitoring o…
Does ORT reduce diarrhoeal mortality
Trends in infant and child mortality from all diarrhoea-related causes and from acute watery diarrhoea were examined in a rural community in Bangladesh, during the three years preceding and the 10 years following the introduction of an oral rehydration therapy (ORT) programme. A significant increase in infant mortality due to acute watery diarrhoea was observed throughout the study period. Child mortality due to acute watery diarrhoea did not dec…
Dietary inadequacies observed in homeless men visiting an emergency night shelter in Paris
Objective To assess the dietary intake and the nutritional status of homeless men. Setting A night emergency shelter in Paris, France. Design Dietary survey (48-h) including alcohol intake and a questionnaire on age, duration of homelessness, smoking habits. Subjects were also weighed and measured. Subjects Ninety-seven men aged 18–72 years (mean 43.3), of whom 54% were homeless for more than 18 months, 82% were smokers and 53% were regular and/o…
Do economic constraints encourage the selection of energy dense diets
Energy-dense diets are associated with lower diet costs
Objective: High consumption of energy-dense foods has been linked to high energy intakes and excess weight gain. This study tested the hypothesis that high energy density of the total diet is associated with lower diet costs. Design: Dietary intakes of 837 French adults, aged 18–76 years, were assessed using a dietary history method. Dietary energy density (MJ kg −1 ) was calculated by dividing total energy by the edible weight of foods consumed.…
Replacing Fats and Sweets With Vegetables and Fruits—A Question of Cost
Objectives. We examined the association between diet quality and estimated diet costs. Methods. Freely chosen diets of 837 French adults were assessed by a dietary history method. Mean national food prices for 57 foods were used to estimate diet costs. Results. Diets high in fat, sugar, and grains were associated with lower diet costs after adjustment for energy intakes, gender, and age. For most levels of energy intake, each additional 100 g of …
Randomized comparison of 3 types of micronutrient supplements for home fortification of complementary foods in Ghana
Supplementary feeding with fortified spread among moderately underweight 6–18‐month‐old rural Malawian children
We aimed to analyse growth and recovery from undernutrition among moderately underweight ambulatory children receiving micronutrient-fortified maize-soy flour (Likuni Phala, LP) or ready-to-use fortified spread (FS) supplementary diet. One hundred and seventy-six 6-18-month-old individuals were randomized to receive 500 g LP or 350 g FS weekly for 12 weeks. Baseline and end of intervention measurements were used to calculate anthropometric gains …
Incidence and duration of severe wasting in two African populations
Objective The present study aimed to compare two situations of endemic malnutrition among Design Secondary analysis of longitudinal studies, conducted several years ago, which allowed incidence and duration to be calculated from transition rates. The first site was Niakhar in Senegal, an area under demographic surveillance, where we followed a cohort of children in 1983–5. The second site was Bwamanda in the Democratic Republic of Congo, where we…
Mid‐upper arm circumference and weight‐for‐height to identify high‐risk malnourished under‐five children
The World Health Organization and UNICEF define non‐oedematous severe acute malnutrition (SAM) either by a mid‐upper arm circumference (MUAC) less than 115 mm or by a weight‐for‐height z‐score (WHZ) less than –3. The objective of this study was to assess whether there was any benefit to identify malnourished children with a high risk of death to combine these two diagnostic criteria. Data of a longitudinal study examining the relationship between…
Developmental outcomes among 18‐month‐old Malawians after a year of complementary feeding with lipid‐based nutrient supplements or corn‐soy flour
The major aim of this trial was to compare the development of 18-month-old infants who received complementary feeding for 1 year either with lipid-based nutrient supplements or micronutrient fortified corn-soy porridge. Our secondary aim was to determine the socio-economic factors associated with developmental outcomes in the same population. A total of 163 six-month-old rural Malawian children were enrolled in a randomized controlled trial where…
Target weight gain for moderately wasted children during supplementation interventions – a population-based approach
Objective In malnourished populations, the weight-for-height Z -score (WHZ) distribution is shifted to the left. The aim of nutrition interventions should be to restore a normal WHZ distribution for the whole population. The present paper examines the WHZ change needed by each individual to achieve this objective. Design We developed a mathematical model of required individual change in WHZ as a function of characteristics of the initial populati…
Screening for anti‐nutritional compounds in complementary foods and food aid products for infants and young children
A range of compounds with negative nutritional impact - 'anti-nutrients' - are found in most plant foods. The contents of anti-nutrients in processed foods depend on the ingredients and processing. Anti-nutrients in complementary foods for children can have a negative impact on nutritional status. The aim of this study was to screen complementary foods from developing countries for the anti-nutritional compounds, phytate, polyphenols, inhibitors …
Validity of anthropometric measurements to assess body composition, including muscle mass, in 3‐year‐old children from the SKOT cohort
Nutritional status of children is commonly assessed by anthropometry both in under and overnutrition. The link between anthropometry and body fat, the body compartment most affected by overnutrition, is well known, but the link with muscle mass, the body compartment most depleted in undernutrition, associated with infections, remains unknown. In this study, we examined the relationship between common anthropometric indices and body composition me…
Designing appropriate complementary feeding recommendations
Suboptimal complementary feeding practices contribute to a rapid increase in the prevalence of stunting in young children from age 6 months. The design of effective programmes to improve infant and young child feeding requires a sound understanding of the local situation and a systematic process for prioritizing interventions, integrating them into existing delivery platforms and monitoring their implementation and impact. The identification of a…
Assessment of the PROBIT approach for estimating the prevalence of global, moderate and severe acute malnutrition from population surveys
Objective Prevalence of acute malnutrition is classically estimated by the proportion of children meeting a case definition in a representative population sample. In 1995 the WHO proposed the PROBIT method, based on converting parameters of a normally distributed variable to cumulative probability, as an alternative method requiring a smaller sample size. The present study compares classical and PROBIT methods for estimating the prevalence of glo…
Adequacy of child anthropometric indicators for measuring nutritional stress at population level
Objective To compare the responsiveness of different anthropometric indicators for measuring nutritional stress among children in developing countries. Design Growth was studied within 6-month intervals in a rural Senegalese community during one dry and two rainy (hungry) seasons. Responsiveness was defined as the change divided by the standard deviation of each anthropometric indicator. Contrast was defined as the difference in responsiveness be…
Impact of lipid‐based nutrient supplements and corn–soy blend on energy and nutrient intake among moderately underweight 8–18‐month‐old children participating in a clinical trial
Nutrition interventions have an effect on growth, energy and nutrient intake, and development, but there are mixed reports on the effect of supplementation of energy-dense foods on dietary intake. This substudy aimed at assessing the effect of supplementation with corn-soy blend (CSB) or lipid-based nutrient supplement (LNS) on energy and nutrient intake in moderately underweight children participating in a clinical trial. A total of 188 children…
Using cross-sectional surveys to estimate the number of severely malnourished children needing to be enrolled in specific treatment programmes
Objective When planning severe acute malnutrition (SAM) treatment services, estimates of the number of children requiring treatment are needed. Prevalence surveys, used with population estimates, can directly estimate the number of prevalent cases but not the number of subsequent incident cases. Health managers often use a prevalence-to-incidence conversion factor ( J ) derived from two African cohort studies to estimate incidence and add the exp…
Concurrent wasting and stunting among under‐five children in Niakhar, Senegal
The study describes the patterns of concurrent wasting and stunting (WaSt) among children age 6–59 months living in the 1980s in Niakhar, a rural area of Senegal under demographic surveillance. Wasting and stunting were defined by z scores lower than −2 in weight for height and height for age. Both conditions were found to be highly prevalent, wasting more so before age 30 months, stunting more so after age 30 months. As a result, concurrent WaSt…
Linear growth faltering and the role of weight attainment
Efforts to reduce the impact of stunting have been largely independent of interventions to reduce the impact of wasting, despite the observation that the conditions can coexist in the same child and increase risk of death. To optimize the management of malnourished children-who can be wasted, stunted, or both-the relationship between stunting and wasting should be elaborated. We aimed to describe the relationship between concurrent weight and hei…
Early development in children with moderate acute malnutrition
Malnutrition impairs cognitive, communication, and motor development, but it is not known how nutrition and health are associated with development in children with moderate acute malnutrition (MAM). We aimed to describe motor and language development of children with MAM and explore its nutrition and health-related correlates. This cross-sectional study used baseline data from a nutritional trial in children with MAM aged 6-23 months in Burkina F…
Improving screening for malnourished children at high risk of death
Objective To investigate whether children with concurrent wasting and stunting require therapeutic feeding and to better understand whether multiple diagnostic criteria are needed to identify children with a high risk of death and in need of treatment. Design Community-based cohort study, following 5751 children through time. Each child was visited up to four times at 6-month intervals. Anthropometric measurements were taken at each visit. Surviv…
Medicine (43 works) · Child Nutrition and Water Access (38 works) · Internal Medicine (26 works) · Child Nutrition and Feeding Issues (23 works) · Environmental health (23 works) · Malnutrition (19 works) · Pediatrics (19 works) · Food Security and Health in Diverse Populations (16 works) · Anthropometry (15 works) · Demography (13 works)