Luke Nyakarahuka
Biographic Data
| ID | 7002232 |
|---|---|
| NAME | Luke Nyakarahuka |
| GIVEN NAMES | Luke |
| FAMILY NAME | Nyakarahuka |
| SIGNATURE | NYAKARAHUKA L |
| AFFILIATIONS | Makerere University |
| ORCID | 0000-0002-2944-9157 |
| VERIFIED | Yes |
| TOTAL WORKS | 16 |
| TOTAL CITATIONS | 0 |
| AUTHOR COUNT | 16 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2014 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 0 |
Patterns of antibiotic use for acute febrile illness in resource-limited settings
Introduction In East Africa and beyond, uncertainty regarding the underlying aetiology of febrile illnesses may result in inappropriate treatment. In our study, we aimed at enhancing our understanding of antibiotic use patterns, prescribing practices and factors influencing antibiotic use in this region by exploring the pathways of care for acute febrile illnesses in three countries in East Africa. Methods Between October 2021 and February 2024, …
Importance of outbreak response research in bridging knowledge gaps on emerging infectious diseases
An important outcome of the devastating 2014 West African Ebola virus disease outbreak and the 2020 COVID-19 pandemic has been the growing promotion of conducting research during outbreaks of emerging infectious diseases (EIDs) as a valuable and acceptable process of acquiring knowledge to enhance our ability to better prevent and control these diseases in the future. Recognising the unique opportunity during outbreaks to leverage increases in ca…
Rift Valley fever outbreak among animal handlers in Kinyogoga Village, Nakaseke District, Central Uganda
Rift Valley fever (RVF) is a viral zoonosis which occurs sporadically in Uganda. On July 24, 2023, a 24-year-old male animal husbandry officer from Nakaseke District presented to a hospital in Kampala District with history of intermittent nosebleeds. He tested positive for Rift Valley fever virus (RVFV) by reverse transcriptase polymerase chain reaction (RT-PCR). We investigated to identify the source, estimate the magnitude, and determine the dr…
Widening geographic range of Rift Valley fever disease clusters associated with climate change in East Africa
BACKGROUND: Recent epidemiology of Rift Valley fever (RVF) disease in Africa suggests growing frequency and expanding geographic range of small disease clusters in regions that previously had not reported the disease. We investigated factors associated with the phenomenon by characterising recent RVF disease events in East Africa. METHODS: Data on 100 disease events (2008-2022) from Kenya, Uganda and Tanzania were obtained from public databases a…
Bat-Borne Pathogens and Public Health in Rural African Artisanal Gold Mines
Marburg virus, the first filovirus discovered and a close cousin to the Ebola virus, is carried by the Egyptian rousette bat, a common cave-dwelling fruit bat endemic to sub-Saharan Africa whose populations can exceed 50 000 individuals. Community outbreaks of Marburg virus can result in high morbidity rates. In eastern Africa, favorite habitats of these bats include rural subterranean gold mines-sometimes worked illegally-that create environment…
Uganda’s experience in Ebola virus disease outbreak preparedness, 2018–2019
BACKGROUND: Since the declaration of the 10th Ebola Virus Disease (EVD) outbreak in DRC on 1st Aug 2018, several neighboring countries have been developing and implementing preparedness efforts to prevent EVD cross-border transmission to enable timely detection, investigation, and response in the event of a confirmed EVD outbreak in the country. We describe Uganda's experience in EVD preparedness. RESULTS: On 4 August 2018, the Uganda Ministry of…
Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970–2016
BACKGROUND: Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations. Understanding how all-cause mortality has changed with respect to development status can identify exemplars for best practice. To accomplish this, the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) estimated age-specific and …
Global, regional, and national levels of maternal mortality, 1990–2015
BACKGROUND: In transitioning from the Millennium Development Goal to the Sustainable Development Goal era, it is imperative to comprehensively assess progress toward reducing maternal mortality to identify areas of success, remaining challenges, and frame policy discussions. We aimed to quantify maternal mortality throughout the world by underlying cause and age from 1990 to 2015. METHODS: We estimated maternal mortality at the global, regional, …
Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015
BACKGROUND: Improving survival and extending the longevity of life for all populations requires timely, robust evidence on local mortality levels and trends. The Global Burden of Disease 2015 Study (GBD 2015) provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015. These results informed an in-depth investigation of observed and expected mortality patterns bas…
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015
BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context. METHODS: We used the comparative risk assessment framework developed for previous iterations of t…
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013
Global, regional, and national disability-adjusted life years (Dalys) for 306 diseases and injuries and healthy life expectancy (Hale) for 188 countries, 1990–2013
Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013
Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013
Global, regional, and national levels and causes of maternal mortality during 1990–2013
Global, regional, and national levels of neonatal, infant, and under-5 mortality during 1990–2013
BACKGROUND: Remarkable financial and political efforts have been focused on the reduction of child mortality during the past few decades. Timely measurements of levels and trends in under-5 mortality are important to assess progress towards the Millennium Development Goal 4 (MDG 4) target of reduction of child mortality by two thirds from 1990 to 2015, and to identify models of success. METHODS: We generated updated estimates of child mortality i…
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Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013
Global, regional, and national levels and causes of maternal mortality during 1990–2013
Global, regional, and national levels of neonatal, infant, and under-5 mortality during 1990–2013
BACKGROUND: Remarkable financial and political efforts have been focused on the reduction of child mortality during the past few decades. Timely measurements of levels and trends in under-5 mortality are important to assess progress towards the Millennium Development Goal 4 (MDG 4) target of reduction of child mortality by two thirds from 1990 to 2015, and to identify models of success. METHODS: We generated updated estimates of child mortality i…
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013
Global, regional, and national disability-adjusted life years (Dalys) for 306 diseases and injuries and healthy life expectancy (Hale) for 188 countries, 1990–2013
Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013
Global, regional, and national levels of maternal mortality, 1990–2015
BACKGROUND: In transitioning from the Millennium Development Goal to the Sustainable Development Goal era, it is imperative to comprehensively assess progress toward reducing maternal mortality to identify areas of success, remaining challenges, and frame policy discussions. We aimed to quantify maternal mortality throughout the world by underlying cause and age from 1990 to 2015. METHODS: We estimated maternal mortality at the global, regional, …
Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015
BACKGROUND: Improving survival and extending the longevity of life for all populations requires timely, robust evidence on local mortality levels and trends. The Global Burden of Disease 2015 Study (GBD 2015) provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015. These results informed an in-depth investigation of observed and expected mortality patterns bas…
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015
BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context. METHODS: We used the comparative risk assessment framework developed for previous iterations of t…
Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970–2016
BACKGROUND: Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations. Understanding how all-cause mortality has changed with respect to development status can identify exemplars for best practice. To accomplish this, the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) estimated age-specific and …
Uganda’s experience in Ebola virus disease outbreak preparedness, 2018–2019
BACKGROUND: Since the declaration of the 10th Ebola Virus Disease (EVD) outbreak in DRC on 1st Aug 2018, several neighboring countries have been developing and implementing preparedness efforts to prevent EVD cross-border transmission to enable timely detection, investigation, and response in the event of a confirmed EVD outbreak in the country. We describe Uganda's experience in EVD preparedness. RESULTS: On 4 August 2018, the Uganda Ministry of…
Widening geographic range of Rift Valley fever disease clusters associated with climate change in East Africa
BACKGROUND: Recent epidemiology of Rift Valley fever (RVF) disease in Africa suggests growing frequency and expanding geographic range of small disease clusters in regions that previously had not reported the disease. We investigated factors associated with the phenomenon by characterising recent RVF disease events in East Africa. METHODS: Data on 100 disease events (2008-2022) from Kenya, Uganda and Tanzania were obtained from public databases a…
Bat-Borne Pathogens and Public Health in Rural African Artisanal Gold Mines
Marburg virus, the first filovirus discovered and a close cousin to the Ebola virus, is carried by the Egyptian rousette bat, a common cave-dwelling fruit bat endemic to sub-Saharan Africa whose populations can exceed 50 000 individuals. Community outbreaks of Marburg virus can result in high morbidity rates. In eastern Africa, favorite habitats of these bats include rural subterranean gold mines-sometimes worked illegally-that create environment…
Importance of outbreak response research in bridging knowledge gaps on emerging infectious diseases
An important outcome of the devastating 2014 West African Ebola virus disease outbreak and the 2020 COVID-19 pandemic has been the growing promotion of conducting research during outbreaks of emerging infectious diseases (EIDs) as a valuable and acceptable process of acquiring knowledge to enhance our ability to better prevent and control these diseases in the future. Recognising the unique opportunity during outbreaks to leverage increases in ca…
Rift Valley fever outbreak among animal handlers in Kinyogoga Village, Nakaseke District, Central Uganda
Rift Valley fever (RVF) is a viral zoonosis which occurs sporadically in Uganda. On July 24, 2023, a 24-year-old male animal husbandry officer from Nakaseke District presented to a hospital in Kampala District with history of intermittent nosebleeds. He tested positive for Rift Valley fever virus (RVFV) by reverse transcriptase polymerase chain reaction (RT-PCR). We investigated to identify the source, estimate the magnitude, and determine the dr…
Patterns of antibiotic use for acute febrile illness in resource-limited settings
Introduction In East Africa and beyond, uncertainty regarding the underlying aetiology of febrile illnesses may result in inappropriate treatment. In our study, we aimed at enhancing our understanding of antibiotic use patterns, prescribing practices and factors influencing antibiotic use in this region by exploring the pathways of care for acute febrile illnesses in three countries in East Africa. Methods Between October 2021 and February 2024, …
Medicine (15 works) · Environmental health (11 works) · Population (9 works) · Disease (8 works) · Demography (7 works) · Global Maternal and Child Health (7 works) · Burden of disease (6 works) · Outbreak (5 works) · Public health (5 works) · Viral Infections and Outbreaks Research (5 works)