Kathleen M Macqueen
Biographic Data
| ID | 83501 |
|---|---|
| NAME | Kathleen M Macqueen |
| GIVEN NAMES | Kathleen M |
| FAMILY NAME | Macqueen |
| SIGNATURE | MACQUEEN K M |
| AFFILIATIONS | Family Health International 360 |
| ORCID | 0000-0003-2436-4741 |
| VERIFIED | Yes |
| TOTAL WORKS | 27 |
| TOTAL CITATIONS | 186 |
| AUTHOR COUNT | 27 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1984 |
| LATEST PUBLICATION YEAR | 2016 |
| H-INDEX | 5 |
Social Context of Adherence in an Open-Label 1 % Tenofovir Gel Trial
CAPRISA 008, an open-label extension study of tenofovir gel with coitally-related dosing, provided an opportunity to explore the relationship between product adherence and gender dynamics in a context where women knew they were receiving an active product with evidence of HIV prevention effectiveness. Interviews with 63 CAPRISA 008 participants and 13 male partners in KwaZulu-Natal, South Africa, highlighted that the process of negotiating gel us…
Developing a Framework for Evaluating Ethical Outcomes of Good Participatory Practices in TB Clinical Drug Trials
Good Participatory Practice Guidelines for TB Drug Trials (GPP-TB) were issued in 2012, based on similar guidelines for HIV prevention and reflecting growing acceptance of the importance of community engagement and participatory strategies in clinical research. Though the need for such strategies is clear, evaluation of the benefits and burdens are needed. Working with a diverse group of global TB stakeholders including advocates, scientists, and…
HIV Testing Experience and Risk Behavior Among Sexually Active Black Young Adults
African Americans are disproportionately affected by the HIV epidemic inclusive of men who have sex with men, heterosexual men, and women. As part of a community‐based participatory research study we assessed HIV testing experience among sexually active 18–30 year old Black men and women in Durham, NC. Of 508 participants, 173 (74 %) men and 236 (86 %; p = 0.0008) women reported ever being tested. Barriers to testing (e.g., perceived risk and sti…
Trial participation disclosure and gel use behavior in the Caprisa 004 tenofovir gel trial
Disclosure, or open communication, by female microbicide trial participants of their trial participation and use of an investigational HIV prevention drug to a sexual partner may affect participants' trial product usage behavior and contribute to poor adherence. With mixed results from recent microbicide clinical trials being linked to differing participant adherence, insights into the communication dynamics between trial participants and their s…
Assessing Adherence in the Caprisa 004 Tenofovir Gel HIV Prevention Trial
Adherence undeniably impacts product effectiveness in microbicide trials, but the connection has proven challenging to quantify using routinely collected behavioral data. We explored this relationship using a nested case-control study in the CAPRISA 004 Tenofovir (TFV) gel HIV prevention trial. Detailed 3-month recall data on sex events, condom and gel use were collected from 72 incident cases and 205 uninfected controls. We then assessed how the…
Impact of an Adherence Intervention on the Effectiveness of Tenofovir Gel in the Caprisa 004 Trial
Adherence in the Caprisa 004 Tenofovir Gel Microbicide Trial
Curriculum Development to Increase Minority Research Literacy for HIV Prevention Research
The iterative process of shared discussion, development, and consensus building strengthened collaboration between stakeholder groups and produced a stronger, more culturally appropriate curriculum to promote HIV prevention research engagement among young Blacks
Applied Thematic Analysis
The Exploitation of “Exploitation” in the Tenofovir PrEP Trial in Cameroon
media coverage influences how clinical trials are perceived internationally and in communities where trials occur, affecting recruitment, retention, and political support for research. We conducted a discourse analysis of news coverage from 2004-2005 of a trial in Cameroon on oral PrEP for HIV prevention, to identify messages, communication techniques, and sources of messages that were amplified via media. We identified two parallel discourses: o…
Partnering for Care in HIV Prevention Trials
QUALITATIVE CASE STUDIES WERE conducted at seven international sites conducting HIV prevention research in Africa, Asia, and the Americas to identify strategies for ensuring that health needs of research participants identified in the course of research are adequately addressed. Key factors were identified that contribute to the balance between direct care and healthcare referrals at a research site, as well as the overall quality of the healthca…
Community perspectives on care options for HIV prevention trial participants
There is on-going global debate and policy-setting concerning researchers' obligations to meet the health needs of people participating in HIV prevention trials in resource-poor settings. The perspectives of local community stakeholders on this issue are poorly understood as most of what is presented on behalf of communities where research takes place is anecdotal commentary. Using qualitative methods (130 in-depth interviews and 20 focus groups)…
Women's Autonomy and Informed Consent in Microbicides Clinical Trials
ACHIEVING RESPECT FOR PERSONS is problematic in settings with concepts of autonomy that differ from Western values. For international research, women's autonomy to consent to participation is an increasingly contentious issue. We present data from ancillary studies conducted in preparation for a clinical trial testing the safety and efficacy of topical microbicides, used to prevent HIV infection. These ancillary studies were conducted in seven co…
Alcohol Use and High-Risk Sexual Behavior Among Men Who Have Sex With Men
Alcohol use may increase HIV sexual risk behavior, although findings have varied across study populations and methods. Using event-level data from 1,712 seronegative men who have sex with men, the authors tested the hypothesis that social context would moderate the effect of alcohol consumption on unprotected anal sex (UAS). For encounters involving a primary partner, rates of UAS did not vary as a function of alcohol use. However, consumption of…
Macqueen and Buehler Respond
In our article we addressed a number of questions regarding the boundary between human subjects research, as defined by federal regulations, and public health practice, as defined by state and federal public health policy and law. The vast majority of work done by public health agencies is not research, and this boundary is usually clear. For example, a randomized controlled trial to evaluate an experimental tuberculosis therapy is human subjects…
Ethics, Practice, and Research in Public Health
Ethical issues that can arise in distinguishing public health research from practice are highlighted in 2 case studies—an investigation of a tuberculosis outbreak in a prison and an evaluation of a program for improving HIV prevention services. Regardless of whether such public health investigations represent research or practice, we see a need for ethics oversight procedures that reflect actual risks and enable timely responses to crises. Such o…
Back to the Rough Ground
Kathleen M. MacQueen, Jeremy Sugarman, Back to the Rough Ground: Working in International HIV Prevention as Ethical Debates Continue, IRB: Ethics & Human Research, Vol. 25, No. 2 (Mar. - Apr., 2003), pp. 11-13
Beyond the Qualitative Interview
The increased use of qualitative research, especially its application in multisite studies, requires robust data collection techniques and the documentation of research procedures. The inappropriate or inadequate preparation of transcripts from audio or digital recordings can delay or negatively affect the analysis process. Although no universal transcription format is adequate for all types of qualitative data collection approaches, settings, or…
What Is Community? An Evidence-Based Definition for Participatory Public Health
Increased emphasis on community collaboration indicates the need for consensus regarding the definition of community within public health. This study examined whether members of diverse US communities described community in similar ways. To identify strategies to support community collaboration in HIV vaccine trials, qualitative interviews were conducted with 25 African Americans in Durham, NC; 26 gay men in San Francisco, Calif; 25 injection dru…
Per-Contact Risk of Human Immunodificiency Virus Tramnsmision between Male Sexual Partners
The risk of human immunodeficiency virus (HIV) transmission from various types of homosexual contact, including oral sex, is of biologic, epidemiologic, and public health importance. The per-contact risk of acquiring HIV infection from specific acts was estimated in a prospective cohort study of 2,189 high-risk homosexual and bisexual men, conducted in San Francisco, California; Denver, Colorado; and Chicago, Illinois, in 1992-1994. During 2,633 …
A Systems Approach to Qualitative Data Management and Analysis
The basic components of qualitative data analysis are systematically organized and described. The authors propose a system centered on a database architecture with four elements that correspond to the fundamental types of information collected in the research process: (1) characteristics of the sources where answers to research questions are sought, (2) primary information collected from the sources, (3) secondary information generated to assist …
Codebook Development for Team-Based Qualitative Analysis
One of the key elements in qualitative data analysis is the systematic coding of text (Strauss and Corbin 1990:57 60; Miles and Huberman 1994:56). Codes are the building blocks for theory or model building and the foundation on which the analyst’s arguments rest. Implicitly or explicitly, they embody the assumptions underlying the analysis. Given the context of the interdisciplinary nature of research at the Centers for Disease Control and Preven…
Alcohol Consumption, Brothel Attendance, and Condom Use
This article investigates the relationship between alcohol consumption and inconsistent condom use with brothel-based commercial sex workers among Thai military conscripts in Northern Thailand. Data from 10 focus groups indicate that alcohol consumption (1) is consciously used by men to reduce inhibitions that constrain their interpersonal interaction with women and with each other; (2) reduces inhibitions of individuals to sexual risk taking; (3…
Aids awareness among a cohort of young Thai men
Structured interviews and focus group discussions were conducted among 834 young Thai men drafted into military service by random lottery in northern Thailand. Level of AIDS risk, exposure to AIDS information, level of knowledge about AIDS, and perception of risk for acquiring HIV and AIDS were assessed at baseline and six months after induction into the Army in 1991. General fear of AIDS was high, yet personal perception of risk for acquiring HI…
The Epidemiology of HIV Transmission
"This review summarizes dynamic processes in human immunodeficiency virus (HIV) transmission. A brief overview of current trends in the HIV epidemic is followed by a discussion of the basic components of HIV transmission. Several epidemiologic models are then described that seek to delineate how HIV transmission is structured by human relationships and the implications of those structural relationships for the evolving epidemic."
Codebook Development for Team-Based Qualitative Analysis
One of the key elements in qualitative data analysis is the systematic coding of text (Strauss and Corbin 1990:57 60; Miles and Huberman 1994:56). Codes are the building blocks for theory or model building and the foundation on which the analyst’s arguments rest. Implicitly or explicitly, they embody the assumptions underlying the analysis. Given the context of the interdisciplinary nature of research at the Centers for Disease Control and Preven…
What Is Community? An Evidence-Based Definition for Participatory Public Health
Increased emphasis on community collaboration indicates the need for consensus regarding the definition of community within public health. This study examined whether members of diverse US communities described community in similar ways. To identify strategies to support community collaboration in HIV vaccine trials, qualitative interviews were conducted with 25 African Americans in Durham, NC; 26 gay men in San Francisco, Calif; 25 injection dru…
Beyond the Qualitative Interview
The increased use of qualitative research, especially its application in multisite studies, requires robust data collection techniques and the documentation of research procedures. The inappropriate or inadequate preparation of transcripts from audio or digital recordings can delay or negatively affect the analysis process. Although no universal transcription format is adequate for all types of qualitative data collection approaches, settings, or…
Alcohol Consumption, Brothel Attendance, and Condom Use
This article investigates the relationship between alcohol consumption and inconsistent condom use with brothel-based commercial sex workers among Thai military conscripts in Northern Thailand. Data from 10 focus groups indicate that alcohol consumption (1) is consciously used by men to reduce inhibitions that constrain their interpersonal interaction with women and with each other; (2) reduces inhibitions of individuals to sexual risk taking; (3…
HIV Testing Experience and Risk Behavior Among Sexually Active Black Young Adults
African Americans are disproportionately affected by the HIV epidemic inclusive of men who have sex with men, heterosexual men, and women. As part of a community‐based participatory research study we assessed HIV testing experience among sexually active 18–30 year old Black men and women in Durham, NC. Of 508 participants, 173 (74 %) men and 236 (86 %; p = 0.0008) women reported ever being tested. Barriers to testing (e.g., perceived risk and sti…
Partnering for Care in HIV Prevention Trials
QUALITATIVE CASE STUDIES WERE conducted at seven international sites conducting HIV prevention research in Africa, Asia, and the Americas to identify strategies for ensuring that health needs of research participants identified in the course of research are adequately addressed. Key factors were identified that contribute to the balance between direct care and healthcare referrals at a research site, as well as the overall quality of the healthca…
Developing a Framework for Evaluating Ethical Outcomes of Good Participatory Practices in TB Clinical Drug Trials
Good Participatory Practice Guidelines for TB Drug Trials (GPP-TB) were issued in 2012, based on similar guidelines for HIV prevention and reflecting growing acceptance of the importance of community engagement and participatory strategies in clinical research. Though the need for such strategies is clear, evaluation of the benefits and burdens are needed. Working with a diverse group of global TB stakeholders including advocates, scientists, and…
Curriculum Development to Increase Minority Research Literacy for HIV Prevention Research
The iterative process of shared discussion, development, and consensus building strengthened collaboration between stakeholder groups and produced a stronger, more culturally appropriate curriculum to promote HIV prevention research engagement among young Blacks
The Exploitation of “Exploitation” in the Tenofovir PrEP Trial in Cameroon
media coverage influences how clinical trials are perceived internationally and in communities where trials occur, affecting recruitment, retention, and political support for research. We conducted a discourse analysis of news coverage from 2004-2005 of a trial in Cameroon on oral PrEP for HIV prevention, to identify messages, communication techniques, and sources of messages that were amplified via media. We identified two parallel discourses: o…
A Systems Approach to Qualitative Data Management and Analysis
The basic components of qualitative data analysis are systematically organized and described. The authors propose a system centered on a database architecture with four elements that correspond to the fundamental types of information collected in the research process: (1) characteristics of the sources where answers to research questions are sought, (2) primary information collected from the sources, (3) secondary information generated to assist …
Women's Autonomy and Informed Consent in Microbicides Clinical Trials
ACHIEVING RESPECT FOR PERSONS is problematic in settings with concepts of autonomy that differ from Western values. For international research, women's autonomy to consent to participation is an increasingly contentious issue. We present data from ancillary studies conducted in preparation for a clinical trial testing the safety and efficacy of topical microbicides, used to prevent HIV infection. These ancillary studies were conducted in seven co…
Patterns of supplementation, nursing behavior, and lactation
The use of computer simulation has many advantages for the study of human milk production. The simulation presented here deals with the interactions between infant calorie requirements and mothers' responses to these requirements, measured in terms of milk production. The simulated mother-infant interactions include: 1) the effects of different patterns of the use of breast milk supplements; 2) the effects of varying degrees of responsiveness on …
The Epidemiology of HIV Transmission
"This review summarizes dynamic processes in human immunodeficiency virus (HIV) transmission. A brief overview of current trends in the HIV epidemic is followed by a discussion of the basic components of HIV transmission. Several epidemiologic models are then described that seek to delineate how HIV transmission is structured by human relationships and the implications of those structural relationships for the evolving epidemic."
The Epidemiology of HIV Transmission
Infrastructures are material forms that allow for the possibility of exchange over space. They are the physical networks through which goods, ideas, waste, power, people, and finance are trafficked. In this article I trace the range of anthropological ...Read More
Aids awareness among a cohort of young Thai men
Structured interviews and focus group discussions were conducted among 834 young Thai men drafted into military service by random lottery in northern Thailand. Level of AIDS risk, exposure to AIDS information, level of knowledge about AIDS, and perception of risk for acquiring HIV and AIDS were assessed at baseline and six months after induction into the Army in 1991. General fear of AIDS was high, yet personal perception of risk for acquiring HI…
Alcohol Consumption, Brothel Attendance, and Condom Use
This article investigates the relationship between alcohol consumption and inconsistent condom use with brothel-based commercial sex workers among Thai military conscripts in Northern Thailand. Data from 10 focus groups indicate that alcohol consumption (1) is consciously used by men to reduce inhibitions that constrain their interpersonal interaction with women and with each other; (2) reduces inhibitions of individuals to sexual risk taking; (3…
Codebook Development for Team-Based Qualitative Analysis
One of the key elements in qualitative data analysis is the systematic coding of text (Strauss and Corbin 1990:57 60; Miles and Huberman 1994:56). Codes are the building blocks for theory or model building and the foundation on which the analyst’s arguments rest. Implicitly or explicitly, they embody the assumptions underlying the analysis. Given the context of the interdisciplinary nature of research at the Centers for Disease Control and Preven…
Per-Contact Risk of Human Immunodificiency Virus Tramnsmision between Male Sexual Partners
The risk of human immunodeficiency virus (HIV) transmission from various types of homosexual contact, including oral sex, is of biologic, epidemiologic, and public health importance. The per-contact risk of acquiring HIV infection from specific acts was estimated in a prospective cohort study of 2,189 high-risk homosexual and bisexual men, conducted in San Francisco, California; Denver, Colorado; and Chicago, Illinois, in 1992-1994. During 2,633 …
A Systems Approach to Qualitative Data Management and Analysis
The basic components of qualitative data analysis are systematically organized and described. The authors propose a system centered on a database architecture with four elements that correspond to the fundamental types of information collected in the research process: (1) characteristics of the sources where answers to research questions are sought, (2) primary information collected from the sources, (3) secondary information generated to assist …
What Is Community? An Evidence-Based Definition for Participatory Public Health
Increased emphasis on community collaboration indicates the need for consensus regarding the definition of community within public health. This study examined whether members of diverse US communities described community in similar ways. To identify strategies to support community collaboration in HIV vaccine trials, qualitative interviews were conducted with 25 African Americans in Durham, NC; 26 gay men in San Francisco, Calif; 25 injection dru…
Back to the Rough Ground
Kathleen M. MacQueen, Jeremy Sugarman, Back to the Rough Ground: Working in International HIV Prevention as Ethical Debates Continue, IRB: Ethics & Human Research, Vol. 25, No. 2 (Mar. - Apr., 2003), pp. 11-13
Beyond the Qualitative Interview
The increased use of qualitative research, especially its application in multisite studies, requires robust data collection techniques and the documentation of research procedures. The inappropriate or inadequate preparation of transcripts from audio or digital recordings can delay or negatively affect the analysis process. Although no universal transcription format is adequate for all types of qualitative data collection approaches, settings, or…
Alcohol Use and High-Risk Sexual Behavior Among Men Who Have Sex With Men
Alcohol use may increase HIV sexual risk behavior, although findings have varied across study populations and methods. Using event-level data from 1,712 seronegative men who have sex with men, the authors tested the hypothesis that social context would moderate the effect of alcohol consumption on unprotected anal sex (UAS). For encounters involving a primary partner, rates of UAS did not vary as a function of alcohol use. However, consumption of…
Macqueen and Buehler Respond
In our article we addressed a number of questions regarding the boundary between human subjects research, as defined by federal regulations, and public health practice, as defined by state and federal public health policy and law. The vast majority of work done by public health agencies is not research, and this boundary is usually clear. For example, a randomized controlled trial to evaluate an experimental tuberculosis therapy is human subjects…
Ethics, Practice, and Research in Public Health
Ethical issues that can arise in distinguishing public health research from practice are highlighted in 2 case studies—an investigation of a tuberculosis outbreak in a prison and an evaluation of a program for improving HIV prevention services. Regardless of whether such public health investigations represent research or practice, we see a need for ethics oversight procedures that reflect actual risks and enable timely responses to crises. Such o…
Women's Autonomy and Informed Consent in Microbicides Clinical Trials
ACHIEVING RESPECT FOR PERSONS is problematic in settings with concepts of autonomy that differ from Western values. For international research, women's autonomy to consent to participation is an increasingly contentious issue. We present data from ancillary studies conducted in preparation for a clinical trial testing the safety and efficacy of topical microbicides, used to prevent HIV infection. These ancillary studies were conducted in seven co…
Community perspectives on care options for HIV prevention trial participants
There is on-going global debate and policy-setting concerning researchers' obligations to meet the health needs of people participating in HIV prevention trials in resource-poor settings. The perspectives of local community stakeholders on this issue are poorly understood as most of what is presented on behalf of communities where research takes place is anecdotal commentary. Using qualitative methods (130 in-depth interviews and 20 focus groups)…
Partnering for Care in HIV Prevention Trials
QUALITATIVE CASE STUDIES WERE conducted at seven international sites conducting HIV prevention research in Africa, Asia, and the Americas to identify strategies for ensuring that health needs of research participants identified in the course of research are adequately addressed. Key factors were identified that contribute to the balance between direct care and healthcare referrals at a research site, as well as the overall quality of the healthca…
The Exploitation of “Exploitation” in the Tenofovir PrEP Trial in Cameroon
media coverage influences how clinical trials are perceived internationally and in communities where trials occur, affecting recruitment, retention, and political support for research. We conducted a discourse analysis of news coverage from 2004-2005 of a trial in Cameroon on oral PrEP for HIV prevention, to identify messages, communication techniques, and sources of messages that were amplified via media. We identified two parallel discourses: o…
Applied Thematic Analysis
Trial participation disclosure and gel use behavior in the Caprisa 004 tenofovir gel trial
Disclosure, or open communication, by female microbicide trial participants of their trial participation and use of an investigational HIV prevention drug to a sexual partner may affect participants' trial product usage behavior and contribute to poor adherence. With mixed results from recent microbicide clinical trials being linked to differing participant adherence, insights into the communication dynamics between trial participants and their s…
Assessing Adherence in the Caprisa 004 Tenofovir Gel HIV Prevention Trial
Adherence undeniably impacts product effectiveness in microbicide trials, but the connection has proven challenging to quantify using routinely collected behavioral data. We explored this relationship using a nested case-control study in the CAPRISA 004 Tenofovir (TFV) gel HIV prevention trial. Detailed 3-month recall data on sex events, condom and gel use were collected from 72 incident cases and 205 uninfected controls. We then assessed how the…
Impact of an Adherence Intervention on the Effectiveness of Tenofovir Gel in the Caprisa 004 Trial
Adherence in the Caprisa 004 Tenofovir Gel Microbicide Trial
Curriculum Development to Increase Minority Research Literacy for HIV Prevention Research
The iterative process of shared discussion, development, and consensus building strengthened collaboration between stakeholder groups and produced a stronger, more culturally appropriate curriculum to promote HIV prevention research engagement among young Blacks
HIV Testing Experience and Risk Behavior Among Sexually Active Black Young Adults
African Americans are disproportionately affected by the HIV epidemic inclusive of men who have sex with men, heterosexual men, and women. As part of a community‐based participatory research study we assessed HIV testing experience among sexually active 18–30 year old Black men and women in Durham, NC. Of 508 participants, 173 (74 %) men and 236 (86 %; p = 0.0008) women reported ever being tested. Barriers to testing (e.g., perceived risk and sti…
Medicine (23 works) · Psychology (15 works) · Family medicine (12 works) · HIV/AIDS Research and Interventions (12 works) · Human immunodeficiency virus (HIV (11 works) · Nursing (11 works) · Political science (11 works) · Sociology (11 works) · Adolescent Sexual and Reproductive Health (9 works) · Ethics in Clinical Research (9 works)