Leyla Sophie Larsson
Biographic Data
| ID | 9064205 |
|---|---|
| NAME | Leyla Sophie Larsson |
| GIVEN NAMES | Leyla Sophie |
| FAMILY NAME | Larsson |
| SIGNATURE | LARSSON L S |
| AFFILIATIONS | Biomedical Research and Training Institute |
| ORCID | 0000-0003-4869-4630 |
| VERIFIED | Yes |
| TOTAL WORKS | 10 |
| TOTAL CITATIONS | 0 |
| AUTHOR COUNT | 10 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2023 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 0 |
Principles and priorities for integrated tuberculosis screening and care
Tuberculosis predominates in communities with multiple health and socioeconomic vulnerabilities. Tuberculosis diagnosis presents an opportunity for expanded health services to tuberculosis-affected households. We conducted a modified Delphi process to ascertain if and how expanded services should be offered to people with tuberculosis and their households. Purposively invited panellists were identified through professional networks and included r…
Refining research outcomes
Most tuberculosis diagnostic validation studies use microbiological or combination reference standards to define tuberculosis. We convened an Endpoint Review Committee (ERC) to define outcomes in ERASE-TB, a longitudinal cohort study across three high tuberculosis-burden countries, aimed at validating novel diagnostics for early detection. Herein, we describe processes and outcomes of the ERC. ERASE-TB enrolled 2,109 household contacts of people …
An extended cost-effectiveness analysis of decentralised TB diagnostic testing with Molbio Truenat MTB/RIF versus hub-and-spoke GeneXpert MTB/RIF in Mozambique and Tanzania
BACKGROUND: In low- and middle-income countries (LMICs), tuberculosis (TB) regained its status as the leading cause of death from a single infectious agent in 2023, surpassing COVID-19. Rapid and accurate diagnosis is critical, with decentralised diagnostic strategies offering a promising solution. Although decentralised diagnostic strategies have been proven cost-effective, further evidence is needed on affordability and equity in high-burden se…
Barriers to and facilitators of linkage to care following hypertension and diabetes screening among health workers in Zimbabwe
The benefits of screening for any condition are only realised if individuals who screen positive link to care services. We investigated linkage to hypertension and diabetes care by healthcare workers accessing a comprehensive health check service. We also explored facilitators and barriers to linkage to care. Between July 2020 and June 2022, a health check with referral and follow-up was offered to healthcare workers (clients) in Zimbabwe. We aim…
Decentralized TB diagnostic testing with Truenat MTB Plus and MTB-RIF Dx vs. hub-and-spoke GeneXpert MTB/RIF Ultra in Mozambique and Tanzania
In low-and middle-income countries, missed or delayed tuberculosis (TB) diagnoses contribute to avoidable morbidity, mortality, and transmission. Decentralized testing platforms, such as the Molbio Truenat, may offer solutions by providing accurate point-of-care testing, improving access, and lowering out-of-pocket costs. Despite these advantages, the overall cost and cost-effectiveness of identifying additional TB cases using the Truenat MTB ass…
Prediction models for Mtb infection among adolescent and adult household contacts in high tuberculosis incidence settings
Tuberculosis household contacts are at high risk of developing tuberculosis. Tuberculosis preventive therapy (TPT) is highly effective, but implementation is hindered by limited accessibility of diagnostic tests aimed at detecting Mycobacterium tuberculosis ( Mtb) infection. Development of Mtb infection prediction models to guide clinical decision-making aims to overcome these challenges. We used data from 1905 tuberculosis household contacts (ag…
Evaluation of a comprehensive health check offered to frontline health workers in Zimbabwe
Health workers are essential for a functioning healthcare system, and their own health is often not addressed. During the COVID-19 pandemic health workers were at high risk of SARS-CoV-2 infection whilst coping with increased healthcare demand. Here we report the development, implementation, and uptake of an integrated health check combining SARS-CoV-2 testing with screening for other communicable and non-communicable diseases for health workers …
Prevalence of chronic conditions and multimorbidity among healthcare workers in Zimbabwe
The burden of non-communicable diseases (NCDs) in southern Africa is expanding and is superimposed on high HIV prevalence. Healthcare workers are a scarce resource; yet are vital to health systems. There are very limited studies on the burden of chronic conditions among healthcare workers in Africa, and none exploring multimorbidity (≥2 chronic conditions). We describe the epidemiology of infectious (HIV) and non-communicable chronic conditions, …
Addressing sociodemographic disparities in Covid-19 vaccine uptake among youth in Zimbabwe
INTRODUCTION: COVID-19 vaccine acceptance research has mostly originated from high-income countries and reasons why youth may not get vaccinated may differ in low-income settings. Understanding vaccination coverage across different population groups and the sociocultural influences in healthcare delivery is important to inform targeted vaccination campaigns. METHODS: A population-based survey was conducted in 24 communities across three provinces…
Exploring Covid-19 vaccine uptake among healthcare workers in Zimbabwe
With COVID-19 no longer categorized as a public health emergency of international concern, vaccination strategies and priority groups for vaccination have evolved. Africa Centres for Diseases Prevention and Control proposed the ‘100-100-70%’ strategy which aims to vaccinate all healthcare workers, all vulnerable groups, and 70% of the general population. Understanding whether healthcare workers were reached during previous vaccination campaigns a…
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Addressing sociodemographic disparities in Covid-19 vaccine uptake among youth in Zimbabwe
INTRODUCTION: COVID-19 vaccine acceptance research has mostly originated from high-income countries and reasons why youth may not get vaccinated may differ in low-income settings. Understanding vaccination coverage across different population groups and the sociocultural influences in healthcare delivery is important to inform targeted vaccination campaigns. METHODS: A population-based survey was conducted in 24 communities across three provinces…
Exploring Covid-19 vaccine uptake among healthcare workers in Zimbabwe
With COVID-19 no longer categorized as a public health emergency of international concern, vaccination strategies and priority groups for vaccination have evolved. Africa Centres for Diseases Prevention and Control proposed the ‘100-100-70%’ strategy which aims to vaccinate all healthcare workers, all vulnerable groups, and 70% of the general population. Understanding whether healthcare workers were reached during previous vaccination campaigns a…
Evaluation of a comprehensive health check offered to frontline health workers in Zimbabwe
Health workers are essential for a functioning healthcare system, and their own health is often not addressed. During the COVID-19 pandemic health workers were at high risk of SARS-CoV-2 infection whilst coping with increased healthcare demand. Here we report the development, implementation, and uptake of an integrated health check combining SARS-CoV-2 testing with screening for other communicable and non-communicable diseases for health workers …
Prevalence of chronic conditions and multimorbidity among healthcare workers in Zimbabwe
The burden of non-communicable diseases (NCDs) in southern Africa is expanding and is superimposed on high HIV prevalence. Healthcare workers are a scarce resource; yet are vital to health systems. There are very limited studies on the burden of chronic conditions among healthcare workers in Africa, and none exploring multimorbidity (≥2 chronic conditions). We describe the epidemiology of infectious (HIV) and non-communicable chronic conditions, …
An extended cost-effectiveness analysis of decentralised TB diagnostic testing with Molbio Truenat MTB/RIF versus hub-and-spoke GeneXpert MTB/RIF in Mozambique and Tanzania
BACKGROUND: In low- and middle-income countries (LMICs), tuberculosis (TB) regained its status as the leading cause of death from a single infectious agent in 2023, surpassing COVID-19. Rapid and accurate diagnosis is critical, with decentralised diagnostic strategies offering a promising solution. Although decentralised diagnostic strategies have been proven cost-effective, further evidence is needed on affordability and equity in high-burden se…
Barriers to and facilitators of linkage to care following hypertension and diabetes screening among health workers in Zimbabwe
The benefits of screening for any condition are only realised if individuals who screen positive link to care services. We investigated linkage to hypertension and diabetes care by healthcare workers accessing a comprehensive health check service. We also explored facilitators and barriers to linkage to care. Between July 2020 and June 2022, a health check with referral and follow-up was offered to healthcare workers (clients) in Zimbabwe. We aim…
Decentralized TB diagnostic testing with Truenat MTB Plus and MTB-RIF Dx vs. hub-and-spoke GeneXpert MTB/RIF Ultra in Mozambique and Tanzania
In low-and middle-income countries, missed or delayed tuberculosis (TB) diagnoses contribute to avoidable morbidity, mortality, and transmission. Decentralized testing platforms, such as the Molbio Truenat, may offer solutions by providing accurate point-of-care testing, improving access, and lowering out-of-pocket costs. Despite these advantages, the overall cost and cost-effectiveness of identifying additional TB cases using the Truenat MTB ass…
Prediction models for Mtb infection among adolescent and adult household contacts in high tuberculosis incidence settings
Tuberculosis household contacts are at high risk of developing tuberculosis. Tuberculosis preventive therapy (TPT) is highly effective, but implementation is hindered by limited accessibility of diagnostic tests aimed at detecting Mycobacterium tuberculosis ( Mtb) infection. Development of Mtb infection prediction models to guide clinical decision-making aims to overcome these challenges. We used data from 1905 tuberculosis household contacts (ag…
Principles and priorities for integrated tuberculosis screening and care
Tuberculosis predominates in communities with multiple health and socioeconomic vulnerabilities. Tuberculosis diagnosis presents an opportunity for expanded health services to tuberculosis-affected households. We conducted a modified Delphi process to ascertain if and how expanded services should be offered to people with tuberculosis and their households. Purposively invited panellists were identified through professional networks and included r…
Refining research outcomes
Most tuberculosis diagnostic validation studies use microbiological or combination reference standards to define tuberculosis. We convened an Endpoint Review Committee (ERC) to define outcomes in ERASE-TB, a longitudinal cohort study across three high tuberculosis-burden countries, aimed at validating novel diagnostics for early detection. Herein, we describe processes and outcomes of the ERC. ERASE-TB enrolled 2,109 household contacts of people …
Medicine (7 works) · Tuberculosis (5 works) · Tuberculosis Research and Epidemiology (5 works) · Disease (4 works) · Environmental health (4 works) · Health care (4 works) · GeneXpert MTB/RIF (3 works) · Internal Medicine (3 works) · Public health (3 works) · Tuberculosis diagnosis (3 works)