Michael J Meaney
Biographic Data
| ID | 97492 |
|---|---|
| NAME | Michael J Meaney |
| GIVEN NAMES | Michael J |
| FAMILY NAME | Meaney |
| SIGNATURE | MEANEY M J |
| AFFILIATIONS | Douglas Mental Health University Institute |
| ORCID | 0000-0002-8605-1997 |
| VERIFIED | Yes |
| TOTAL WORKS | 32 |
| TOTAL CITATIONS | 29 |
| AUTHOR COUNT | 32 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1997 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 4 |
Early Maternal Parenting Profiles and Subsequent Child Well‐Being in an Asian Cohort
Objective To identify parenting profiles among Singaporean mothers of young children and to examine the longitudinal implications of these profiles for children's well‐being during middle childhood. Background The universality of traditional parenting styles (e.g., authoritative, authoritarian), established in Western contexts, and their implications for child well‐being, has been called into question, with studies conducted with Asian population…
Feeding practices and concerns as mediators between maternal mental health and eating behaviours in early childhood
BACKGROUND: The impact of maternal mental health on child eating beyond infancy is understudied. This study explores whether maternal feeding practices and concerns mediate the association between maternal depression and anxiety symptoms and eating behaviours at age three years. METHODS: Data from 409 mother-child dyads in the Growing Up in Singapore Towards healthy Outcomes cohort were analysed. Maternal mental health was assessed using the Beck…
Grandparents' and domestic helpers' childcare support
ObjectiveTo investigate whether childcare support from grandparents and domestic helpers is associated with family well-being in Singapore, with a focus on parent and child psychological well-being as well as the quality of interactions and relationships within the family.BackgroundResearch on the implications of childcare support from maternal grandparents, paternal grandparents, and domestic helpers for family well-being remains a gap in the li…
The prospective associations of 24-hour movement behaviors and domain-specific activities with executive function and academic achievement among school-aged children in Singapore
Background Physical activity (PA), sedentary behavior (SB), and sleep are collectively referred to as 24-h movement behaviors, which may be linked to cognitive development in children. However, most of the evidence was based on cross-sectional studies and/or solely relied on parent-reported information on children’s behaviors, and it remains uncertain whether all domains/contexts of PA and SB are similarly associated with executive function and a…
Effects of maternal childhood trauma on child emotional health
BACKGROUND: Experiences of early life adversity pose significant psychological and physical health risks to exposed individuals. Emerging evidence suggests that these health risks can be transmitted across generations; however, the mechanisms underlying the intergenerational impacts of maternal early-life trauma on child health remain unknown. METHODS: The current study used a prospective longitudinal design to determine the unique and joint cont…
Combined polygenic risk scores of different psychiatric traits predict general and specific psychopathology in childhood
BACKGROUND: Polygenic risk scores (PRSs) operationalize genetic propensity toward a particular mental disorder and hold promise as early predictors of psychopathology, but before a PRS can be used clinically, explanatory power must be increased and the specificity for a psychiatric domain established. To enable early detection, it is crucial to study these psychometric properties in childhood. We examined whether PRSs associate more with general …
Receptive Language Abilities for Females Exposed to Early Life Adversity
ELA is associated with significant differences in development of receptive language abilities with the most pronounced differences observed for females with accelerated epigenetic ages at mid-life. These findings suggest that epigenetic age acceleration could serve as an indicator of differences in cognitive aging and portend to later adulthood cognitive functioning
Diminished insulin sensitivity is associated with altered brain activation to food cues and with risk for obesity – Implications for individuals born small for gestational age
Network Analyses of Maternal Pre- and Post-Partum Symptoms of Depression and Anxiety
The differences between pre- and post-partum networks suggest that the presentation of maternal mental health problems varies over the peripartum period. This variation is not captured by traditional symptom scale scores. The bridging symptoms also suggest that anxiety symptoms may precede the development of maternal depression. Interventions and public health policies should thus be tailored to specific pre- and post-partum symptom profiles
Is breastfeeding associated with later child eating behaviours
Genetically predicted gene expression of prefrontal DRD4 gene and the differential susceptibility to childhood emotional eating in response to positive environment
Does social capital moderate the association between children's emotional overeating and parental stress? A cross-sectional study of the stress-buffering hypothesis in a sample of mother-child dyads
Once and Again
Prospective associations between parental feeding practices and children's oral processing behaviours
Previous research demonstrated that faster eating rates are linked with increased intake of energy during a meal. Here, we examined whether within-meal parental feeding practices show cross-sectional and prospective associations with children's oral processing behaviours and whether the previously demonstrated association between faster eating rates and higher energy intakes varies by parental feeding practices. A subset (n = 155) of children and…
Fetal growth interacts with multilocus genetic score reflecting dopamine signaling capacity to predict spontaneous sugar intake in children
Oral processing behaviours that promote children's energy intake are associated with parent-reported appetitive traits
An Attachment-Based Model of the Relationship Between Childhood Adversity and Somatization in Children and Adults
OBJECTIVE: An attachment model was used to understand how maternal sensitivity and adverse childhood experiences are related to somatization. METHODS: We examined maternal sensitivity at 6 and 18 months and somatization at 5 years in 292 children in a longitudinal cohort study. We next examined attachment insecurity and somatization (health anxiety, physical symptoms) in four adult cohorts: healthy primary care patients (AC1, n = 67), ulcerative …
Psychometric analysis of an eating behaviour questionnaire for an overweight and obese Chinese population in Singapore
Anxiety and Depression During Pregnancy and Temperament in Early Infancy
Maternal antenatal mood is associated with negative infant temperament. This link has not been substantiated in Asian populations. We evaluated the association between antenatal maternal mood and infant temperament among Asian mother–infant pairs. Antenatal maternal depression and anxiety were assessed using the Edinburgh Postnatal Depression Scale (J. Cox, J. Holden, & R. Sagovsky, 1987) and the State‐Trait Anxiety Inventory (C. Spielberger, R. …
Better quality of mother–child interaction at 4 years of age decreases emotional overeating in Iugr girls
Association between the seven-repeat allele of the dopamine-4 receptor gene (DRD4) and spontaneous food intake in pre-school children
Low maternal sensitivity at 6 months of age predicts higher BMI in 48 month old girls but not boys
Epigenetic Biomarkers as Predictors and Correlates of Symptom Improvement Following Psychotherapy in Combat Veterans with PTSD
Epigenetic alterations offer promise as diagnostic or prognostic markers, but it is not known whether these measures associate with, or predict, clinical state. These questions were addressed in a pilot study with combat veterans with PTSD to determine whether cytosine methylation in promoter regions of the glucocorticoid related NR3C1 and FKBP51 genes would predict or associate with treatment outcome. Veterans with PTSD received prolonged exposu…
Epigenetics and the Biological Definition of Gene × Environment Interactions
Variations in phenotype reflect the influence of environmental conditions during development on cellular functions, including that of the genome. The recent integration of epigenetics into developmental psychobiology illustrates the processes by which environmental conditions in early life structurally alter DNA, providing a physical basis for the influence of the perinatal environmental signals on phenotype over the life of the individual. This …
Socioeconomic status and the brain
Psychometric analysis of an eating behaviour questionnaire for an overweight and obese Chinese population in Singapore
Better quality of mother–child interaction at 4 years of age decreases emotional overeating in Iugr girls
Oral processing behaviours that promote children's energy intake are associated with parent-reported appetitive traits
Anxiety and Depression During Pregnancy and Temperament in Early Infancy
Maternal antenatal mood is associated with negative infant temperament. This link has not been substantiated in Asian populations. We evaluated the association between antenatal maternal mood and infant temperament among Asian mother–infant pairs. Antenatal maternal depression and anxiety were assessed using the Edinburgh Postnatal Depression Scale (J. Cox, J. Holden, & R. Sagovsky, 1987) and the State‐Trait Anxiety Inventory (C. Spielberger, R. …
Association between the seven-repeat allele of the dopamine-4 receptor gene (DRD4) and spontaneous food intake in pre-school children
Is breastfeeding associated with later child eating behaviours
Does social capital moderate the association between children's emotional overeating and parental stress? A cross-sectional study of the stress-buffering hypothesis in a sample of mother-child dyads
Grandparents' and domestic helpers' childcare support
ObjectiveTo investigate whether childcare support from grandparents and domestic helpers is associated with family well-being in Singapore, with a focus on parent and child psychological well-being as well as the quality of interactions and relationships within the family.BackgroundResearch on the implications of childcare support from maternal grandparents, paternal grandparents, and domestic helpers for family well-being remains a gap in the li…
Diminished insulin sensitivity is associated with altered brain activation to food cues and with risk for obesity – Implications for individuals born small for gestational age
Fetal growth interacts with multilocus genetic score reflecting dopamine signaling capacity to predict spontaneous sugar intake in children
Low maternal sensitivity at 6 months of age predicts higher BMI in 48 month old girls but not boys
Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress
Variations in maternal care affect the development of individual differences in neuroendocrine responses to stress in rats. As adults, the offspring of mothers that exhibited more licking and grooming of pups during the first 10 days of life showed reduced plasma adrenocorticotropic hormone and corticosterone responses to acute stress, increased hippocampal glucocorticoid receptor messenger RNA expression, enhanced glucocorticoid feedback sensiti…
Nongenomic Transmission Across Generations of Maternal Behavior and Stress Responses in the Rat
In the rat, variations in maternal care appear to influence the development of behavioral and endocrine responses to stress in the offspring. The results of cross-fostering studies reported here provide evidence for (i) a causal relationship between maternal behavior and stress reactivity in the offspring and (ii) the transmission of such individual differences in maternal behavior from one generation of females to the next. Moreover, an environm…
Maternal Care, Gene Expression, and the Transmission of Individual Differences in Stress Reactivity Across Generations
Naturally occurring variations in maternal care alter the expression of genes that regulate behavioral and endocrine responses to stress, as well as hippocampal synaptic development. These effects form the basis for the development of stable, individual differences in stress reactivity and certain forms of cognition. Maternal care also influences the maternal behavior of female offspring, an effect that appears to be related to oxytocin receptor …
Epigenetic programming by maternal behavior
Maternal care programs appetite and weight gain in rats
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
Epigenetics and the Biological Definition of Gene × Environment Interactions
Variations in phenotype reflect the influence of environmental conditions during development on cellular functions, including that of the genome. The recent integration of epigenetics into developmental psychobiology illustrates the processes by which environmental conditions in early life structurally alter DNA, providing a physical basis for the influence of the perinatal environmental signals on phenotype over the life of the individual. This …
Socioeconomic status and the brain
Quality of Parental Emotional Care and Calculated Risk for Coronary Heart Disease
OBJECTIVE: To evaluate associations between perceived quality of parental emotional care and calculated 10-year risk for coronary heart disease (CHD). Little is understood about the role of parental emotional care in contributing to the risk for CHD. METHODS: The study sample was composed of 267 participants from the New England Family Study. Quality of parental emotional care was measured, using a validated short version of the Parental Bonding …
Epigenetic Biomarkers as Predictors and Correlates of Symptom Improvement Following Psychotherapy in Combat Veterans with PTSD
Epigenetic alterations offer promise as diagnostic or prognostic markers, but it is not known whether these measures associate with, or predict, clinical state. These questions were addressed in a pilot study with combat veterans with PTSD to determine whether cytosine methylation in promoter regions of the glucocorticoid related NR3C1 and FKBP51 genes would predict or associate with treatment outcome. Veterans with PTSD received prolonged exposu…
Better quality of mother–child interaction at 4 years of age decreases emotional overeating in Iugr girls
Association between the seven-repeat allele of the dopamine-4 receptor gene (DRD4) and spontaneous food intake in pre-school children
Low maternal sensitivity at 6 months of age predicts higher BMI in 48 month old girls but not boys
Psychometric analysis of an eating behaviour questionnaire for an overweight and obese Chinese population in Singapore
Anxiety and Depression During Pregnancy and Temperament in Early Infancy
Maternal antenatal mood is associated with negative infant temperament. This link has not been substantiated in Asian populations. We evaluated the association between antenatal maternal mood and infant temperament among Asian mother–infant pairs. Antenatal maternal depression and anxiety were assessed using the Edinburgh Postnatal Depression Scale (J. Cox, J. Holden, & R. Sagovsky, 1987) and the State‐Trait Anxiety Inventory (C. Spielberger, R. …
An Attachment-Based Model of the Relationship Between Childhood Adversity and Somatization in Children and Adults
OBJECTIVE: An attachment model was used to understand how maternal sensitivity and adverse childhood experiences are related to somatization. METHODS: We examined maternal sensitivity at 6 and 18 months and somatization at 5 years in 292 children in a longitudinal cohort study. We next examined attachment insecurity and somatization (health anxiety, physical symptoms) in four adult cohorts: healthy primary care patients (AC1, n = 67), ulcerative …
Prospective associations between parental feeding practices and children's oral processing behaviours
Previous research demonstrated that faster eating rates are linked with increased intake of energy during a meal. Here, we examined whether within-meal parental feeding practices show cross-sectional and prospective associations with children's oral processing behaviours and whether the previously demonstrated association between faster eating rates and higher energy intakes varies by parental feeding practices. A subset (n = 155) of children and…
Fetal growth interacts with multilocus genetic score reflecting dopamine signaling capacity to predict spontaneous sugar intake in children
Oral processing behaviours that promote children's energy intake are associated with parent-reported appetitive traits
Once and Again
Network Analyses of Maternal Pre- and Post-Partum Symptoms of Depression and Anxiety
The differences between pre- and post-partum networks suggest that the presentation of maternal mental health problems varies over the peripartum period. This variation is not captured by traditional symptom scale scores. The bridging symptoms also suggest that anxiety symptoms may precede the development of maternal depression. Interventions and public health policies should thus be tailored to specific pre- and post-partum symptom profiles
Is breastfeeding associated with later child eating behaviours
Genetically predicted gene expression of prefrontal DRD4 gene and the differential susceptibility to childhood emotional eating in response to positive environment
Does social capital moderate the association between children's emotional overeating and parental stress? A cross-sectional study of the stress-buffering hypothesis in a sample of mother-child dyads
Combined polygenic risk scores of different psychiatric traits predict general and specific psychopathology in childhood
BACKGROUND: Polygenic risk scores (PRSs) operationalize genetic propensity toward a particular mental disorder and hold promise as early predictors of psychopathology, but before a PRS can be used clinically, explanatory power must be increased and the specificity for a psychiatric domain established. To enable early detection, it is crucial to study these psychometric properties in childhood. We examined whether PRSs associate more with general …
Medicine (28 works) · Psychology (26 works) · Developmental psychology (14 works) · Internal Medicine (13 works) · Biology (11 works) · Clinical Psychology (10 works) · Psychiatry (10 works) · Obesity, Physical Activity, Diet (9 works) · Pregnancy (9 works) · Maternal Mental Health During Pregnancy and Postpartum (8 works)