Slow Acceptance of Universal Antiretroviral Therapy (ART) Among Mothers Enrolled in Impaact PROMISE Studies Across the Globe

Bibliographic Data

ID15336849
Authorsfor the PROMISE study team (University of Zimbabwe, corresponding author), Lynda Stranix‐Chibanda (0000-0003-3566-1688, Boston University), Sean S Brummel (0000-0002-4116-404X, Boston University), S Brummel, J H Pilotto (0000-0003-0521-8597, University of Zimbabwe), J Pilotto, Mercy Mutambanengwe (University of Zimbabwe), Vongai Chanaiwa (University of Zimbabwe), Tsungai Mhembere (University of Zimbabwe), Moreen Kamateeka (0000-0001-7431-9485, MUJHU Research Collaboration), Jim Aizire (0000-0002-4408-8839, MUJHU Research Collaboration), Gaerolwe Masheto (0000-0002-2388-9637, University of Malawi), Rachel Chamanga (0000-0003-1298-7669, University of Malawi), Miriam Maluwa (Centre for the AIDS Programme of Research in South Africa), Sherika Hanley (0000-0002-4343-7646, Centre for the AIDS Programme of Research in South Africa), Esaú João (0000-0002-2412-0627, Stellenbosch University), Gerhard Theron (0000-0001-8888-1436, B. J. Medical College & Sassoon Hospital), Neetal Nevrekar (0000-0001-8496-5341, B. J. Medical College & Sassoon Hospital), Mandisa Nyati (Hospital Nossa Senhora da Conceição), Breno Santos (0000-0002-2888-2573, Hospital Nossa Senhora da Conceição), Linda Aurpibul (0000-0003-0246-8187, Centre for Infectious Disease Research in Zambia), Mwangelwa Mubiana‐Mbewe (0000-0002-7122-842X, Universidade Federal do Rio de Janeiro), M Mubiana-Mbewe, Ricardo Oliveira (0000-0002-9181-4004, Universidade Federal do Rio de Janeiro), Thanomsak Anekthananon (Siriraj Hospital), Pendo Mlay (0000-0002-6446-2533, Boston University), Konstantia Angelidou (0000-0001-7213-9982, Boston University), C Tierney (Boston University), Lauren Ziemba (Boston University), Anne Coletti (0000-0003-1787-9966, Family Health International 360), Katie McCarthy (Family Health International 360), Michael Basar (Frontier Science & Technology Research Foundation, Inc), Nahida Chakhtoura (National Institute of Allergy and Infectious Diseases), R Browning (0000-0002-1404-0789), JS Currier (Johns Hopkins University), Mary Glenn Fowler (0000-0003-4484-9009, St. Jude Children's Research Hospital), Pat Flynn (St. Jude Children's Research Hospital)
Year2019
Volume23
Issue9
Pages2522-2531
Publication date2019-08-09
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAIDS and Behavior (JOURNAL)
Journal identifiersISSN: 1090-7165 • E-ISSN: 1573-3254
PublisherSpringer Science+Business Media (PUBLISHER • DE)
DOI10.1007/s10461-019-02624-3
PMID31399793
OpenAlexW2967275918
LanguageEN
Citations received1
References cited30

The PROMISE trial enrolled asymptomatic HIV-infected pregnant and postpartum women not eligible for antiretroviral treatment (ART) per local guidelines and randomly assigned proven antiretroviral strategies to assess relative efficacy for perinatal prevention plus maternal/infant safety and maternal health. The START study subsequently demonstrated clear benefit in initiating ART regardless of CD4 count. Active PROMISE participants were informed of results and women not receiving ART were strongly recommended to immediately initiate treatment to optimize their own health. We recorded their decision and the primary reason given for accepting or rejecting the universal ART offer after receiving the START information. One-third of participants did not initiate ART after the initial session, wanting more time to consider. Six sessions were required to attain 95% uptake. The slow uptake of universal ART highlights the need to prepare individuals and sensitize communities regarding the personal and population benefits of the "Treat All" strategy

Alternative medicine · Antiretroviral therapy · Asymptomatic · Environmental health · Family medicine · Health psychology · Human immunodeficiency virus (HIV · Population · Public health · Session (web analytics · Viral load · Adolescent Sexual and Reproductive Health · HIV, Drug Use, Sexual Risk · HIV/AIDS Research and Interventions · Medicine · Nursing · Internal Medicine