Associations Among Suicidal Ideation, White Matter Integrity and Cognitive Deficit in First-Episode Schizophrenia
Bibliographic Data
| ID | 15518158 |
|---|---|
| Authors | Yicheng Long (0000-0003-4231-2136, Central South University), Xuan Ouyang (0009-0004-1288-7531, Second Xiangya Hospital of Central South University, corresponding author), Zhening Liu (0000-0001-6893-2427, Second Xiangya Hospital of Central South University), Xudong Chen (0000-0002-6929-5279, Central South University), Xinran Hu (0009-0003-6282-8620, Second Xiangya Hospital of Central South University), Edwin Lee (0000-0002-8909-0676, University of Hong Kong), Eric Chen (0000-0002-5247-3593, University of Hong Kong), Eric Y H Chen, Weidan Pu (0000-0002-7975-4758, Central South University), Baoci Shan (0000-0001-7417-5063, Chinese Academy of Sciences), Robert M Rohrbaugh (0000-0002-4969-4352, Yale University) |
| Year | 2018 |
| Volume | 9 |
| Pages | 391-391 |
| Publication date | 2018-08-28 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2018.00391 |
| PMID | 30210372 |
| OpenAlex | W2889302022 |
| Language | EN |
| Citations received | 3 |
| References cited | 63 |
Objective: The study was aimed to investigate the possible associations among suicidal ideation, brain white matter (WM) integrity and cognitive deficit in first-episode schizophrenia (FES) using diffusion tensor imaging. Methods: The sample contained 18 FES patients with suicidal ideation (SI+), 45 FES patients without suicidal ideation (SI-) and 44 healthy controls. The Calgary Depression Scale for Schizophrenia was used to measure the suicidal ideation and depression symptoms. The whole brain WM integrity and three domains of cognitive function: working memory, verbal comprehension as well as processing speed were compared between the three groups. Results: Compared with SI-, SI+ showed preserved WM integrity as indicated by significantly higher factional anisotropy (FA) or lower mean diffusivity (MD) in multiple WM tracts, and higher FA coupled with lower MD in bilateral posterior corona radiata. Compared with SI-, SI+ were more depressed and had less cognitive deficit in working memory and verbal comprehension. The fiber tracts in bilateral posterior corona radiata connect to the precuneus as shown by probabilistic tractography, and their WM integrity disruptions were found to be positively associated with the cognitive deficits in the FES patients. Discussion: Preserved WM integrity may be a risk factor for suicidal ideation in FES patients. One possible explanation is that it contributes to preserved cognitive function, especially in working memory and verbal comprehension, which may be associated with greater insight and could lead to increased depression and suicidal ideation. The posterior corona radiata and the precuneus may be linked to the related biological processes
Cognition · Cognitive deficit · Cognitive impairment · Corona radiata (embryology) · Fractional anisotropy · Injury prevention · Magnetic resonance imaging · Poison control · Precuneus · Psychiatry · Schizophrenia (object-oriented programming · Suicidal ideation · Wechsler Adult Intelligence Scale · White matter · Working memory · Advanced MRI Techniques and Applications · Advanced Neuroimaging Techniques and Applications · Clinical Psychology · Functional Brain Connectivity Studies · Medicine · Psychology · Internal Medicine
| Unique citing works | 3 |
|---|---|
| Citations per year | 0,5 |
| Citation span | 2020 - 2022 (3) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 3 |