Preliminary Evidence That the Short Allele of 5-HTTLPR Moderates the Association of Psychiatric Symptom Severity on Suicide Attempt

The Example in Obsessive-Compulsive Disorder

Bibliographic Data

ID15524666
AuthorsGhina Harika‐Germaneau (0000-0002-1953-0509, Centre National de la Recherche Scientifique), Claire Lafay‐Chebassier (0000-0001-8970-5514, Université de Poitiers), Nicolas Langbour (0000-0001-6779-9484, Centre de Recherches sur la Cognition et l'Apprentissage), Bérangère Thirioux (0009-0001-2520-7740, Université de Poitiers), Issa Wassouf (Centre de Recherches sur la Cognition et l'Apprentissage), Xavier Noël (0000-0002-4604-8144, Centre Hospitalier Universitaire Brugmann), Nemat Jaafari (0000-0003-2669-4509, Centre National de la Recherche Scientifique), Armand Chatard (0000-0003-4823-2903, Centre Hospitalier Henri Laborit, corresponding author)
Year2022
Volume13
Pages770414-770414
Publication date2022-04-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2022.770414
PMID35432015
OpenAlexW4220662265
LanguageEN
References cited9

This study provides preliminary evidence for the gene-by-stress interaction on suicide attempt when stress is operationalized as symptom severity. Progress in suicide research may come from efforts to investigate the gene-by-symptoms interaction hypothesis in a variety of diseases

5-HTTLPR · Distress · Medical emergency · Odds ratio · Poison control · Psychiatry · Risk factor · Serotonin transporter · Stressor · Suicide attempt · Suicide prevention · Clinical Psychology · Medicine · Neurotransmitter Receptor Influence on Behavior · Obsessive-Compulsive Spectrum Disorders · Psychology · Tryptophan and brain disorders · Internal Medicine