Variants of the Aggression-Related RBFOX1 Gene in a Population Representative Birth Cohort Study
Aggressiveness, Personality, and Alcohol Use Disorder
Bibliographic Data
Background: Recently, RBFOX1 , a gene encoding an RNA binding protein, has consistently been associated with aggressive and antisocial behavior. Several loci in the gene have been nominally associated with aggression in genome-wide association studies, the risk alleles being more frequent in the general population. We have hence examined the association of four RBFOX1 single nucleotide polymorphisms, previously found related to aggressive traits, with aggressiveness, personality, and alcohol use disorder in birth cohort representative samples. Methods: We used both birth cohorts of the Estonian Children Personality Behavior and Health Study (ECPBHS; original n = 1,238). Aggressiveness was assessed using the Buss-Perry Aggression Questionnaire and the Lifetime History of Aggressiveness structured interview at age 25 (younger cohort) or 33 (older cohort). Big Five personality at age 25 was measured with self-reports and the lifetime occurrence of alcohol use disorder assessed with the MINI interview. RBFOX1 polymorphisms rs809682, rs8062784, rs12921846, and rs6500744 were genotyped in all participants. Given the restricted size of the sample, correction for multiple comparisons was not applied. Results: Aggressiveness was not significantly associated with the RBFOX1 genotype. RBFOX1 rs8062784 was associated with neuroticism and rs809682 with extraversion. Two out of four analyzed RBFOX1 variants, rs8062784 and rs12921846, were associated with the occurrence of alcohol use disorder. Conclusions: In the birth cohort representative sample of the ECPBHS, no association of RBFOX1 with aggressiveness was found, but RBFOX1 variants affected basic personality traits and the prevalence of alcohol use disorder. Future studies on RBFOX1 should consider the moderating role of personality and alcohol use patterns in aggressiveness
Aggression · Alcohol · Alcohol use disorder · Biology · Cohort · Gene · Genome-wide association study · Genotype · Neuroticism · Personality · Population · Psychiatry · Single-nucleotide polymorphism · Clinical Psychology · Cognitive Abilities and Testing · Genetic Associations and Epidemiology · Genetics and Neurodevelopmental Disorders · Medicine · Psychology · Genetics · Internal Medicine
Conflict monitoring and decision making
Neuroimaging Studies of Aggressive and Violent Behavior
Personality and aggression
On the Relationship between Extraversion and Aggression
Relationship between Assertiveness and Aggressiveness
Neural correlates of proactive and reactive aggression in adolescent twins
Continuity of aggression from childhood to early adulthood as a predictor of life outcomes
The Aggression Questionnaire
An Introduction to the Five-Factor Model and Its Applications
Handbook of Personality Theory and Research
| Citation velocity | historical |
|---|---|
| Highly cited | No |