Tetrahydrocortisol/Tetrahydrocortisone Ratio (H4F/H4E) as an Indicator of Depressive Feelings
Bibliographic Data
| ID | 19302859 |
|---|---|
| Authors | Harold Persky (Hospital of the University of Pennsylvania, corresponding author) |
| Year | 1976 |
| Volume | 38 |
| Issue | 1 |
| Pages | 13-18 |
| Publication date | 1976-01-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Psychosomatic Medicine (JOURNAL) |
| Journal identifiers | ISSN: 0033-3174 • E-ISSN: 1534-7796 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) (PUBLISHER) |
| DOI | 10.1097/00006842-197601000-00003 |
| PMID | 1257380 |
| OpenAlex | W2322490597 |
| Language | EN |
| Citations received | 2 |
Tetrahydrocortisol (H4F) and tetrahydrocortisone (H4E) were determined for a group of 15 depressed patients and 25 normal controls following the administration of cortisol-4-C14. The ratio, H4F/H4E, was significantly greater for the depressed patients than for the normal controls (P less than 0.001), although the sum of the two metabolites, H4F + H4E, was not significantly different. Three of four objective test measures of depressive feelings likewise discriminated between the two groups. All four depression measures correlated significantly with the H4F/H4E ratio at the 0.01 level or better. It is suggested that the data of the present report and those of Zumoff et al. (J Clin Endocrinol Metab 39:1120, 1974) may be explained by the paradigm: depressive feelings leads to reduced thyroid function leads to elevated H4F/H4E ratio
Feeling · Clinical Psychology · Psychology · Social Psychology · Stress Responses and Cortisol
| Unique citing works | 2 |
|---|---|
| Citations per year | 0,04 |
| Citation span | 1978 - 1994 (17) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 2 |