Serotonergic Changes in Specific Areas of Rat Brain Associated with Activity-Stress Gastric Lesions
Bibliographic Data
| ID | 19304621 |
|---|---|
| Authors | Dirk H Hellhammer (0000-0001-9262-6681, German Academic Exchange Service, corresponding author), JOSEPH N HINGTGEN, Stephen E Wade (Indiana University – Purdue University Indianapolis), Philip A Shea (Indiana University School of Medicine), M H Aprison (Indiana University School of Medicine) |
| Year | 1983 |
| Volume | 45 |
| Issue | 2 |
| Pages | 115-122 |
| Publication date | 1983-05-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Psychosomatic Medicine (JOURNAL) |
| Journal identifiers | ISSN: 0033-3174 • E-ISSN: 1534-7796 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) (PUBLISHER) |
| DOI | 10.1097/00006842-198305000-00004 |
| PMID | 6191350 |
| OpenAlex | W2324975601 |
| Language | EN |
| Citations received | 1 |
To study serotonergic involvement in the development of gastric lesions following activity wheel stress, three groups of rats (gastric lesions, no gastric lesions, and home--cage controls) were killed following exposure to the experimental procedures. The brains were dissected into eight specific areas and subjected to analyses for serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) using high performance liquid chromatography with EC detection. Lower levels of 5-HT were found in the midbrain, cortex, and hippocampus of rats with gastric lesions compared to either the no lesion group, subjected to shorter periods of activity--stress, or the home--cage control group. Levels of 5-HT and 5-HIAA were elevated in the pons/medulla oblongata of both the lesion and the no lesion groups compared to the home--cage controls. Corticosterone levels in blood were also significantly elevated in the lesion group. These data on serotonin changes in the CNS suggest a possible role for this neurotransmitter in stress-induced gastric pathology
5-Hydroxyindoleacetic acid · Biology · Central nervous system · Cortex (anatomy) · Corticosterone · Hippocampus · Lesion · Medulla · Medulla oblongata · Midbrain · Neurotransmitter · Pathology · Pons · Receptor · Serotonergic · Serotonin · Endocrinology · Gastrointestinal motility and disorders · Helicobacter pylori-related gastroenterology studies · Internal Medicine · Medicine · Neuroscience
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,04 |
| Citation span | 2002 - 2002 (1) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 1 |