Structural and Electrical Myocardial Remodeling in a Rodent Model of Depression
Bibliographic Data
| ID | 19308564 |
|---|---|
| Authors | Luca Carnevali (0000-0001-9053-7976, University of Parma), Mimosa Trombini (University of Parma), Stefano Rossi (0000-0003-1692-5342, University of Groningen), Gallia Graiani (0000-0003-1926-7568, University of Groningen), Massimo Manghi (0000-0001-6413-3046, University of Groningen), Jaap M Koolhaas (University of Groningen), Federico Quaini (0000-0003-2377-4810, University of Parma), Emilio Macchi (0000-0002-8993-3987, University of Parma), Eugene Nalivaiko (0000-0002-6449-8181, University of Groningen), Andrea Sgoifo (0000-0002-9428-6198, University of Groningen, corresponding author) |
| Year | 2013 |
| Volume | 75 |
| Issue | 1 |
| Pages | 42-51 |
| Publication date | 2013-01-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Psychosomatic Medicine (JOURNAL) |
| Journal identifiers | ISSN: 0033-3174 • E-ISSN: 1534-7796 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) (PUBLISHER) |
| DOI | 10.1097/psy.0b013e318276cb0d |
| PMID | 23257930 |
| OpenAlex | W2148166641 |
| Language | EN |
| Citations received | 1 |
| References cited | 27 |
OBJECTIVE: Despite a well-documented association between stress and depression with cardiac morbidity and mortality, there is no satisfactory explanation for the mechanisms linking affective and cardiac disorders. This study investigated cardiac electrophysiological properties in an animal model of depression. METHODS: Depression-relevant physiological and behavioral parameters were measured in adult male wild-type rats during and after a period of intermittent social defeat stress (n = 12) or empty cage exposure (control, n = 11). Nine days after the last defeat/empty cage exposure, high-definition epicardial mapping was performed under anesthesia. RESULTS: Stressed animals versus controls displayed a larger reduction in the circadian amplitude of heart rate (-32% [3%] versus -13 [2%]; p = .001) and body temperature (-33% [4%] versus -5% [2%]; p = .001) rhythms, had smaller body weight gain (+11% [1%] versus +17% [1%]; p < .001), and showed a larger reduction in sucrose solution intake (-19% [6%] versus -7% [4%]; p = .006). Epicardial mapping analysis revealed a decrease in the transversal conduction velocity of the wavefront (0.23 [0.0] versus 0.27 [0.1] m/s; p = .02) and a shortening of the effective refractory period (86.8 [2.1] versus 95.9 [3.0] milliseconds; p = .01) in stressed animals. Upon killing, moderate left ventricular fibrosis was observed in the stressed group. CONCLUSIONS: Intermittent social stress procedure is associated with depression-like symptoms and altered myocardial electrical stability in a potentially proarrhythmic manner. In particular, reduced myocardial refractoriness and impaired conduction, which are considered major determinants of arrhythmogenesis, represent possible mechanisms underlying cardiac vulnerability
Anesthesia · Cardiac Electrophysiology · Cardiology · Depression (economics) · Effective refractory period · Electrophysiology · Nerve conduction velocity · Refractory period · Cardiac electrophysiology and arrhythmias · Cardiac Fibrosis and Remodeling · Endocrinology · Internal Medicine · Medicine · Stress Responses and Cortisol
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,11 |
| Citation span | 2017 - 2017 (1) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 1 |