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Alcohol and other drug use among HIV-affected adolescents and young adults in Zambia

A qualitative study of multilevel drivers and preferences for prevention and treatment approaches

Bibliographic Data

ID19491669
AuthorsJeremy C Kane (0000-0002-6598-3840, Columbia University, corresponding author), Tukiya Kanguya (Centre for Infectious Disease Research in Zambia), Alejandra Paniagua-Avila (0000-0002-1152-3785, Columbia University), Marksman Foloko (Centre for Infectious Disease Research in Zambia), Clovis Mwamba (0000-0002-7626-6273, Centre for Infectious Disease Research in Zambia), Chanda Mwamba, Judith A Hahn (0000-0002-2697-8264, University of California, San Francisco), Carl Latkin (0000-0002-7931-2116, Johns Hopkins University), Sílvia S Martins (0000-0003-3059-9993, Columbia University), G Chander (0000-0002-2216-6330, University of Washington), Rhea Pawar (Columbia University), M Claire Greene (0000-0002-4631-4764, Institute of Population and Public Health), Kabwe Mwamba (Centre for Infectious Disease Research in Zambia), Anjali Sharma (0000-0001-6297-3113, Centre for Infectious Disease Research in Zambia)
Year2026
Volume9
Pages100613
Publication date2026-06-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueSSM - Mental Health (JOURNAL)
Journal identifiersISSN: 2666-5603 • E-ISSN: 2666-5603
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.ssmmh.2026.100613
PMID42488506
OpenAlexW7135384985
LanguageEN
References cited27

Background Alcohol and other drug (AOD) use is a growing public health problem among AYA and young adults (AYA) globally. AYA who are affected by HIV in low-and-middle-income countries (LMICs) may have high risk for AOD use problems, yet the context of AOD use remains an understudied area in this population. Method ology: In this qualitative study, we conducted 16 focus group discussions with HIV-affected AYA (ages 16-24), caregivers, and healthcare workers, and eight key informant interviews with mental health experts in Lusaka, Zambia. Thematic analysis with open coding explored multi-level determinants of AOD use among HIV-affected AYA, as well as perceptions of intervention approaches. Results The study included N=40 AYA, N=50 caregivers, N=40 lay healthcare workers, and M=41 professional healthcare workers. Substance use among AYA was commonly initiated as a coping mechanism for trauma and perpetuated by withdrawal symptoms. Perceived benefits included enhanced cognitive (boys) or sexual (girls) performance. Interpersonal factors, including peer pressure, bullying, and lack of family support contributed to initiation and continuation of use. Structurally, limited access to recreational facilities, poverty, unemployment, and widespread availability of inexpensive substances facilitated use. At the health system level, the absence of standardized treatment guidelines, insufficient AYA-specific services, and pervasive stigma surrounding AOD care impeded access to services. Current prevention efforts were seen as limited by targeting HIV alone, having limited accessibility, and favoring girls in implementation. Conclusion Findings underscore the need for integrated HIV and AOD services, gender-responsive and trauma-informed interventions, and structural approaches addressing youth unemployment and service accessibility

Alcohol · Drug · Multilevel model · Poison control · Qualitative analysis · Qualitative research · Young adult · Adolescent Sexual and Reproductive Health · HIV/AIDS Impact and Responses · Human Factors and Ergonomics · Poverty, Education, and Child Welfare

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Citation velocityhistorical
Highly citedNo
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