Innovative Development of Research Engagement Manual
Strategies to Enhance Recruitment and Retention of Black Individuals in Clinical Trials for Substance Use Disorders
Bibliographic Data
| ID | 19578530 |
|---|---|
| Authors | Geoffrey Obel (The University of Texas Health Science Center at Tyler), DeWanda Harris-Trimiar (North Central Texas Council of Governments), Joshua S Elmore (0000-0002-1926-5696, Southwestern Medical Center), Taryn L Mayes (0000-0002-5992-6081, Southwestern Medical Center), Adrienne Mays (Southwestern Medical Center), Angela Casey-Willingham (Southwestern Medical Center), Srividya Vasu (0000-0002-6625-9184, Southwestern Medical Center), Steven Shoptaw (0000-0002-3583-0026, University of California, Los Angeles), Madhukar H Trivedi (0000-0002-2983-1110, Southwestern Medical Center, corresponding author) |
| Year | 2025 |
| Volume | 9 |
| Issue | 1 |
| Pages | 387-396 |
| Publication date | 2025-08-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Health Equity (JOURNAL) |
| Journal identifiers | ISSN: 2473-1242 • E-ISSN: 2473-1242 |
| Publisher | SAGE Publications (PUBLISHER • US) |
| DOI | 10.1177/24731242251362181 |
| PMID | 40918627 |
| OpenAlex | W4414078436 |
| Language | EN |
| References cited | 48 |
Background: The participation of Black individuals in clinical trials remains lower than that of other racial and ethnic groups. Substance abuse adds additional barriers to recruitment and retention. While significant attention has been devoted to identifying barriers to recruitment/retention, efforts have been largely unsuccessful in increasing the participation of Black individuals in clinical trials. This article details Phase 1 efforts to develop sustainable strategies to increase enrollment/recruitment of Black participants in clinical trials through an Innovative Development of Research Engagement Manual. Methods: Phase 1 involved a literature review and the establishment of an Expert Diversity Advisory Board, which identified barriers to Black individual participation in substance use disorder (SUD) research. Identified barriers included lack of awareness of research, mistrust, lack of comfort with research, lack of information, and time/resource constraints. Focus groups were conducted to assess the importance of the identified factors in 61 Black participants with SUD history. Results: Among the focus group participants, 37.7% indicated mistrust, 45.9% indicated a lack of knowledge, and 27.9% stated safety concerns as reasons for not engaging with researchers. They considered compensation, research benefits, study duration, privacy, safety, and side effects as vital information that informed their decisions on clinical trial participation. The focus groups identified financial incentives, potential treatment options, and potential for improved awareness about substance abuse treatment as factors that determine retention in a study. Conclusion: With barriers identified, future efforts will focus on qualitative assessments of focus group material and developing and evaluating the manual
Alternative medicine · Clinical trial · Focus group · MEDLINE · Qualitative research · Substance use · Ethics in Clinical Research · Pharmacogenetics and Drug Metabolism · Race, Genetics, and Society
More than Tuskegee
Distrust, Race, and Research
The PhenX Toolkit
If You Want to Know About the Book, Ask the Author”
Measurement Invariance of the Short Inventory of Problems-Revised across African-American and Non-Latino White Substance Users
Health Disparities, Transportation Equity and Complete Streets
Transportation Barriers to Health Care in the United States
It's not just what you say, it's also how you say it
The role of socioeconomic factors in Black-White health inequities across the life course
Is Racism a Fundamental Cause of Inequalities in Health
| Citation velocity | historical |
|---|---|
| Highly cited | No |