Aflatoxicosis outbreak and its associated factors in Kiteto, Chemba and Kondoa Districts, Tanzania

Bibliographic Data

ID19590933
AuthorsErick S Kinyenje (0000-0001-8434-2232, Muhimbili University of Health and Allied Sciences, corresponding author), Rogath Kishimba (0000-0002-5437-7589, corresponding author), Mohamed Mohamed (0000-0002-2447-5639, corresponding author), Ambele Mwafulango (corresponding author), Eliudi S Eliakimu (0000-0003-2383-9530, Ministry of Health, Community Development, Gender, Elderly and Children, corresponding author), Eliudi Eliakimu, G Kwesigabo (0000-0003-3302-6736, Muhimbili University of Health and Allied Sciences, corresponding author)
EditorsReuben Kiggundu (0000-0001-6141-9436)
Year2023
Volume3
Issue8
Pagese0002191
Publication date2023-08-08
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenuePLOS Global Public Health (JOURNAL)
Journal identifiersISSN: 2767-3375 • E-ISSN: 2767-3375
PublisherPublic Library of Science (PLoS) (PUBLISHER)
DOI10.1371/journal.pgph.0002191
PMID37552664
OpenAlexW4385655393
LanguageEN
Citations received2
References cited51

Tanzania had experienced hundreds of cases of aflatoxicosis in the districts of Kiteto, Chemba, and Kondoa for the three consecutive years since 2016. Cases may end up with liver cancer. Aflatoxin-induced liver cancer had resulted in the demise of roughly three persons per 100,000 in the country during the same year, 2016. We investigated to characterize the latest outbreak of 2019 and identify its risk factors. This case-control study enrolled all patients presented with acute jaundice of unknown origin and laboratory test results confirmed an acute liver injury with or without abdominal pain, distension, vomiting, or fever during the period of June to November 2019 and had epidemiological link with cases confirmed with Aflatoxin-B1-Lysine. Adjusted odds ratios (AOR) with 95% confidence intervals (CI) were used to identify independent factors associated with aflatoxicosis. We analyzed 62 cases with median age of 7 years (0.58–50 years) and 186 controls with median age of 24 years (range 0.42–55) with onset of symptoms ranging from 1 st June 2019 to 16 th July 2019. Case-parents had higher serum aflatoxin-B1–lysine adduct concentrations than did controls; 208.80 ng/mg (n = 45) vs. 32.2 ng/mg (n = 26); p

Aflatoxin · Biology · Confidence interval · Jaundice · Odds ratio · Outbreak · Pathology · Vomiting · Medicine · Mycotoxins in Agriculture and Food · Plant Pathogens and Resistance · Wheat and Barley Genetics and Pathology · Biotechnology · Epidemiology · Gastroenterology · Internal Medicine