Factors associated with delayed diagnosis of pulmonary tuberculosis in Chitwan district of Nepal

Bibliographic Data

ID19591594
AuthorsSusmita Sharma (Chitwan Medical College), Jiwan Kumar Poudyal (0000-0003-2451-5060, Chitwan Medical College, corresponding author), Varun Kumar Sharma (0000-0001-8575-6939, Noida International University), Sumitra Parajuli (0009-0009-7812-6475, Chitwan Medical College), Govinda Prasad Dhungana (0000-0003-3993-1614, Tribhuvan University)
EditorsGraeme Hoddinott (0000-0001-5915-8126)
Year2026
Volume6
Issue1
Pagese0005718
Publication date2026-01-08
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenuePLOS Global Public Health (JOURNAL)
Journal identifiersISSN: 2767-3375 • E-ISSN: 2767-3375
PublisherPublic Library of Science (PLoS) (PUBLISHER)
DOI10.1371/journal.pgph.0005718
PMID41505478
OpenAlexW7119499673
LanguageEN
References cited23

Pulmonary Tuberculosis (PTB) remains a major public health issue in Nepal and is among the top ten causes of death from a single infectious agent globally. Diagnostic delay refers to the time lag between the onset of symptoms and the confirmation of a correct diagnosis. Delayed diagnosis increases disease severity, prolongs infectivity, and hinders timely treatment. This study aimed to identify factors contributing to diagnostic delays of PTB in Chitwan district, Nepal. A cross-sectional study was conducted among 317 PTB patients receiving Directly-Observed Therapy short-course (DOTS) treatment across all DOTS centers in Chitwan district, using complete enumerative sampling. Data were collected using a semi-structured questionnaire through face-to-face interviews, then analyzed using SPSS version 22 with descriptive and multivariate analysis at a 95% confidence level. Of the 317 PTB patients, 42.6% experienced patient delay, 33.8% health system delay, and 58% total delay. The median delays were 25 days (patient), 5 days (health system), and 30 days (total). Self-medication significantly increased the likelihood of patient delay (AOR = 5.893, 95% CI: 2.133–16.285), as did lack of TB knowledge (AOR = 3.355, 95% CI: 1.603–7.018), poor economic status (AOR = 2.149, 95% CI: 1.109–4.162), and domestic preoccupation (AOR = 2.017, 95% CI: 1.154–3.528). Health system delay was strongly associated with a lack of trained health workers (AOR = 66.202, 95% CI: 27.070–161.906), poor quality services (AOR = 1.102, 95% CI: 1.102–11.078), and distant health facilities (AOR = 4.830, 95% CI: 1.554–15.017). The study identified significant diagnostic delays in Pulmonary Tuberculosis, primarily influenced by self-medication, poor TB knowledge, low socioeconomic status, lack of trained health workers and domestic responsibilities. The findings emphasize the need for community awareness, socioeconomic support, and strengthened primary health services to promote early diagnosis and timely treatment for effective TB control

Disease · Health care · Infectious disease (medical specialty) · Multivariate analysis · Public health · Pulmonary tuberculosis · Socioeconomic status · Tuberculosis · Diverse Scientific Research Studies · Global Health and Epidemiology · Tuberculosis Research and Epidemiology