Hospitalization and mortality outcomes among adult persons living with HIV in a tertiary hospital in South-western Nigeria
A cross-sectional study
Bibliographic Data
| ID | 19591966 |
|---|---|
| Authors | Ayanfe Omololu (0000-0003-0052-7622, Federal Medical Centre, corresponding author), Asukwo Onukak (0000-0002-3228-7283, University of Uyo, corresponding author), Mfon Effiong (Akwa Ibom State University, corresponding author), Olaide Oke (0000-0001-8303-000X, Federal Medical Centre, corresponding author), Samson E Isa (0000-0002-1949-4683, University of Jos, corresponding author), Abdulrazaq G Habib (0000-0003-4219-8724, Bayero University Kano, corresponding author) |
| Editors | Claudia P Cortés (0000-0001-9101-9783) |
| Year | 2024 |
| Volume | 4 |
| Issue | 7 |
| Pages | e0003487 |
| Publication date | 2024-07-11 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | PLOS Global Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2767-3375 • E-ISSN: 2767-3375 |
| Publisher | Public Library of Science (PLoS) (PUBLISHER) |
| DOI | 10.1371/journal.pgph.0003487 |
| PMID | 38990938 |
| OpenAlex | W4400527241 |
| Language | EN |
| References cited | 23 |
HIV infection continues to be a major public health issue, with significant morbidity and mortality especially in resource poor areas. Infection with HIV results in an increased risk of opportunistic infections and other complications, which may lead to hospital admission and death. Morbidity and mortality patterns among hospitalized persons living with HIV (PLHIV) have been well documented in high income countries, but there is paucity of such data in Nigeria. We investigated the reasons for hospitalization and predictors of death among adult PLHIV at the Federal Medical Center (FMC) Abeokuta, Nigeria. This was a hospital based cross-sectional study carried out over a 15-month period between January 2018 and March 2019. All consenting hospitalized adult PLHIV who met the inclusion criteria were enrolled into the study. Causes of hospitalization and death were obtained and analyzed. Over the study period, 193 hospitalizations of PLHIV were studied. Although a number of clinical syndromes were documented, Sepsis and Tuberculosis were the commonest causes of hospitalization and mortality. Mortality rate was 37(19.2%) for outcomes on day 30, with anaemia [OR 3.00 (95% C.I: 1.04–8.67)], poor adherence with Cotrimoxazole [OR 4.07 (95% C.I: 1.79–9.28)], poor adherence with cART [OR 13.40 (95% C.I: 3.92–45.44)], and a longer duration of fever [OR 3.34 (95% C.I: 1.10–9.99)] being predictors of mortality. Part of the study’s limitation was resource-constraint of some of the indigent patient which affected their ability to access some diagnostic investigations and get optimal care thereby impacting on their outcome. Despite the upscaling of cART, opportunistic infections and sepsis remain common causes of hospitalization and death in adult PLHIV. More attention should therefore be placed on early diagnosis, prevention of immunosuppression and sepsis through timely administration and adherence to cART and other prophylactic measures
Cross-sectional study · Family medicine · Mortality rate · Public health · Tuberculosis · HIV-related health complications and treatments · HIV/AIDS Research and Interventions · Medicine · Pneumocystis jirovecii pneumonia detection and treatment · Internal Medicine · Pediatrics
The WHO public-health approach to antiretroviral treatment against HIV in resource-limited settings
Why reinvent the wheel? Leveraging the lessons of HIV scale-up to confront non-communicable diseases
The HIV Epidemic in South Africa
Causes of hospitalization and predictors of HIV-associated mortality at the main referral hospital in Sierra Leone
| Citation velocity | historical |
|---|---|
| Highly cited | No |