Nigeria healthcare worker Sars-CoV-2 serology study

Results from a prospective, longitudinal cohort

Bibliographic Data

ID19593245
AuthorsDike Ojji (0000-0002-2084-1988, University of Abuja Teaching Hospital, corresponding author), Amelia Sancilio (0000-0002-4823-3829, Northwestern University), Gabriel L Shedul (0000-0003-2295-908X, University of Abuja), Ikechukwu A Orji (0000-0001-5028-5428, University of Abuja), Aashima Chopra (Northwestern University), Joel Abu (University of Abuja), Blessing Akor (University of Abuja), Nana Ripiye (0000-0002-7737-900X, University of Abuja), Oluwafunmilayo Akinlade (0000-0002-3548-870X, Johns Hopkins University), Douglas Okoye (University of Abuja), Emmanuel Okpetu (0000-0001-9103-9899, University of Abuja), Helen Eze (University of Abuja), Emmanuel Odoh (National Primary Health Care Development Agency), Abigail S Baldridge (0000-0002-1573-0554, Northwestern University), Priya Tripathi (Northwestern University), Haruna Abubakar (University of Abuja Teaching Hospital), Abubakar M Jamda (0000-0002-6066-8526, University of Abuja), Lisa R Hirschhorn (0000-0002-4355-7437, Northwestern University), T W Mcdade (0000-0001-5829-648X, Northwestern University), Thomas Mcdade, Mark D Huffman (0000-0001-7412-2519, Northwestern University)
EditorsAnete Trajman (0000-0002-4000-4984)
Year2023
Volume3
Issue1
Pagese0000549
Publication date2023-01-17
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenuePLOS Global Public Health (JOURNAL)
Journal identifiersISSN: 2767-3375 • E-ISSN: 2767-3375
PublisherPublic Library of Science (PLoS) (PUBLISHER)
DOI10.1371/journal.pgph.0000549
PMID36962953
OpenAlexW4317038863
LanguageEN
Citations received1
References cited15

Healthcare workers, both globally and in Nigeria, have an increased risk for SARS-CoV-2 infection compared with the general population due to higher risk contacts, including occupational exposures. In addition, primary healthcare workers represent an important group for estimating prior infection to SARS-CoV-2 because they work at the first point-of-contact for most patients yet have not been included in prior COVID-19 seroepidemiology research in Nigeria. We sought to evaluate baseline seroprevalence, rates of seroconversion (IgG- to IgG+) and seroreversion (IgG+ to IgG-), change in IgG concentration at 3- and 6-month follow-up, and factors associated with seropositivity. From June 2020 to December 2020, we conducted a longitudinal seroepidemiology study among frontline health care workers in Nigeria using a validated dried blood spot assay. Among 525 participants, mean (SD) age was 39.1 (9.7) years, 61.0% were female, and 45.1% were community health workers. The six-month follow-up rate was 93.5%. Seropositivity rates increased from 31% (95% CI: 27%, 35%) at baseline to 45% (95% CI: 40%, 49%) at 3-month follow-up, and 70% (95% CI: 66%, 74%) at 6-month follow-up. There was a corresponding increase in IgG levels from baseline (median = 0.18 ug/mL) to 3-month (median = 0.35 ug/mL) and 6-month follow-up (median = 0.59 ug/mL, P trend Trial registration: NCT04158154

Antibody · Cohort · Cohort study · Environmental health · Health care · Longitudinal study · Population · Prospective cohort study · Seroconversion · Serology · Seroprevalence · COVID-19 Clinical Research Studies · Demography · Medicine · SARS-CoV-2 and COVID-19 Research · SARS-CoV-2 detection and testing · Immunology · Internal Medicine