HIV clinical outcomes among people with HIV and diabetes mellitus in Kampala, Uganda; A matched retrospective cohort study

Bibliographic Data

ID19595056
AuthorsRita Nakalega (0000-0002-5044-6487, MUJHU Research Collaboration, corresponding author), Fred C Semitala (0000-0002-0624-7640, Makerere University, corresponding author), Edrisa Ibrahim Mutebi, Edrisa Mutebi (Makerere University, corresponding author), Denis Mawanda (corresponding author), Zubair Lukyamuzi (0000-0003-3744-8346, MUJHU Research Collaboration, corresponding author), Robert Menge (0000-0003-0636-0122, Umeå University, corresponding author), Juliet Allen Babirye (Makerere University, corresponding author), Sharon Miriam Namiiro, Sharon Namiiro (Makerere University, corresponding author), Cleopatra Daphne Kugonza (Makerere University, corresponding author), Nelson Mukiza (corresponding author), Andrew Mujugira (0000-0001-6646-6733, Infectious Diseases Institute, corresponding author)
EditorsJoseph Baruch Baluku (0000-0002-5852-9674)
Year2025
Volume5
Issue1
Pagese0003922
Publication date2025-01-16
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenuePLOS Global Public Health (JOURNAL)
Journal identifiersISSN: 2767-3375 • E-ISSN: 2767-3375
PublisherPublic Library of Science (PLoS) (PUBLISHER)
DOI10.1371/journal.pgph.0003922
PMID39820139
OpenAlexW4406456799
LanguageEN
References cited44

Suppressive antiretroviral treatment (ART) has resulted into prolonged survival of people with HIV (PWH) in Sub-Saharan Africa (SSA) with resultant increase in the incidence of non-communicable diseases (NCD), such as diabetes mellitus (DM). However, there is a lack of data on the effect of DM on HIV-related outcomes among PWH in this setting. The study aimed to compare HIV clinical outcomes (viral load suppression, retention in care, hospitalization, tuberculosis, and mortality) between PWH with DM and those without at two large HIV clinics in Kampala, Uganda. We conducted a matched retrospective cohort study using secondary data of PWH with DM and PWH without DM from January 2020 to June 2022. We used descriptive statistics to compare baseline characteristics and a chi-square test to compare the outcomes between the HIV/DM and HIV/no DM groups. The cohort consisted of 243 PWH diagnosed with DM matched with 1221 PWH without DM. We analysed 1,469 participant records: 1,009 (68.7%) from Mulago ISS clinic and 460 (31.3%) from Kisenyi HC IV. Most study participants (63.6%) were female, and the mean age was 43 years (standard deviation [SD] 11) and 38 years (SD 10) for those with DM and without DM, respectively. PWH with DM had significantly higher odds of hospitalization (adjusted odds ratio [AOR] 4.94; 95% CI: 1.93–12.66; p = 0.001) and were less likely to be retained in care (AOR 0.12, 95% CI: 0.07–0.20 p

Cohort · Cohort study · Diabetes mellitus · Family medicine · Retrospective cohort study · Chronic Disease Management Strategies · HIV-related health complications and treatments · HIV/AIDS Research and Interventions · Medicine · Endocrinology · Gerontology · Internal Medicine