Admixture Patterns and Genetic Differentiation in Negrito Groups from West Malaysia Estimated from Genome-wide SNP Data

Bibliographic Data

ID20669111
AuthorsTimothy A Jinam (0000-0003-4757-096X, The Graduate University for Advanced Studies, SOKENDAI), Timothy A Jinam Timothy A Jinam, Maude Elvira Phipps (0000-0001-8314-068X), Maude E Phipps Maude E Phipps, Naruya Saitou (The Graduate University for Advanced Studies, SOKENDAI, corresponding author), Naruya Saitou Naruya Saitou
Year2013
Volume85
Issue1-3
Pages173
Publication date2013-01-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueHuman Biology (JOURNAL)
Journal identifiersISSN: 0018-7143 • E-ISSN: 1534-6617
PublisherProject MUSE (PUBLISHER • US)
DOI10.13110/humanbiology.85.1-3.0173
OpenAlexW4238901212
LanguageEN
References cited12

Southeast Asia houses various culturally and linguistically diverse ethnic groups.In Malaysia, where the Malay, Chinese, and Indian ethnic groups form the majority, there exist minority groups such as the "negritos" who are believed to be descendants of the earliest settlers of Southeast Asia.Here we report patterns of genetic substructure and admixture in two Malaysian negrito populations ( Jehai and Kensiu), using ~50,000 genomewide single-nucleotide polymorphism (SNP) data.We found traces of recent admixture in both the negrito populations, particularly in the Jehai, with the Malay through principal component analysis and STRUCTURE analysis software, which suggested that the admixture was as recent as one generation ago.We also identified significantly differentiated nonsynonymous SNPs and haplotype blocks related to intracellular transport, metabolic processes, and detection of stimulus.These results highlight the different levels of admixture experienced by the two Malaysian negritos.Delineating admixture and differentiated genomic regions should be of importance in designing and interpretation of molecular anthropology and disease association studies

Biology · Evolutionary biology · Gene · Genetic data · Genetic genealogy · Genome · Genome-wide association study · Genotype · Geography · Population · Single-nucleotide polymorphism · SNP · Sociology · Demography · Forensic and Genetic Research · Genetics