A Polymorphism in the Serotonin Transporter Gene Moderates Cardiovascular Reactivity to Psychosocial Stress
Bibliographic Data
| ID | 20971103 |
|---|---|
| Authors | Baldwin M Way (0000-0002-9618-0979, University of California, Los Angeles), Shelley E Taylor (The Ohio State University, corresponding author) |
| Year | 2011 |
| Volume | 73 |
| Issue | 4 |
| Pages | 310-317 |
| Publication date | 2011-05-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Psychosomatic Medicine (JOURNAL) |
| Journal identifiers | ISSN: 0033-3174 • E-ISSN: 1534-7796 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) (PUBLISHER) |
| DOI | 10.1097/psy.0b013e31821195ed |
| PMID | 21364196 |
| PMCID | PMC3090451 |
| OpenAlex | W2031646637 |
| Language | EN |
| Citations received | 3 |
| References cited | 61 |
OBJECTIVE: To examine whether a polymorphism (5-HTTLPR: serotonin transporter linked polymorphic region) in the promoter of the serotonin transporter gene (SLC6A4) moderates cardiovascular reactivity to social threat. METHODS: Psychologically healthy young adults delivered a speech and performed mental arithmetic in one of three conditions: a) an evaluative audience condition that gave disapproving and negative nonverbal social signals (n = 59); b) an evaluative audience condition that provided supportive social signals (n = 60); or c) a no audience condition (n = 65). Heart rate (HR) and systolic and diastolic blood pressures (DBP) were measured before, during, and after the stress tasks to assess cardiovascular reactivity and recovery. RESULTS: In the negative audience condition, there was a significant association between the 5-HTTLPR and systolic blood pressure, DBP, and HR reactivity. Individuals with the short/short genotype showed the greatest reactivity. The DBP and HR reactivity of short/short individuals in the negative audience condition was also greater than that of individuals with the short/short genotype in the no audience condition. These associations of the 5-HTLPR with HR reactivity were moderated by gender, being limited to females. With respect to cardiovascular recovery, short/short individuals in the negative audience condition exhibited impaired DBP recovery relative to other genotypes in the same condition, as well as short/short individuals in the no audience condition. CONCLUSIONS: The 5-HTTLPR moderates cardiovascular reactivity to stress in a threatening evaluative social context, which suggests that the serotonin system may be involved in the processes by which stressful, conflict-ridden social environments affect risk for cardiovascular-related health outcomes
Biology · Blood pressure · Context (archaeology) · Developmental psychology · Gene · Genotype · Heart rate · Psychiatry · Psychosocial · Reactivity (psychology) · Serotonin transporter · Clinical Psychology · Genetics · Heart Rate Variability and Autonomic Control · Internal Medicine · Medicine · Neurotransmitter Receptor Influence on Behavior · Psychology · Stress Responses and Cortisol
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| Unique citing works | 3 |
|---|---|
| Citations per year | 0,23 |
| Citation span | 2013 - 2014 (2) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 2 |