Long-Acting HIV Pre-exposure Prophylaxis Preferences Through Pregnancy and the Postpartum Period Among Women in Kenya

A Latent Transition Analysis

Bibliographic Data

ID21651424
AuthorsTessa Concepcion (0000-0003-2180-3534, University of Washington, corresponding author), Salphine Watoyi (0000-0002-9085-1663, Kenyatta National Hospital), Brian Flaherty (0000-0002-8369-9851, University of Washington), Felix Otieno (0000-0003-0257-2160, Kenyatta National Hospital), Eunita Akim (0000-0001-7914-7328, Kenyatta National Hospital), Laurén Gómez (0000-0003-2731-0781, University of Washington), Grace John‐Stewart (0000-0002-4301-1573, University of Washington), Emmaculate M Nzove (0009-0001-1259-4884, Kenyatta National Hospital), Nancy Ngumbau (0000-0003-4176-5950, Kenyatta National Hospital), Jerusha N Mogaka (0000-0001-9913-9034, University of Washington), Ben Odhiambo (0000-0002-9802-1648, Kenyatta National Hospital), Anjuli D Wagner (0000-0002-5851-1220, University of Washington), John Kinuthia (0000-0001-6571-8927, Kenyatta National Hospital), Jillian Pintye (0000-0003-1255-7191, University of Washington)
Year2026
Publication date2026-06-29
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAIDS and Behavior (JOURNAL)
Journal identifiersISSN: 1090-7165 • E-ISSN: 1573-3254
PublisherSpringer Science and Business Media LLC (PUBLISHER)
DOI10.1007/s10461-026-05197-0
PMID42371241
OpenAlexW7166438565
LanguageEN
References cited32

Adherence to daily oral HIV PrEP wanes over pregnancy and postpartum and new long-acting injectable HIV PrEP (LAI-PrEP) methods may address barriers to effective use. Understanding changing LAI-PrEP preferences during the perinatal period could inform the integration into maternal healthcare. We used data from a randomized trial of pregnant women initiating daily oral HIV PrEP at five public maternal child health facilities in western Kenya, followed through 9 months postpartum (NCT04472884). Participants completed surveys on LAI-PrEP interest from the third trimester through postpartum. Latent Transition Analysis (LTA) examined underlying patterns of LAI-PrEP interest. Predictors of transitions between statuses were assessed using univariate logistic regression. Overall, 598 pregnant women were enrolled (median age: 25 years). We identified three preferences statuses: “No interest in LAI-PrEP”, “Willing to pay (WTP) for LAI-PrEP”, and “Prefers free LAI-PrEP”. About 10% comprised the “No interest in LAI-PrEP” at each time point. In pregnancy, 36.8% belonged to the “Prefers free LAI-PrEP” status, with participants increasingly transitioning to “WTP for LAI-PrEP” through the postpartum period. The “WTP for LAI-PrEP” status grew from 53.2% in third trimester to 76.6% at nine months postpartum, however women who were primigravida had 5-fold higher odds of transitioning out of “WTP for LAI-PrEP” to “Prefers free LAI-PrEP” (95% CI: 5.29–5.39, p ClinicalTrials.gov registration number : NCT04472884

Health psychology · Human immunodeficiency virus (HIV) · Logistic regression · Odds · Odds ratio · Postpartum period · Pregnancy · Public health · HIV Research and Treatment · HIV, Drug Use, Sexual Risk · HIV/AIDS Research and Interventions