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Race, Age, and Allostatic Load Among Men in the Nashville Stress and Health Study

Bibliographic Data

ID21748780
AuthorsRoland J Thorpe (0000-0002-4448-4997, Johns Hopkins University, corresponding author), Angela Gutierrez (0009-0003-6388-5184, Western University of Health Sciences), Paul Archibald (0000-0002-2826-5292, College of Staten Island), Amy Thierry (0000-0002-6247-977X, Xavier University of Louisiana), Amy D Thierry (Xavier University of Louisiana), M A Bruce (0000-0002-0643-1640, University of Houston), Corina Mills (0009-0006-5859-1327, Johns Hopkins University), Keith Norris (University of California, Los Angeles), Courtney S Thomas Tobin (0000-0002-8018-0843, University of California, Los Angeles)
Year2025
Volume19
Issue1
Pages15579883251317095-15579883251317095
Publication date2025-01-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Men s Health (JOURNAL)
Journal identifiersISSN: 1557-9883 • E-ISSN: 1557-9891
PublisherSAGE Publications (PUBLISHER • US)
DOI10.1177/15579883251317095
PMID39953836
OpenAlexW4407605931
LanguageEN
References cited45

High allostatic load (AL), a measure of physiological dysregulation, has been linked with premature morbidity and mortality. There is a paucity of research assessing AL among non-Hispanic Black (NHB) and non-Hispanic White (NHW) American men of various age groups. This study investigated racial differences in AL among NHB and NHW adult men and assessed whether racial differences in AL varied by age. Data were drawn from NHB ( n = 232) and NHW ( n = 246) men in the Nashville Stress and Health Study. AL was based on the sum of 10 biomarkers that was dichotomized as high AL (four or more high-risk biomarkers) or low AL (fewer than four high-risk biomarkers). Modified Poisson regression models were estimated to assess race differences in AL, adjusting for age, socioeconomic status (SES), and health behaviors. Interactions assessed whether racial differences in AL varied between young (22–49 years) and older (50–69) men. NHB men had a higher prevalence of being in the high AL group (prevalence ratio [PR] = 1.54, confidence interval [CI] = [1.09, 2.18]), relative to NHW men in the total sample. Among young men ages 22 to 49 years, NHB men had a higher prevalence of being in the high AL group (PR = 2.09, CI = [1.25, 3.49]), relative to NHW men. Among older men ages 50 to 69 years, there were no racial differences in AL. Findings underscore the importance of identifying factors that are associated with high AL, which is critical to mitigate premature morbidity and mortality, among NHB men

Allostatic load · Confidence interval · Environmental health · Poisson regression · Population · Socioeconomic status · Young adult · Demography · Health disparities and outcomes · Health, psychology, and well-being · Medicine · Stress Responses and Cortisol · Gerontology · Internal Medicine

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