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Excess Mortality in Italy During the Covid-19 Pandemic

Assessing the Differences Between the First and the Second Wave, Year 2020

Bibliographic Data

ID22082001
AuthorsMaria Dorrucci (0000-0002-8543-6430, Istituto Superiore di Sanità, corresponding author), Giada Minelli (0000-0002-2752-9989, Istituto Superiore di Sanità), Stefano Boros (0000-0003-2521-0883, Istituto Superiore di Sanità), Valerio Manno (0000-0003-0382-5940, Istituto Superiore di Sanità), Sabrina Prati (0000-0003-0849-1775, Istituto Nazionale di Statistica), Marco Battaglini (0000-0001-9690-0721, Istituto Nazionale di Statistica), Gianni Corsetti (Istituto Nazionale di Statistica), Xanthi Andrianou (0000-0002-2906-5743, Istituto Superiore di Sanità), Flavia Riccardo (0000-0002-1582-6329, Istituto Superiore di Sanità), Massimo Fabiani (0000-0002-5893-7117, Istituto Superiore di Sanità), Maria Fenicia Vescio (0000-0002-3285-919X, Istituto Superiore di Sanità), Matteo Spuri (0000-0002-1483-5303, Istituto Superiore di Sanità), Alberto Mateo‐Urdiales (0000-0002-0480-8723, Istituto Superiore di Sanità), Alberto Mateo Urdiales, Del Manso Martina (Istituto Superiore di Sanità), Graziano Onder (0000-0003-3400-4491, Istituto Superiore di Sanità), Patrizio Pezzotti (0000-0002-0805-2927, Istituto Superiore di Sanità), Antonino Bella (0000-0002-6615-4227, Istituto Superiore di Sanità)
Year2021
Volume9
Pages669209-669209
Publication date2021-07-16
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2021.669209
PMID34336767
OpenAlexW3186154091
LanguageEN
Citations received15
References cited10

COVID-19 dramatically influenced mortality worldwide, in Italy as well, the first European country to experience the Sars-Cov2 epidemic. Many countries reported a two-wave pattern of COVID-19 deaths; however, studies comparing the two waves are limited. The objective of the study was to compare all-cause excess mortality between the two waves that occurred during the year 2020 using nationwide data. All-cause excess mortalities were estimated using negative binomial models with time modeled by quadratic splines. The models were also applied to estimate all-cause excess deaths “not directly attributable to COVD-19”, i.e., without a previous COVID-19 diagnosis. During the first wave (25th February−31st May), we estimated 52,437 excess deaths (95% CI: 49,213–55,863) and 50,979 (95% CI: 50,333–51,425) during the second phase (10th October−31st December), corresponding to percentage 34.8% (95% CI: 33.8%–35.8%) in the second wave and 31.0% (95%CI: 27.2%–35.4%) in the first. During both waves, all-cause excess deaths percentages were higher in northern regions (59.1% during the first and 42.2% in the second wave), with a significant increase in the rest of Italy (from 6.7% to 27.1%) during the second wave. Males and those aged 80 or over were the most hit groups with an increase in both during the second wave. Excess deaths not directly attributable to COVID-19 decreased during the second phase with respect to the first phase, from 10.8% (95% CI: 9.5%–12.4%) to 7.7% (95% CI: 7.5%–7.9%), respectively. The percentage increase in excess deaths from all causes suggests in Italy a different impact of the SARS-CoV-2 virus during the second wave in 2020. The decrease in excess deaths not directly attributable to COVID-19 may indicate an improvement in the preparedness of the Italian health care services during this second wave, in the detection of COVID-19 diagnoses and/or clinical practice toward the other severe diseases

Disease · Excess mortality · Pandemic · Population · Climate Change and Health Impacts · COVID-19 and healthcare impacts · COVID-19 Clinical Research Studies · Demography · Medicine · Internal Medicine

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Unique citing works15
Citations per year3,75
Citation span2022 - 2025 (4)
Citation velocityrecent
Highly citedNo
Citation typesNeutral: 12
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