The effect of insulin resistance in the association between obesity and hypertension incidence among Chinese middle-aged and older adults

Data from China health and retirement longitudinal study (CHARLS)

Bibliographic Data

ID22088641
AuthorsZe‐Jiaxin Niu (First Affiliated Hospital of Xi'an Jiaotong University), Ze-Jiaxin Niu, Ying Cui (0000-0003-3685-2582), Tian Wei (0000-0002-9588-2004, First Affiliated Hospital of Xi'an Jiaotong University), Meng Dou (0000-0002-5546-043X, First Affiliated Hospital of Xi'an Jiaotong University), Bing-Xuan Zheng (First Affiliated Hospital of Xi'an Jiaotong University), Ge Deng (First Affiliated Hospital of Xi'an Jiaotong University), Pu-Xun Tian, Puxun Tian (0000-0002-7175-9175, First Affiliated Hospital of Xi'an Jiaotong University, corresponding author), Yang Wang (0009-0007-0551-9820, First Affiliated Hospital of Xi'an Jiaotong University, corresponding author)
Year2024
Volume12
Pages1320918-1320918
Publication date2024-02-13
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Public Health (JOURNAL)
Journal identifiersISSN: 2296-2565 • E-ISSN: 2296-2565
PublisherFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2024.1320918
PMID38414903
OpenAlexW4391774441
LanguageEN
Citations received1
References cited55

Background and aims: Obesity and insulin resistance are well-known important risk factors for hypertension. This study aimed to investigate the mediating effect of the triglyceride-glucose index (TyG) in the association between Chinese visceral obesity index (CVAI) and hypertension among Chinese middle-aged and older adults. Methods: A total of 10,322 participants aged 45 years and older from CHARLS (2011-2018) were included. Baseline data were collected in 2011 and hypertension incidence data were gathered during follow-up in 2013, 2015 and 2018. Multivariate logistic regression models were constructed to investigate the association of CVAI and TyG with the incidence of hypertension. Additionally, mediation analyses were conducted to evaluate the mediating role of the TyG index in the relationship between CVAI and hypertension. Subgroup analysis was also performed. Results: A total of 2,802 participants developed hypertension during the follow-up period. CVAI and TyG index were independently and significantly associated with hypertension incidence. Increasing quartiles of CVAI and TyG index were associated with high hypertension incidence in middle-aged and older adults. The TyG index was identified as a mediator in the relationship between CVAI and hypertension incidence, with a mediation effect (95% confidence interval) was 12.38% (6.75, 31.81%). Conclusion: Our study found that CVAI and TyG were independently associated with hypertension incidence. TyG played a partial mediating effect in the positive association between CVAI and hypertension incidence

Blood pressure · Body mass index · China · Chinese people · Confidence interval · Diabetes mellitus · Insulin resistance · Logistic regression · Longitudinal study · Mediation · Obesity · Prehypertension · Quartile · Adipokines, Inflammation, and Metabolic Diseases · Bariatric Surgery and Outcomes · Diabetes, Cardiovascular Risks, and Lipoproteins · Medicine · Endocrinology · Internal Medicine