Genetic Interactions with Prenatal Social Environment
Effects on Academic and Behavioral Outcomes
Bibliographic Data
| ID | 2316456 |
|---|---|
| Authors | D Conley (0000-0002-5174-7222, New York University, corresponding author), E Rauscher (0000-0002-5384-4667, University of Kansas) |
| Year | 2013 |
| Volume | 54 |
| Issue | 1 |
| Pages | 109-127 |
| Publication date | 2013-03-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Health and Social Behavior (JOURNAL) |
| Journal identifiers | ISSN: 0022-1465 • E-ISSN: 2150-6000 |
| Publisher | SAGE Publications Inc (PUBLISHER) |
| DOI | 10.1177/0022146512473758 |
| PMID | 23475742 |
| OpenAlex | W2163766829 |
| Language | EN |
| Citations received | 24 |
| References cited | 47 |
Numerous studies report gene-environment interactions, suggesting that specific alleles have different effects on social outcomes depending on environment. In all these studies, however, environmental conditions are potentially endogenous to unmeasured genetic characteristics. That is, it could be that the observed interaction effects actually reflect underlying genetic tendencies that lead individuals into certain environments. What is critical to move this literature forward is random environmental variation that we know is not correlated with innate characteristics of subjects. We exploit a natural experiment that randomizes a particular stressor-birth weight discordance within twin pairs-to address this challenge and ask: Do random differences in early environment (prenatal nutrition) moderate genetic effects on depression, delinquency, or GPA? Using Add Health data, the only consistently significant allele-birth weight interaction we reveal works in the opposite direction of Caspi et al.'s classic finding regarding the interaction of maltreatment with genetic variation in the serotonin transporter promoter. Less robust interactions found for DRD2 and MAOA are consistent with this pattern that reverses prior findings. These results do not necessarily overturn existing research but support our methodological point that gene-environment research must address endogeneity
Allele · Behavioural genetics · Biology · Developmental psychology · Econometrics · Economics · Endogeneity · Gene · Gene–environment interaction · Heritability · Stressor · Twin study · Birth, Development, and Health · Child and Adolescent Psychosocial and Emotional Development · Clinical Psychology · Cognitive Abilities and Testing · Genetics · Psychology
Enhancing the Gene-Environment Interaction Framework Through a Quasi-Experimental Research Design
Beyond Orchids and Dandelions
Critical Need for Family-Based, Quasi-Experimental Designs in Integrating Genetic and Social Science Research
The Challenge of Causal Inference in Gene–Environment Interaction Research
Genetics and Sociologya
Does education attenuate the genetic risk of obesity? Evidence from U.K. Twins
Interactive effects of in utero nutrition and genetic inheritance on cognition
Gene-Environment Complementarity in Educational Attainment
Sociology and evolutionary biology
Status Attainment and Social Mobility
Biology and American Sociology, Part II
The Genetics of Political Participation
Persistent Inequalities
The Long Arm of Adolescence
Can education rescue genetic liability for cognitive decline
Education, Smoking, and Cohort Change
The Emergence of Socio-Genomics
Socio-Genomic Research Using Genome-Wide Molecular Data
Exploring the Fetal Origins Hypothesis Using Genetic Data
Peer Influence, Genetic Propensity, and Binge Drinking
Genetic architecture of socioeconomic outcomes
Plastic and immobile
Opportunities and challenges of big data for the social sciences
Sibling genes as environment
Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976
Genetic Sensitivity to the Environment
Abnormal Behavior Associated with a Point Mutation in the Structural Gene for Monoamine Oxidase A
Outcomes in Young Adulthood for Very-Low-Birth-Weight Infants
Principal components analysis corrects for stratification in genome-wide association studies
Screening for Adolescent Depression
Role of Genotype in the Cycle of Violence in Maltreated Children
Influence of Life Stress on Depression
Biological Sensitivity to Context
Maoa, maltreatment, and gene–environment interaction predicting children's mental health
The Abuse of Power
The National Longitudinal Study of Adolescent Health (Add Health) Twin Data
Returns to Birthweight
Environmental Contingencies and Genetic Propensities
Is Biology Destiny? Birth Weight and Life Chances
The Integration of Genetic Propensities into Social-Control Models of Delinquency and Violence among Male Youths
The Social Influences on the Realization of Genetic Potential for Intellectual Development
Birth Weight and Income
Under the Influence of Genetics
| Unique citing works | 24 |
|---|---|
| Citations per year | 1,85 |
| Citation span | 2013 - 2026 (14) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 20 |