Neuroscience, Molecular Biology, and the Childhood Roots of Health Disparities
Building a New Framework for Health Promotion and Disease Prevention
Bibliographic Data
| ID | 23316137 |
|---|---|
| Authors | Jack P Shonkoff (Harvard University), W Thomas Boyce (University of British Columbia), Bruce S Mcewen (0000-0002-5288-7892, Rockefeller University) |
| Year | 2009 |
| Volume | 301 |
| Issue | 21 |
| Pages | 2252 |
| Publication date | 2009-06-03 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | JAMA (JOURNAL) |
| Journal identifiers | ISSN: 0098-7484 • E-ISSN: 1538-3598 |
| Publisher | American Medical Association (AMA) (PUBLISHER) |
| DOI | 10.1001/jama.2009.754 |
| PMID | 19491187 |
| OpenAlex | W2073537354 |
| Language | EN |
| Citations received | 414 |
| References cited | 45 |
A scientific consensus is emerging that the origins of adult disease are often found among developmental and biological disruptions occurring during the early years of life. These early experiences can affect adult health in 2 ways--either by cumulative damage over time or by the biological embedding of adversities during sensitive developmental periods. In both cases, there can be a lag of many years, even decades, before early adverse experiences are expressed in the form of disease. From both basic research and policy perspectives, confronting the origins of disparities in physical and mental health early in life may produce greater effects than attempting to modify health-related behaviors or improve access to health care in adulthood.
Affect (linguistics) · Developmental psychology · Disease · Early childhood · Mental health · Pathology · Psychiatry · Birth, Development, and Health · Child and Adolescent Health · Early Childhood Education and Development · Medicine · Psychology · Gerontology
Life Course Neighborhood Socioeconomic Disadvantage and Chronic Disease Accumulation in Mid- to Late Adulthood
Stress Processes and Resilience Pathways of Sexually and Gender Diverse Communities
A técnica da distração no alívio da dor em crianças hospitalizadas
Medical-Legal Partnerships
Health and Self-Regulation among School-Age Children Experiencing Family Homelessness
The effects of economic and sociocultural stressors on the well-being of children of Latino immigrants living in poverty
Variations in links between educational success and health
Commentary
Reducción de la desnutrición crónica en las bases biosociales para la promoción de la salud y el desarrollo
Understanding associations among race, socioeconomic status, and health
An evaluation of welfare and child welfare system integration on rates of child maltreatment in Colorado
Challenges in studying the interplay of genes and environment. A study of childhood financial distress moderating genetic predisposition for peak smoking
Cumulative risk and child development
The evolutionary basis of risky adolescent behavior
Children rectify inequalities for disadvantaged groups
Enhancing cognitive and social–emotional development through a simple-to-administer mindfulness-based school program for elementary school children
Cumulative socioeconomic status risk, allostatic load, and adjustment
A new life-span approach to conscientiousness and health
Physical punishment as a predictor of early cognitive development
The long arm of childhood
Maternal scaffolding and home stimulation
Linking typologies of childhood adversity to adult incarceration
Mediating and moderating effects of social support in the study of child abuse and adult physical and mental health
The psychosocial impact of detention and deportation on U.S. Migrant children and families
Predictors of maternal depressive symptom trajectories over the first 18 months in home visiting
Long-term effects of a community-based positive youth development program for Black youth
Rigorous evaluation of a substance use and teen pregnancy prevention program for American Indian girls and their female caregivers
The impact of the social environment on children's mental health in a prosperous city
The Building Blocks Collaborative
Evaluation of Community Programs for Early Childhood Development
Cardiovascular Health at the Intersection of Race and Gender
Residential Mobility and Adolescent Achievement and Behavior
Attentional Bias for Academic Stressors and Classroom Climate Predict Adolescents’ Grades and Socioemotional Functioning
Preface
Social and Emotional Development in Infancy
The Developmental Psychobiology of Stress and Emotion in Childhood
Health Psychology
Adverse Childhood Experiences and Child Health in Early Adolescence
Violence, Crime, and Abuse Exposure in a National Sample of Children and Youth
Improving the Adverse Childhood Experiences Study Scale
Annual Research Review
Science Does Not Speak for Itself
The Effects of Parental Undocumented Status on the Developmental Contexts of Young Children in Immigrant Families
Beyond Risk and Protective Factors
Adverse childhood experiences and trauma informed care
Adverse Childhood Experiences of Low-Income Urban Youth
Developmental histories of perceived racial discrimination and diurnal cortisol profiles in adulthood
Is Resilience Only Skin Deep?
What is Resilience?
Nurturing Mindfulness in Children and Youth
Measuring mortality and the burden of adult disease associated with adverse childhood experiences in England
Building a New Biodevelopmental Framework to Guide the Future of Early Childhood Policy
Prevalence of adverse childhood experiences (ACEs) among US children
Midlife as a pivotal period in the life course
The burden of child maltreatment in China
Early Childhood Adversity, Toxic Stress, and the Role of the Pediatrician
Early Childhood Adversity, Toxic Stress, and the Impacts of Racism on the Foundations of Health
Allostatic Load and Its Impact on Health
Socioeconomic status and executive function
Social influences on neuroplasticity
Childhood Poverty, Cumulative Risk Exposure, and Mental Health in Emerging Adults
Effects of Poly-Victimization on Adolescent Social Support, Self-Concept, and Psychological Distress
Cumulative Neighborhood Risk of Psychosocial Stress and Allostatic Load in Adolescents
Rethinking minority stress
Annual Research Review
Child and adolescent mental health worldwide
Adverse childhood experiences, allostasis, allostatic load, and age-related disease
The Resilience Activation Framework
Social vulnerabilities for substance use
Consequences of bullying victimization in childhood and adolescence
Resilience and protective factors among people with a history of child maltreatment
Poverty and Health
Long-term Physical Health Consequences of Childhood Sexual Abuse
The Emerging Field of Human Social Genomics
Racial Disparities in Child Adversity in the U.S.
Allostatic load biomarkers of chronic stress and impact on health and cognition
Child Development in the Context of Disaster, War, and Terrorism
Toxic Stress in Children and Adolescents
Systematic review of pediatric health outcomes associated with childhood adversity
Early-Life Adversity and Physical and Emotional Health Across the Lifespan
Methods to Assess Adverse Childhood Experiences of Children and Families
The Neuroscience of Socioeconomic Status
Linear Growth and Child Development in Low- and Middle-Income Countries
An Integrated Scientific Framework for Child Survival and Early Childhood Development
Effects of childhood poverty and chronic stress on emotion regulatory brain function in adulthood
Evaluating Strategies For Reducing Health Disparities By Addressing The Social Determinants Of Health
Childhood adversity and the risk of substance use and delinquency
Feasibility and Preliminary Outcomes of a School-Based Mindfulness Intervention for Urban Youth
Childhood Maltreatment Predicts Unfavorable Course of Illness and Treatment Outcome in Depression
Best Practices in Conceptualizing and Measuring Social Class in Psychological Research
Social Determinants of Risk and Outcomes for Cardiovascular Disease
Death of family members as an overlooked source of racial disadvantage in the United States
Childhood Adversity and Adult Chronic Disease
Life course pathways of adverse childhood experiences toward adult psychological well-being
Annual Research Review
Resilience Processes in Development
Building a Framework for Global Surveillance of the Public Health Implications of Adverse Childhood Experiences
Socioeconomic status and the brain
Leveraging the biology of adversity to address the roots of disparities in health and development
The Long-Term Health Consequences of Child Physical Abuse, Emotional Abuse, and Neglect
From Neurons to Neighborhoods
A Life Course Approach to Chronic Disease Epidemiology
The neurobiology of stress
Relationship Between Multiple Forms of Childhood Maltreatment and Adult Mental Health in Community Respondents
Poverty and obesity
Preschool and Child Care Expulsion and Suspension
Trends in the Black-White Life Expectancy Gap in the United States, 1983-2003
Physiology and Neurobiology of Stress and Adaptation
Gene–environment interplay and psychopathology
Childhood poverty
Childhood maltreatment predicts adult inflammation in a life-course study
Weight in Infancy and Death From Ischaemic Heart Disease
Role of Genotype in the Cycle of Violence in Maltreated Children
The Role of Chaos in Poverty and Children's Socioemotional Adjustment
Influence of Life Stress on Depression
Continuities and discontinuities in psychopathology between childhood and adult life
Socially Isolated Children 20 Years Later
Early growth and coronary heart disease in later life
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
The Victimization of Children and Youth
Trajectories of Growth among Children Who Have Coronary Events as Adults
The fetal and infant origins of adult disease.
Insights Into Causal Pathways for Ischemic Heart Disease
Developmental plasticity and human health
The Association Between Adverse Childhood Experiences and Adolescent Pregnancy, Long-Term Psychosocial Consequences, and Fetal Death
Epigenetic programming by maternal behavior
Adverse childhood experiences and the risk of depressive disorders in adulthood
Childhood Poverty and Health
Socioeconomic Status and Chronic Stress
Conceptual Issues in Studies of Resilience
Socioeconomic Inequalities in Health in 22 European Countries
The enduring effects of abuse and related adverse experiences in childhood
Protective and Damaging Effects of Stress Mediators
Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults
Social determinants of health inequalities
Discrimination and racial disparities in health
Closing the gap in a generation
Meaningful Differences in the Everyday Experience of Young American Children
Life history and the early origins of health differentials
Adverse childhood experiences and mental health in young adults
Weathering” and Age Patterns of Allostatic Load Scores Among Blacks and Whites in the United States
The Environment of Childhood Poverty
Black/white differences in the relationship of maternal age to birthweight
Prevention as cumulative protection
The Impact of Childhood Abuse and Neglect on Adult Mental Health
| Unique citing works | 414 |
|---|---|
| Citations per year | 25,88 |
| Citation span | 2010 - 2026 (17) |
| Citation velocity | current |
| Highly cited | Yes |
| Citation types | Neutral: 389 |