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Factors Affecting Adherence to Antiretroviral Therapy

Bibliographic Data

ID23338659
AuthorsMargaret A Chesney (0000-0001-6038-3486, University of California, San Francisco, corresponding author)
Year2000
Volume30
IssueSupplement_2
PagesS171-S176
Publication date2000-06-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueClinical Infectious Diseases (JOURNAL)
Journal identifiersISSN: 1058-4838 • E-ISSN: 1537-6591
PublisherOxford University Press (OUP) (PUBLISHER)
DOI10.1086/313849
PMID10860902
OpenAlexW2043390279
LanguageEN
Citations received63
References cited5

In both clinical trials and clinical practice, nonadherence to medications is widespread among patients with chronic diseases. The shift to combination therapies for treating human immunodeficiency virus (HIV)-infected individuals has increased adherence challenges for both patients and health-care providers. Estimates of average rates of nonadherence to antiretroviral therapy range from 50% to 70%. Adherence rates of <80% are associated with detectable viremia in a majority of patients. The principal factors associated with nonadherence appear to be patient-related, including substance and alcohol abuse. However, other factors may also contribute, such as inconvenient dosing frequency, dietary restrictions, pill burden, and side effects; patient-health-care provider relationships; and the system of care. We discuss the major reasons reported by HIV-infected individuals for not taking their medications. Improving adherence probably requires clarifying the treatment regimen and tailoring it to patient lifestyles.

Antiretroviral therapy · Dosing · Family medicine · Health care · Human immunodeficiency virus (HIV) · Intensive care medicine · Pill · Regimen · Viral load · Viremia · HIV/AIDS drug development and treatment · HIV/AIDS Research and Interventions · Internal Medicine · LGBTQ Health, Identity, and Policy · Medicine · Nursing

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Unique citing works63
Citations per year2,63
Citation span2002 - 2026 (25)
Citation velocitycurrent
Highly citedNo
Citation typesNeutral: 59
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