Survival of HIV-positive patients starting antiretroviral therapy between 1996 and 2013
A collaborative analysis of cohort studies
Bibliographic Data
| ID | 23356299 |
|---|---|
| Authors | Adam Trickey (0000-0003-3462-2898), Margaret May (0000-0002-9733-1003), MARGARET T MAY, Jorg-Janne Vehreschild, Jörg Janne Vehreschild (0000-0002-5446-7170), Niels Obel (0000-0002-5031-0045, Institute of Clinical Research), M John Gill (0000-0002-8546-8790), Heidi M Crane (0000-0002-3308-7005), Christoph Boesecke (0000-0003-0686-6537), Sophie Patterson (0000-0002-5503-7447), Sophie Grabar (0000-0002-4816-4261), Charles Cazanave (0000-0002-4613-3963), Matthias Cavassini (0000-0003-0933-7833), Leah Shepherd (0000-0002-8227-830X), Antonella d’Arminio Monforte (0000-0003-0073-1789), Ard van Sighem (0000-0002-6656-0516), M S Saag, Mike Saag, Fiona Lampe (0000-0001-6851-5471), Vicky Hernando, Marta Montero (0000-0002-3432-5394), Robert Zangerle (0000-0002-5375-7299), Amy C Justice (0000-0003-0139-5502), Timothy R Sterling (0000-0002-4822-6979), Timothy Sterling, Suzanne M Ingle (0000-0003-3057-6636), Jonathan Sterne (0000-0001-8496-6053) |
| Year | 2017 |
| Volume | 4 |
| Issue | 8 |
| Pages | e349-e356 |
| Publication date | 2017-08-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | The Lancet HIV (JOURNAL) |
| Journal identifiers | ISSN: 2352-3018 • E-ISSN: 2405-4704 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/s2352-3018(17)30066-8 |
| PMID | 28501495 |
| OpenAlex | W2614048460 |
| Language | EN |
| Citations received | 63 |
| References cited | 25 |
BACKGROUND: Health care for people living with HIV has improved substantially in the past two decades. Robust estimates of how these improvements have affected prognosis and life expectancy are of utmost importance to patients, clinicians, and health-care planners. We examined changes in 3 year survival and life expectancy of patients starting combination antiretroviral therapy (ART) between 1996 and 2013. METHODS: We analysed data from 18 European and North American HIV-1 cohorts. Patients (aged ≥16 years) were eligible for this analysis if they had started ART with three or more drugs between 1996 and 2010 and had at least 3 years of potential follow-up. We estimated adjusted (for age, sex, AIDS, risk group, CD4 cell count, and HIV-1 RNA at start of ART) all-cause and cause-specific mortality hazard ratios (HRs) for the first year after ART initiation and the second and third years after ART initiation in four calendar periods (1996-99, 2000-03 [comparator], 2004-07, 2008-10). We estimated life expectancy by calendar period of initiation of ART. FINDINGS: 88 504 patients were included in our analyses, of whom 2106 died during the first year of ART and 2302 died during the second or third year of ART. Patients starting ART in 2008-10 had lower all-cause mortality in the first year after ART initiation than did patients starting ART in 2000-03 (adjusted HR 0·71, 95% CI 0·61-0·83). All-cause mortality in the second and third years after initiation of ART was also lower in patients who started ART in 2008-10 than in those who started in 2000-03 (0·57, 0·49-0·67); this decrease was not fully explained by viral load and CD4 cell count at 1 year. Rates of non-AIDS deaths were lower in patients who started ART in 2008-10 (vs 2000-03) in the first year (0·48, 0·34-0·67) and second and third years (0·29, 0·21-0·40) after initiation of ART. Between 1996 and 2010, life expectancy in 20-year-old patients starting ART increased by about 9 years in women and 10 years in men. INTERPRETATION: Even in the late ART era, survival during the first 3 years of ART continues to improve, which probably reflects transition to less toxic antiretroviral drugs, improved adherence, prophylactic measures, and management of comorbidity. Prognostic models and life expectancy estimates should be updated to account for these improvements. FUNDING: UK Medical Research Council, UK Department for International Development, EU EDCTP2 programme.
Antiretroviral therapy · Cohort · Cohort study · Family medicine · Human immunodeficiency virus (HIV) · MEDLINE · Viral load · HIV-related health complications and treatments · HIV/AIDS drug development and treatment · HIV/AIDS Research and Interventions · Internal Medicine · Medicine
Well-being in people with HIV after one year of long-acting cabotegravir and rilpivirine
Exploring core mental health symptoms among persons living with HIV
Barriers and Facilitators of Smoking Cessation among Latinos Living with HIV
The Effect of Cognitive-Behavioral Group Therapy Using Art as a Medium on Depressive Symptoms and HIV Antiretroviral Medication Adherence
Provider, researcher, and community perspectives on comorbidities affecting the health-related quality of life of people living with HIV in Spain
The Burden of Covid-19 in People Living with HIV
Noncommunicable disease burden among HIV patients in care
Hypertension control in integrated HIV and chronic disease clinics in Uganda in the SEARCH study
The HIV epidemic in Colombia
Survival times of HIV/Aids in different Aids Diagnostic and Treatment Guidelines from 2006 to 2020 in Liuzhou, China
Retracted
Hope level and associated factors among older people living with HIV/Aids
Behavioral intervention grounded in motivational interviewing and behavioral economics shows promise with Black and English-speaking Latino persons living with HIV with unsuppressed HIV viral load in New York City
Ability to Monitor National Responses to the HIV Epidemic “Beyond Viral Suppression”
Survival analysis and factors influencing survival time of adult HIV/Aids patients receiving antiretroviral therapy from 2012 to 2022 in Chongqing, China
The effectiveness and sustainability of peer support interventions for persons living with HIV
HIV and cardiovascular diseases
Cancer Incidence and Cancer Screening Practices Among a Cohort of Persons Receiving HIV Care in Washington, DC
Does educational expansion decrease suicide rates in European countries? The compositional effect in educational stratification of suicides
HIV Status and Antiretroviral Therapy as Predictors of Disability among Older South Africans
In Short, We Will Deport You’
The challenge of dealing with non-Aids comorbidities for people living with HIV
HIV and aging among adults aged 50 years and older on antiretroviral therapy in Eswatini
Perceived HIV-related stigma among university students in South Africa
Substance use and perceived barriers to antiretroviral therapy adherence among people living with HIV in Guangxi, China
Baseline and Process Factors of Anti-Retroviral Therapy That Predict Loss to Follow-up Among People Living with HIV/Aids in China
Reproductive Desires and Considerations of HIV-Positive Men in Heterosexual Relationships in New York City
Health Worker Perspectives on Barriers and Facilitators of Assisted Partner Notification for HIV for Refugees and Ugandan Nationals
Pilot Trial of a Transdiagnostic Cognitive Behavioral Therapy (CBT)-Based Group Intervention to Reduce Psychological Distress, Facilitate Positive Behavior Change, and Mitigate Inflammation in Older People with HIV
The Role of Religious Service Attendance, Psychosocial and Behavioral Determinants of Antiretroviral Therapy (ART) Adherence
Impaired Neurocognitive Performance and Mortality in HIV
Antiretroviral Adherence Trajectories Among Black Americans Living with HIV
Patterns of Cannabis Use among Women With HIV in the United States
Patient-Reported Outcomes After Switching to a 2-Drug Regimen of Fixed-Dose Combination Dolutegravir/Lamivudine
Intimate Partner Violence Experiences Among Men Living with HIV in Rural Appalachia
Drug Use Among Adolescents and Young Adults with Unsuppressed HIV Who Use Alcohol
Prevalence of and Time to Suboptimal Treatment Patterns Among People with HIV on Antiretroviral Therapy in the United States
HIV-positive migrants’ experience of living in Sweden
From activism to secrecy
Physical activity and quality of life in people living with HIV
Five-year survival analysis and predictors of death in HIV-positive serology patients attending the Military Hospital of Nampula, Mozambique
Association between diet quality, physical activity and anthropometric status of people living with HIV in Cape Town
Self-efficacy and HIV testing among Latino emerging adults
Longitudinal assessments of viral rebound among people with HIV in South Carolina
Economic and clinical burdens and associated health disparities in HIV/Aids management using big data
Sociodemographic and psychosocial predictors of longitudinal antiretroviral therapy (ART) adherence among first-time ART initiators in Cape Town, South Africa
Depression, social support, and stigma as predictors of quality of life over time
Association between frailty phenotype, quantification of plasma HIV-1 RNA, CD4 cell count and Haart in HIV-positive subjects
Hypertension burden, treatment, and control among people with HIV at a clinical care center in the Southeastern US, 2014–2019
Anxiety, depression and treatment adherence among HIV-infected migrants
Assessing psychological symptom networks related to HIV-positive duration among people living with HIV
Evaluation of spill-over effects of antiretroviral treatment on sharing injecting equipment in a sociometric network of people who inject drugs
Diet quality and nutritional status in people living with HIV on dolutegravir therapy
Assessing the individual benefits of reducing HIV diagnosis delay and increasing adherence to HIV care and treatment
The experience and management of HIV stigma among HIV-negative adults in heterosexual serodiscordant relationships in New York City
Prevalence and predictors of fatigue among people living with HIV in Norway
Prevalence of pain in women living with HIV aged 45–60
Perceived social support and associated factors in people living with HIV in Chiang Mai, Thailand
Factors associated with lack of care engagement among older, rural‐dwelling adults living with HIV in the United States
Racial Differences in the Effect of HIV Status on Motor and Pulmonary Function and Mobility Disability in Older Adults
Optimal Allocation of Societal HIV Prevention Resources to Reduce HIV Incidence in the United States
Forgetting to take HIV antiretroviral therapy
Mortality from Aids and tuberculosis-HIV coinfection in the Chilean Aids Cohort of 2000-2017
| Unique citing works | 63 |
|---|---|
| Citations per year | 7 |
| Citation span | 2017 - 2026 (10) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 59 |