High Prevalence of Obesity in Severe Acute Respiratory Syndrome Coronavirus‐2 (Sars‐CoV‐2) Requiring Invasive Mechanical Ventilation

Bibliographic Data

ID23356331
AuthorsArthur Simonnet (0000-0003-1529-3259, Centre Hospitalier Universitaire de Lille), Mikael Chetboun (0000-0001-9870-4310, Inserm), Julien Poissy (Centre Hospitalier Universitaire de Lille), Violeta Raverdy (0000-0001-5754-2028, Inserm), Jerome Noulette (0000-0002-8913-5053, Inserm), Alain Duhamel (0000-0003-0392-7701, Université de Lille), Julien Labreuche (0000-0002-3384-0423, Université de Lille), Daniel Mathieu (0000-0003-3538-7180, Centre Hospitalier Universitaire de Lille), François Pattou (0000-0001-8388-3766, Inserm, corresponding author), Merce Jourdain (0000-0001-9450-192X, Inserm, corresponding author)
Year2020
Volume28
Issue7
Pages1195-1199
Publication date2020-07-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueObesity (JOURNAL)
Journal identifiersISSN: 1930-7381 • E-ISSN: 1930-739X
PublisherWiley (PUBLISHER • GB)
DOI10.1002/oby.22831
PMID32271993
OpenAlexW3016182787
LanguageEN
Citations received71
References cited17

Objective The COVID‐19 pandemic is rapidly spreading worldwide, notably in Europe and North America where obesity is highly prevalent. The relation between obesity and severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) has not been fully documented. Methods This retrospective cohort study analyzed the relationship between clinical characteristics, including BMI, and the requirement for invasive mechanical ventilation (IMV) in 124 consecutive patients admitted in intensive care for SARS‐CoV‐2 in a single French center. Results Obesity (BMI > 30) and severe obesity (BMI > 35) were present in 47.6% and 28.2% of cases, respectively. Overall, 85 patients (68.6%) required IMV. The proportion of patients who required IMV increased with BMI categories ( P 35 (85.7%). In multivariate logistic regression, the need for IMV was significantly associated with male sex ( P 35 versus patients with BMI < 25 was 7.36 (1.63‐33.14; P = 0.02). Conclusions The present study showed a high frequency of obesity among patients admitted in intensive care for SARS‐CoV‐2. Disease severity increased with BMI. Obesity is a risk factor for SARS‐CoV‐2 severity, requiring increased attention to preventive measures in susceptible individuals.

Diabetes mellitus · Intensive care · Intensive care medicine · Logistic regression · Mechanical ventilation · Obesity · Odds ratio · Retrospective cohort study · COVID-19 Clinical Research Studies · Endocrinology · Internal Medicine · Long-Term Effects of COVID-19 · Medicine · Respiratory Support and Mechanisms