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Sex Differences in Insomnia

A Meta-Analysis

Bibliographic Data

ID23367269
AuthorsBin Zhang (0009-0002-1717-0375, Chinese University of Hong Kong), Yun Kwok Wing (0000-0002-5745-5474, Chinese University of Hong Kong), Yun-Kwok Wing
Year2006
Volume29
Issue1
Pages85-93
Publication date2006-01-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueSleep (JOURNAL)
Journal identifiersISSN: 0161-8105 • E-ISSN: 1550-9109
PublisherOxford University Press (OUP) (PUBLISHER)
DOI10.1093/sleep/29.1.85
PMID16453985
OpenAlexW2156263062
LanguageEN
Citations received89
References cited18

STUDY OBJECTIVE: Most but not all epidemiologic evidence suggests a female predisposition of insomnia. We applied meta-analytic methods to investigate sex differences in the risk of insomnia among the published epidemiologic studies. DESIGN: Meta-analysis with Comprehensive Meta-Analysis (Englewood, NJ); 9 different analyses were performed to investigate the sex difference of insomnia among different conditions. SETTING: A comprehensive search of the medical literature databases was performed to identify epidemiologic studies of insomnia. A rolling snowball method was also used. PARTICIPANTS: General population. INTERVENTIONS: N/A. RESULT: Thirty-one related papers were found, but 2 studies only reported the subtype prevalence of insomnia. All other studies (1,265,015 participants, female/male: 718,828/546,187) were included in the overall analysis of insomnia. A risk ratio of 1.41 [95% confidence interval: 1.28-1.55] for female versus male was found. The female excess in the risk of insomnia in large and quality studies was much higher than that of small and nonquality studies. The trend of female predisposition was consistent and progressive across age, with more significance in the elderly. The use of various criteria and frequency and duration of insomnia did not influence the predisposition of female in the risk of developing insomnia. Although obvious female excess in the risk of insomnia exists among different regions, there was a relatively lower female excess in East Asia. CONCLUSION: This meta-analysis confirmed a female predisposition of insomnia. Further studies will be needed to examine the roles of different factors in leading to the sex difference of insomnia.

Confidence interval · Environmental health · Insomnia · Meta-analysis · Population · Primary Insomnia · Psychiatry · Sleep disorder · Internal Medicine · Medicine · Sleep and related disorders · Sleep and Wakefulness Research · Sleep and Work-Related Fatigue

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Unique citing works89
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