Applying CFIR to assess multi-level barriers to PrEP delivery in rural South Africa

Processes, gaps and opportunities for service delivery of current and future PrEP modalities

Bibliographic Data

ID4602223
AuthorsDeborah Baron (0000-0001-5439-2538), Hannah H Leslie (0000-0002-7464-3645, New School), Denny Mabetha (0000-0001-8062-4750, Agincourt Health and Socio-Demographic Surveillance System), Nozipho Becker (0000-0002-1780-7682, Colorado State University), Kathleen Kahn (0000-0003-3339-3931, Agincourt Health and Socio-Demographic Surveillance System), Sheri A Lippman (0000-0003-3152-9372, New School)
Year2024
Volume361
Pages117370
Publication date2024-11-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueSocial Science & Medicine (JOURNAL)
Journal identifiersISSN: 0277-9536 • E-ISSN: 1873-5347
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.socscimed.2024.117370
PMID39366151
OpenAlexW4402878969
LanguageEN
Citations received6
References cited35

Despite established efficacy for oral pre-exposure prophylaxis (PrEP) in reducing HIV incidence, multi-level barriers within the health system, clinics, and the processes that shape practice have hindered service delivery and subsequent population-level effects. We applied the Consolidated Framework for Implementation Research (CFIR) to assess the context of PrEP delivery for adolescent girls and young women (AGYW) in rural South Africa and identify the factors supporting and impeding PrEP implementation to develop strategies to improve PrEP delivery. Between 2021 and 2022, we conducted in-depth interviews with five young women with PrEP use experience and 11 healthcare providers as well as four key informant stakeholder interviews. Tailored interviews organized around the CFIR domains provided multiple perspectives on the inter-connected processes, gaps, and opportunities between health systems, clinics, communities, and PrEP services. Shifts in PrEP policies, funding pressures, and inconsistent communications from the National Department of Health spurred fragmented planning, engagement, execution, and monitoring of PrEP delivery processes within clinics already struggling to address multiple population health needs. Resulting challenges included: conflicting priorities within clinics and across NGO partners, unclear goals and targets, staffing and space constraints, and insufficient community engagement. Individual clinics' implementation climate and readiness to deliver PrEP varied in terms of operational plans and delivery models. Interviewees reported complexity of initiation procedures and support for PrEP maintenance, with opportunities to improve systems communications and processes to facilitate integrated services and more user-friendly experiences. Applying CFIR identified opportunities to strengthen PrEP delivery across levels within this complex service delivery setting

Business · Environmental health · Implementation research · Modalities · Political science · Psychological intervention · Service (business · Service delivery framework · Social science · Sociology · Community Development and Social Impact · Environmental and Social Impact Assessments · Global Maternal and Child Health · Medicine · Nursing