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Experimental (Re)structuring

The Clinical Trial as Turning Point Among Medical Research Participants

Bibliographic Data

ID4646436
AuthorsKenneth Jaffe (0000-0002-5084-4100, British Columbia Centre on Substance Use, Vancouver, British Columbia, Canada), Kaitlyn Jaffe, P Todd Korthuis (0000-0001-5556-3597, Oregon Health & Science University, Portland, Oregon, USA), Lindsey Richardson (0000-0001-6376-8891, British Columbia Centre on Substance Use, Vancouver, British Columbia, Canada, corresponding author)
Year2021
Volume31
Issue8
Pages1504-1517
Publication date2021-07-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueQualitative Health Research (JOURNAL)
Journal identifiersISSN: 1049-7323 • E-ISSN: 1552-7557
PublisherSAGE Publications Inc (PUBLISHER)
DOI10.1177/10497323211016408
PMID34078194
OpenAlexW3164212433
LanguageEN
Citations received4
References cited59

Amid the growth of addiction medicine randomized controlled trials (RCTs), scholars have begun examining participants' study experiences, highlighting facilitators and barriers to enrollment. However, this work can overlook the interplay between trial participation and social-structural dimensions among people with substance use disorders linked to the social nature of use, socioeconomic marginalization, and time demands of substance procurement and use. To effectively conduct RCTs with this unique population, it is necessary to examine the broader social context of study participation. We conducted nested qualitative interviews with 22 participants involved in an RCT testing a treatment for alcohol and opioid use disorders in HIV clinics. Thematic analyses revealed social-structural circumstances shaping RCT participation as well as how participation constitutes a turning point, prompting individuals to reconfigure social networks, reorient to spatial environments, and reorganize day-to-day life-with implications for how substance use disorder RCTs should be approached by researchers

Addiction · Environmental health · Geography · Population · Psychiatry · Qualitative research · Randomized controlled trial · Social science · Socioeconomic status · Sociology · Thematic analysis · HIV, Drug Use, Sexual Risk · Medicine · Mental Health and Patient Involvement · Psychology · Substance Abuse Treatment and Outcomes

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Unique citing works4
Citations per year1
Citation span2022 - 2026 (5)
Citation velocitycurrent
Highly citedNo
Citation typesNeutral: 4
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