Genotype frequencies of the ABCC11 gene in 2000-3000-year-old human bones from the Epi-Jomon and Jomon sites in Hokkaido, Japan

Bibliographic Data

ID6135789
AuthorsHisako Kazuta (Hokkaido University), Takehiro Sato (0000-0001-9866-0346, Hokkaido University), Yukio Dodo (Tohoku University School of Medicine, Sendai), H Matsumura (0000-0001-5453-7987, Sapporo Medical University, Sapporo), Tetsuya Amano (0000-0001-6576-3410, Hokkaido University Museum, Sapporo), Hajime Ishida (0000-0002-5781-7914, University of the Ryukyus), Ryuichi Masuda (0000-0002-6843-0053, Hokkaido University)
Year2010
Volume119
Issue1
Pages81-86
Publication date2010-10-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAnthropological Science (JOURNAL)
Journal identifiersISSN: 0918-7960 • E-ISSN: 1348-8570
PublisherAnthropological Society of Nippon (PUBLISHER • JP)
DOI10.1537/ase.100416
OpenAlexW1964339253
LanguageEN
Citations received2
References cited17

In order to investigate further the allele frequencies of the adenosine triphosphate-binding cassette sub-family C11 (ABCC11) gene, which determines earwax phenotypes, among ancient populations in Hokkaido, Japan, the single-nucleotide polymorphism and the 27 bp deletion in the ABCC11 gene were analyzed in ancient DNA extracted from 38 Epi-Jomon, 24 Jomon, and one Satsumon specimens excavated from various archaeological sites in Hokkaido. Of the specimens analyzed, 10 Epi-Jomon and three Jomon specimens were successfully genotyped. One homozygote for the 27 bp deletion was found first in one Epi-Jomon specimen. Including previously reported data on the Okhotsk people and modern Ainu, exact tests of population differentiation showed that allele frequencies of the ABCC11 gene between the Jomon people and Ainu were statistically significantly different, whereas those between the Jomon and Epi-Jomon people and those between the Epi-Jomon people and Ainu were not significantly different. This result indicates that the Ainu, direct descendants of the Jomon people, were genetically affected by populations who possessed high frequencies of allele A (recessive dry allele) of the ABCC11 locus after the Jomon period

Allele · Allele frequency · Ancient DNA · Biology · Gene · Genotype · Locus (genetics · Population · Zoology · Demography · Forensic and Genetic Research · Identification and Quantification in Food · RNA regulation and disease · Genetics