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Association between ancient bone preservation and dna yield

A multidisciplinary approach

Bibliographic Data

ID8313340
AuthorsCecilia Sosa (0000-0003-2907-0427, Universidad de Zaragoza, corresponding author), Eugenio Vispe (0000-0002-4921-4734, Universidad de Zaragoza), Carolina Nuñez (0000-0001-5643-3970, Universidad de Zaragoza), Miriam Baeta (0000-0002-6869-1413, Universidad de Zaragoza), Yolanda Casalod (Universidad de Zaragoza), M Bolea (Department of Forensic Medicine Faculty of Medicine University of Zaragoza C/Domingo Miral s/n Zaragoza 50009 Spain), R E M Hedges (Research Laboratory for Archaeology and the History of Art University of Oxford Oxford OX1 3QY UK), Begoña Martínez‐jarreta (0000-0001-6469-9189, Universidad de Zaragoza)
Year2013
Volume151
Issue1
Pages102-109
Publication date2013-05-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Physical Anthropology (JOURNAL)
Journal identifiersISSN: 0002-9483 • E-ISSN: 1096-8644
PublisherWiley (PUBLISHER • GB)
DOI10.1002/ajpa.22262
PMID23595645
OpenAlexW1600924530
LanguageEN
Citations received16
References cited46

Ancient molecular typing depends on DNA survival in archaeological bones. Finding valuable tools to predict DNA presence in ancient samples, which can be measured prior to undertaking a genetic study, has become an important issue as a consequence of the peculiarities of archaeological samples. Since the survival of DNA is explained by complex interrelations of multiple variables, the aim of the present study was to analyze morphological, structural, chemical, and biological aspects of a set of medieval human bones, to provide an accurate reflection of the state of preservation of the bony components and to relate it with DNA presence. Archaeological bones that yielded amplifiable DNA presented high collagen content (generally more than 12%), low racemization values of aspartic acid (lesser than 0.08), leucine and glutamic acid, low infrared splitting factor, small size of crystallite, and more compact appearance of bone in the scanning electron micrographs. Whether these patterns are characteristic of ancient bones or specific of each burial site or specimen requires further investigation. Am J Phys Anthropol 151:102–109, 2013. © 2013 Wiley Periodicals, Inc

Ancient DNA · Archaeology · Biology · DNA · Evolutionary biology · Mineralogy · Yield (engineering) · Archaeology and ancient environmental studies · Biochemistry · Chemistry · Forensic and Genetic Research · Forensic Anthropology and Bioarchaeology Studies · History · Materials Science · Medicine

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Unique citing works16
Citations per year1,33
Citation span2014 - 2025 (12)
Citation velocityrecent
Highly citedNo
Citation typesNeutral: 15
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