K K Cheng
Datos Biográficos
| ID | 106351 |
|---|---|
| NOMBRE | K K Cheng |
| NOMBRES | K K |
| APELLIDO | Cheng |
| FIRMA | CHENG K K |
| AFILIACIONES | University of Birmingham |
| ORCID | 0000-0002-1516-1857 |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 51 |
| TOTAL DE CITAS | 56 |
| TOTAL COMO AUTOR | 51 |
| TOTAL COMO EDITOR | 0 |
| PRIMER AÑO DE PUBLICACIÓN | 2001 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2025 |
| ÍNDICE H | 5 |
Association between sarcopenic obesity, obesity, sarcopenia and quality of life in middle-aged and older Chinese
SO was associated with lower physical health-related QoL compared to obesity or sarcopenia alone, but non-significantly associated with mental health-related QoL
Association of oral health with all-cause and cause-specific mortality in older Chinese adults
Background: Poor oral hygiene is associated with overall wellness, but evidence regarding associations of oral health with all-cause mortality remain inconclusive. We aimed to examine the associations of oral health with all-cause and cause-specific mortality in middle-aged and older Chinese adults. Methods: 28 006 participants were recruited from 2003-2008 and followed up until 2021. Oral health was assessed by face-to-face interview and causes …
Randomised controlled trial testing effectiveness of feedback about lung age or exhaled CO combined with very brief advice for smoking cessation compared to very brief advice alone in North Macedonia
The trial was registered at http://www.isrctn.com (ISRCTN54228638) on the 07/09/2018
Wearing face masks in the community during the Covid-19 pandemic
Obesity indicators as mediators of association between daytime napping and type 2 diabetes mellitus
Our results showed significant mediating effects of WC, WHR and WHtR on the association between daytime napping and T2DM, suggesting that waist circumference management could be important in daytime nappers
Covid-19
A long list is emerging from largely unadjusted analyses, with age near the top
Quality of primary health care in China
Chinese Women’s Acceptance and Uptake of Referral after Screening for Perinatal Depression
China recently issued a national plan on perinatal depression (PND) screening. Previous studies elsewhere suggested that uptake of referral after screening for PND is suboptimal, but little is known in China. In this cohort study including 1126 women in Hunan, we identified women at a high risk of PND using the Edinburgh Postpartum Depression Scale (EPDS) over multiple time points. We texted them and offered free consultations with a psychiatrist…
White blood cell count and all-cause and cause-specific mortality in the Guangzhou biobank cohort study
Elevated WBC, specifically granulocyte, count was associated with all-cause, CHD and respiratory mortality in southern Chinese. Further investigation is warranted to clarify whether decreasing inflammation would attenuate WBC count associated mortality
The primary health-care system in China
Are babies conceived during Ramadan born smaller and sooner than babies conceived at other times of the year? A Born in Bradford Cohort Study
BACKGROUND: It is not known whether infants exposed to intermittent maternal fasting at conception are born smaller or have a higher risk of premature birth than those who are not. Doctors are therefore unsure about what advice to give women about the safety of Ramadan fasting. This cohort study aimed to investigate these questions in Muslim mother-infant pairs to inform prenatal care. METHODS: Routinely collected data accessed from maternity rec…
Socioeconomic determinants of childhood obesity among primary school children in Guangzhou, China
The socioeconomic gradient for childhood obesity in China is the reverse of the patterns seen in countries at more advanced stages of the obesity epidemic. This presents an opportunity to intervene and prevent the onset of social inequalities that are likely to ensue with further economic development. The marked gender inequality in obesity needs further exploration
Childhood secondhand smoke exposure and pregnancy loss in never smokers
Childhood SHS exposure was associated with higher risks of pregnancy loss in middle-aged and older Chinese women
A cluster-randomised controlled trial to assess the effectiveness and cost-effectiveness of a childhood obesity prevention programme delivered through schools, targeting 6–7 year old children
Current Controlled Trials ISRCTN97000586 (registered May 2010)
Effectiveness of additional follow-up telephone counseling in a smoking cessation clinic in Beijing and predictors of quitting among Chinese male smokers
Using systematically collected data from real-world practice, our smoking cessation clinic has shown that the additional telephone follow-up counseling sessions doubled the quit rate
Systematic review of modifiable risk factors associated with childhood obesity in China, a population undergoing rapid social and economic transition
Are grandparents the key to childhood obesity prevention in China? Evidence from a mixed methods study
Liver enzymes and incident diabetes in China
BACKGROUND: Impaired liver function has been shown to be associated with incident diabetes. The independent role of the different liver enzymes, including γ-glutamyltransferase (GGT), alanine transaminase (ALT) and aspartate transaminase (AST), has not been addressed properly, taking into account their high collinearity. We used partial least squares (PLS) regression to identify the contribution of ALT, AST and GGT, which appears causally associa…
Height, its components, and coagulability among older Chinese
OBJECTIVES: The causal role of some cardiovascular risk factors, such as HDL cholesterol, has been increasingly challenged and attention is returning to all elements of Virchow's triad, i.e., hypercoagulability (including viscosity) as well as endothelial function and blood flow. We examined the life course origins of coagulability. METHODS: We used multivariable linear regression to assess whether childhood influences, proxied by height and its …
Leg length is associated with lower values of inflammatory markers in older Chinese
Factors enabling more early growth may also lead to changes in immunity that are associated with reduced CVD risk
Teachers’ high maintenance behaviour as perceived by university students in Taiwan, and their coping strategies
Genetically predicted 17β-estradiol and systemic inflammation in women
BACKGROUND: Many chronic diseases are characterised by low-grade systemic inflammation. Oestrogens may promote immune response consistent with sex-specific patterns of diseases. In vitro culture and animal experiments suggest oestrogens are anti-inflammatory and might thereby protect against low-grade systemic inflammation. Evidence from epidemiological studies is limited. Using a Mendelian randomisation analysis with a separate-sample instrument…
Study protocol for “Moving Bright, Eating Smart”– A phase 2 clinical trial on the acceptability and feasibility of a diet and physical activity intervention to prevent recurrence in colorectal cancer …
ClinicalTrials.gov No: NCT01708824
Inequality and inequity in access to health care and treatment for chronic conditions in China
Non-communicable diseases (NCDs) are a large and rapidly-growing problem in China and other middle-income countries. Clinical treatment of NCDs is long-term and expensive, so it may present particular problems for equality and horizontal equity (equal treatment for equal need) in access to health care, although little is known about this at present in low- and middle-income countries. To address this gap, and inform policy for a substantial propo…
Systematic differences among never, occasional and moderate alcohol users in southern China, and its use in alcohol research
BACKGROUND: Western observational studies show moderate alcohol use, compared with never use, positively associated with health. Moderate users differ systematically from others, making these observations vulnerable to confounding. Observations from other contexts may help distinguish whether these associations are confounded. To assess whether southern Chinese would provide a more suitable setting to examine the association of moderate alcohol u…
The influence of school culture on smoking among pupils
Are height and leg length universal markers of childhood conditions? The Guangzhou Biobank cohort study
OBJECTIVE: In developed western populations longer legs have been shown to be a marker of better early childhood conditions. In the first generations to experience the epidemiologic transition and associated economic development, epigenetic constraints on growth might preclude improved childhood conditions from increasing leg growth or height. DESIGN, SETTING AND PARTICIPANTS: Multivariable linear regression was used to assess the association of …
Inequality and inequity in access to health care and treatment for chronic conditions in China
Non-communicable diseases (NCDs) are a large and rapidly-growing problem in China and other middle-income countries. Clinical treatment of NCDs is long-term and expensive, so it may present particular problems for equality and horizontal equity (equal treatment for equal need) in access to health care, although little is known about this at present in low- and middle-income countries. To address this gap, and inform policy for a substantial propo…
Is leg length a biomarker of childhood conditions in older Chinese women? The Guangzhou Biobank Cohort Study
OBJECTIVE: In developed western populations longer legs have been shown to be a biomarker of better early childhood conditions. It was hypothesised that in transitioning populations better childhood conditions may bring forward puberty and thus decrease leg length, counteracting the overall positive effect of a favourable childhood environment on leg growth. DESIGN: Structural equation modelling was used to assess the interrelationship of age, ed…
Height, Its Components, and Cardiovascular Risk Among Older Chinese
Objectives. Better childhood conditions, inferred from height and specifically leg length, are usually protective against ischemic heart disease and its risk factors in Western countries. In other geoethnic populations, height is less clearly protective, casting doubt on there being a biological etiology. To clarify the role of childhood conditions, we examined the associations of height and its components with cardiovascular risk among older Chi…
Socioeconomic influences at different life stages on health in Guangzhou, China
The risk of smoking in relation to engagement with a school-based smoking intervention
Intergenerational 'mismatch' and adiposity in a developing population
Liver enzymes and incident diabetes in China
BACKGROUND: Impaired liver function has been shown to be associated with incident diabetes. The independent role of the different liver enzymes, including γ-glutamyltransferase (GGT), alanine transaminase (ALT) and aspartate transaminase (AST), has not been addressed properly, taking into account their high collinearity. We used partial least squares (PLS) regression to identify the contribution of ALT, AST and GGT, which appears causally associa…
Smoking cessation and carotid atherosclerosis
INTRODUCTION: Smoking has been shown to be associated with carotid atherosclerosis in cross-sectional and prospective studies in Western populations. However, few studies have examined the reversal of risk resulting from quitting smoking, and the results are conflicting. METHODS: 959 men aged 50-85 years were randomly selected from phase III (2006-2007) of the Guangzhou Biobank Cohort Study into this cross-sectional study. Common carotid artery i…
Alcohol use and fasting glucose in a developing southern Chinese population
BACKGROUND: In observational studies, mainly from Western Caucasian populations, moderate alcohol use has been shown to be associated with a lower risk of diabetes. However, whether the protection is due to the attributes of alcohol or to those of moderate alcohol users is difficult to disentangle. A population with a different distribution of alcohol consumption and diabetes prevalence from Western populations was studied as a counterfactual com…
Olive oil and colorectal cancer
Editor,—In a recent article on diet and colorectal cancer, Stoneham et al 1reported that 76% of the variation in incidence rates between 28 countries could be explained by three significant dietary factors (meat, fish, and olive oil). The authors concluded that olive oil may have a protective effect on the development of colorectal cancer. While a plausible mechanism is proposed, it is worth noting that 21 of the 28 populations included in the ec…
A cluster randomised controlled trial of smoking cessation in pregnant women comparing interventions based on the transtheoretical (stages of change) model to standard care
While there is a small borderline significant increase in quitting in the combined intervention arms compared with the controls, the effect of the intervention is small. At 30 weeks gestation and at 10 days postnatal, only about 3% of the intervention groups achieved sustained cessation, with numbers needed to treat of 67 (30 weeks of gestation) and 53 (10 weeks postnatal) for one additional woman to achieve sustained confirmed cessation. Given a…
The importance of social sources of cigarettes to school students
The passing and selling of cigarettes in school is a common activity, which from the young persons perspective, ensures that all share cross counter purchases. A few people are prepared to use the peer market for monetary gain and it appears to be responsive to external conditions. The peer market might mean that efforts to control illegal sales of cigarettes are not as effective as hoped
The risk of smoking in relation to engagement with a school-based smoking intervention
A methodological and substantive review of the evidence that schools cause pupils to smoke
The influence of school culture on smoking among pupils
The influence of in-pregnancy smoking cessation programmes on partner quitting and women's social support mobilization
The stage-based interventions tested in this trial aimed partly to influence women's mobilization of support and might have influenced partners' quitting, but there was no evidence that they did so. Given that women and their partners often stopped smoking together, future interventions to prevent smoking in pregnant women could encourage both partners to quit together
Height, Its Components, and Cardiovascular Risk Among Older Chinese
Objectives. Better childhood conditions, inferred from height and specifically leg length, are usually protective against ischemic heart disease and its risk factors in Western countries. In other geoethnic populations, height is less clearly protective, casting doubt on there being a biological etiology. To clarify the role of childhood conditions, we examined the associations of height and its components with cardiovascular risk among older Chi…
Are longer legs associated with enhanced fertility in Chinese women?☆
Are height and leg length universal markers of childhood conditions? The Guangzhou Biobank cohort study
OBJECTIVE: In developed western populations longer legs have been shown to be a marker of better early childhood conditions. In the first generations to experience the epidemiologic transition and associated economic development, epigenetic constraints on growth might preclude improved childhood conditions from increasing leg growth or height. DESIGN, SETTING AND PARTICIPANTS: Multivariable linear regression was used to assess the association of …
Is leg length a biomarker of childhood conditions in older Chinese women? The Guangzhou Biobank Cohort Study
OBJECTIVE: In developed western populations longer legs have been shown to be a biomarker of better early childhood conditions. It was hypothesised that in transitioning populations better childhood conditions may bring forward puberty and thus decrease leg length, counteracting the overall positive effect of a favourable childhood environment on leg growth. DESIGN: Structural equation modelling was used to assess the interrelationship of age, ed…
Alcohol use and fasting glucose in a developing southern Chinese population
BACKGROUND: In observational studies, mainly from Western Caucasian populations, moderate alcohol use has been shown to be associated with a lower risk of diabetes. However, whether the protection is due to the attributes of alcohol or to those of moderate alcohol users is difficult to disentangle. A population with a different distribution of alcohol consumption and diabetes prevalence from Western populations was studied as a counterfactual com…
Leg length and age of puberty among men and women from a developing population
OBJECTIVES: Leg length and relative leg length are considered to be reliable markers of prepubertal living conditions. Cessation of leg growth, driven by estrogen, occurs earlier in puberty in girls than boys. We hypothesized that leg length and relative leg length, as sitting height to leg ratio, might have sex-specific associations with age of puberty. METHODS: We used multivariable linear regression in 10,046 older (>or=50 years) Chinese from …
Estimated birth weight and adult cardiovascular risk factors in a developing southern Chinese population
Birth weight may impact blood pressure; however associations of birth weight with other cardiovascular risk factors may not be related to foetal exposures, but speculatively could be an historical co-incidence, with corresponding implications for prevention
Smoking cessation and carotid atherosclerosis
INTRODUCTION: Smoking has been shown to be associated with carotid atherosclerosis in cross-sectional and prospective studies in Western populations. However, few studies have examined the reversal of risk resulting from quitting smoking, and the results are conflicting. METHODS: 959 men aged 50-85 years were randomly selected from phase III (2006-2007) of the Guangzhou Biobank Cohort Study into this cross-sectional study. Common carotid artery i…
Intergenerational 'mismatch' and adiposity in a developing population
Intergenerational influences on diabetes in a developing population
OBJECTIVES: Intergenerational "mismatch" and/or growth conditions may be relevant to the epidemic of diabetes in developing populations. In a rapidly developing southern Chinese population, we tested whether maternal environment, proxied by maternal literacy, or family socio-economic position (SEP), proxied by paternal literacy, were associated with fasting glucose and diabetes. To assess if intergenerational mismatch contributed, we tested wheth…
Childhood meat eating and inflammatory markers
If confirmed, this hypothesis implies that economic development and the associated improvements in nutrition at puberty may be less beneficial among men than women; consistent with the widening sex differentials in life expectancy with economic development
Does childhood meat eating contribute to sex differences in risk factors for ischaemic heart disease in a developing population
BACKGROUND: A male epidemic of ischaemic heart disease (IHD) emerges with economic development. It has previously been hypothesised that this epidemic is due to nutritionally driven levels of pubertal sex steroids, which lead to a more atherogenic body shape and lipid profile in boys but not girls, without any sex-specific effects on glucose metabolism. This study tests this hypothesis by examining the association of childhood meat eating with IH…
P2-395 Socioeconomic influences at different life stages on self-rated health in Guangzhou, China
Introduction In long-term developed countries socioeconomic position across the life course is positively associated with health. We examined these associations in a developing country with a history of efforts to reorganise social hierarchy. Methods Taking a life course perspective, we used multivariable logistic regression to analyse the association of socioeconomic disadvantage at four life stages (measured by parental possessions, education, …
P2-133 Muscle mass is associated with diabetes in a developing population
Introduction Asian populations tend to be more susceptible to type 2 diabetes. In Asians low muscle-mass may also be a contributory factor. In a rapidly developing southern Chinese population, we examined whether skeletal muscle-mass, proxied by serum creatinine, was associated with diabetes or adiposity. Methods In 9768 older (≥50 years) adults from the Guangzhou Biobank Cohort Study (phase 1) examined in 2003–2004, we used multivariable logisti…
P1-4 ALDH2 is a valid instrument for mendelian randomisation studies in alcohol epidemiology—the Guangzhou Biobank Cohort Study
Introduction Western observational studies show moderate alcohol use positively associated with many health outcomes. Moderate alcohol users differ systematically from others, making these observations susceptible to residual confounding. A randomised controlled trial of moderate alcohol use is unlikely to be possible. A Mendelian randomisation design using a genetic polymorphism affecting alcohol use ( ALDH2 ) as an instrumental variable offers …
P2-132 Intergenerational influences on diabetes in a developing population
Introduction Intergenerational “mismatch” has been suggested as being relevant to the emergent epidemic of diabetes in developing populations. Conversely, constrained growth conditions over generations may also increase susceptibility to diabetes. In a rapidly developing southern Chinese population, we tested whether maternal environment, proxied by maternal literacy, or family socio-economic position (SEP), proxied by paternal literacy, were ass…
P2-471 Liver function related viruses and diabetes in China
Introduction Compared to western populations, diabetes mellitus is prevalent in China despite a relatively non-obese population. Exposures beyond lifestyle and genetics may be relevant. We hypothesised that liver infections, common in China, increase vulnerability to diabetes, via the physiological consequences of poor liver function. Methods We used multivariable regression to examine the adjusted associations of alanine transaminase (ALT) and a…
Socioeconomic influences at different life stages on health in Guangzhou, China
Medicine (49 obras) · Internal Medicine (32 obras) · Demography (26 obras) · Environmental health (26 obras) · Cohort (25 obras) · Cohort study (25 obras) · Population (23 obras) · Gerontology (16 obras) · Birth, Development, and Health (14 obras) · Psychology (14 obras)