Per Tynelius
Datos Biográficos
| ID | 108272 |
|---|---|
| NOMBRE | Per Tynelius |
| NOMBRES | Per |
| APELLIDO | Tynelius |
| FIRMA | TYNELIUS P |
| AFILIACIONES | Karolinska Institutet |
| ORCID | 0000-0001-8155-7406 |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 28 |
| TOTAL DE CITAS | 35 |
| TOTAL COMO AUTOR | 28 |
| TOTAL COMO EDITOR | 0 |
| PRIMER AÑO DE PUBLICACIÓN | 2006 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2025 |
| ÍNDICE H | 4 |
Temporal Trends in Sexual Identity and Sociodemographic Disparities in Stockholm, Sweden, 2010–2021
Objectives. To examine temporal trends in sexual identity and sociodemographic disparities in Sweden after gender-neutral marriage legislation in 2009. Methods. We analyzed 3 cross-sectional surveys from the Stockholm Public Health Cohort (2010, 2014, 2021) that included 76 083 participants 16 years or older. Weighted Poisson regression was used to estimate associations between sexual identity and sociodemographic covariates. Survey weights and m…
Worldwide trends in underweight and obesity from 1990 to 2022
BACKGROUND: Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. METHODS: ). For school-aged children and adolescents, we report thinness (BMI 2 SD above the median). FINDINGS: From 1990 to 20…
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019
BACKGROUND: Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. METHODS: We used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blo…
Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories
BACKGROUND: Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. METHODS: For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease …
Rising rural body-mass index is the main driver of the global obesity epidemic in adults
Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities 1,2 . This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity 3–6 . Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean B…
The association of mobility disability and obesity with risk of unemployment in two cohorts from Sweden
People with MD and/or obesity are vulnerable groups at risk of prolonged unemployment during their working life in a country with a highly developed welfare system
Meeting physical activity recommendations is associated with health-related quality of life in women before and after Roux-en-Y gastric bypass surgery
Meeting the PA recommendations and overall engaging in more PA was associated with higher HRQoL, pre-, and post-RYGB surgery, highlighting the importance of PA both pre- and post-surgery
Adolescent mental health and unemployment over the lifespan
Education, cognitive ability, and cause-specific mortality
Education is negatively associated with most major causes of death. Prior work ignores the premise that cause-specific hazards are interdependent and that both education and mortality depend on cognitive ability. We analyse Swedish men aged 18-63, focusing on months lost due to specific causes-which solves the interdependence problem-and use a structural model that accounts for confounding due to cognitive ability. In a standard Cox model control…
Worldwide trends in blood pressure from 1975 to 2015
BACKGROUND: Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. METHODS: For this analysis, we pooled national, subnational, or comm…
Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016
BACKGROUND: Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide trends in mean body-mass index (BMI) and a comprehensive set of BMI categories that cover underweight to obesity in children and adolescents, and to compare trends with those of adults. METHODS: We pooled 2416 population-based studies with measurements of height…
Objectively measured physical activity patterns, sedentary time and parent-reported screen-time across the day in four-year-old Swedish children
Four-year old Swedish children display different activity patterns across the day on weekdays compared to weekend days, with preschool hours during weekdays being the most active segments and preschool hours during weekend days being the least active segments of the day
No effects of increased alcohol availability during adolescence on alcohol-related morbidity and mortality during four decades
BACKGROUND: A strict high legal age limit for alcohol purchases decreases adolescents' access to alcohol, but little is known about long-term health effects. The aim was to estimate the effect of increased alcohol availability during adolescence on alcohol-related morbidity and mortality. METHODS: A nationwide register-based study using data from a natural experiment setting. In two regions of Sweden, strong beer (4.5%-5.6% alcohol by volume) bec…
Educational gains in cause-specific mortality
A negative educational gradient has been found for many causes of death. This association may be partly explained by confounding factors that affect both educational attainment and mortality. We correct the cause-specific educational gradient for observed individual background and unobserved family factors using an innovative method based on months lost due to a specific cause of death re-weighted by the probability of attaining a higher educatio…
Primary prevention of childhood obesity through counselling sessions at Swedish child health centres
ISRCTN16991919
Association of paternal IQ in early adulthood with offspring mortality and hospital admissions for injuries
BACKGROUND: Higher intelligence (IQ) has been related to a lower risk of mortality and hospital admissions for injuries, but little is known about the effect of parental IQ on offspring outcomes. We explored associations of paternal IQ with mortality and hospitalisations for injuries from all external causes in offspring. METHODS: A cohort of 503 492 Swedish children under 5 years of age with information on paternal IQ was obtained by record link…
Sex of preceding sibling and anthropometrics of subsequent offspring at birth and in young adulthood
In many mammal species with sexual dimorphism producing sons is energetically more demanding to the mother than producing daughters. Although some studies in humans have suggested that offspring born after a brother have a smaller birth weight and adult height when compared with those born after a sister, little is known about this intergenerational cost of producing sons. We aimed to study whether the sex of preceding sibling is associated with …
The association between height and birth order
BACKGROUND: Birth order is associated with outcomes such as birth weight and adult socioeconomic position (SEP), but little is known about the association with adult height. This potential birth order-height association is important because height predicts health, and because the association may help explain population-level height trends. We studied the birth order-height association and whether it varies by family characteristics or birth cohor…
OP42 Mental Disorders Across the Adult Lifecourse and Future Coronary Heart Disease
Background Depression, anxiety, and psychotic disorders have been associated with an increased risk of developing coronary heart disease (CHD). The underlying mechanisms are uncertain. It is unclear whether the association between mental health and risk of CHD is present across a wider range of mental disorders, and whether it varies according to the chronicity of the disorder. We used data on over a million Swedish men who underwent psychiatric …
Associations of mortality with own height using son's height as an instrumental variable
Height is associated with mortality from many diseases, but it remains unclear whether the association is causal or due to confounding by social factors, genetic pleiotropy,(1) or existing ill-health. The authors investigated whether the association of height with mortality is causal by using a son's height as an instrumental variable (IV) for parents' height among the parents of a cohort of 1,036,963 Swedish men born between 1951 and 1980 who ha…
Associations of mortality rates with height using son's height as an instrumental variable
Objectives Height has been negatively associated with mortality from circulatory disease, but positively associated with mortality from most forms of cancer. These results are vulnerable to confounding, including the confounding effect of early stages of disease causing shrinkage and later death. To avoid these problems, we used the height of subjects' sons as an instrument for subjects' own height. Design A record linkage cohort study of over 2 …
Intelligence in Early Adulthood and Subsequent Risk of Assault
OBJECTIVE: To examine the association between low intelligence (IQ) and increased risk of assault. Previous studies have been relatively small, have not adjust for socioeconomic status, and have not examined method-specific assaults. METHODS: Cox proportional hazards regression was used to explore IQ associations with assault by any means and by four specific methods in a large prospective cohort of 1,120,988 Swedish men. Study members had IQ mea…
Association between intelligence and type-specific stroke
BACKGROUND: Inverse associations between IQ and stroke have been reported in a few studies, but none have investigated subtypes of stroke, nor have they studied fatal and non-fatal stroke separately. Stroke is a heterogenic disease and strength of associations with IQ and putative causal pathways cannot be assumed to be identical for different subtypes. METHODS: IQ was measured for 1.1 million Swedish men, born 1951 to 1976. Data from several nat…
Intelligence in early adulthood and subsequent risk of unintentional injury over two decades
BACKGROUND: There is growing evidence of an inverse association between intelligence (IQ) and unintentional injuries. METHODS: Analyses are based on a cohort of 1 109 475 Swedish men with IQ measured in early adulthood. Men were followed up for an average 24 years, and hospital admissions for unintentional injury were recorded. RESULTS: 198 133 (17.9%) men had at least one hospital admission for any unintentional injury during follow-up. The most…
Associations between IQ and cigarette smoking among Swedish male twins
The association between height and birth order
BACKGROUND: Birth order is associated with outcomes such as birth weight and adult socioeconomic position (SEP), but little is known about the association with adult height. This potential birth order-height association is important because height predicts health, and because the association may help explain population-level height trends. We studied the birth order-height association and whether it varies by family characteristics or birth cohor…
Adolescent mental health and unemployment over the lifespan
Association between intelligence and type-specific stroke
BACKGROUND: Inverse associations between IQ and stroke have been reported in a few studies, but none have investigated subtypes of stroke, nor have they studied fatal and non-fatal stroke separately. Stroke is a heterogenic disease and strength of associations with IQ and putative causal pathways cannot be assumed to be identical for different subtypes. METHODS: IQ was measured for 1.1 million Swedish men, born 1951 to 1976. Data from several nat…
Intelligence in early adulthood and subsequent risk of unintentional injury over two decades
BACKGROUND: There is growing evidence of an inverse association between intelligence (IQ) and unintentional injuries. METHODS: Analyses are based on a cohort of 1 109 475 Swedish men with IQ measured in early adulthood. Men were followed up for an average 24 years, and hospital admissions for unintentional injury were recorded. RESULTS: 198 133 (17.9%) men had at least one hospital admission for any unintentional injury during follow-up. The most…
Educational gains in cause-specific mortality
A negative educational gradient has been found for many causes of death. This association may be partly explained by confounding factors that affect both educational attainment and mortality. We correct the cause-specific educational gradient for observed individual background and unobserved family factors using an innovative method based on months lost due to a specific cause of death re-weighted by the probability of attaining a higher educatio…
Association between offspring intelligence and parental mortality
BACKGROUND: An inverse association of IQ with mortality has been observed in previous studies. Analyses of associations between offspring's IQ and parental mortality in biological and non-biological family relations may shed light on genetic and environmental influences. METHODS: In a target cohort of 1,235,375 Swedish men, 931,825 (75%) men had complete data on all variables used. IQ of offspring was measured at age 18 and mothers and father wer…
Sex of preceding sibling and anthropometrics of subsequent offspring at birth and in young adulthood
In many mammal species with sexual dimorphism producing sons is energetically more demanding to the mother than producing daughters. Although some studies in humans have suggested that offspring born after a brother have a smaller birth weight and adult height when compared with those born after a sister, little is known about this intergenerational cost of producing sons. We aimed to study whether the sex of preceding sibling is associated with …
Associations between IQ and cigarette smoking among Swedish male twins
Education, cognitive ability, and cause-specific mortality
Education is negatively associated with most major causes of death. Prior work ignores the premise that cause-specific hazards are interdependent and that both education and mortality depend on cognitive ability. We analyse Swedish men aged 18-63, focusing on months lost due to specific causes-which solves the interdependence problem-and use a structural model that accounts for confounding due to cognitive ability. In a standard Cox model control…
Association of paternal IQ in early adulthood with offspring mortality and hospital admissions for injuries
BACKGROUND: Higher intelligence (IQ) has been related to a lower risk of mortality and hospital admissions for injuries, but little is known about the effect of parental IQ on offspring outcomes. We explored associations of paternal IQ with mortality and hospitalisations for injuries from all external causes in offspring. METHODS: A cohort of 503 492 Swedish children under 5 years of age with information on paternal IQ was obtained by record link…
Physical activity, diet and gene–environment interactions in relation to body mass index and waist circumference
Objective The aim of the present study was to examine the relationships between genetic susceptibility to obesity, physical activity (PA), dietary fibre, sugar and fat intakes and 4-year changes in body mass index (BMI) and attained waist circumference (WC) in a cohort of 287 monozygotic and 189 dizygotic young adult male twin pairs. Increased knowledge about interactions between genes and environment may provide insight into why some individuals…
Genetic regulation of growth from birth to 18 years of age
Growth is a complex process, and only little is known on the genetic regulation of it. We analyzed the effect of genetic and environmental factors on growth in a longitudinal Swedish cohort of 231 monozygotic and 144 dizygotic twin pairs born 1973–1979 with length or height measured annually from birth to age 18. The data were analyzed by two different multivariate variance component models for twin data using the Mx statistical package. At birth…
Association between offspring intelligence and parental mortality
BACKGROUND: An inverse association of IQ with mortality has been observed in previous studies. Analyses of associations between offspring's IQ and parental mortality in biological and non-biological family relations may shed light on genetic and environmental influences. METHODS: In a target cohort of 1,235,375 Swedish men, 931,825 (75%) men had complete data on all variables used. IQ of offspring was measured at age 18 and mothers and father wer…
Intelligence in Early Adulthood and Subsequent Risk of Assault
OBJECTIVE: To examine the association between low intelligence (IQ) and increased risk of assault. Previous studies have been relatively small, have not adjust for socioeconomic status, and have not examined method-specific assaults. METHODS: Cox proportional hazards regression was used to explore IQ associations with assault by any means and by four specific methods in a large prospective cohort of 1,120,988 Swedish men. Study members had IQ mea…
Association between intelligence and type-specific stroke
BACKGROUND: Inverse associations between IQ and stroke have been reported in a few studies, but none have investigated subtypes of stroke, nor have they studied fatal and non-fatal stroke separately. Stroke is a heterogenic disease and strength of associations with IQ and putative causal pathways cannot be assumed to be identical for different subtypes. METHODS: IQ was measured for 1.1 million Swedish men, born 1951 to 1976. Data from several nat…
Intelligence in early adulthood and subsequent risk of unintentional injury over two decades
BACKGROUND: There is growing evidence of an inverse association between intelligence (IQ) and unintentional injuries. METHODS: Analyses are based on a cohort of 1 109 475 Swedish men with IQ measured in early adulthood. Men were followed up for an average 24 years, and hospital admissions for unintentional injury were recorded. RESULTS: 198 133 (17.9%) men had at least one hospital admission for any unintentional injury during follow-up. The most…
Associations between IQ and cigarette smoking among Swedish male twins
Associations of mortality rates with height using son's height as an instrumental variable
Objectives Height has been negatively associated with mortality from circulatory disease, but positively associated with mortality from most forms of cancer. These results are vulnerable to confounding, including the confounding effect of early stages of disease causing shrinkage and later death. To avoid these problems, we used the height of subjects' sons as an instrument for subjects' own height. Design A record linkage cohort study of over 2 …
Associations of mortality with own height using son's height as an instrumental variable
Height is associated with mortality from many diseases, but it remains unclear whether the association is causal or due to confounding by social factors, genetic pleiotropy,(1) or existing ill-health. The authors investigated whether the association of height with mortality is causal by using a son's height as an instrumental variable (IV) for parents' height among the parents of a cohort of 1,036,963 Swedish men born between 1951 and 1980 who ha…
The association between height and birth order
BACKGROUND: Birth order is associated with outcomes such as birth weight and adult socioeconomic position (SEP), but little is known about the association with adult height. This potential birth order-height association is important because height predicts health, and because the association may help explain population-level height trends. We studied the birth order-height association and whether it varies by family characteristics or birth cohor…
OP42 Mental Disorders Across the Adult Lifecourse and Future Coronary Heart Disease
Background Depression, anxiety, and psychotic disorders have been associated with an increased risk of developing coronary heart disease (CHD). The underlying mechanisms are uncertain. It is unclear whether the association between mental health and risk of CHD is present across a wider range of mental disorders, and whether it varies according to the chronicity of the disorder. We used data on over a million Swedish men who underwent psychiatric …
Primary prevention of childhood obesity through counselling sessions at Swedish child health centres
ISRCTN16991919
Association of paternal IQ in early adulthood with offspring mortality and hospital admissions for injuries
BACKGROUND: Higher intelligence (IQ) has been related to a lower risk of mortality and hospital admissions for injuries, but little is known about the effect of parental IQ on offspring outcomes. We explored associations of paternal IQ with mortality and hospitalisations for injuries from all external causes in offspring. METHODS: A cohort of 503 492 Swedish children under 5 years of age with information on paternal IQ was obtained by record link…
Sex of preceding sibling and anthropometrics of subsequent offspring at birth and in young adulthood
In many mammal species with sexual dimorphism producing sons is energetically more demanding to the mother than producing daughters. Although some studies in humans have suggested that offspring born after a brother have a smaller birth weight and adult height when compared with those born after a sister, little is known about this intergenerational cost of producing sons. We aimed to study whether the sex of preceding sibling is associated with …
Worldwide trends in blood pressure from 1975 to 2015
BACKGROUND: Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. METHODS: For this analysis, we pooled national, subnational, or comm…
Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016
BACKGROUND: Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide trends in mean body-mass index (BMI) and a comprehensive set of BMI categories that cover underweight to obesity in children and adolescents, and to compare trends with those of adults. METHODS: We pooled 2416 population-based studies with measurements of height…
Objectively measured physical activity patterns, sedentary time and parent-reported screen-time across the day in four-year-old Swedish children
Four-year old Swedish children display different activity patterns across the day on weekdays compared to weekend days, with preschool hours during weekdays being the most active segments and preschool hours during weekend days being the least active segments of the day
No effects of increased alcohol availability during adolescence on alcohol-related morbidity and mortality during four decades
BACKGROUND: A strict high legal age limit for alcohol purchases decreases adolescents' access to alcohol, but little is known about long-term health effects. The aim was to estimate the effect of increased alcohol availability during adolescence on alcohol-related morbidity and mortality. METHODS: A nationwide register-based study using data from a natural experiment setting. In two regions of Sweden, strong beer (4.5%-5.6% alcohol by volume) bec…
Educational gains in cause-specific mortality
A negative educational gradient has been found for many causes of death. This association may be partly explained by confounding factors that affect both educational attainment and mortality. We correct the cause-specific educational gradient for observed individual background and unobserved family factors using an innovative method based on months lost due to a specific cause of death re-weighted by the probability of attaining a higher educatio…
Rising rural body-mass index is the main driver of the global obesity epidemic in adults
Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities 1,2 . This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity 3–6 . Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean B…
The association of mobility disability and obesity with risk of unemployment in two cohorts from Sweden
People with MD and/or obesity are vulnerable groups at risk of prolonged unemployment during their working life in a country with a highly developed welfare system
Meeting physical activity recommendations is associated with health-related quality of life in women before and after Roux-en-Y gastric bypass surgery
Meeting the PA recommendations and overall engaging in more PA was associated with higher HRQoL, pre-, and post-RYGB surgery, highlighting the importance of PA both pre- and post-surgery
Adolescent mental health and unemployment over the lifespan
Education, cognitive ability, and cause-specific mortality
Education is negatively associated with most major causes of death. Prior work ignores the premise that cause-specific hazards are interdependent and that both education and mortality depend on cognitive ability. We analyse Swedish men aged 18-63, focusing on months lost due to specific causes-which solves the interdependence problem-and use a structural model that accounts for confounding due to cognitive ability. In a standard Cox model control…
Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories
BACKGROUND: Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. METHODS: For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease …
Medicine (27 obras) · Demography (24 obras) · Population (19 obras) · Environmental health (15 obras) · Internal Medicine (14 obras) · Cohort (11 obras) · Cohort study (10 obras) · Confounding (9 obras) · Internal Medicine (9 obras) · Body mass index (8 obras)