Giovanni Destro Bisol
Datos Biográficos
| ID | 109515 |
|---|---|
| NOMBRE | Giovanni Destro Bisol |
| NOMBRES | Giovanni Destro |
| APELLIDO | Bisol |
| FIRMA | BISOL G D |
| AFILIACIONES | Sapienza University of Rome |
| ORCID | 0000-0002-4232-9715 |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 36 |
| TOTAL DE CITAS | 30 |
| TOTAL COMO AUTOR | 36 |
| TOTAL COMO EDITOR | 0 |
| PRIMER AÑO DE PUBLICACIÓN | 1986 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2024 |
| ÍNDICE H | 3 |
Mitochondrial DNA Variation in Southern Tunisian Populations
Due to its complex history of migrations and colonization of African, European, and Asian people, the Tunisian territory is an ideal area to study the effects of cultural change on the genetic structure of human populations. This study investigated genetic variation in the mitochondrial DNA of Tunisian populations to detect the possible impact of recent historical events on their gene pool. Two Arab and three Berber communities were analyzed usin…
Biocultural Diversity in Italy
As an initial step in more extensive research into the links between biological and cultural diversity in present-day Italy, we reviewed Biocultural Diversity studies that explore the relationship between biological and cultural patterns of diversity to determine whether any direct causal relationships or common drivers could be inferred. We found no significant attempts to quantitatively measure biocultural diversity in the country as a whole. I…
Retracted
Our study provides evidence that the relationships between genetic and cultural diversity of old and new inhabitants of North Africa in southern Tunisia follow different patterns. The Berbers seem to have preserved a significant part of their common genomic heritage despite Islamization, Arab cultural influence, and linguistic diversity. Compared to Morocco and Algeria, southern Tunisian Arabs have retained a higher level of Arabian ancestry. Thi…
Evaluating mtDNA patterns of genetic isolation using a re-sampling procedure
The analysis revealed that the use of population genetic statistics combined with re-sampling procedure can help detect signatures of genetic isolation in human populations, even using a single, although highly informative, locus like mtDNA
Reevaluating a Model of Gender-Biased Gene Flow among Sub-Saharan Hunter-Gatherers and Farmers
In a previous study, we proposed a model for genetic admixture between African hunter-gatherers and food producers, in which we integrated demographic and genetic aspects together with ethnographic knowledge (Destro-Bisol et al. 2004b). In that study it was possible to test the model only using genetic information from widely dispersed and genetically heterogeneous populations. Here we reevaluate the congruence between the model and patterns of g…
Reevaluating a Model of Gender-Biased Gene Flow among Sub-Saharan Hunter-Gatherers and Farmers
In a previous study, we proposed a model for genetic admixture between African hunter-gatherers and food producers, in which we integrated demographic and genetic aspects together with ethnographic knowledge (). In that study it was possible to test the model only using genetic information from widely dispersed and genetically heterogeneous populations. Here we reevaluate the congruence between the model and patterns of genetic variation using an…
African Pygmies, What's Behind a Name
By combining past and current knowledge regarding both evolutionary and cultural aspects, we have shown how the category “Pygmy” can be misleading when used to describe culturally, morphologically and biologically heterogeneous populations. However, when appropriately used, this same term can be successfully considered to address numerous questions of fundamental importance for the understanding of human evolution in Central Africa. Caution invok…
African Pygmies, What’s Behind a Name
African Pygmies, What’s Behind a Name? Paul Verdu and Giovanni Destro-Bisol Keywords African Pygmy, Genetic Diversity, Biological Anthropology, Cultural Anthropology, Pygmy Stature, Linguistics, Evolution, Adaptation, Interdisciplinary Perspectives Numerous populations spread out across Central Africa were named Pygmies by Western explorers, since the 19th century, in reference to the mythical Pygmy population from Homer (“A people of short statu…
Interview with Sarah Tishkoff
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Clinal Variation in the Nuclear DNA of Europeans
Allele frequencies are clinally distributed for many protein polymorphisms in Europe, suggesting that the current populations are derived from an ancestral group that expanded from the Near East. It is not yet fully established whether that expansion took place during the Neolithic or earlier or whether the detectable protein variation faithfully reflects the underlying molecular variation. In this study we address the latter question by describi…
A multi‐perspective view of genetic variation in Cameroon
In this study, we report the genetic variation of autosomal and Y‐chromosomal microsatellites in a large Cameroon population dataset (a total of 11 populations) and jointly analyze novel and previous genetic data (mitochondrial DNA and protein coding loci) taking geographic and cultural factors into consideration. The complex pattern of genetic variation of Cameroon can in part be described by contrasting two geographic areas (corresponding to th…
Tracing the distribution and evolution of lactase persistence in Southern Europe through the study of the T ‐13910 variant
We investigated the occurrence and intra‐allelic variability of the T ‐13910 variant located upstream of the lactase gene in 965 individuals from 20 different locations of Italy and Greece. The T ‐13910 frequency ranges from 0.072 (Sardinia) to 0.237 (North‐East Italy), with a statistically significant difference between North‐East Italians and other Italian populations. The comparison of the lactose tolerance predicted by T ‐13910 and that asses…
Human Microevolution and the Atlantic Slave Trade
Populations derived from the Atlantic slaving process provide unique opportunities for studying key evolutionary determinants of current patterns of human cultural and biological variation. Examination of the genetic patterning of the small plantation island of São Tomé (Gulf of Guinea) using a study design that avoids the use of preconceived ethno-linguistic labels to define genetic sampling units reveals that, despite the fact that maximum dist…
Genetic variation and social structure
Brief communication
The hypervariable region‐1 and four nucleotide positions (10400, 10873, 12308, and 12705) of the coding region of mitochondrial DNA (mtDNA) were analyzed in 441 individuals belonging to eight populations (Daba, Fali, Fulbe, Mandara, Uldeme, Podokwo, Tali, and Tupuri) from North Cameroon and four populations (Bakaka, Bassa, Bamileke, and Ewondo) from South Cameroon. All mtDNAs were assigned to five haplogroups: three sub‐Saharan (L1, L2, and L3), …
Binary and microsatellite polymorphisms of the Y‐chromosome in the Mbenzele Pygmies from the Central African Republic
Binary and microsatellite polymorphisms of the Y‐chromosome in the Mbenzele pygmies from the Central African Republic
This study analyzes the variation of six binary polymorphisms and six microsatellites in the Mbenzele Pygmies from the Central African Republic. Five different haplogroups (B2b, E(xE3a), E3a, P and BR(xB2b,DE,P)) were observed, with frequencies ranging from 0.022 (haplogroup P) to 0.609 (haplogroup E3a). A comparison of haplogroup frequencies indicates a close genetic affinity between the Mbenzele and the Biaka Pygmies, a finding consistent with …
A Study of Y-Chromosome Microsatellite Variation in Sub-Saharan Africa
Seven Y-chromosome microsatellite loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, and DYS393) were analyzed in three populations from sub-Saharan Africa: the Bamileke and Ewondo populations from Cameroon and the Hutu from Rwanda. Complete typing was obtained for 112 individuals, and a total of 53 different haplotypes was observed. The single-locus gene diversity, averaged across populations, ranges from 0.100 for the DYS392 locus to 0.610…
A Back Migration from Asia to Sub-Saharan Africa Is Supported by High-Resolution Analysis of Human Y-Chromosome Haplotypes
Variation at 10 protein coding loci in the mbenzele pygmies from the central african republic and a comparison with microsatellite data
Ten protein coding loci (6-PGD, A1-AT, ACP1, CaII, ESD, GC, GPX1, Hb beta, PGM1, and TF) were analyzed in the Mbenzele Pygmies from the Central African Republic. The frequency data were used to calculate the genetic distances between Mbenzele Pygmies and other African groups. In the principal coordinate plot of FST genetic distances, the Mbenzele cluster together with other Pygmies of the western cluster, the Biaka from C.A.R., Gielli from Camero…
Biological and cultural contradictions? A reply to MacEachern
In his comment appearing in this issue of the AmericanJournal of Physical Anthropology, MacEachern(2001) questions some conclusions drawn in our longtermsurvey of genetic variation in Cameroon (Spediniet al., 1999). In our reply, we would like toclarify certain points so as to put AJPA readers in aposition whereby they understand both viewpoints
Genetic variation at the ApoB 3? HVR minisatellite locus in the Mbenzele Pygmies from the Central African Republic
This study analyzes the polymorphic minisatellite ApoB 3' HVR in the Mbenzele Pygmies from the Central African Republic. A total of 14 alleles was observed, with frequencies ranging from 0.020 (19, 21, 27, and 45 repeat unit alleles) to 0.210 (37 repeat unit allele). Departure from Hardy-Weinberg equilibrium was not statistically significant. The estimated heterozygosity was 0.874 +/- 0.016. Taking data from the literature into consideration, the…
Microsatellite variation in Central Africa
As a part of a research project on molecular variation in Central Africa, we have analyzed 10 microsatellites (CD4, CSFO, D3S1358, D18S51, D21S11, F13A1, FES, TH01, TPOX, and VWA) in the Bamileke and Ewondo from Cameroon and the Sanga and Mbenzele Pygmies from the Central African Republic (a total of 390 chromosomes). A statistically significant trend towards heterozygote deficiency was detected in the Mbenzele Pygmies. This was established throu…
The peopling of Sub-Saharan Africa
This study analyzes the distribution of ten protein genetic polymorphisms in eighteen populations from the most densely inhabited areas of Cameroon. The languages spoken belong to three different linguistic families [Afro-Asiatic (AA), Nilo-Saharan (NS) and Niger-Kordofanian (NK)]. The analysis of variation of allele frequencies indicates that the level of genetic interpopulation differentiation is rather low (F(st) = 0.011 +/- 0.006) but statist…
The peopling of Sub-Saharan Africa
Brief communication
The hypervariable region‐1 and four nucleotide positions (10400, 10873, 12308, and 12705) of the coding region of mitochondrial DNA (mtDNA) were analyzed in 441 individuals belonging to eight populations (Daba, Fali, Fulbe, Mandara, Uldeme, Podokwo, Tali, and Tupuri) from North Cameroon and four populations (Bakaka, Bassa, Bamileke, and Ewondo) from South Cameroon. All mtDNAs were assigned to five haplogroups: three sub‐Saharan (L1, L2, and L3), …
Human Microevolution and the Atlantic Slave Trade
Populations derived from the Atlantic slaving process provide unique opportunities for studying key evolutionary determinants of current patterns of human cultural and biological variation. Examination of the genetic patterning of the small plantation island of São Tomé (Gulf of Guinea) using a study design that avoids the use of preconceived ethno-linguistic labels to define genetic sampling units reveals that, despite the fact that maximum dist…
A Study of Y-Chromosome Microsatellite Variation in Sub-Saharan Africa
Seven Y-chromosome microsatellite loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, and DYS393) were analyzed in three populations from sub-Saharan Africa: the Bamileke and Ewondo populations from Cameroon and the Hutu from Rwanda. Complete typing was obtained for 112 individuals, and a total of 53 different haplotypes was observed. The single-locus gene diversity, averaged across populations, ranges from 0.100 for the DYS392 locus to 0.610…
African Pygmies, What's Behind a Name
By combining past and current knowledge regarding both evolutionary and cultural aspects, we have shown how the category “Pygmy” can be misleading when used to describe culturally, morphologically and biologically heterogeneous populations. However, when appropriately used, this same term can be successfully considered to address numerous questions of fundamental importance for the understanding of human evolution in Central Africa. Caution invok…
Biological and cultural contradictions? A reply to MacEachern
In his comment appearing in this issue of the AmericanJournal of Physical Anthropology, MacEachern(2001) questions some conclusions drawn in our longtermsurvey of genetic variation in Cameroon (Spediniet al., 1999). In our reply, we would like toclarify certain points so as to put AJPA readers in aposition whereby they understand both viewpoints
Retracted
Our study provides evidence that the relationships between genetic and cultural diversity of old and new inhabitants of North Africa in southern Tunisia follow different patterns. The Berbers seem to have preserved a significant part of their common genomic heritage despite Islamization, Arab cultural influence, and linguistic diversity. Compared to Morocco and Algeria, southern Tunisian Arabs have retained a higher level of Arabian ancestry. Thi…
A multi‐perspective view of genetic variation in Cameroon
In this study, we report the genetic variation of autosomal and Y‐chromosomal microsatellites in a large Cameroon population dataset (a total of 11 populations) and jointly analyze novel and previous genetic data (mitochondrial DNA and protein coding loci) taking geographic and cultural factors into consideration. The complex pattern of genetic variation of Cameroon can in part be described by contrasting two geographic areas (corresponding to th…
A bio-anthropological study on the Bakakas of Cameroon
Bakakas are native Bantus belonging to the Mbo-Bakossi group, peopling the Cameroon's Littoral region. In the context of a wide bio-anthropological study project focused on the bio-historical processes involved in the areas, 278 adults of both sexes from the villages of Ebone and Bakwat (Bakaka Canton) were investigated for 14 erythrocyte and serum genetic polymorphisms (ACP1, ADA, EsD, GLO, Hb beta, GPX1, CAII, PGM1, SAHH, 6-PGD, Hp, Pi, Gc and …
Biocultural Diversity in Italy
As an initial step in more extensive research into the links between biological and cultural diversity in present-day Italy, we reviewed Biocultural Diversity studies that explore the relationship between biological and cultural patterns of diversity to determine whether any direct causal relationships or common drivers could be inferred. We found no significant attempts to quantitatively measure biocultural diversity in the country as a whole. I…
Genetic variation and social structure
A seven year anthropobiological survey on the distribution of abnormal hemoglobins in Cameroon
Within the frame of an anthropobiological survey on some populations of Cameroon (1985-1991), Hb beta data were collected from numerous ethnic groups including Bakaka, Bamileke, Daba, Fali, Guiziga, Kanuri, Mada, Mafa, Mundang, Uldeme, Podokwo, Tali, Tupuri, Fulbe, Mandara, Ewondo and Bassa. Hb beta *S allele frequencies ranged from 0.008 +/- 0.003 (among Fali) to 0.152 +/- 0.020 (among Mandara) and 0.152 +/- 0.044 (among Podokwo), whereas Hb bet…
Anthropological survey on some populations of the congo. I. Subtyping of phosphoglucomutase (PGM1) polymorphism
Further data on the distribution of PGM1 and Caii polymorphisms among the Subsaharan populations (Central African Republic and Benin)
PGM1 and CAII polymorphisms were studied in four population samples of the Central African Republic (Mbugu and Sango) and of Benin (Goun and Nago). The results are compared with those reported on other African populations.
The esterase D polymorphism by ultrathin layer isoelectric-focusing
The distribution of EsD phenotypes in the population of Rome was investigated by cellulose-acetate electrophoresis and isoelectric-focusing. The gene frequencies were found to be: EsD1 = 0.8451, EsD2 = 0.1363, EsD5 = 0.0186. These frequencies were compared with those reported in other populations.
Anthropological survey on red cell glutathione peroxidase (GPX1) polymorphism in Central Western Africa
Phenotype and allele frequencies for erythrocyte glutathione peroxidase (GPX1) polymorphism are reported in the Mbugu and Sango (Central African Republic), Goun (Benin), and Bamileke (Cameroon) ethnic groups. The GPX1*2 allele frequencies (from 0.012 in the Sango to 0.058 in the Bamileke) fit into the range of the data already known for the Subsaharan populations. The value of GPX1*2 for study of the genetic admixture between Negro and Pygmy popu…
A bio-anthropological study on the Bakakas of Cameroon
Bakakas are native Bantus belonging to the Mbo-Bakossi group, peopling the Cameroon's Littoral region. In the context of a wide bio-anthropological study project focused on the bio-historical processes involved in the areas, 278 adults of both sexes from the villages of Ebone and Bakwat (Bakaka Canton) were investigated for 14 erythrocyte and serum genetic polymorphisms (ACP1, ADA, EsD, GLO, Hb beta, GPX1, CAII, PGM1, SAHH, 6-PGD, Hp, Pi, Gc and …
Migrations, Genetic Variability, and DNA Polymorphisms
This is an overview on the potential of DNA polymorphisms to advance anthropological studies, with a focus on the recostruction of migratory events
Interaction between oxidized hemoglobin and the cell membrane
This paper focuses on the interaction between oxidized hemoglobin and the erythrocyte membrane, and its relevance to some falciparum malaria-linked genetic traits. We first present the experimental evidence which suggests that the interaction between hemoglobin derivatives and membrane proteins is an important cellular mechanism for the erythrocytes carrying HbS, HbE, HbF, α- and β-thalassemia, and G6PD deficiency. Thereafter, we show how the Hb/…
Interaction between oxidized hemoglobin and the cell membrane
A seven year anthropobiological survey on the distribution of abnormal hemoglobins in Cameroon
Within the frame of an anthropobiological survey on some populations of Cameroon (1985-1991), Hb beta data were collected from numerous ethnic groups including Bakaka, Bamileke, Daba, Fali, Guiziga, Kanuri, Mada, Mafa, Mundang, Uldeme, Podokwo, Tali, Tupuri, Fulbe, Mandara, Ewondo and Bassa. Hb beta *S allele frequencies ranged from 0.008 +/- 0.003 (among Fali) to 0.152 +/- 0.020 (among Mandara) and 0.152 +/- 0.044 (among Podokwo), whereas Hb bet…
The peopling of Sub-Saharan Africa
This study analyzes the distribution of ten protein genetic polymorphisms in eighteen populations from the most densely inhabited areas of Cameroon. The languages spoken belong to three different linguistic families [Afro-Asiatic (AA), Nilo-Saharan (NS) and Niger-Kordofanian (NK)]. The analysis of variation of allele frequencies indicates that the level of genetic interpopulation differentiation is rather low (F(st) = 0.011 +/- 0.006) but statist…
The peopling of Sub-Saharan Africa
Resistance to Falciparum malaria in α‐thalassemia, oxidative stress, and hemoglobin oxidation
A recent survey conducted on Vanuatu Island suggests that resistance to Plasmodium falciparum in alpha-thalassemic individuals may have an immunological basis. This study is important since it seems to undermine the current idea that red-cell genetic defects give protection against falciparum malaria by reducing intraerythrocytic growth and development of the parasite. However, the mechanisms underlying these clinical and genetic observations are…
Resistance to Falciparum malaria in α-thalassemia, oxidative stress, and hemoglobin oxidation
A recent survey conducted on Vanuatu Island suggests that resistance to Plasmodium falciparum in α-thalassemic individuals may have an immunological basis. This study is important since it seems to undermine the current idea that red-cell genetic defects give protection against falciparum malaria by reducing intraerythrocytic growth and development of the parasite. However, the mechanisms underlying these clinical and genetic observations are not…
Genetic variation at the ApoB 3? HVR minisatellite locus in the Mbenzele Pygmies from the Central African Republic
This study analyzes the polymorphic minisatellite ApoB 3' HVR in the Mbenzele Pygmies from the Central African Republic. A total of 14 alleles was observed, with frequencies ranging from 0.020 (19, 21, 27, and 45 repeat unit alleles) to 0.210 (37 repeat unit allele). Departure from Hardy-Weinberg equilibrium was not statistically significant. The estimated heterozygosity was 0.874 +/- 0.016. Taking data from the literature into consideration, the…
Microsatellite variation in Central Africa
As a part of a research project on molecular variation in Central Africa, we have analyzed 10 microsatellites (CD4, CSFO, D3S1358, D18S51, D21S11, F13A1, FES, TH01, TPOX, and VWA) in the Bamileke and Ewondo from Cameroon and the Sanga and Mbenzele Pygmies from the Central African Republic (a total of 390 chromosomes). A statistically significant trend towards heterozygote deficiency was detected in the Mbenzele Pygmies. This was established throu…
Variation at 10 protein coding loci in the mbenzele pygmies from the central african republic and a comparison with microsatellite data
Ten protein coding loci (6-PGD, A1-AT, ACP1, CaII, ESD, GC, GPX1, Hb beta, PGM1, and TF) were analyzed in the Mbenzele Pygmies from the Central African Republic. The frequency data were used to calculate the genetic distances between Mbenzele Pygmies and other African groups. In the principal coordinate plot of FST genetic distances, the Mbenzele cluster together with other Pygmies of the western cluster, the Biaka from C.A.R., Gielli from Camero…
Biological and cultural contradictions? A reply to MacEachern
In his comment appearing in this issue of the AmericanJournal of Physical Anthropology, MacEachern(2001) questions some conclusions drawn in our longtermsurvey of genetic variation in Cameroon (Spediniet al., 1999). In our reply, we would like toclarify certain points so as to put AJPA readers in aposition whereby they understand both viewpoints
A Back Migration from Asia to Sub-Saharan Africa Is Supported by High-Resolution Analysis of Human Y-Chromosome Haplotypes
A Study of Y-Chromosome Microsatellite Variation in Sub-Saharan Africa
Seven Y-chromosome microsatellite loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, and DYS393) were analyzed in three populations from sub-Saharan Africa: the Bamileke and Ewondo populations from Cameroon and the Hutu from Rwanda. Complete typing was obtained for 112 individuals, and a total of 53 different haplotypes was observed. The single-locus gene diversity, averaged across populations, ranges from 0.100 for the DYS392 locus to 0.610…
Binary and microsatellite polymorphisms of the Y‐chromosome in the Mbenzele Pygmies from the Central African Republic
Binary and microsatellite polymorphisms of the Y‐chromosome in the Mbenzele pygmies from the Central African Republic
This study analyzes the variation of six binary polymorphisms and six microsatellites in the Mbenzele Pygmies from the Central African Republic. Five different haplogroups (B2b, E(xE3a), E3a, P and BR(xB2b,DE,P)) were observed, with frequencies ranging from 0.022 (haplogroup P) to 0.609 (haplogroup E3a). A comparison of haplogroup frequencies indicates a close genetic affinity between the Mbenzele and the Biaka Pygmies, a finding consistent with …
Genetic variation and social structure
Brief communication
The hypervariable region‐1 and four nucleotide positions (10400, 10873, 12308, and 12705) of the coding region of mitochondrial DNA (mtDNA) were analyzed in 441 individuals belonging to eight populations (Daba, Fali, Fulbe, Mandara, Uldeme, Podokwo, Tali, and Tupuri) from North Cameroon and four populations (Bakaka, Bassa, Bamileke, and Ewondo) from South Cameroon. All mtDNAs were assigned to five haplogroups: three sub‐Saharan (L1, L2, and L3), …
Tracing the distribution and evolution of lactase persistence in Southern Europe through the study of the T ‐13910 variant
We investigated the occurrence and intra‐allelic variability of the T ‐13910 variant located upstream of the lactase gene in 965 individuals from 20 different locations of Italy and Greece. The T ‐13910 frequency ranges from 0.072 (Sardinia) to 0.237 (North‐East Italy), with a statistically significant difference between North‐East Italians and other Italian populations. The comparison of the lactose tolerance predicted by T ‐13910 and that asses…
Human Microevolution and the Atlantic Slave Trade
Populations derived from the Atlantic slaving process provide unique opportunities for studying key evolutionary determinants of current patterns of human cultural and biological variation. Examination of the genetic patterning of the small plantation island of São Tomé (Gulf of Guinea) using a study design that avoids the use of preconceived ethno-linguistic labels to define genetic sampling units reveals that, despite the fact that maximum dist…
Biology (33 obras) · Evolutionary biology (22 obras) · Geography (20 obras) · Sociology (17 obras) · Forensic and Genetic Research (16 obras) · Gene (16 obras) · Population (16 obras) · Demography (15 obras) · Genetics (15 obras) · Genetics (15 obras)