Luís Fernando Tófoli
Datos Biográficos
| ID | 132473 |
|---|---|
| NOMBRE | Luís Fernando Tófoli |
| NOMBRES | Luís Fernando |
| APELLIDO | Tófoli |
| FIRMA | TÓFOLI L F |
| AFILIACIONES | Universidade Estadual de Campinas (UNICAMP) |
| ORCID | 0000-0003-2262-8272 |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 33 |
| TOTAL DE CITAS | 51 |
| TOTAL COMO AUTOR | 33 |
| TOTAL COMO EDITOR | 0 |
| PRIMER AÑO DE PUBLICACIÓN | 2004 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2026 |
| ÍNDICE H | 4 |
Integration of the Psychedelic Experience Among Brazilians
This study examines psychedelic integration among Brazilian users by validating a Brazilian Portuguese version of the Psychedelic Integration Scales (PIS), developed through translation and cultural adaptation to ensure relevance and applicability within the Brazilian sociocultural context. A cross-sectional survey was conducted with 1379 participants recruited online. Confirmatory Factor Analysis supported a unidimensional structure for the Braz…
The Brazilian Version of the Mystical Orientation Scale Revised (Mosr-BR)
Mystical experiences are commonly described in the context of psychedelic use and other forms of expanded states of consciousness. Although the Mystical Orientation Scale Revised (MOSR) has been used in international studies, no Brazilian Portuguese version had been tested to date. This exploratory study aimed to translate, culturally adapt, and examine the psychometric properties of the MOSR for the Brazilian population (MOSR-BR). The process fo…
Integration or commodification? A critical review of individual-centered approaches in psychedelic healing
In this article, we provide a genealogy of the concept of integration and a discussion of the multiplicity of practices it encompasses in the field of psychedelic medicine. Reflecting on our observations of psychedelic integration practices, we make three key observations. The first is that integration services tend to focus on the individual, at the expense of considering how societal factors lead to dis-ease. The second observation is that inte…
Patterns of cannabis use for medical reasons in Brazil
The study revealed heterogeneity among Brazilian medical cannabis patients, identifying distinct typologies with specific needs. Findings highlight how sociodemographic factors shape use patterns and inform ongoing reflections on access and care within a shifting regulatory context
Psychedelics for substance use disorders
INTRODUCTION: Substance use disorders (SUDs) are a prevalent health issue that affects individuals globally. Research is currently being conducted on the potential use of psychedelics as a new approach to treating SUDs. Women have been shown to respond differently than men to SUDs treatments and women-specific approaches have been recommended. This scoping review explores the ways in which studies examining the potential therapeutic effect of psy…
Death Anxiety Among Users and Non-Users of Psychedelics
This study is a survey-type, cross-sectional study conducted in Brazil ( n = 517), with online data collection taking place from April to June 2022. The main objective of this study was to evaluate the death anxiety in users and non-users of psychedelics. To this end, we also assessed the validity and reliability of the Death Anxiety Scale in Brazil. The following instruments were used for data collection: a questionnaire for sociodemographic cha…
Dificuldades no cuidado em saúde para as pessoas que fazem uso problemático de drogas
O estudo teve como objetivo conhecer as dificuldades para o cuidado em saúde de pessoas que fazem uso problemático de drogas, dentro do contexto dos serviços especializados em saúde mental nacionais e internacionais. Trata-se de uma revisão integrativa realizada nas bases de dados PubMed, LILACS, Web of Science, Scopus e Embase, com os descritores: usuários de drogas; serviços de saúde mental; cuidado em saúde. Foram selecionados 18 estudos, send…
Psychoanalysis and psychedelics
Associations Between Ayahuasca Use in Naturalistic Settings and Mental Health and Wellbeing Outcomes
Emerging evidence indicates that ayahuasca consumption may have beneficial mental health effects. This study undertakes the largest analysis to date of associations between naturalistic ayahuasca use and current mental health status via an online cross-sectional survey. The sample included 7,576 participants (average age 41, 47% female) who had consumed ayahuasca in religious, traditional, or non-traditional settings in over 50 countries. Bivaria…
Systematic Review of Psychometric Instruments Used in Research with Psychedelics
Spiritual Well-Being Among Users and Non-Users of Psychedelics
This study evaluated the psychometric properties of the Spiritual Well-Being Scale (SWBS) in a Brazilian sample. We analyzed spiritual well-being, defined as existential well-being (EWB) and religious well-being (RWB), among individuals with varying religious and spiritual experiences, both users and non-users of psychedelics. The online cross-sectional survey was conducted in Brazil, from April to June 2022. The psychometric analyses demonstrate…
Associations between ayahuasca consumption in naturalistic settings and current alcohol and drug use
Adverse effects of ayahuasca
Introduction Ayahuasca is a plant-based decoction native to Amazonia, where it has a long history of use in traditional medicine. Contemporary ritual use of ayahuasca has been expanding throughout the world for mental health purposes, and for spiritual and personal growth. Although researchers have been conducting clinical trials and observational studies reporting medical and psychological benefits, most of these do not report ayahuasca’s immedi…
Competências do nutricionista para a Atenção Primária à Saúde
A Educação Baseada em Competências propõe o uso de um currículo derivado da construção de um perfil de competências, o que se torna norteador para a formação acadêmica de uma determinada profissão. As Diretrizes Curriculares Nacionais (DCN) no Brasil têm apontado para a construção de currículos com foco em competências. Buscando contribuir com esse debate, o objetivo deste estudo foi construir um perfil de competências para os nutricionistas na A…
A sacred plant of neuronal effect
This research qualitatively investigated four treatments for addiction in Brazil that use ibogaine as the main tool in the process. Ibogaine is a substance derived from an African plant, Tabernanthe iboga, traditionally used in its region of origin and which leads to intense sensations during its acute effects and also different experiences of oneself and the surrounding world in the period after its use. It's considered a non-typical psychedelic…
Ceremonial Ayahuasca in Amazonian Retreats—Mental Health and Epigenetic Outcomes From a Six-Month Naturalistic Study
Ayahuasca is a natural psychoactive brew, used in traditional ceremonies in the Amazon basin. Recent research has indicated that ayahuasca is pharmacologically safe and its use may be positively associated with improvements in psychiatric symptoms. The mechanistic effects of ayahuasca are yet to be fully established. In this prospective naturalistic study, 63 self-selected participants took part in ayahuasca ceremonies at a retreat centre in the …
Ayahuasca Lyophilization (Freeze-drying) Protocol with Pre- and Post-procedure Alkaloids Quantification
Ayahuasca is a psychoactive brew from the decoction of different Amazonian plants, traditionally used in several cultures, religions, and rituals. Scientific studies with ayahuasca are rapidly increasing due to its subjective effects and therapeutic potential. Although ayahuasca is traditionally used in its liquid presentation, lyophilized (freeze-dried) ayahuasca is often used in scientific experimentation settings. However, there is no standard…
Chemical Composition of Traditional and Analog Ayahuasca
Traditional ayahuasca can be defined as a brew made from Amazonian vine Banisteriopsis caapi and Amazonian admixture plants. Ayahuasca is used by indigenous groups in Amazonia, as a sacrament in syncretic Brazilian religions, and in healing and spiritual ceremonies internationally. The study aimed to determine concentrations of the main bio- and psychoactive components of ayahuasca used in different locations and traditions. We collected 102 samp…
The ritual use of ayahuasca during treatment of severe physical illnesses
Diseases that threaten life raise existential questions that can be a source of psychological distress. Studies with psychedelics demonstrate therapeutic effects for anxiety and depression associated with life-threatening illnesses. Ayahuasca has been proposed as a possible therapeutic agent in the treatment of psychiatric disorders. Preliminary studies suggest that ayahuasca could promote therapeutic effects for people with physical illnesses. T…
Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression
Background Recent open-label trials show that psychedelics, such as ayahuasca, hold promise as fast-onset antidepressants in treatment-resistant depression. Methods To test the antidepressant effects of ayahuasca, we conducted a parallel-arm, double-blind randomized placebo-controlled trial in 29 patients with treatment-resistant depression. Patients received a single dose of either ayahuasca or placebo. We assessed changes in depression severity…
Política de drogas e Saúde Coletiva
A hegemonia atual das políticas de drogas ilícitas tem implicações à Saúde Coletiva que necessitam ser discutidas de forma aprofundada. Este ensaio procura explorar, à luz das melhores evidências, o impacto das políticas sobre drogas focadas na criminalização do plantio, comércio e consumo de substâncias psicoativas sobre a saúde das populações. O contexto de análise principal será o brasileiro. Os pontos principais abordados por este trabalho in…
Dor lombar e transtornos mentais comuns na Estratégia Saúde da Família
Objetivo: Descrever o perfil sociodemográfico dos pacientes atendidos na Estratégia Saúde da Família de quatro capitais brasileiras (Rio de Janeiro, São Paulo, Porto Alegre e Fortaleza) com dor lombar e investigar a associação entre dor lombar e depressão, ansiedade e somatização. Métodos: Estudo de corte transversal com 1857 pacientes atendidos nos anos de 2009 (setembro a novembro) e 2010 (junho a agosto). Instrumentos: rastreio de somatização …
Assessment of Alcohol and Tobacco Use Disorders Among Religious Users of Ayahuasca
The aims of this study were to assess the impact of ceremonial use of ayahuasca -a psychedelic brew containing N,N-dimethyltryptamine (DMT) and β-carboline -and attendance at União do Vegetal (UDV) meetings on substance abuse; here we report the findings related to alcohol and tobacco use disorder. A total of 1,947 members of UDV 18+ years old were evaluated in terms of years of membership and ceremonial attendance during the previous 12 months. …
A violência urbana é a maior causa de acidente de trabalho fatal no Brasil
OBJETIVO: Este estudo visou quantificar a ocorrência de mortes diretamente associadas à violência urbana dentre os acidentes de trabalho fatais. MÉTODOS: Foram realizadas autópsias verbais com familiares e colegas de trabalho de moradores de Campinas, SP, falecidos por causas externas no ano 2015. Também foram analisados boletins de ocorrência e laudos do Instituto Médio Legal relativos a essas mortes. RESULTADOS: Foram identificados 82 acidentes…
Treating drug dependence with the aid of ibogaine
Substance use disorders are important contributors to the global burden of disease, but current treatments are not associated with high rates of recovery. The lack of approved and effective treatments is acutely problematic for psychostimulants like cocaine and crack cocaine. One promising alternative in the treatment of drug dependence in general and psychostimulants in particular is the use of the psychedelic alkaloid ibogaine combined with psy…
Brazilian multicentre study of common mental disorders in primary care
Mental health problems are common in primary health care, particularly anxiety and depression. This study aims to estimate the prevalence of common mental disorders and their associations with socio-demographic characteristics in primary care in Brazil (Family Health Strategy). It involved a multicenter cross-sectional study with patients from Rio de Janeiro, São Paulo, Fortaleza (Ceará State) and Porto Alegre (Rio Grande do Sul State), assessed …
Apoio matricial em saúde mental na atenção primária à saúde
O desafio da efetivação da integralidade da atenção no Sistema Único de Saúde (SUS) favorece a discussão sobre o apoio matricial (AM) para a Estratégia Saúde da Família (ESF) e evidencia a necessidade de mais estudos sobre o tema. Neste artigo analisa-se criticamente o apoio matricial por meio de publicações em periódicos e documentos do Ministério da Saúde, especialmente aqueles focados no apoio matricial em saúde mental (SM) na atenção primária…
Política de drogas e Saúde Coletiva
A hegemonia atual das políticas de drogas ilícitas tem implicações à Saúde Coletiva que necessitam ser discutidas de forma aprofundada. Este ensaio procura explorar, à luz das melhores evidências, o impacto das políticas sobre drogas focadas na criminalização do plantio, comércio e consumo de substâncias psicoativas sobre a saúde das populações. O contexto de análise principal será o brasileiro. Os pontos principais abordados por este trabalho in…
Treating drug dependence with the aid of ibogaine
Substance use disorders are important contributors to the global burden of disease, but current treatments are not associated with high rates of recovery. The lack of approved and effective treatments is acutely problematic for psychostimulants like cocaine and crack cocaine. One promising alternative in the treatment of drug dependence in general and psychostimulants in particular is the use of the psychedelic alkaloid ibogaine combined with psy…
A phenomenological analysis of the subjective experience elicited by ibogaine in the context of a drug dependence treatment
Objective This report documents the phenomenology of the subjective experiences of 22 patients with substance-related disorders who were involved in a treatment combining cognitive–behavioral therapy and hospital sessions with ibogaine in Brazil. Methods Participants underwent a one-to-one semi-structured interview exploring the subjective effects of ibogaine. We employed interpretative phenomenological analysis to identify relevant phenomenologi…
Investigação categorial e dimensional sobre sintomas físicos e síndromes somatoformes na população geral
BACKGROUND: Somatoform symptoms are frequent and are associated with mental distress in several settings and in the general population. Many of these interactions are not well understood or not understood at all. OBJECTIVE AND METHODS: Based on bibliographical research, to investigate: a) the history of somatization-related illnesses; b) its many categories according to contemporary psychiatric and non-psychiatric concepts (somatoform disorders, …
A família no apoio matricial em saúde mental
Scientific output that addresses family relationships and health has reached new dimensions with the shift of care strategies based on the individual to those based on the family as instigated by the Family Health Program. The objective of this study was to analyze the concepts of family and care practices in the scientific output on matrix support in mental health in primary care available in the Virtual Health Library database from 1998 to 2010…
Family in the matrix support in mental health
Scientific output that addresses family relationships and health has reached new dimensions with the shift of care strategies based on the individual to those based on the family as instigated by the Family Health Program. The objective of this study was to analyze the concepts of family and care practices in the scientific output on matrix support in mental health in primary care available in the Virtual Health Library database from 1998 to 2010…
Apoio matricial em saúde mental na atenção primária à saúde
O desafio da efetivação da integralidade da atenção no Sistema Único de Saúde (SUS) favorece a discussão sobre o apoio matricial (AM) para a Estratégia Saúde da Família (ESF) e evidencia a necessidade de mais estudos sobre o tema. Neste artigo analisa-se criticamente o apoio matricial por meio de publicações em periódicos e documentos do Ministério da Saúde, especialmente aqueles focados no apoio matricial em saúde mental (SM) na atenção primária…
Construção social da aprendizagem em saúde mental e saúde da família
O livro apresenta os múltiplos sentidos relacionados aos temas que envolvem o ensino/aprendizagem em saúde mental no cenário da Estratégia de Saúde da Família e também da formação nas instituições de ensino superior
Brazilian multicentre study of common mental disorders in primary care
Mental health problems are common in primary health care, particularly anxiety and depression. This study aims to estimate the prevalence of common mental disorders and their associations with socio-demographic characteristics in primary care in Brazil (Family Health Strategy). It involved a multicenter cross-sectional study with patients from Rio de Janeiro, São Paulo, Fortaleza (Ceará State) and Porto Alegre (Rio Grande do Sul State), assessed …
Social support network, mental health and quality of life
The objective of this study was to identify the association between emotional distress and social support networks with quality of life in primary care patients. This was a cross-sectional study involving 1,466 patients in the cities of São Paulo and Rio de Janeiro, Brazil, in 2009/2010. The General Health Questionnaire, the Hospital Anxiety and Depression Scale and the brief version of the World Health Organization Quality of Life Instrument wer…
A violência urbana é a maior causa de acidente de trabalho fatal no Brasil
OBJETIVO: Este estudo visou quantificar a ocorrência de mortes diretamente associadas à violência urbana dentre os acidentes de trabalho fatais. MÉTODOS: Foram realizadas autópsias verbais com familiares e colegas de trabalho de moradores de Campinas, SP, falecidos por causas externas no ano 2015. Também foram analisados boletins de ocorrência e laudos do Instituto Médio Legal relativos a essas mortes. RESULTADOS: Foram identificados 82 acidentes…
Treating drug dependence with the aid of ibogaine
Substance use disorders are important contributors to the global burden of disease, but current treatments are not associated with high rates of recovery. The lack of approved and effective treatments is acutely problematic for psychostimulants like cocaine and crack cocaine. One promising alternative in the treatment of drug dependence in general and psychostimulants in particular is the use of the psychedelic alkaloid ibogaine combined with psy…
A phenomenological analysis of the subjective experience elicited by ibogaine in the context of a drug dependence treatment
Objective This report documents the phenomenology of the subjective experiences of 22 patients with substance-related disorders who were involved in a treatment combining cognitive–behavioral therapy and hospital sessions with ibogaine in Brazil. Methods Participants underwent a one-to-one semi-structured interview exploring the subjective effects of ibogaine. We employed interpretative phenomenological analysis to identify relevant phenomenologi…
Dor lombar e transtornos mentais comuns na Estratégia Saúde da Família
Objetivo: Descrever o perfil sociodemográfico dos pacientes atendidos na Estratégia Saúde da Família de quatro capitais brasileiras (Rio de Janeiro, São Paulo, Porto Alegre e Fortaleza) com dor lombar e investigar a associação entre dor lombar e depressão, ansiedade e somatização. Métodos: Estudo de corte transversal com 1857 pacientes atendidos nos anos de 2009 (setembro a novembro) e 2010 (junho a agosto). Instrumentos: rastreio de somatização …
Assessment of Alcohol and Tobacco Use Disorders Among Religious Users of Ayahuasca
The aims of this study were to assess the impact of ceremonial use of ayahuasca -a psychedelic brew containing N,N-dimethyltryptamine (DMT) and β-carboline -and attendance at União do Vegetal (UDV) meetings on substance abuse; here we report the findings related to alcohol and tobacco use disorder. A total of 1,947 members of UDV 18+ years old were evaluated in terms of years of membership and ceremonial attendance during the previous 12 months. …
Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression
Background Recent open-label trials show that psychedelics, such as ayahuasca, hold promise as fast-onset antidepressants in treatment-resistant depression. Methods To test the antidepressant effects of ayahuasca, we conducted a parallel-arm, double-blind randomized placebo-controlled trial in 29 patients with treatment-resistant depression. Patients received a single dose of either ayahuasca or placebo. We assessed changes in depression severity…
Política de drogas e Saúde Coletiva
A hegemonia atual das políticas de drogas ilícitas tem implicações à Saúde Coletiva que necessitam ser discutidas de forma aprofundada. Este ensaio procura explorar, à luz das melhores evidências, o impacto das políticas sobre drogas focadas na criminalização do plantio, comércio e consumo de substâncias psicoativas sobre a saúde das populações. O contexto de análise principal será o brasileiro. Os pontos principais abordados por este trabalho in…
Chemical Composition of Traditional and Analog Ayahuasca
Traditional ayahuasca can be defined as a brew made from Amazonian vine Banisteriopsis caapi and Amazonian admixture plants. Ayahuasca is used by indigenous groups in Amazonia, as a sacrament in syncretic Brazilian religions, and in healing and spiritual ceremonies internationally. The study aimed to determine concentrations of the main bio- and psychoactive components of ayahuasca used in different locations and traditions. We collected 102 samp…
The ritual use of ayahuasca during treatment of severe physical illnesses
Diseases that threaten life raise existential questions that can be a source of psychological distress. Studies with psychedelics demonstrate therapeutic effects for anxiety and depression associated with life-threatening illnesses. Ayahuasca has been proposed as a possible therapeutic agent in the treatment of psychiatric disorders. Preliminary studies suggest that ayahuasca could promote therapeutic effects for people with physical illnesses. T…
Ceremonial Ayahuasca in Amazonian Retreats—Mental Health and Epigenetic Outcomes From a Six-Month Naturalistic Study
Ayahuasca is a natural psychoactive brew, used in traditional ceremonies in the Amazon basin. Recent research has indicated that ayahuasca is pharmacologically safe and its use may be positively associated with improvements in psychiatric symptoms. The mechanistic effects of ayahuasca are yet to be fully established. In this prospective naturalistic study, 63 self-selected participants took part in ayahuasca ceremonies at a retreat centre in the …
Ayahuasca Lyophilization (Freeze-drying) Protocol with Pre- and Post-procedure Alkaloids Quantification
Ayahuasca is a psychoactive brew from the decoction of different Amazonian plants, traditionally used in several cultures, religions, and rituals. Scientific studies with ayahuasca are rapidly increasing due to its subjective effects and therapeutic potential. Although ayahuasca is traditionally used in its liquid presentation, lyophilized (freeze-dried) ayahuasca is often used in scientific experimentation settings. However, there is no standard…
Associations between ayahuasca consumption in naturalistic settings and current alcohol and drug use
Adverse effects of ayahuasca
Introduction Ayahuasca is a plant-based decoction native to Amazonia, where it has a long history of use in traditional medicine. Contemporary ritual use of ayahuasca has been expanding throughout the world for mental health purposes, and for spiritual and personal growth. Although researchers have been conducting clinical trials and observational studies reporting medical and psychological benefits, most of these do not report ayahuasca’s immedi…
Competências do nutricionista para a Atenção Primária à Saúde
A Educação Baseada em Competências propõe o uso de um currículo derivado da construção de um perfil de competências, o que se torna norteador para a formação acadêmica de uma determinada profissão. As Diretrizes Curriculares Nacionais (DCN) no Brasil têm apontado para a construção de currículos com foco em competências. Buscando contribuir com esse debate, o objetivo deste estudo foi construir um perfil de competências para os nutricionistas na A…
A sacred plant of neuronal effect
This research qualitatively investigated four treatments for addiction in Brazil that use ibogaine as the main tool in the process. Ibogaine is a substance derived from an African plant, Tabernanthe iboga, traditionally used in its region of origin and which leads to intense sensations during its acute effects and also different experiences of oneself and the surrounding world in the period after its use. It's considered a non-typical psychedelic…
Systematic Review of Psychometric Instruments Used in Research with Psychedelics
Spiritual Well-Being Among Users and Non-Users of Psychedelics
This study evaluated the psychometric properties of the Spiritual Well-Being Scale (SWBS) in a Brazilian sample. We analyzed spiritual well-being, defined as existential well-being (EWB) and religious well-being (RWB), among individuals with varying religious and spiritual experiences, both users and non-users of psychedelics. The online cross-sectional survey was conducted in Brazil, from April to June 2022. The psychometric analyses demonstrate…
Dificuldades no cuidado em saúde para as pessoas que fazem uso problemático de drogas
O estudo teve como objetivo conhecer as dificuldades para o cuidado em saúde de pessoas que fazem uso problemático de drogas, dentro do contexto dos serviços especializados em saúde mental nacionais e internacionais. Trata-se de uma revisão integrativa realizada nas bases de dados PubMed, LILACS, Web of Science, Scopus e Embase, com os descritores: usuários de drogas; serviços de saúde mental; cuidado em saúde. Foram selecionados 18 estudos, send…
Psychology (22 obras) · Psychedelics and Drug Studies (20 obras) · Medicine (19 obras) · Psychiatry (18 obras) · Ayahuasca (11 obras) · Cannabis and Cannabinoid Research (9 obras) · Clinical Psychology (9 obras) · Mental health (9 obras) · Sociology (7 obras) · Anxiety (6 obras)