John H Krystal
Datos Biográficos
| ID | 1661547 |
|---|---|
| NOMBRE | John H Krystal |
| NOMBRES | John H |
| APELLIDO | Krystal |
| FIRMA | KRYSTAL J H |
| AFILIACIONES | Yale University |
| ORCID | 0000-0001-6952-1726 |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 13 |
| TOTAL DE CITAS | 8 |
| TOTAL COMO AUTOR | 13 |
| TOTAL COMO EDITOR | 0 |
| PRIMER AÑO DE PUBLICACIÓN | 1986 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2025 |
| ÍNDICE H | 1 |
Eulogy
Hello, my name is John Krystal. I am the chair of the Yale Psychiatry Department and I have the sad task of saying goodbye, on behalf of the Department of Psychiatry and Yale University, to a man t
DSM-5 criterion-a-based trauma types in service members and veterans seeking treatment for posttraumatic stress disorder
Because of discrepancies between participant and assessor typologies, clinical researchers should use participants' ratings, and these should trump assessor judgment. Differences in pretreatment behavioral and mental health problems across some participant-endorsed trauma types partially support the validity of the participant ratings. (PsycInfo Database Record (c) 2024 APA, all rights reserved)
Saracatinib Fails to Reduce Alcohol-Seeking and Consumption in Mice and Human Participants
More effective treatments to reduce pathological alcohol drinking are needed. The glutamatergic system and the NMDA receptor (NMDAR), in particular, are implicated in behavioral and molecular consequences of chronic alcohol use, making the NMDAR a promising target for novel pharmacotherapeutics. Ethanol exposure upregulates Fyn, a protein tyrosine kinase that indirectly modulates NMDAR signaling by phosphorylating the NR2B subunit. The Src/Fyn ki…
How mental health care should change as a consequence of the Covid-19 pandemic
Impaired Potentiation of Theta Oscillations During a Visual Cortical Plasticity Paradigm in Individuals With Schizophrenia
Long-term potentiation (LTP) is a form of experience-dependent synaptic plasticity mediated by glutamatergic transmission at N-methyl-D-aspartate receptors (NMDARs). Impaired neuroplasticity has been implicated in the pathophysiology of schizophrenia, possibly due to underlying NMDAR hypofunction. Analogous to the high frequency electrical stimulation used to induce LTP in vitro and in vivo in animal models, repeated high frequency presentation o…
Multivariate genome-wide analysis of education, socioeconomic status and brain phenome
Association between physical exercise and mental health in 1·2 million individuals in the USA between 2011 and 2015
Why are some individuals more resilient than others
Trauma is an inextricable component of the human condition. Most individuals are exposed to one or more traumas during their lifetime, but there is great psychological and neurobiological variability in how people respond to these events. While the majority of individuals are largely psychologically resistant or resilient to the negative consequences of trauma, a significant minority develop chronic, debilitating psychological symptoms that marke…
Real-Time fMRI Neurofeedback with War Veterans with Chronic PTSD
Many patients with post-traumatic stress disorder (PTSD), especially war veterans, do not respond to available treatments. Here, we describe a novel neurofeedback (NF) intervention using real-time functional magnetic resonance imaging for treating and studying PTSD. The intervention involves training participants to control amygdala activity after exposure to personalized trauma scripts. Three combat veterans with chronic PTSD participated in thi…
A quantitative meta-analysis of neurocognitive functioning in posttraumatic stress disorder
Posttraumatic stress disorder (PTSD) is associated with regional alterations in brain structure and function that are hypothesized to contribute to symptoms and cognitive deficits associated with the disorder. We present here the first systematic meta-analysis of neurocognitive outcomes associated with PTSD to examine a broad range of cognitive domains and describe the profile of cognitive deficits, as well as modifying clinical factors and study…
Psychometrically improved, abbreviated versions of three classic measures of impulsivity and self-control.
Self-reported impulsivity confers risk factor for substance abuse. However, the psychometric properties of many self-report impulsivity measures have been questioned, thereby undermining the interpretability of study findings using these measures. To better understand these measurement limitations and to suggest a path to assessing self-reported impulsivity with greater psychometric stability, we conducted a comprehensive psychometric evaluation …
Connectivity, Pharmacology, and Computation
Neuropsychiatric diseases such as schizophrenia and bipolar illness alter the structure and function of distributed neural networks. Functional neuroimaging tools have evolved sufficiently to reliably detect system-level disturbances in neural networks. This review focuses on recent findings in schizophrenia and bipolar illness using resting-state neuroimaging, an advantageous approach for biomarker development given its ease of data collection a…
Assessment of alexithymia in posttraumatic stress disorder and somatic illness
The authors examined ratings on four scales of alexithymia in 45 patients in four groups: Vietnam veterans in inpatient (Inpt-PTSD) or outpatient (Outpt-PTSD) treatment for posttraumatic stress disorder (PTSD), patients on a medical service with somatic illnesses that have been the subject of psychosomatic research (Somatic), and a comparison group of psychiatric inpatients with a diagnosis of affective disorder (Affective). The data suggest a gr…
A quantitative meta-analysis of neurocognitive functioning in posttraumatic stress disorder
Posttraumatic stress disorder (PTSD) is associated with regional alterations in brain structure and function that are hypothesized to contribute to symptoms and cognitive deficits associated with the disorder. We present here the first systematic meta-analysis of neurocognitive outcomes associated with PTSD to examine a broad range of cognitive domains and describe the profile of cognitive deficits, as well as modifying clinical factors and study…
Multivariate genome-wide analysis of education, socioeconomic status and brain phenome
Assessment of alexithymia in posttraumatic stress disorder and somatic illness
The authors examined ratings on four scales of alexithymia in 45 patients in four groups: Vietnam veterans in inpatient (Inpt-PTSD) or outpatient (Outpt-PTSD) treatment for posttraumatic stress disorder (PTSD), patients on a medical service with somatic illnesses that have been the subject of psychosomatic research (Somatic), and a comparison group of psychiatric inpatients with a diagnosis of affective disorder (Affective). The data suggest a gr…
Connectivity, Pharmacology, and Computation
Neuropsychiatric diseases such as schizophrenia and bipolar illness alter the structure and function of distributed neural networks. Functional neuroimaging tools have evolved sufficiently to reliably detect system-level disturbances in neural networks. This review focuses on recent findings in schizophrenia and bipolar illness using resting-state neuroimaging, an advantageous approach for biomarker development given its ease of data collection a…
Psychometrically improved, abbreviated versions of three classic measures of impulsivity and self-control.
Self-reported impulsivity confers risk factor for substance abuse. However, the psychometric properties of many self-report impulsivity measures have been questioned, thereby undermining the interpretability of study findings using these measures. To better understand these measurement limitations and to suggest a path to assessing self-reported impulsivity with greater psychometric stability, we conducted a comprehensive psychometric evaluation …
A quantitative meta-analysis of neurocognitive functioning in posttraumatic stress disorder
Posttraumatic stress disorder (PTSD) is associated with regional alterations in brain structure and function that are hypothesized to contribute to symptoms and cognitive deficits associated with the disorder. We present here the first systematic meta-analysis of neurocognitive outcomes associated with PTSD to examine a broad range of cognitive domains and describe the profile of cognitive deficits, as well as modifying clinical factors and study…
Why are some individuals more resilient than others
Trauma is an inextricable component of the human condition. Most individuals are exposed to one or more traumas during their lifetime, but there is great psychological and neurobiological variability in how people respond to these events. While the majority of individuals are largely psychologically resistant or resilient to the negative consequences of trauma, a significant minority develop chronic, debilitating psychological symptoms that marke…
Real-Time fMRI Neurofeedback with War Veterans with Chronic PTSD
Many patients with post-traumatic stress disorder (PTSD), especially war veterans, do not respond to available treatments. Here, we describe a novel neurofeedback (NF) intervention using real-time functional magnetic resonance imaging for treating and studying PTSD. The intervention involves training participants to control amygdala activity after exposure to personalized trauma scripts. Three combat veterans with chronic PTSD participated in thi…
Association between physical exercise and mental health in 1·2 million individuals in the USA between 2011 and 2015
How mental health care should change as a consequence of the Covid-19 pandemic
Impaired Potentiation of Theta Oscillations During a Visual Cortical Plasticity Paradigm in Individuals With Schizophrenia
Long-term potentiation (LTP) is a form of experience-dependent synaptic plasticity mediated by glutamatergic transmission at N-methyl-D-aspartate receptors (NMDARs). Impaired neuroplasticity has been implicated in the pathophysiology of schizophrenia, possibly due to underlying NMDAR hypofunction. Analogous to the high frequency electrical stimulation used to induce LTP in vitro and in vivo in animal models, repeated high frequency presentation o…
Multivariate genome-wide analysis of education, socioeconomic status and brain phenome
Saracatinib Fails to Reduce Alcohol-Seeking and Consumption in Mice and Human Participants
More effective treatments to reduce pathological alcohol drinking are needed. The glutamatergic system and the NMDA receptor (NMDAR), in particular, are implicated in behavioral and molecular consequences of chronic alcohol use, making the NMDAR a promising target for novel pharmacotherapeutics. Ethanol exposure upregulates Fyn, a protein tyrosine kinase that indirectly modulates NMDAR signaling by phosphorylating the NR2B subunit. The Src/Fyn ki…
DSM-5 criterion-a-based trauma types in service members and veterans seeking treatment for posttraumatic stress disorder
Because of discrepancies between participant and assessor typologies, clinical researchers should use participants' ratings, and these should trump assessor judgment. Differences in pretreatment behavioral and mental health problems across some participant-endorsed trauma types partially support the validity of the participant ratings. (PsycInfo Database Record (c) 2024 APA, all rights reserved)
Eulogy
Hello, my name is John Krystal. I am the chair of the Yale Psychiatry Department and I have the sad task of saying goodbye, on behalf of the Department of Psychiatry and Yale University, to a man t
Psychiatry (10 obras) · Psychology (10 obras) · Medicine (8 obras) · Clinical Psychology (5 obras) · Clinical Psychology (4 obras) · Traumatic Brain Injury Research (4 obras) · Environmental health (3 obras) · Functional Brain Connectivity Studies (3 obras) · Neuroscience (3 obras) · Posttraumatic Stress Disorder Research (3 obras)