Tim D Spector
Datos Biográficos
| ID | 1728232 |
|---|---|
| NOMBRE | Tim D Spector |
| NOMBRES | Tim D |
| APELLIDO | Spector |
| FIRMA | SPECTOR T D |
| AFILIACIONES | King's College London |
| ORCID | 0000-0002-9795-0365 |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 16 |
| TOTAL DE CITAS | 6 |
| TOTAL COMO AUTOR | 16 |
| TOTAL COMO EDITOR | 0 |
| PRIMER AÑO DE PUBLICACIÓN | 1991 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2022 |
| ÍNDICE H | 2 |
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12–16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half th…
Knowledge barriers in a national symptomatic-Covid-19 testing programme
Symptomatic testing programmes are crucial to the COVID-19 pandemic response. We sought to examine United Kingdom (UK) testing rates amongst individuals with test-qualifying symptoms, and factors associated with not testing. We analysed a cohort of untested symptomatic app users (N = 1,237), nested in the Zoe COVID Symptom Study (Zoe, N = 4,394,948); and symptomatic respondents who wanted, but did not have a test (N = 1,956), drawn from a Univers…
Attributes and predictors of long Covid
Real-time tracking of self-reported symptoms to predict potential Covid-19
Risk of Covid-19 among front-line health-care workers and the general community
BACKGROUND: Data for front-line health-care workers and risk of COVID-19 are limited. We sought to assess risk of COVID-19 among front-line health-care workers compared with the general community and the effect of personal protective equipment (PPE) on risk. METHODS: We did a prospective, observational cohort study in the UK and the USA of the general community, including front-line health-care workers, using self-reported data from the COVID Sym…
Genome-wide association study identifies 48 common genetic variants associated with handedness
Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10−8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichmen…
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders
Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. We conducted a meta-analysis of genome-wide association studies (GWAS) of gram/day (g/d) alcohol consumption in UK-Biobank, AlcGen and CHARGE+ consortia accumulating 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 novel, common loci, and investigate…
Does education attenuate the genetic risk of obesity? Evidence from U.K. Twins
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Genome-wide association study identifies 74 loci associated with educational attainment
Genetic studies of body mass index yield new insights for obesity biology
Beyond the gene roundtable discussion
This virtual discussion between biomedical researchers and academics in the literary humanities took place in June–July 2013, through the medium of blog and email. The participants are Tim Spector (Genetic Epidemiology), Karen Temple (Medical Genetics), Angelique Richardson (Literary Studies), Deborah J.G. Mackay (Human Genetics) and Peter Garratt (Literary Studies). The conversation was initiated and convened by Mandy Bloomfield (Literary Studie…
Twins
Epigenetic differences arise during the lifetime of monozygotic twins
Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to disease and a wide range of anthropomorphic features. There are several possible explanations for these observations, but one is the existence of epigenetic differences. To address this issue, we examined the global and locus-specific differences in DN…
Heritability of Adult Body Height
A major component of variation in body height is due to genetic differences, but environmental factors have a substantial contributory effect. In this study we aimed to analyse whether the genetic architecture of body height varies between affluent western societies. We analysed twin data from eight countries comprising 30,111 complete twin pairs by using the univariate genetic model of the Mx statistical package. Body height and zygosity were se…
The potential and limitations of meta-analysis
We are currently wimessing an "epidemic" of meta-analyses and overviews in the scientific literature. This is a relatively new phenomenon and this article addresses some of the important issues raised by their increasing use. In particular the differing applications and limitations of meta- analysis are discussed, with a review of the analytic methods used and the problems and biases encountered
Genome-wide association study identifies 48 common genetic variants associated with handedness
Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10−8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichmen…
Twins
The potential and limitations of meta-analysis
We are currently wimessing an "epidemic" of meta-analyses and overviews in the scientific literature. This is a relatively new phenomenon and this article addresses some of the important issues raised by their increasing use. In particular the differing applications and limitations of meta- analysis are discussed, with a review of the analytic methods used and the problems and biases encountered
The potential and limitations of meta-analysis
We are currently wimessing an "epidemic" of meta-analyses and overviews in the scientific literature. This is a relatively new phenomenon and this article addresses some of the important issues raised by their increasing use. In particular the differing applications and limitations of meta- analysis are discussed, with a review of the analytic methods used and the problems and biases encountered
Heritability of Adult Body Height
A major component of variation in body height is due to genetic differences, but environmental factors have a substantial contributory effect. In this study we aimed to analyse whether the genetic architecture of body height varies between affluent western societies. We analysed twin data from eight countries comprising 30,111 complete twin pairs by using the univariate genetic model of the Mx statistical package. Body height and zygosity were se…
Epigenetic differences arise during the lifetime of monozygotic twins
Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to disease and a wide range of anthropomorphic features. There are several possible explanations for these observations, but one is the existence of epigenetic differences. To address this issue, we examined the global and locus-specific differences in DN…
Twins
Genetic studies of body mass index yield new insights for obesity biology
Beyond the gene roundtable discussion
This virtual discussion between biomedical researchers and academics in the literary humanities took place in June–July 2013, through the medium of blog and email. The participants are Tim Spector (Genetic Epidemiology), Karen Temple (Medical Genetics), Angelique Richardson (Literary Studies), Deborah J.G. Mackay (Human Genetics) and Peter Garratt (Literary Studies). The conversation was initiated and convened by Mandy Bloomfield (Literary Studie…
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Genome-wide association study identifies 74 loci associated with educational attainment
Does education attenuate the genetic risk of obesity? Evidence from U.K. Twins
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders
Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. We conducted a meta-analysis of genome-wide association studies (GWAS) of gram/day (g/d) alcohol consumption in UK-Biobank, AlcGen and CHARGE+ consortia accumulating 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 novel, common loci, and investigate…
Real-time tracking of self-reported symptoms to predict potential Covid-19
Risk of Covid-19 among front-line health-care workers and the general community
BACKGROUND: Data for front-line health-care workers and risk of COVID-19 are limited. We sought to assess risk of COVID-19 among front-line health-care workers compared with the general community and the effect of personal protective equipment (PPE) on risk. METHODS: We did a prospective, observational cohort study in the UK and the USA of the general community, including front-line health-care workers, using self-reported data from the COVID Sym…
Genome-wide association study identifies 48 common genetic variants associated with handedness
Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10−8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichmen…
Attributes and predictors of long Covid
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12–16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half th…
Knowledge barriers in a national symptomatic-Covid-19 testing programme
Symptomatic testing programmes are crucial to the COVID-19 pandemic response. We sought to examine United Kingdom (UK) testing rates amongst individuals with test-qualifying symptoms, and factors associated with not testing. We analysed a cohort of untested symptomatic app users (N = 1,237), nested in the Zoe COVID Symptom Study (Zoe, N = 4,394,948); and symptomatic respondents who wanted, but did not have a test (N = 1,956), drawn from a Univers…
Biology (10 obras) · Genetic Associations and Epidemiology (7 obras) · Medicine (7 obras) · Gene (6 obras) · Genotype (6 obras) · Genetics (5 obras) · Genome-wide association study (5 obras) · Single-nucleotide polymorphism (5 obras) · Birth, Development, and Health (4 obras) · Demography (4 obras)