Tomáš Paus
Datos Biográficos
| ID | 1753207 |
|---|---|
| NOMBRE | Tomáš Paus |
| NOMBRES | Tomáš |
| APELLIDO | Paus |
| FIRMA | PAUS T |
| AFILIACIONES | University of Toronto |
| ORCID | 0000-0003-1495-9338 |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 17 |
| TOTAL DE CITAS | 4 |
| TOTAL COMO AUTOR | 16 |
| TOTAL COMO EDITOR | 1 |
| PRIMER AÑO DE PUBLICACIÓN | 1999 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2024 |
| ÍNDICE H | 1 |
Digital Ethology
An edited collection that looks deeply at how humans transform their environments and how these environments, in turn, shape humans. Countless permutations of physical, built, and social environments surround us in space and time, influencing the air we breathe, how hot or cold we are, how many steps we take, and with whom we interact as we go about our daily lives. Assessing the dynamic processes that play out between humans and the environment …
The genetic architecture of the human hypothalamus and its involvement in neuropsychiatric behaviours and disorders
Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways
BACKGROUND: Specific pathways of intergenerational transmission of behavioral traits remain unclear. Here, we aim to investigate how parental genetics influence offspring cognition, educational attainment, and psychopathology in youth. METHODS: Participants for the discovery sample were 2,189 offspring (aged 6-14 years), 1898 mothers and 1,017 fathers who underwent genotyping, psychiatric, and cognitive assessments. We calculated polygenic scores…
Trajectories of cortical structures associated with stress across adolescence
BACKGROUND: Stress exposure in childhood and adolescence has been linked to reductions in cortical structures and cognitive functioning. However, to date, most of these studies have been cross-sectional, limiting the ability to make long-term inferences, given that most cortical structures continue to develop through adolescence. METHODS: Here, we used a subset of the IMAGEN population cohort sample (N = 502; assessment ages: 14, 19, and 22 years…
Longitudinal Associations between Peer and Family Relationships, Emotional Symptoms, and Regional Brain Volume across Adolescence
The period of adolescence brings with it a dynamic interaction between social context and behaviour, structural brain development, and anxiety and depressive symptoms. The rate of volumetric change in the ventromedial prefrontal cortex (vmPFC) and amygdala have been implicated in socioemotional development in adolescence; typically, there is thinning of grey matter volume (GMV) in the vmPFC and growth in the amygdala during this time. The directi…
Genetic architectures of cerebral ventricles and their overlap with neuropsychiatric traits
The cerebral ventricles are recognized as windows into brain development and disease, yet their genetic architectures, underlying neural mechanisms and utility in maintaining brain health remain elusive. Here we aggregated genetic and neuroimaging data from 61,974 participants (age range, 9 to 98 years) in five cohorts to elucidate the genetic basis of ventricular morphology and examined their overlap with neuropsychiatric traits. Genome-wide ass…
Endocannabinoid Gene × Gene Interaction Association to Alcohol Use Disorder in Two Adolescent Cohorts
Genetic markers of the endocannabinoid system have been linked to a variety of addiction-related behaviors that extend beyond cannabis use. In the current study we investigate the relationship between endocannabinoid (eCB) genetic markers and alcohol use disorder (AUD) in European adolescents (14-18 years old) followed in the IMAGEN study ( n = 2,051) and explore replication in a cohort of North American adolescents from Canadian Saguenay Youth S…
Global urbanicity is associated with brain and behaviour in young people
Urbanicity is a growing environmental challenge for mental health. Here, we investigate correlations of urbanicity with brain structure and function, neuropsychology and mental illness symptoms in young people from China and Europe (total n = 3,867). We developed a remote-sensing satellite measure (UrbanSat) to quantify population density at any point on Earth. UrbanSat estimates of urbanicity were correlated with brain volume, cortical surface a…
Age-Related Changes of Peak Width Skeletonized Mean Diffusivity (PSMD) Across the Adult Lifespan
Parameters of water diffusion in white matter derived from diffusion-weighted imaging (DWI), such as fractional anisotropy (FA), mean, axial, and radial diffusivity (MD, AD, and RD), and more recently, peak width of skeletonized mean diffusivity (PSMD), have been proposed as potential markers of normal and pathological brain ageing. However, their relative evolution over the entire adult lifespan in healthy individuals remains partly unknown duri…
Sex continuum in the brain and body during adolescence and psychological traits
Neurobehavioural characterisation and stratification of reinforcement-related behaviour
Neighborhood greenspace and health in a large urban center
Studies have shown that natural environments can enhance health and here we build upon that work by examining the associations between comprehensive greenspace metrics and health. We focused on a large urban population center (Toronto, Canada) and related the two domains by combining high-resolution satellite imagery and individual tree data from Toronto with questionnaire-based self-reports of general health perception, cardio-metabolic conditio…
Do you see what I see? Sex differences in the discrimination of facial emotions during adolescence
During adolescence social relationships become increasingly important. Establishing and maintaining these relationships requires understanding of emotional stimuli, such as facial emotions. A failure to adequately interpret emotional facial expressions has previously been associated with various mental disorders that emerge during adolescence. The current study examined sex differences in emotional face processing during adolescence. Participants…
Are dietary patterns in childhood associated with IQ at 8 years of age? A population-based cohort study
BACKGROUND: Little is known about the effects of overall diet in childhood and intelligence later in life. METHODS: The current study, based on the Avon Longitudinal Study of Parents and Children, uses data on children's diet reported by parents in food-frequency questionnaires at 3, 4, 7 and 8.5 years of age. Dietary patterns were identified using principal-components analysis and scores computed at each age. IQ was assessed using the Wechsler I…
Why do many psychiatric disorders emerge during adolescence?
Mapping brain maturation and cognitive development during adolescence
Brain development during childhood and adolescence
Are dietary patterns in childhood associated with IQ at 8 years of age? A population-based cohort study
BACKGROUND: Little is known about the effects of overall diet in childhood and intelligence later in life. METHODS: The current study, based on the Avon Longitudinal Study of Parents and Children, uses data on children's diet reported by parents in food-frequency questionnaires at 3, 4, 7 and 8.5 years of age. Dietary patterns were identified using principal-components analysis and scores computed at each age. IQ was assessed using the Wechsler I…
Global urbanicity is associated with brain and behaviour in young people
Urbanicity is a growing environmental challenge for mental health. Here, we investigate correlations of urbanicity with brain structure and function, neuropsychology and mental illness symptoms in young people from China and Europe (total n = 3,867). We developed a remote-sensing satellite measure (UrbanSat) to quantify population density at any point on Earth. UrbanSat estimates of urbanicity were correlated with brain volume, cortical surface a…
Brain development during childhood and adolescence
Mapping brain maturation and cognitive development during adolescence
Why do many psychiatric disorders emerge during adolescence?
Are dietary patterns in childhood associated with IQ at 8 years of age? A population-based cohort study
BACKGROUND: Little is known about the effects of overall diet in childhood and intelligence later in life. METHODS: The current study, based on the Avon Longitudinal Study of Parents and Children, uses data on children's diet reported by parents in food-frequency questionnaires at 3, 4, 7 and 8.5 years of age. Dietary patterns were identified using principal-components analysis and scores computed at each age. IQ was assessed using the Wechsler I…
Do you see what I see? Sex differences in the discrimination of facial emotions during adolescence
During adolescence social relationships become increasingly important. Establishing and maintaining these relationships requires understanding of emotional stimuli, such as facial emotions. A failure to adequately interpret emotional facial expressions has previously been associated with various mental disorders that emerge during adolescence. The current study examined sex differences in emotional face processing during adolescence. Participants…
Neighborhood greenspace and health in a large urban center
Studies have shown that natural environments can enhance health and here we build upon that work by examining the associations between comprehensive greenspace metrics and health. We focused on a large urban population center (Toronto, Canada) and related the two domains by combining high-resolution satellite imagery and individual tree data from Toronto with questionnaire-based self-reports of general health perception, cardio-metabolic conditio…
Age-Related Changes of Peak Width Skeletonized Mean Diffusivity (PSMD) Across the Adult Lifespan
Parameters of water diffusion in white matter derived from diffusion-weighted imaging (DWI), such as fractional anisotropy (FA), mean, axial, and radial diffusivity (MD, AD, and RD), and more recently, peak width of skeletonized mean diffusivity (PSMD), have been proposed as potential markers of normal and pathological brain ageing. However, their relative evolution over the entire adult lifespan in healthy individuals remains partly unknown duri…
Sex continuum in the brain and body during adolescence and psychological traits
Neurobehavioural characterisation and stratification of reinforcement-related behaviour
Endocannabinoid Gene × Gene Interaction Association to Alcohol Use Disorder in Two Adolescent Cohorts
Genetic markers of the endocannabinoid system have been linked to a variety of addiction-related behaviors that extend beyond cannabis use. In the current study we investigate the relationship between endocannabinoid (eCB) genetic markers and alcohol use disorder (AUD) in European adolescents (14-18 years old) followed in the IMAGEN study ( n = 2,051) and explore replication in a cohort of North American adolescents from Canadian Saguenay Youth S…
Global urbanicity is associated with brain and behaviour in young people
Urbanicity is a growing environmental challenge for mental health. Here, we investigate correlations of urbanicity with brain structure and function, neuropsychology and mental illness symptoms in young people from China and Europe (total n = 3,867). We developed a remote-sensing satellite measure (UrbanSat) to quantify population density at any point on Earth. UrbanSat estimates of urbanicity were correlated with brain volume, cortical surface a…
Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways
BACKGROUND: Specific pathways of intergenerational transmission of behavioral traits remain unclear. Here, we aim to investigate how parental genetics influence offspring cognition, educational attainment, and psychopathology in youth. METHODS: Participants for the discovery sample were 2,189 offspring (aged 6-14 years), 1898 mothers and 1,017 fathers who underwent genotyping, psychiatric, and cognitive assessments. We calculated polygenic scores…
Trajectories of cortical structures associated with stress across adolescence
BACKGROUND: Stress exposure in childhood and adolescence has been linked to reductions in cortical structures and cognitive functioning. However, to date, most of these studies have been cross-sectional, limiting the ability to make long-term inferences, given that most cortical structures continue to develop through adolescence. METHODS: Here, we used a subset of the IMAGEN population cohort sample (N = 502; assessment ages: 14, 19, and 22 years…
Longitudinal Associations between Peer and Family Relationships, Emotional Symptoms, and Regional Brain Volume across Adolescence
The period of adolescence brings with it a dynamic interaction between social context and behaviour, structural brain development, and anxiety and depressive symptoms. The rate of volumetric change in the ventromedial prefrontal cortex (vmPFC) and amygdala have been implicated in socioemotional development in adolescence; typically, there is thinning of grey matter volume (GMV) in the vmPFC and growth in the amygdala during this time. The directi…
Genetic architectures of cerebral ventricles and their overlap with neuropsychiatric traits
The cerebral ventricles are recognized as windows into brain development and disease, yet their genetic architectures, underlying neural mechanisms and utility in maintaining brain health remain elusive. Here we aggregated genetic and neuroimaging data from 61,974 participants (age range, 9 to 98 years) in five cohorts to elucidate the genetic basis of ventricular morphology and examined their overlap with neuropsychiatric traits. Genome-wide ass…
Digital Ethology
An edited collection that looks deeply at how humans transform their environments and how these environments, in turn, shape humans. Countless permutations of physical, built, and social environments surround us in space and time, influencing the air we breathe, how hot or cold we are, how many steps we take, and with whom we interact as we go about our daily lives. Assessing the dynamic processes that play out between humans and the environment …
The genetic architecture of the human hypothalamus and its involvement in neuropsychiatric behaviours and disorders
Psychology (15 obras) · Medicine (11 obras) · Developmental psychology (8 obras) · Neuroscience (8 obras) · Biology (7 obras) · Cognition (7 obras) · Psychiatry (6 obras) · Brain size (5 obras) · Cohort (5 obras) · Internal Medicine (5 obras)