Laurie J Hannigan
Datos Biográficos
| ID | 1940451 |
|---|---|
| NOMBRE | Laurie J Hannigan |
| NOMBRES | Laurie J |
| APELLIDO | Hannigan |
| FIRMA | HANNIGAN L J |
| AFILIACIONES | Nic Waals Institute Lovisenberg Diaconal Hospital Oslo Norway |
| ORCID | 0000-0003-3123-5411 |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 14 |
| TOTAL DE CITAS | 1 |
| TOTAL COMO AUTOR | 14 |
| TOTAL COMO EDITOR | 0 |
| PRIMER AÑO DE PUBLICACIÓN | 2016 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2026 |
| ÍNDICE H | 1 |
Co‐development of ADHD symptoms and emotional problems from childhood to adulthood
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) symptoms and emotional problems frequently co-occur. Longitudinal data provide opportunities to understand how and why they co-develop. METHODS: Data were drawn from the Twins Early Development Study, which included 27,890 participants. Emotional problems and ADHD symptoms were parent-reported using the Strengths and Difficulties Questionnaire and Conners' Parent Rating scales. We modele…
Navigating early risks
BACKGROUND: It has been proposed that early risk constellations link differentially to later developmental outcomes. However, existing studies often use a limited set of risk indicators, excluding genetic and child-based risks. It is also unclear if the protective effects of potential moderators, such as kindergarten experiences, differ across risk groups. METHODS: Using data from the Norwegian Mother, Father and Child (MoBa) cohort study (n = 7,…
Developmental trajectories of child and adolescent emotional problems
BACKGROUND: Whether emotional problems during childhood and adolescence are longitudinally associated with adult alcohol use behaviors is unclear. This study examined associations between developmental trajectories of emotional problems and early adult alcohol use behaviors, while considering co-occurring conduct problems, developmental change/timing, sex differences, and potential confounds. METHODS: Participants were from the Twins Early Develo…
Childhood trajectories of emotional and behavioral difficulties are related to polygenic liability for mood and anxiety disorders
Background Symptoms related to mood and anxiety disorders (emotional disorders) often present in childhood and adolescence. Some of the genetic liability for mental disorders, and emotional and behavioral difficulties seems to be shared. Yet, it is unclear how genetic liability for emotional disorders and related traits influence trajectories of childhood behavioral and emotional difficulties, and if specific developmental patterns are associated…
Direct and indirect genetic effects on early neurodevelopmental traits
BACKGROUND: Neurodevelopmental conditions are highly heritable. Recent studies have shown that genomic heritability estimates can be confounded by genetic effects mediated via the environment (indirect genetic effects). However, the relative importance of direct versus indirect genetic effects on early variability in traits related to neurodevelopmental conditions is unknown. METHODS: The sample included up to 24,692 parent-offspring trios from t…
Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry
Age at onset of walking is an important early childhood milestone which is used clinically and in public health screening. In this genome-wide association study meta-analysis of age at onset of walking ( N = 70,560 European-ancestry infants), we identified 11 independent genome-wide significant loci. SNP-based heritability was 24.13% (95% confidence intervals = 21.86–26.40) with ~11,900 variants accounting for about 90% of it, suggesting high pol…
Aetiology of shame and its association with adolescent depression and anxiety
BACKGROUND: Shame is considered a maladaptive self-conscious emotion that commonly co-occurs alongside depression and anxiety. Little is known, however, about the aetiology of shame and its associations with depression and anxiety. We estimated, for the first time, genetic and environmental influences on shame and on its associations with depression and anxiety in adolescence. METHODS: = 16.97, SD = 1.64, age range: 14-23). Participants completed…
Early manifestations of genetic risk for neurodevelopmental disorders
BACKGROUND: Attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (autism) and schizophrenia are highly heritable neurodevelopmental disorders, affecting the lives of many individuals. It is important to increase our understanding of how the polygenic risk for neurodevelopmental disorders manifests during childhood in boys and girls. METHODS: Polygenic risk scores (PRS) for ADHD, autism and schizophrenia were calculated in a s…
Parental criticism and adolescent internalising symptoms
BACKGROUND: Parental criticism is correlated with internalising symptoms in adolescent offspring. This correlation could in part reflect their genetic relatedness, if the same genes influence behaviours in both parents and offspring. We use a Children-of-Twins design to assess whether parent-reported criticism and offspring internalising symptoms remain associated after controlling for shared genes. To aid interpretation of our results and those …
Commentary
Neurodevelopmental disorders are widely acknowledged to be complex and multifactorial in origin, but this is rarely reflected in the approaches used to study them. We reflect on the 2021 Annual Research review and its introduction of a new conceptual framework designed to make the complexity of early neurodevelopment more empirically tractable. We evaluate the review authors’ justification, explanation, and guidance for implementation of their fr…
Genetic and environmental contributions to co-occurring ADHD and emotional problems in school-aged children
Children with attention deficit hyperactivity disorder (ADHD) often experience co-occurring emotional problems. ADHD with this comorbidity is associated with poorer outcomes than ADHD without comorbidity. Better understanding of the etiology of comorbidity could improve prevention of negative outcomes for children with ADHD. The sample consisted of 567 twin pairs, 3,632 sibling pairs, and 2,340 cousin pairs from the Norwegian Mother, Father and C…
Reciprocal links between anxiety sensitivity and obsessive–compulsive symptoms in youth
BACKGROUND: Anxiety sensitivity, the tendency to fear the symptoms of anxiety, is a key risk factor for the development anxiety disorders. Although obsessive-compulsive disorder was previously classified as an anxiety disorder, the prospective relationship between anxiety sensitivity and obsessive-compulsive symptoms (OCS) has been largely overlooked. Furthermore, a lack of genetically informative studies means the aetiology of the link between a…
Genetics of co-developing conduct and emotional problems during childhood and adolescence
Etiological Influences on Perceptions of Parenting
Children and their parents often differ in their perception of the relationship they share. As this relationship changes developmentally, the nature of these differences may also change. Longitudinal genetic designs can be used to investigate the developmental etiologies of shared and distinct perceptions. In this study, we used longitudinal psychometric models to analyze child and parent reports of negative parenting for 6417 twin pairs from the…
Etiological Influences on Perceptions of Parenting
Children and their parents often differ in their perception of the relationship they share. As this relationship changes developmentally, the nature of these differences may also change. Longitudinal genetic designs can be used to investigate the developmental etiologies of shared and distinct perceptions. In this study, we used longitudinal psychometric models to analyze child and parent reports of negative parenting for 6417 twin pairs from the…
Etiological Influences on Perceptions of Parenting
Children and their parents often differ in their perception of the relationship they share. As this relationship changes developmentally, the nature of these differences may also change. Longitudinal genetic designs can be used to investigate the developmental etiologies of shared and distinct perceptions. In this study, we used longitudinal psychometric models to analyze child and parent reports of negative parenting for 6417 twin pairs from the…
Genetics of co-developing conduct and emotional problems during childhood and adolescence
Reciprocal links between anxiety sensitivity and obsessive–compulsive symptoms in youth
BACKGROUND: Anxiety sensitivity, the tendency to fear the symptoms of anxiety, is a key risk factor for the development anxiety disorders. Although obsessive-compulsive disorder was previously classified as an anxiety disorder, the prospective relationship between anxiety sensitivity and obsessive-compulsive symptoms (OCS) has been largely overlooked. Furthermore, a lack of genetically informative studies means the aetiology of the link between a…
Commentary
Neurodevelopmental disorders are widely acknowledged to be complex and multifactorial in origin, but this is rarely reflected in the approaches used to study them. We reflect on the 2021 Annual Research review and its introduction of a new conceptual framework designed to make the complexity of early neurodevelopment more empirically tractable. We evaluate the review authors’ justification, explanation, and guidance for implementation of their fr…
Genetic and environmental contributions to co-occurring ADHD and emotional problems in school-aged children
Children with attention deficit hyperactivity disorder (ADHD) often experience co-occurring emotional problems. ADHD with this comorbidity is associated with poorer outcomes than ADHD without comorbidity. Better understanding of the etiology of comorbidity could improve prevention of negative outcomes for children with ADHD. The sample consisted of 567 twin pairs, 3,632 sibling pairs, and 2,340 cousin pairs from the Norwegian Mother, Father and C…
Aetiology of shame and its association with adolescent depression and anxiety
BACKGROUND: Shame is considered a maladaptive self-conscious emotion that commonly co-occurs alongside depression and anxiety. Little is known, however, about the aetiology of shame and its associations with depression and anxiety. We estimated, for the first time, genetic and environmental influences on shame and on its associations with depression and anxiety in adolescence. METHODS: = 16.97, SD = 1.64, age range: 14-23). Participants completed…
Early manifestations of genetic risk for neurodevelopmental disorders
BACKGROUND: Attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (autism) and schizophrenia are highly heritable neurodevelopmental disorders, affecting the lives of many individuals. It is important to increase our understanding of how the polygenic risk for neurodevelopmental disorders manifests during childhood in boys and girls. METHODS: Polygenic risk scores (PRS) for ADHD, autism and schizophrenia were calculated in a s…
Parental criticism and adolescent internalising symptoms
BACKGROUND: Parental criticism is correlated with internalising symptoms in adolescent offspring. This correlation could in part reflect their genetic relatedness, if the same genes influence behaviours in both parents and offspring. We use a Children-of-Twins design to assess whether parent-reported criticism and offspring internalising symptoms remain associated after controlling for shared genes. To aid interpretation of our results and those …
Navigating early risks
BACKGROUND: It has been proposed that early risk constellations link differentially to later developmental outcomes. However, existing studies often use a limited set of risk indicators, excluding genetic and child-based risks. It is also unclear if the protective effects of potential moderators, such as kindergarten experiences, differ across risk groups. METHODS: Using data from the Norwegian Mother, Father and Child (MoBa) cohort study (n = 7,…
Developmental trajectories of child and adolescent emotional problems
BACKGROUND: Whether emotional problems during childhood and adolescence are longitudinally associated with adult alcohol use behaviors is unclear. This study examined associations between developmental trajectories of emotional problems and early adult alcohol use behaviors, while considering co-occurring conduct problems, developmental change/timing, sex differences, and potential confounds. METHODS: Participants were from the Twins Early Develo…
Childhood trajectories of emotional and behavioral difficulties are related to polygenic liability for mood and anxiety disorders
Background Symptoms related to mood and anxiety disorders (emotional disorders) often present in childhood and adolescence. Some of the genetic liability for mental disorders, and emotional and behavioral difficulties seems to be shared. Yet, it is unclear how genetic liability for emotional disorders and related traits influence trajectories of childhood behavioral and emotional difficulties, and if specific developmental patterns are associated…
Direct and indirect genetic effects on early neurodevelopmental traits
BACKGROUND: Neurodevelopmental conditions are highly heritable. Recent studies have shown that genomic heritability estimates can be confounded by genetic effects mediated via the environment (indirect genetic effects). However, the relative importance of direct versus indirect genetic effects on early variability in traits related to neurodevelopmental conditions is unknown. METHODS: The sample included up to 24,692 parent-offspring trios from t…
Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry
Age at onset of walking is an important early childhood milestone which is used clinically and in public health screening. In this genome-wide association study meta-analysis of age at onset of walking ( N = 70,560 European-ancestry infants), we identified 11 independent genome-wide significant loci. SNP-based heritability was 24.13% (95% confidence intervals = 21.86–26.40) with ~11,900 variants accounting for about 90% of it, suggesting high pol…
Co‐development of ADHD symptoms and emotional problems from childhood to adulthood
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) symptoms and emotional problems frequently co-occur. Longitudinal data provide opportunities to understand how and why they co-develop. METHODS: Data were drawn from the Twins Early Development Study, which included 27,890 participants. Emotional problems and ADHD symptoms were parent-reported using the Strengths and Difficulties Questionnaire and Conners' Parent Rating scales. We modele…
Psychology (12 obras) · Developmental psychology (10 obras) · Clinical Psychology (8 obras) · Child and Adolescent Psychosocial and Emotional Development (7 obras) · Psychiatry (7 obras) · Heritability (5 obras) · Medicine (5 obras) · Twin study (5 obras) · Anxiety (4 obras) · Cognitive Abilities and Testing (4 obras)